ATE312172T1 - Immunschützendes influenzaantigen und dessen verwendung zur impfung - Google Patents
Immunschützendes influenzaantigen und dessen verwendung zur impfungInfo
- Publication number
- ATE312172T1 ATE312172T1 AT98946321T AT98946321T ATE312172T1 AT E312172 T1 ATE312172 T1 AT E312172T1 AT 98946321 T AT98946321 T AT 98946321T AT 98946321 T AT98946321 T AT 98946321T AT E312172 T1 ATE312172 T1 AT E312172T1
- Authority
- AT
- Austria
- Prior art keywords
- antigen
- influency
- immunoprotective
- vaccination
- influenza
- Prior art date
Links
- 239000000427 antigen Substances 0.000 title abstract 6
- 102000036639 antigens Human genes 0.000 title abstract 6
- 108091007433 antigens Proteins 0.000 title abstract 6
- 230000002480 immunoprotective effect Effects 0.000 title 1
- 238000002255 vaccination Methods 0.000 title 1
- 206010022000 influenza Diseases 0.000 abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 108010052285 Membrane Proteins Proteins 0.000 abstract 1
- 102000018697 Membrane Proteins Human genes 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 230000004927 fusion Effects 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 229920001059 synthetic polymer Polymers 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/472—Complement proteins, e.g. anaphylatoxin, C3a, C5a
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2730/00—Reverse transcribing DNA viruses
- C12N2730/00011—Details
- C12N2730/10011—Hepadnaviridae
- C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
- C12N2730/10122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Virology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Zoology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Toxicology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Pulmonology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP97202434 | 1997-08-05 | ||
| PCT/EP1998/005106 WO1999007839A2 (en) | 1997-08-05 | 1998-08-05 | Immunoprotective influenza antigen and its use in vaccination |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE312172T1 true ATE312172T1 (de) | 2005-12-15 |
Family
ID=8228624
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98946321T ATE312172T1 (de) | 1997-08-05 | 1998-08-05 | Immunschützendes influenzaantigen und dessen verwendung zur impfung |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US7732130B2 (de) |
| EP (1) | EP0996717B1 (de) |
| JP (2) | JP5132851B2 (de) |
| AT (1) | ATE312172T1 (de) |
| AU (1) | AU745951B2 (de) |
| CA (1) | CA2297786C (de) |
| DE (1) | DE69832706T2 (de) |
| DK (1) | DK0996717T3 (de) |
| ES (1) | ES2255181T3 (de) |
| WO (1) | WO1999007839A2 (de) |
Families Citing this family (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69832706T2 (de) | 1997-08-05 | 2006-08-10 | Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw. | Immunschützendes influenzaantigen und dessen verwendung zur impfung |
| US7731972B1 (en) | 2000-02-04 | 2010-06-08 | Vlaams Interuniversitair Instituut Voor Biotechnologie | Immunoprotective influenza antigen and its use in vaccination |
| CN1193791C (zh) | 1998-11-30 | 2005-03-23 | 希托斯生物技术股份公司 | 抗原的有序分子呈递,制备及使用的方法 |
| GB0008582D0 (en) * | 2000-04-08 | 2000-05-31 | Adprotech Plc | DNA immunization vectors |
| EP1276852B1 (de) * | 2000-04-14 | 2010-11-17 | Wisconsin Alumni Research Foundation | Mutiertes ionenkanalprotein enthaltende viren |
| EP1282640A2 (de) * | 2000-05-01 | 2003-02-12 | Powderject Vaccines, Inc. | Impfung durch nukleinsäure |
| WO2001085208A2 (en) | 2000-05-05 | 2001-11-15 | Cytos Biotechnology Ag | Molecular antigen arrays and vaccines |
| GB0025229D0 (en) * | 2000-10-14 | 2000-11-29 | Adprotech Ltd | Veterinary immunisation vectors |
| US7320793B2 (en) * | 2001-01-19 | 2008-01-22 | Cytos Biotechnology Ag | Molecular antigen array |
