ATE268353T1 - Verfahren zur herstellung von mit antioxidant gedoptem uhmwpe und daraus hergestelltes implantat - Google Patents

Verfahren zur herstellung von mit antioxidant gedoptem uhmwpe und daraus hergestelltes implantat

Info

Publication number
ATE268353T1
ATE268353T1 AT00909859T AT00909859T ATE268353T1 AT E268353 T1 ATE268353 T1 AT E268353T1 AT 00909859 T AT00909859 T AT 00909859T AT 00909859 T AT00909859 T AT 00909859T AT E268353 T1 ATE268353 T1 AT E268353T1
Authority
AT
Austria
Prior art keywords
antioxidant
produced therefrom
implant produced
uhmwpe doped
producing uhmwpe
Prior art date
Application number
AT00909859T
Other languages
English (en)
Inventor
Lars Lidgren
Peter Bengtsson
Peter Sjoevall
Bengt Wesslen
Original Assignee
Bone Support Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bone Support Ab filed Critical Bone Support Ab
Application granted granted Critical
Publication of ATE268353T1 publication Critical patent/ATE268353T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/20—Compounding polymers with additives, e.g. colouring
    • C08J3/205—Compounding polymers with additives, e.g. colouring in the presence of a continuous liquid phase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/16—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K5/00—Use of organic ingredients
    • C08K5/04—Oxygen-containing compounds
    • C08K5/15—Heterocyclic compounds having oxygen in the ring
    • C08K5/151—Heterocyclic compounds having oxygen in the ring having one oxygen atom in the ring
    • C08K5/1545—Six-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2323/00—Characterised by the use of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Derivatives of such polymers
    • C08J2323/02—Characterised by the use of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Derivatives of such polymers not modified by chemical after treatment
    • C08J2323/04—Homopolymers or copolymers of ethene

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Materials For Medical Uses (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Treatments Of Macromolecular Shaped Articles (AREA)
AT00909859T 1999-02-17 2000-02-17 Verfahren zur herstellung von mit antioxidant gedoptem uhmwpe und daraus hergestelltes implantat ATE268353T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9900519A SE9900519D0 (sv) 1999-02-17 1999-02-17 A method for the preparation of UHMWPE doped with an antioxidant and an implant made thereof
PCT/SE2000/000314 WO2000049079A1 (en) 1999-02-17 2000-02-17 A method for the preparation of uhmwpe doped with an antioxidant and an implant made thereof

Publications (1)

Publication Number Publication Date
ATE268353T1 true ATE268353T1 (de) 2004-06-15

Family

ID=20414490

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00909859T ATE268353T1 (de) 1999-02-17 2000-02-17 Verfahren zur herstellung von mit antioxidant gedoptem uhmwpe und daraus hergestelltes implantat

Country Status (7)

Country Link
US (1) US6448315B1 (de)
EP (1) EP1161489B1 (de)
AT (1) ATE268353T1 (de)
AU (1) AU3203800A (de)
DE (1) DE60011243T2 (de)
SE (1) SE9900519D0 (de)
WO (1) WO2000049079A1 (de)

