ATE268353T1 - Verfahren zur herstellung von mit antioxidant gedoptem uhmwpe und daraus hergestelltes implantat - Google Patents

Verfahren zur herstellung von mit antioxidant gedoptem uhmwpe und daraus hergestelltes implantat

Info

Publication number
ATE268353T1
ATE268353T1 AT00909859T AT00909859T ATE268353T1 AT E268353 T1 ATE268353 T1 AT E268353T1 AT 00909859 T AT00909859 T AT 00909859T AT 00909859 T AT00909859 T AT 00909859T AT E268353 T1 ATE268353 T1 AT E268353T1
Authority
AT
Austria
Prior art keywords
antioxidant
produced therefrom
implant produced
uhmwpe doped
producing uhmwpe
Prior art date
Application number
AT00909859T
Other languages
English (en)
Inventor
Lars Lidgren
Peter Bengtsson
Peter Sjoevall
Bengt Wesslen
Original Assignee
Bone Support Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bone Support Ab filed Critical Bone Support Ab
Application granted granted Critical
Publication of ATE268353T1 publication Critical patent/ATE268353T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/20—Compounding polymers with additives, e.g. colouring
    • C08J3/205—Compounding polymers with additives, e.g. colouring in the presence of a continuous liquid phase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/16—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K5/00—Use of organic ingredients
    • C08K5/04—Oxygen-containing compounds
    • C08K5/15—Heterocyclic compounds having oxygen in the ring
    • C08K5/151—Heterocyclic compounds having oxygen in the ring having one oxygen atom in the ring
    • C08K5/1545—Six-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2323/00—Characterised by the use of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Derivatives of such polymers
    • C08J2323/02—Characterised by the use of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Derivatives of such polymers not modified by chemical after treatment
    • C08J2323/04—Homopolymers or copolymers of ethene

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Transplantation (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dermatology (AREA)
  • Materials For Medical Uses (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Treatments Of Macromolecular Shaped Articles (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
AT00909859T 1999-02-17 2000-02-17 Verfahren zur herstellung von mit antioxidant gedoptem uhmwpe und daraus hergestelltes implantat ATE268353T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9900519A SE9900519D0 (sv) 1999-02-17 1999-02-17 A method for the preparation of UHMWPE doped with an antioxidant and an implant made thereof
PCT/SE2000/000314 WO2000049079A1 (en) 1999-02-17 2000-02-17 A method for the preparation of uhmwpe doped with an antioxidant and an implant made thereof

Publications (1)

Publication Number Publication Date
ATE268353T1 true ATE268353T1 (de) 2004-06-15

Family

ID=20414490

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00909859T ATE268353T1 (de) 1999-02-17 2000-02-17 Verfahren zur herstellung von mit antioxidant gedoptem uhmwpe und daraus hergestelltes implantat

Country Status (7)

Country Link
US (1) US6448315B1 (de)
EP (1) EP1161489B1 (de)
AT (1) ATE268353T1 (de)
AU (1) AU3203800A (de)
DE (1) DE60011243T2 (de)
SE (1) SE9900519D0 (de)
WO (1) WO2000049079A1 (de)