| US7094409B2 (en) | 2001-01-19 | 2006-08-22 | Cytos Biotechnology Ag | Antigen arrays for treatment of allergic eosinophilic diseases |
| US7128911B2 (en) | 2001-01-19 | 2006-10-31 | Cytos Biotechnology Ag | Antigen arrays for treatment of bone disease |
| US7361352B2 (en) | 2001-08-15 | 2008-04-22 | Acambis, Inc. | Influenza immunogen and vaccine |
| DE60234375D1 (de) | 2001-09-14 | 2009-12-24 | Cytos Biotechnology Ag | VERPACKUNG VON IMMUNSTIMULIERENDEM CpG IN VIRUSÄHNLICHEN PARTIKELN: HERSTELLUNGSVERFAHREN UND VERWENDUNG |
| US7115266B2 (en) | 2001-10-05 | 2006-10-03 | Cytos Biotechnology Ag | Angiotensin peptide-carrier conjugates and uses thereof |
| US7351413B2 (en) | 2002-02-21 | 2008-04-01 | Lorantis, Limited | Stabilized HBc chimer particles as immunogens for chronic hepatitis |
| GB0204154D0 (en) * | 2002-02-22 | 2002-04-10 | Adprotech Ltd | Cat immunisation vectors |
| KR20040111402A (ko) * | 2002-03-13 | 2004-12-31 | 기린 비루 가부시키가이샤 | 인플루엔자 м2 단백질에 대한 인간 모노클로날 항체 및그의 제조 및 사용 방법 |
| AU2003246690B2 (en) | 2002-07-17 | 2010-03-11 | Cytos Biotechnology Ag | Molecular antigen arrays using a virus like particle derived from the AP205 coat protein |
| NZ537003A (en) | 2002-07-18 | 2008-03-28 | Cytos Biotechnology Ag | Hapten-carrier conjugates comprising virus like particles and uses thereof |
| EP1524994B1 (de) | 2002-07-19 | 2011-04-27 | Cytos Biotechnology AG | Impfstoffzusammensetzungen enthaltende amyloid beta 1-6 antigenarrays |
| MXPA05011250A (es) * | 2003-04-23 | 2006-03-30 | Wisconsin Alumni Res Found | Virus recombinantes de la influenza que mantienen una mutacion en un gen de proteina transmembranal. |
| CA2530363C (en) * | 2003-06-23 | 2013-05-07 | Baxter International Inc. | Carrier proteins for vaccines |
| EP1814990A2 (de) | 2004-11-19 | 2007-08-08 | Wisconsin Alumni Research Foundation | Rekombinante influenza-vektoren mit transkriptionseinheiten, die in tandem vorliegen |
| US8124091B2 (en) | 2004-12-06 | 2012-02-28 | Kyowa Hakko Kirin Co., Ltd. | Human monoclonal antibodies to influenza M2 protein and methods of making and using same |
| US20090162400A1 (en) * | 2004-12-21 | 2009-06-25 | Powell Thomas J | Compositions of influenza viral proteins and methods of use thereof |
| CA2628837C (en) * | 2005-11-07 | 2018-11-27 | Sidney Kimmel Cancer Center | Cd40 ligand fusion protein vaccine |
| ES2385842T3 (es) | 2005-12-06 | 2012-08-01 | Yeda Research And Development Co., Ltd. | Vacuna mejorada contra la gripe |
| EP3011969A1 (de) * | 2006-03-07 | 2016-04-27 | Vaxinnate Corporation | Zusammensetzungen mit hämagglutinin, verfahren zur herstellung und verfahren zur verwendung davon |
| JP2009532352A (ja) | 2006-03-31 | 2009-09-10 | ダブリュエーアールエフ−ウィスコンシン アラムナイ リサーチ ファウンデーション | ワクチンのための高力価組み換えインフルエンザ・ウィルス |
| JP2009543554A (ja) | 2006-07-14 | 2009-12-10 | サノフィ パスツール バイオロジクス カンパニー | ベクターウイルスタンパク質への外来免疫決定基の直接トランスポゾン媒介挿入による組換え型ウイルスワクチンの構築 |
| CA2664791A1 (en) | 2006-09-29 | 2008-08-21 | Sanofi Pasteur Biologics Co. | Recombinant rhinovirus vectors |
| CA2669485C (en) * | 2006-11-15 | 2017-01-03 | Folia Biotech Inc. | Papaya mosaic virus-based vaccines for influenza |
| US9474798B2 (en) | 2007-06-18 | 2016-10-25 | Wisconsin Alumni Research Foundation | Influenza M2 protein mutant viruses as live influenza attenuated vaccines |
| MX2010001284A (es) | 2007-08-02 | 2010-08-31 | Biondvax Pharmaceuticals Ltd | Vacunas contra la influenza con multiepitope multimerico. |
| EP2217064A4 (de) * | 2007-11-12 | 2012-10-03 | Univ Pennsylvania | Neue impfstoffe gegen mehrere subtypen des influenzavirus |
| WO2009128952A2 (en) | 2008-04-18 | 2009-10-22 | Vaxinnate Corporation | Compositions of papillomavirus proteins and methods of use |