Families Citing this family (89)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2317905T3 (es) 2000-04-27 2009-05-01 Orthopaedic Hospital Polietilenos resistentes a la oxidacion y resistentes al desgaste para protesis articulares humanas y procedimientos para prepararlos.
US20030208278A1 (en) * 2000-09-29 2003-11-06 Robert Richard Supercritical fluid treatment of irradiated polyethylene
US6894093B2 (en) * 2001-05-10 2005-05-17 George D. Bittner Materials free of endorine disruptive chemicals
WO2003049930A1 (en) * 2001-12-12 2003-06-19 Depuy Products, Inc. Orthopaedic device and method for making same
US7819925B2 (en) * 2002-01-28 2010-10-26 Depuy Products, Inc. Composite prosthetic bearing having a crosslinked articulating surface and method for making the same
AU2003245420A1 (en) * 2002-06-21 2004-01-06 Massachusetts General Hospital Metal back or mesh crosslinking
EP1596755B1 (de) 2003-01-16 2016-10-12 Massachusetts General Hospital Verfahren zur herstellung von oxidationsbeständigem polymermaterial
AT412969B (de) * 2003-05-19 2005-09-26 Klaus Dr Lederer Vernetztes, ultra-hochmolekulares polyethylen (uhmw-pe)
US7214764B2 (en) 2003-06-30 2007-05-08 Depuy Products, Inc. Free radical quench process for irradiated ultrahigh molecular weight polyethylene
AU2005209868B8 (en) * 2004-02-03 2010-06-03 The General Hospital Corporation Dba Massachusetts General Hospital Highly crystalline cross-linked oxidation-resistant polyethylene
AU2005244062B8 (en) 2004-05-11 2010-08-05 Cambridge Polymer Group, Inc. Methods for making oxidation resistant polymeric material
US7344672B2 (en) 2004-10-07 2008-03-18 Biomet Manufacturing Corp. Solid state deformation processing of crosslinked high molecular weight polymeric materials
US7335697B2 (en) * 2004-12-23 2008-02-26 Depuy Products, Inc. Polymer composition comprising cross-linked polyethylene and methods for making the same
WO2006125082A2 (en) * 2005-05-18 2006-11-23 The General Hospital Corporation Dba Massachusetts General Hospital Hydrogels and hydrogel particles
US7803310B2 (en) * 2005-06-14 2010-09-28 Omni Life Science, Inc. Crosslinked polyethylene article
WO2007011708A2 (en) 2005-07-15 2007-01-25 Micell Technologies, Inc. Stent with polymer coating containing amorphous rapamycin
ES2691646T3 (es) * 2005-07-15 2018-11-28 Micell Technologies, Inc. Revestimientos poliméricos que contienen polvo de fármaco de morfología controlada
AU2012203503B2 (en) * 2005-08-18 2014-01-30 Zimmer Gmbh Ultra high molecular weight polyethylene articles and methods of forming ultra high molecular weight polyethylene articles
CA2619502C (en) 2005-08-18 2012-11-20 Zimmer Gmbh Ultra high molecular weight polyethylene articles and methods of forming ultra high molecular weight polyethylene articles
EP2441780A1 (de) 2005-08-22 2012-04-18 The General Hospital Corporation d/b/a Massachusetts General Hospital Hochkristallines Polyethylen
ATE529464T1 (de) * 2005-08-22 2011-11-15 Gen Hospital Corp Dba Massachusetts General Hospital Oxidationsbeständiges homogenisiertes polymermaterial
US8343230B2 (en) * 2005-09-22 2013-01-01 Depuy Products, Inc. Orthopaedic bearing material
US20070077268A1 (en) * 2005-09-30 2007-04-05 Depuy Products, Inc. Hydrophobic carrier modified implants for beneficial agent delivery
US20100068245A1 (en) * 2006-03-15 2010-03-18 Manders Christian D Preparation and storage of stable, biologically active materials
US8425614B2 (en) * 2006-03-20 2013-04-23 Biomet Manufacturing Corp. Modular center pegged glenoid
US7812098B2 (en) 2006-03-31 2010-10-12 Depuy Products, Inc. Bearing material of medical implant having reduced wear rate and method for reducing wear rate
CA2996768C (en) 2006-04-26 2020-12-08 Micell Technologies, Inc. Coatings containing multiple drugs
ES2350708T3 (es) * 2006-08-25 2011-01-26 Depuy Products, Inc. Material de soporte de implante médico.
WO2008042909A2 (en) 2006-10-02 2008-04-10 Micell Technologies Inc. Surgical sutures having increased strength
JP5336382B2 (ja) 2006-10-23 2013-11-06 ミセル テクノロジーズ、インコーポレイテッド コーティングの間に基板を荷電するためのホルダー
CN101711137B (zh) 2007-01-08 2014-10-22 米歇尔技术公司 具有可生物降解层的支架
US11426494B2 (en) 2007-01-08 2022-08-30 MT Acquisition Holdings LLC Stents having biodegradable layers
EP2110002B1 (de) * 2007-01-25 2012-04-25 The General Hospital Corporation Verfahren zur herstellung von oxidationsbeständigem vernetztem polymermaterial
DE102007006086B4 (de) 2007-02-07 2009-12-03 Kisielinski, Kajetan Stefan, Dr. med. Vorrichtung und Verfahren zum Erfassen des Verschleißes eines Implantatwerkstoffes und ein entsprechend hergestelltes Implantat
CA2679274C (en) 2007-03-02 2018-02-20 The General Hospital Corporation Cross-linking of antioxidant-containing polymers
WO2008113388A1 (en) * 2007-03-20 2008-09-25 Plus Orthopedics Ag Oxidation resistant highly-crosslinked uhmwpe
US8664290B2 (en) * 2007-04-10 2014-03-04 Zimmer, Inc. Antioxidant stabilized crosslinked ultra-high molecular weight polyethylene for medical device applications
AU2014274546B2 (en) * 2007-04-10 2016-06-02 Zimmer, Inc. An antioxidant stabilized crosslinked ultra-high molecular weight polyethylene for medical device applications
ES2662102T3 (es) * 2007-04-10 2018-04-05 Zimmer, Inc. Un polietileno reticulado de peso molecular ultra alto estabilizado con antioxidantes para aplicaciones en dispositivos médicos
CN101815540B (zh) 2007-05-25 2015-08-19 米歇尔技术公司 用于医疗器材涂层的聚合物膜
US8641959B2 (en) 2007-07-27 2014-02-04 Biomet Manufacturing, Llc Antioxidant doping of crosslinked polymers to form non-eluting bearing components