Families Citing this family (89)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE418933T1 (de) * 2000-04-27 2009-01-15 Orthopaedic Hospital Oxidationsbeständige und abriebfeste polyethylene fur menschlichen gelenkersatz und verfahren zu deren herstellung
EP1330347B1 (de) * 2000-09-29 2006-08-16 Depuy Orthopaedics, Inc. Behandlung eines bestrahlten vorformlings eines prothetischen lagerelementes aus polyethylen mit einem überkritischen fluid
US6894093B2 (en) * 2001-05-10 2005-05-17 George D. Bittner Materials free of endorine disruptive chemicals
AU2002364530B2 (en) * 2001-12-12 2008-09-25 Depuy Products, Inc. Orthopaedic device and method for making same
US7819925B2 (en) * 2002-01-28 2010-10-26 Depuy Products, Inc. Composite prosthetic bearing having a crosslinked articulating surface and method for making the same
US20050146070A1 (en) * 2002-06-21 2005-07-07 Massachusetts General Hospital Meta lback or mesh crosslinking
WO2004064618A2 (en) * 2003-01-16 2004-08-05 Massachusetts General Hospital Methods for making oxidation resistant polymeric material
AT412969B (de) 2003-05-19 2005-09-26 Klaus Dr Lederer Vernetztes, ultra-hochmolekulares polyethylen (uhmw-pe)
US7214764B2 (en) * 2003-06-30 2007-05-08 Depuy Products, Inc. Free radical quench process for irradiated ultrahigh molecular weight polyethylene
US8426486B2 (en) * 2004-02-03 2013-04-23 The General Hospital Corporation Highly crystalline cross-linked oxidation-resistant polyethylene
EP1750614B1 (de) 2004-05-11 2017-09-27 The General Hospital Corporation Verfahren zur herstellung von oxidationsbeständigem polymermaterial
US7344672B2 (en) 2004-10-07 2008-03-18 Biomet Manufacturing Corp. Solid state deformation processing of crosslinked high molecular weight polymeric materials
US7335697B2 (en) * 2004-12-23 2008-02-26 Depuy Products, Inc. Polymer composition comprising cross-linked polyethylene and methods for making the same
WO2006125082A2 (en) * 2005-05-18 2006-11-23 The General Hospital Corporation Dba Massachusetts General Hospital Hydrogels and hydrogel particles
US7803310B2 (en) * 2005-06-14 2010-09-28 Omni Life Science, Inc. Crosslinked polyethylene article
WO2007011708A2 (en) 2005-07-15 2007-01-25 Micell Technologies, Inc. Stent with polymer coating containing amorphous rapamycin
WO2007011707A2 (en) 2005-07-15 2007-01-25 Micell Technologies, Inc. Polymer coatings containing drug powder of controlled morphology
ATE449618T1 (de) 2005-08-18 2009-12-15 Zimmer Gmbh Ultrahochmolekulare polyethylen-artikel und verfahren zur herstellung von ultrahochmolekularen polyethylen-artikeln
AU2012203503B2 (en) * 2005-08-18 2014-01-30 Zimmer Gmbh Ultra high molecular weight polyethylene articles and methods of forming ultra high molecular weight polyethylene articles
US8461225B2 (en) 2005-08-22 2013-06-11 The General Hospital Corporation Oxidation resistant homogenized polymeric material
EP1924614A4 (de) 2005-08-22 2009-08-26 Gen Hospital Corp Hochkristallines polyethylen
US8343230B2 (en) * 2005-09-22 2013-01-01 Depuy Products, Inc. Orthopaedic bearing material
US20070077268A1 (en) * 2005-09-30 2007-04-05 Depuy Products, Inc. Hydrophobic carrier modified implants for beneficial agent delivery
WO2007106582A2 (en) * 2006-03-15 2007-09-20 Promethean Lifesciences, Inc. Preparation and storage of stable, biologically active materials
US8425614B2 (en) * 2006-03-20 2013-04-23 Biomet Manufacturing Corp. Modular center pegged glenoid
US7812098B2 (en) 2006-03-31 2010-10-12 Depuy Products, Inc. Bearing material of medical implant having reduced wear rate and method for reducing wear rate
ES2540059T3 (es) 2006-04-26 2015-07-08 Micell Technologies, Inc. Recubrimientos que contienen múltiples fármacos
DE602007009345D1 (de) 2006-08-25 2010-11-04 Depuy Products Inc Material zum Tragen eines medizinischen Implantats
WO2008042909A2 (en) 2006-10-02 2008-04-10 Micell Technologies Inc. Surgical sutures having increased strength
US9539593B2 (en) 2006-10-23 2017-01-10 Micell Technologies, Inc. Holder for electrically charging a substrate during coating
US11426494B2 (en) 2007-01-08 2022-08-30 MT Acquisition Holdings LLC Stents having biodegradable layers
CA2679712C (en) 2007-01-08 2016-11-15 Micell Technologies, Inc. Stents having biodegradable layers
EP2456283B1 (de) 2007-01-25 2015-12-16 The General Hospital Corporation Verfahren zur herstellung von oxidationsbeständigem vernetztem polymermaterial
DE102007006086B4 (de) 2007-02-07 2009-12-03 Kisielinski, Kajetan Stefan, Dr. med. Vorrichtung und Verfahren zum Erfassen des Verschleißes eines Implantatwerkstoffes und ein entsprechend hergestelltes Implantat
AU2008222967B2 (en) 2007-03-02 2012-12-13 Cambridge Polymer Group, Inc. Cross-linking of antioxidant-containing polymers
US20100144930A1 (en) * 2007-03-20 2010-06-10 Smith & Nephew Orthopaedics Ag Oxidation resistant highly-crosslinked uhmwpe
AU2014274546B2 (en) * 2007-04-10 2016-06-02 Zimmer, Inc. An antioxidant stabilized crosslinked ultra-high molecular weight polyethylene for medical device applications
EP2578248B1 (de) * 2007-04-10 2021-05-19 Zimmer, Inc. Antioxidans-stabilisiertes, vernetztes Polyethylen mit ultrahohem Molekulargewicht für Medizingeräteanwendungen
US8664290B2 (en) * 2007-04-10 2014-03-04 Zimmer, Inc. Antioxidant stabilized crosslinked ultra-high molecular weight polyethylene for medical device applications
US9433516B2 (en) 2007-04-17 2016-09-06 Micell Technologies, Inc. Stents having controlled elution
EP2170418B1 (de) 2007-05-25 2016-03-16 Micell Technologies, Inc. Polymerfilme zur beschichtung von medizinprodukten