| WO2010012069A1 (en) * | 2008-07-30 | 2010-02-04 | Folio Biotech Inc. | Multivalent vaccines based on papaya mosaic virus and uses thereof |
| EP2168987A1 (de) * | 2008-09-22 | 2010-03-31 | Mucosis B.V. | Multifunktionelles Linker-Protein enthaltend einen anti-Hämagglutinin-Antikörper, ein konserviertes Influenza-Antigen und eine immunostimulierende Träger-Bindungsdomäne |
| RU2012107702A (ru) | 2009-07-31 | 2013-09-10 | Пэксвэкс, Инк. | Векторы на основе аденовирусов |
| EP2471915B1 (de) | 2009-08-28 | 2018-05-23 | The Chemo-Sero-Therapeutic Research Institute | Aus influenza-m2 gewonnener modifizierter peptidimpfstoff |
| WO2011046925A1 (en) * | 2009-10-12 | 2011-04-21 | Technovax, Inc. | Respiratory syncytial virus (rsv) virus-like particles (vlps) |
| ES2813347T3 (es) | 2009-10-26 | 2021-03-23 | Wisconsin Alumni Res Found | Virus recombinantes de la influenza de alto título con replicación mejorada en células Vero |
| WO2011054995A2 (es) | 2009-11-06 | 2011-05-12 | Chimera Pharma, S. L. U. | VACUNAS PROFILACTICAS DE GRIPE A PARTIR DE CAPSIDAS VIRALES DE BIRNAVIRUS CONTENIENDO EL ANTIGENO M2e DEL VIRUS DE LA GRIPE |
| US10130697B2 (en) | 2010-03-23 | 2018-11-20 | Wisconsin Alumni Research Foundation (Warf) | Vaccines comprising mutant attenuated influenza viruses |
| AU2011360572B2 (en) | 2011-02-22 | 2017-03-02 | Biondvax Pharmaceuticals Ltd. | Multimeric multiepitope polypeptides in improved seasonal and pandemic influenza vaccines |
| ES2655051T3 (es) | 2011-08-26 | 2018-02-16 | Wisconsin Alumni Research Foundation | Virus de la gripe con segmento génico PB2 mutante como vacunas vivas atenuadas |
| US8932598B2 (en) | 2012-08-28 | 2015-01-13 | Vaxinnate Corporation | Fusion proteins and methods of use |
| AU2014290203B2 (en) | 2013-07-15 | 2020-12-24 | Wisconsin Alumni Research Foundation | High titer recombinant influenza viruses with enhanced replication in MDCK or vero cells or eggs |
| US10053671B2 (en) | 2014-06-20 | 2018-08-21 | Wisconsin Alumni Research Foundation (Warf) | Mutations that confer genetic stability to additional genes in influenza viruses |
| US10633422B2 (en) | 2015-06-01 | 2020-04-28 | Wisconsin Alumni Research Foundation (Warf) | Influenza virus replication by inhibiting microRNA lec7C binding to influenza viral cRNA and mRNA |
| EP3103474A1 (de) * | 2015-06-12 | 2016-12-14 | Institut Pasteur | Lebendes rekombinantes masern-m2-virus und dessen verwendung bei auslösung von immunität gegen influenzaviren |
| WO2017007839A1 (en) | 2015-07-06 | 2017-01-12 | Wisconsin Alumni Research Foundation (Warf) | Improved influenza virus replication for vaccine development |
| AU2017221444B2 (en) | 2016-02-19 | 2021-07-29 | Wisconsin Alumni Research Foundation (Warf) | Improved influenza B virus replication for vaccine development |
| US11197926B2 (en) | 2017-10-25 | 2021-12-14 | Wisconsin Alumni Research Foundation (Warf) | Recombinant influenza viruses with stabilized HA for replication in eggs |
| US12343390B2 (en) | 2018-08-07 | 2025-07-01 | Wisconsin Alumni Research Foundation (Warf) | Recombinant biologically contained filovirus vaccine |
| US11389523B2 (en) | 2018-08-20 | 2022-07-19 | Wisconsin Alumni Research Foundation (Warf) | Vectors for eliciting immune responses to non-dominant epitopes in the hemagglutinin (HA) protein |
| EP3914295A2 (de) | 2019-01-23 | 2021-12-01 | Yoshihiro Kawaoka | Mutationen zur verleihung von genetischer stabilität gegenüber zusätzlichen genen bei grippeviren |
| CN113874496A (zh) | 2019-02-08 | 2021-12-31 | 威斯康星校友研究基金会(Warf) | 人源化细胞系 |
| WO2020223699A1 (en) | 2019-05-01 | 2020-11-05 | Wisconsin Alumni Research Foundation (Warf) | Improved influenza virus replication for vaccine development |
| JP7627911B2 (ja) | 2019-08-27 | 2025-02-07 | ウィスコンシン アルムニ リサーチ ファンデイション | 卵内複製のための安定化されたhaを持つ組換えインフルエンザウイルス |