JP6223653B2 (ja) * 2007-09-04 2017-11-01 スミス・アンド・ネフュー・オルソペディクス・アーゲー 関節面用の超高分子量ポリエチレン
CN101888957B (zh) * 2007-10-12 2013-01-02 大元半导体包装产业有限公司 带有交错壁结构的晶圆容器
JP5571580B2 (ja) * 2008-01-30 2014-08-13 ジンマー,インコーポレイティド 低剛性の整形外科部品
CA2721832C (en) 2008-04-17 2018-08-07 Micell Technologies, Inc. Stents having bioabsorbable layers
BRPI0822692A2 (pt) * 2008-05-13 2015-07-07 Smith & Nephew Orthopaedics Ag Uhmwpe altamente reticulado resistente a oxidação
JP5311457B2 (ja) * 2008-06-20 2013-10-09 ナカシマメディカル株式会社 人工関節用摺動部材の成形方法及びこの方法によって成形された人工関節用摺動部材
DE102008047009B4 (de) 2008-07-11 2020-08-06 Mathys Ag Bettlach Gelenkpfanne mit physiologischer Lastübertragung
WO2010009335A1 (en) 2008-07-17 2010-01-21 Micell Technologies, Inc. Drug delivery medical device
US20100022678A1 (en) * 2008-07-24 2010-01-28 Zimmer, Inc. Reduction of free radicals in crosslinked polyethylene by infrared heating
US8133436B2 (en) 2008-08-05 2012-03-13 Howmedica Osteonics Corp. Polyethylene cross-linked with an anthocyanin
DE102008053793A1 (de) 2008-10-21 2010-04-22 Aesculap Ag Antioxidativ wirksames, synthetisches Polymermaterial
US9745462B2 (en) * 2008-11-20 2017-08-29 Zimmer Gmbh Polyethylene materials
US8834913B2 (en) 2008-12-26 2014-09-16 Battelle Memorial Institute Medical implants and methods of making medical implants
WO2010096771A2 (en) 2009-02-20 2010-08-26 The General Hospital Corporation Dba High temperature melting
WO2010117752A1 (en) * 2009-03-31 2010-10-14 Zimmer, Inc. Surface modification of ultrahigh molecular weight polyethylene
CN102481195B (zh) 2009-04-01 2015-03-25 米歇尔技术公司 涂覆支架
EP3366326A1 (de) 2009-04-17 2018-08-29 Micell Technologies, Inc. Stents mit gesteuerter elution
DE102009023651B4 (de) 2009-05-26 2021-07-01 Aesculap Ag Verfahren zur Herstellung eines mit einem Stabilisator dotierten Polyethylens und Verwendung eines nach diesem Verfahren hergestellten Polyethylens
EP2453834A4 (de) 2009-07-16 2014-04-16 Micell Technologies Inc Medizinische wirkstofffreisetzungsvorrichtung
GB0922339D0 (en) 2009-12-21 2010-02-03 Mcminn Derek J W Acetabular cup prothesis and introducer thereof
EP2531140B1 (de) 2010-02-02 2017-11-01 Micell Technologies, Inc. Stent und stenteinsatzsystem mit verbesserter einsetzbarkeit
US8795762B2 (en) 2010-03-26 2014-08-05 Battelle Memorial Institute System and method for enhanced electrostatic deposition and surface coatings
WO2011133655A1 (en) 2010-04-22 2011-10-27 Micell Technologies, Inc. Stents and other devices having extracellular matrix coating
US8399535B2 (en) 2010-06-10 2013-03-19 Zimmer, Inc. Polymer [[s]] compositions including an antioxidant
WO2012009684A2 (en) 2010-07-16 2012-01-19 Micell Technologies, Inc. Drug delivery medical device
US8858979B1 (en) 2011-01-28 2014-10-14 Clemson University Service induced byproducts for localized drug delivery in orthopaedic implants
WO2012166819A1 (en) 2011-05-31 2012-12-06 Micell Technologies, Inc. System and process for formation of a time-released, drug-eluting transferable coating
US20130018476A1 (en) 2011-07-13 2013-01-17 Biomet Manufacturing Corp. Shoulder prosthesis
US8506638B2 (en) 2011-07-13 2013-08-13 Biomets Manufacturing, LLC Shoulder prosthesis
US10117972B2 (en) 2011-07-15 2018-11-06 Micell Technologies, Inc. Drug delivery medical device
US10188772B2 (en) 2011-10-18 2019-01-29 Micell Technologies, Inc. Drug delivery medical device
US9889224B2 (en) * 2012-08-06 2018-02-13 The General Hospital Corporation Spatial control of additives by high temperature
CN110269959A (zh) 2013-03-12 2019-09-24 脉胜医疗技术公司 可生物吸收的生物医学植入物
WO2014186532A1 (en) 2013-05-15 2014-11-20 Micell Technologies, Inc. Bioabsorbable biomedical implants
US9586370B2 (en) 2013-08-15 2017-03-07 Biomet Manufacturing, Llc Method for making ultra high molecular weight polyethylene
EP3052562B1 (de) 2013-10-01 2017-11-08 Zimmer, Inc. Polymerzusammensetzungen, enthaltend ein oder mehrere geschützte antioxidantien
US10220547B2 (en) 2013-10-17 2019-03-05 The General Hospital Corporation Peroxide cross-linking and high temperature melting
EP3116941A1 (de) * 2014-03-12 2017-01-18 Zimmer, Inc. Schmelzstabilisiertes polyethylen mit ultrahohem molekulargewicht und verfahren zu seiner herstellung
US9707314B2 (en) * 2014-03-26 2017-07-18 DePuy Synthes Products, Inc. Acrylic bone cement having a delayed release polymerization inhibitor such as an anti-oxidant for increased working time
CA2969751C (en) 2014-12-03 2020-09-22 Zimmer, Inc. Antioxidant-infused ultra high molecular weight polyethylene
CZ2015267A3 (cs) 2015-04-21 2016-11-09 Ústav makromolekulární chemie AV ČR, v. v. i. Směs pro stabilizaci polyethylenu, polyethylen a způsob jeho přípravy, polyethylenové implantáty
WO2017083476A1 (en) 2015-11-12 2017-05-18 The General Hospital Corporation Methods of making therapeutic polymeric material
EP3411422A1 (de) 2016-02-05 2018-12-12 The General Hospital Corporation Medikamenteneluierendes polymer aus biologisch abbaubaren polymeren zum auftragen auf die oberfläche von medizinprodukten
WO2017181164A1 (en) 2016-04-15 2017-10-19 The General Hospital Corporation Systems and methods of radioprotection of allografts
WO2019046243A2 (en) 2017-08-29 2019-03-07 The General Hospital Corporation UV-INITIATED REACTIONS IN POLYMERIC MATERIALS
CN110448723B (zh) * 2019-07-12 2022-04-05 四川大学 协同抗氧型高交联超高分子量聚乙烯人工关节材料及其制备方法
AU2021200854B2 (en) 2020-03-03 2026-06-25 Howmedica Osteonics Corp. Glenoid implant with additively manufactured fixation posts
US11970600B2 (en) 2021-03-31 2024-04-30 The General Hospital Corporation Di-cumyl peroxide crosslinking of UHMWPE