US8641959B2 (en) 2007-07-27 2014-02-04 Biomet Manufacturing, Llc Antioxidant doping of crosslinked polymers to form non-eluting bearing components
WO2009032909A2 (en) * 2007-09-04 2009-03-12 Smith & Nephew Orthopaedics Ag Ultra high molecular weight polyethylene for bearing surfaces
CN101888957B (zh) * 2007-10-12 2013-01-02 大元半导体包装产业有限公司 带有交错壁结构的晶圆容器
US8652212B2 (en) 2008-01-30 2014-02-18 Zimmer, Inc. Orthopedic component of low stiffness
MX2010011485A (es) 2008-04-17 2011-03-01 Micell Technologies Inc Stents que contienen capas bioadsorbibles.
CA2723929A1 (en) * 2008-05-13 2009-11-19 Smith & Nephew Orthopaedics Ag Oxidation resistant highly-crosslinked uhmwpe
JP5311457B2 (ja) * 2008-06-20 2013-10-09 ナカシマメディカル株式会社 人工関節用摺動部材の成形方法及びこの方法によって成形された人工関節用摺動部材
DE102008047009B4 (de) 2008-07-11 2020-08-06 Mathys Ag Bettlach Gelenkpfanne mit physiologischer Lastübertragung
US9510856B2 (en) 2008-07-17 2016-12-06 Micell Technologies, Inc. Drug delivery medical device
WO2010009335A1 (en) 2008-07-17 2010-01-21 Micell Technologies, Inc. Drug delivery medical device
US20100022678A1 (en) * 2008-07-24 2010-01-28 Zimmer, Inc. Reduction of free radicals in crosslinked polyethylene by infrared heating
US8133436B2 (en) 2008-08-05 2012-03-13 Howmedica Osteonics Corp. Polyethylene cross-linked with an anthocyanin
DE102008053793A1 (de) 2008-10-21 2010-04-22 Aesculap Ag Antioxidativ wirksames, synthetisches Polymermaterial
WO2010057644A1 (en) * 2008-11-20 2010-05-27 Zimmer Gmbh Polyethylene materials
US8834913B2 (en) 2008-12-26 2014-09-16 Battelle Memorial Institute Medical implants and methods of making medical implants
WO2010096771A2 (en) 2009-02-20 2010-08-26 The General Hospital Corporation Dba High temperature melting
WO2010117752A1 (en) * 2009-03-31 2010-10-14 Zimmer, Inc. Surface modification of ultrahigh molecular weight polyethylene
WO2010120552A2 (en) 2009-04-01 2010-10-21 Micell Technologies, Inc. Coated stents
DE102009023651B4 (de) 2009-05-26 2021-07-01 Aesculap Ag Verfahren zur Herstellung eines mit einem Stabilisator dotierten Polyethylens und Verwendung eines nach diesem Verfahren hergestellten Polyethylens
GB0922339D0 (en) 2009-12-21 2010-02-03 Mcminn Derek J W Acetabular cup prothesis and introducer thereof
WO2011097103A1 (en) 2010-02-02 2011-08-11 Micell Technologies, Inc. Stent and stent delivery system with improved deliverability
US8795762B2 (en) 2010-03-26 2014-08-05 Battelle Memorial Institute System and method for enhanced electrostatic deposition and surface coatings
US10232092B2 (en) 2010-04-22 2019-03-19 Micell Technologies, Inc. Stents and other devices having extracellular matrix coating
US8399535B2 (en) 2010-06-10 2013-03-19 Zimmer, Inc. Polymer [[s]] compositions including an antioxidant
EP2593039B1 (de) 2010-07-16 2022-11-30 Micell Technologies, Inc. Medizinische wirkstofffreisetzungsvorrichtung
US8858979B1 (en) 2011-01-28 2014-10-14 Clemson University Service induced byproducts for localized drug delivery in orthopaedic implants
US10464100B2 (en) 2011-05-31 2019-11-05 Micell Technologies, Inc. System and process for formation of a time-released, drug-eluting transferable coating
US20130018476A1 (en) 2011-07-13 2013-01-17 Biomet Manufacturing Corp. Shoulder prosthesis
US8506638B2 (en) 2011-07-13 2013-08-13 Biomets Manufacturing, LLC Shoulder prosthesis
CA2841360A1 (en) 2011-07-15 2013-01-24 Micell Technologies, Inc. Drug delivery medical device
US10188772B2 (en) 2011-10-18 2019-01-29 Micell Technologies, Inc. Drug delivery medical device
WO2014025636A1 (en) * 2012-08-06 2014-02-13 The General Hospital Corporation Spatial control of additives by high temperature
CN105307597A (zh) 2013-03-12 2016-02-03 脉胜医疗技术公司 可生物吸收的生物医学植入物
US10272606B2 (en) 2013-05-15 2019-04-30 Micell Technologies, Inc. Bioabsorbable biomedical implants
US9586370B2 (en) 2013-08-15 2017-03-07 Biomet Manufacturing, Llc Method for making ultra high molecular weight polyethylene
EP3052562B1 (de) 2013-10-01 2017-11-08 Zimmer, Inc. Polymerzusammensetzungen, enthaltend ein oder mehrere geschützte antioxidantien
CA2927056A1 (en) * 2013-10-17 2015-04-23 The General Hospital Corporation Peroxide cross-linking and high temperature melting
US10184031B2 (en) 2014-03-12 2019-01-22 Zimmer, Inc. Melt-stabilized ultra high molecular weight polyethylene and method of making the same
US9707314B2 (en) * 2014-03-26 2017-07-18 DePuy Synthes Products, Inc. Acrylic bone cement having a delayed release polymerization inhibitor such as an anti-oxidant for increased working time
EP3227360B1 (de) 2014-12-03 2024-10-16 Zimmer, Inc. Mit antioxidationsmittel infundiertes polyethylen mit ultrahohem molekulargewicht
CZ2015267A3 (cs) 2015-04-21 2016-11-09 Ústav makromolekulární chemie AV ČR, v. v. i. Směs pro stabilizaci polyethylenu, polyethylen a způsob jeho přípravy, polyethylenové implantáty
WO2017083476A1 (en) 2015-11-12 2017-05-18 The General Hospital Corporation Methods of making therapeutic polymeric material
AU2017214566A1 (en) 2016-02-05 2018-08-23 The General Hospital Corporation Drug eluting polymer composed of biodegradable polymers applied to surface of medical device
WO2017181164A1 (en) 2016-04-15 2017-10-19 The General Hospital Corporation Systems and methods of radioprotection of allografts
US11667762B2 (en) 2017-08-29 2023-06-06 The General Hospital Corporation UV-initiated reactions in polymeric materials
CN110448723B (zh) * 2019-07-12 2022-04-05 四川大学 协同抗氧型高交联超高分子量聚乙烯人工关节材料及其制备方法
AU2021200854A1 (en) 2020-03-03 2021-09-16 Howmedica Osteonics Corp. Glenoid implant with additively manufactured fixation posts
US11970600B2 (en) 2021-03-31 2024-04-30 The General Hospital Corporation Di-cumyl peroxide crosslinking of UHMWPE