| WO2021150874A1 (en) | 2020-01-24 | 2021-07-29 | Wisconsin Alumni Research Foundation (Warf) | Recombinant influenza viruses with stabilized na |
| WO2021195410A1 (en) | 2020-03-25 | 2021-09-30 | Wisconsin Alumni Research Foundation (Warf) | Recombinant multivalent influenza viruses |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3919044A (en) | 1973-03-28 | 1975-11-11 | Armour Pharma | Processes for concentrating and purifying viruses and viral antigens |
| NZ219516A (en) * | 1987-02-10 | 1991-02-26 | Wellcome Found | Fusion proteins of hbcag (hepatitis b virus core antigen) |
| JPH06508623A (ja) * | 1991-06-19 | 1994-09-29 | エス・アール・アイ・インターナシヨナル | 抗ウィルス剤としてのインフルエンザウィルスのm−蛋白質ペプチド |
| FR2695563B1 (fr) | 1992-09-11 | 1994-12-02 | Pasteur Institut | Microparticules portant des antigènes et leur utilisation pour l'induction de réponses humorales ou cellulaires. |
| CA2161445C (en) * | 1993-04-27 | 2009-06-30 | Anna Efim Ladd | Immunogenic lhrh peptide constructs and synthetic universal immune stimulators for vaccines |
| US5759551A (en) | 1993-04-27 | 1998-06-02 | United Biomedical, Inc. | Immunogenic LHRH peptide constructs and synthetic universal immune stimulators for vaccines |
| EP0712442B1 (de) * | 1993-07-30 | 2002-03-27 | Medeva Holdings B.V. | Rekombinante tetc-fusionsprotein enthaltene impfstoffzusammensetzungen |
| US5691189A (en) * | 1994-01-19 | 1997-11-25 | Bristol-Myers Squibb Company | Saccharomyces cerevisiae expressing M2 protein of influenza A virus |
| GB9424631D0 (en) * | 1994-12-06 | 1995-01-25 | Lynxvale Ltd | Modulating the immune response |
| GB9521568D0 (en) * | 1995-10-20 | 1995-12-20 | Lynxvale Ltd | Delivery of biologically active polypeptides |
| AU736318B2 (en) | 1996-11-26 | 2001-07-26 | Nventa Biopharmaceuticals Corporation | Immune responses using compositions containing stress proteins |
| DE69832706T2 (de) | 1997-08-05 | 2006-08-10 | Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw. | Immunschützendes influenzaantigen und dessen verwendung zur impfung |
| US6169175B1 (en) | 1997-08-06 | 2001-01-02 | Centers For Disease Control And Prevention | Preparation and use of recombinant influenza A virus M2 construct vaccines |
| US20020015951A1 (en) | 2000-01-06 | 2002-02-07 | Bader Joel S. | Method of analyzing a nucleic acid |
-
1998
- 1998-08-05 DE DE69832706T patent/DE69832706T2/de not_active Expired - Lifetime
- 1998-08-05 JP JP2000506324A patent/JP5132851B2/ja not_active Expired - Lifetime
- 1998-08-05 AT AT98946321T patent/ATE312172T1/de active
- 1998-08-05 EP EP98946321A patent/EP0996717B1/de not_active Revoked
- 1998-08-05 ES ES98946321T patent/ES2255181T3/es not_active Expired - Lifetime
- 1998-08-05 WO PCT/EP1998/005106 patent/WO1999007839A2/en not_active Ceased
- 1998-08-05 DK DK98946321T patent/DK0996717T3/da active
- 1998-08-05 AU AU93416/98A patent/AU745951B2/en not_active Expired
- 1998-08-05 CA CA2297786A patent/CA2297786C/en not_active Expired - Lifetime
-
2006
- 2006-03-14 US US11/374,922 patent/US7732130B2/en active Active
-
2009
- 2009-10-16 JP JP2009239092A patent/JP2010059164A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP0996717B1 (de) | 2005-12-07 |
| DK0996717T3 (da) | 2006-04-10 |
| JP2010059164A (ja) | 2010-03-18 |
| JP2001512748A (ja) | 2001-08-28 |
| DE69832706T2 (de) | 2006-08-10 |
| AU745951B2 (en) | 2002-04-11 |
| CA2297786A1 (en) | 1999-02-18 |
| WO1999007839A2 (en) | 1999-02-18 |
| US20060246092A1 (en) | 2006-11-02 |
| EP0996717A2 (de) | 2000-05-03 |
| US7732130B2 (en) | 2010-06-08 |
| JP5132851B2 (ja) | 2013-01-30 |
| CA2297786C (en) | 2011-06-14 |
| AU9341698A (en) | 1999-03-01 |
| WO1999007839A3 (en) | 1999-05-14 |
| DE69832706D1 (de) | 2006-01-12 |
| ES2255181T3 (es) | 2006-06-16 |
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