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CS221404B1 (cs) * 1981-12-23 1983-04-29 Bretislav Dolezel Způsob stabilizace polyolefinů pro dosažení zvýšené odolnosti proti biologické degradaci v organismu
US4439420A (en) 1982-11-16 1984-03-27 Ethicon, Inc. Absorbable hemostatic composition
GB8724897D0 (en) 1987-10-23 1987-11-25 Downes S Material
SE464912B (sv) 1989-10-25 1991-07-01 Bioapatite Ab Implantationsmaterial foer aaterstaellning av benvaevnad samt saett foer dess tillverkning
US5236456A (en) 1989-11-09 1993-08-17 Osteotech, Inc. Osteogenic composition and implant containing same
DE4306593A1 (de) * 1993-03-03 1994-09-08 Hoechst Ag Stabilisierte Formmasse aus Polyethylen, ein Verfahren zur Herstellung und Verwendung
DE4433201A1 (de) 1994-09-17 1996-03-21 Merck Patent Gmbh Verfahren zur Herstellung von wirkstoffhaltigen Knochenzementen
US5844027A (en) 1996-05-03 1998-12-01 Ciba Specialty Chemicals Corporation Stabilizer composition for thermoplastic materials
US5827904A (en) * 1996-09-27 1998-10-27 Hahn; David Medical implant composition
IT1289935B1 (it) 1997-02-20 1998-10-19 Great Lakes Chemical Italia Forma solida di uno stabilizzante per polimeri organici
SE9802528D0 (sv) 1998-07-13 1998-07-13 Gs Dev Ab Bone tissue restoring composition
WO2000007639A1 (en) 1998-08-07 2000-02-17 Tissue Engineering, Inc. Bone precursor compositions
EP0995449A1 (de) 1998-10-21 2000-04-26 Sulzer Orthopädie AG UHMW-Polyethylen für Implantate