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CS221404B1 (cs) * 1981-12-23 1983-04-29 Bretislav Dolezel Způsob stabilizace polyolefinů pro dosažení zvýšené odolnosti proti biologické degradaci v organismu
US4439420A (en) 1982-11-16 1984-03-27 Ethicon, Inc. Absorbable hemostatic composition
GB8724897D0 (en) 1987-10-23 1987-11-25 Downes S Material
SE464912B (sv) 1989-10-25 1991-07-01 Bioapatite Ab Implantationsmaterial foer aaterstaellning av benvaevnad samt saett foer dess tillverkning
US5236456A (en) 1989-11-09 1993-08-17 Osteotech, Inc. Osteogenic composition and implant containing same
DE4306593A1 (de) * 1993-03-03 1994-09-08 Hoechst Ag Stabilisierte Formmasse aus Polyethylen, ein Verfahren zur Herstellung und Verwendung
DE4433201A1 (de) 1994-09-17 1996-03-21 Merck Patent Gmbh Verfahren zur Herstellung von wirkstoffhaltigen Knochenzementen
US5844027A (en) 1996-05-03 1998-12-01 Ciba Specialty Chemicals Corporation Stabilizer composition for thermoplastic materials
US5827904A (en) 1996-09-27 1998-10-27 Hahn; David Medical implant composition
IT1289935B1 (it) 1997-02-20 1998-10-19 Great Lakes Chemical Italia Forma solida di uno stabilizzante per polimeri organici
SE9802528D0 (sv) 1998-07-13 1998-07-13 Gs Dev Ab Bone tissue restoring composition
WO2000007639A1 (en) 1998-08-07 2000-02-17 Tissue Engineering, Inc. Bone precursor compositions
EP0995449A1 (de) 1998-10-21 2000-04-26 Sulzer Orthopädie AG UHMW-Polyethylen für Implantate

Also Published As

Publication number Publication date
US6448315B1 (en) 2002-09-10
AU3203800A (en) 2000-09-04
DE60011243T2 (de) 2005-06-23
EP1161489A1 (de) 2001-12-12
DE60011243D1 (de) 2004-07-08
EP1161489B1 (de) 2004-06-02
SE9900519D0 (sv) 1999-02-17
WO2000049079A1 (en) 2000-08-24

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