Also Published As

Publication number Publication date
EP1161489A1 (de) 2001-12-12
EP1161489B1 (de) 2004-06-02
DE60011243D1 (de) 2004-07-08
SE9900519D0 (sv) 1999-02-17
DE60011243T2 (de) 2005-06-23
WO2000049079A1 (en) 2000-08-24
AU3203800A (en) 2000-09-04
US6448315B1 (en) 2002-09-10

Similar Documents

Publication Publication Date Title
DE60011243D1 (de) Verfahren zur herstellung von mit antioxidant gedoptem uhmwpe und daraus hergestelltes implantat
DE59803468D1 (de) Verfahren zur herstellung von lösungsmittelfreien nicht-kristallinen biologisch aktiven substanzen
DE69435096D1 (de) Zusammensetzung zur in vivo erzeugung von therapeutischen produkten
EP1596755A4 (de) Verfahren zur herstellung von oxidationsbeständigem polymermaterial
DE58906718D1 (de) Kunststeine, verfahren zur herstellung und verwendung derselben.
DE60138804D1 (de) Verfahren zur herstellung von physiologisch aktiven substanzen enthaltenden dispersionen unter anwendung von hochdruck und hochscherkraft
DE69714045D1 (de) Verfahren zur herstellung von tantalpulver mit kontrollierter grössenverteilung sowie damit hergestellte formkörper
DE69010276D1 (de) Methode zur Herstellung von hydrophilem-hydrophobem Copolymer-Pulver.
ATE302229T1 (de) Methoden zur herstellung von im wesentlichen monodispersen polymermischungen mit polyethylenglykoleinheiten
DE59902314D1 (de) Oligomerisiertes Organopolysiloxan-Cokondensat, dessen Herstellung und dessen Verwendung zur Behandlung von Oberflächen
DE59410052D1 (de) Verwendung von nona- und dekapeptiden zur herstellung eines arzneimittels zur bekämpfung von aids
DE69941954D1 (de) Oxetanderivate, oxetancopolymer, und verfahren zur herstellung von oxetanderivaten
ATE180409T1 (de) Kollagenzubereitung zur gesteuerten abgabe von wirkstoffen
DE50014532D1 (de) Verwendung von (+)-tramadol, o-demethyltramadol, o-desmethyl-n-mono-desmethyl-tramadol zur therapie der harninkontinenz
ATE357469T1 (de) Sterilisierende polymere und deren herstellung und verwendung
DE69001573D1 (de) Zusammensetzungen zur herstellung von in dosisformen aktiven vitaminen d3 sowie verfahren zur herstellung stabiler, in dosisformen aktiver vitamine d3 unter deren verwendung.
ATE279900T1 (de) Verwendung von chitosanmikropaseln zur herstellung dekorativer kosmetischer zubereitungen
ATE290003T1 (de) Verfahren zur herstellung von pyrazolo-(4,3- d)pyrimidin-7-ones und zwischenprodukte davon
DE68908223D1 (de) Verfahren zur herstellung von sehr reiner, dichter grossteiliger kieselsaeure.
WO2003020327A3 (en) A cross-linked collagenous biomaterial
DE3778089D1 (de) Verfahren zur herstellung und verwendung fester, pflanzenwirksamer zusammensetzungen.
BG104291A (en) 3-substituted tetrahydropyridopyrimidinone derivatives, method for producing the same, and their use
ATE252112T1 (de) Prozess zur herstellung von aza zyclohexapeptide
DE69626816D1 (de) Verwendung von selegilin zur behandlung von gehörverlust bei säugetieren
DE69930253D1 (de) Verfahren zur polymerherstellung, polymer und härtbare zusammensetzung enthaltend das polymer

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties