ATE312628T1 - Kontrolliertes abbaubares polymer-biomolekül oder wirkstoffträger und verfahren zur synthese dieses trägers - Google Patents

Kontrolliertes abbaubares polymer-biomolekül oder wirkstoffträger und verfahren zur synthese dieses trägers

Info

Publication number
ATE312628T1
ATE312628T1 AT03728863T AT03728863T ATE312628T1 AT E312628 T1 ATE312628 T1 AT E312628T1 AT 03728863 T AT03728863 T AT 03728863T AT 03728863 T AT03728863 T AT 03728863T AT E312628 T1 ATE312628 T1 AT E312628T1
Authority
AT
Austria
Prior art keywords
carrier
synthesis
degradable polymer
present
controlled degradable
Prior art date
Application number
AT03728863T
Other languages
English (en)
Inventor
Lei Yu
Fusheng Du
Shouping Ji
Kenji Matsumoto
Original Assignee
Nitto Denko Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nitto Denko Corp filed Critical Nitto Denko Corp
Application granted granted Critical
Publication of ATE312628T1 publication Critical patent/ATE312628T1/de

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/02—Polyamines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/593—Polyesters, e.g. PLGA or polylactide-co-glycolide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
    • A61K48/0025—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid
    • A61K48/0041—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid the non-active part being polymeric

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Polyamides (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT03728863T 2002-05-14 2003-05-13 Kontrolliertes abbaubares polymer-biomolekül oder wirkstoffträger und verfahren zur synthese dieses trägers ATE312628T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US37816402P 2002-05-14 2002-05-14
US10/270,788 US20030215395A1 (en) 2002-05-14 2002-10-11 Controllably degradable polymeric biomolecule or drug carrier and method of synthesizing said carrier
PCT/US2003/015003 WO2003097107A2 (en) 2002-05-14 2003-05-13 Controllably degradable polymeric biomolecule or drug carrier and method of synthesizing said carrier

Publications (1)

Publication Number Publication Date
ATE312628T1 true ATE312628T1 (de) 2005-12-15

Family

ID=29423239

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03728863T ATE312628T1 (de) 2002-05-14 2003-05-13 Kontrolliertes abbaubares polymer-biomolekül oder wirkstoffträger und verfahren zur synthese dieses trägers

Country Status (11)

Country Link
US (2) US20030215395A1 (de)
EP (1) EP1503802B1 (de)
JP (1) JP4425128B2 (de)
KR (1) KR100994523B1 (de)
CN (1) CN1646174B (de)
AT (1) ATE312628T1 (de)
AU (1) AU2003234423A1 (de)
CA (1) CA2482458A1 (de)
DE (1) DE60302784T2 (de)
ES (1) ES2257672T3 (de)
WO (1) WO2003097107A2 (de)

Families Citing this family (102)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5610659B2 (ja) * 2000-07-21 2014-10-22 ルバンス セラピュティックス インク．Ｒｅｖａｎｃｅ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． 多成分生物学的輸送システム
US20040220100A1 (en) * 2000-07-21 2004-11-04 Essentia Biosystems, Inc. Multi-component biological transport systems
US20070269891A9 (en) * 2003-01-13 2007-11-22 Yasunobu Tanaka Solid surface with immobilized degradable cationic polymer for transfecting eukaryotic cells
US20040138154A1 (en) * 2003-01-13 2004-07-15 Lei Yu Solid surface for biomolecule delivery and high-throughput assay
WO2004087777A2 (en) * 2003-03-28 2004-10-14 Carnegie Mellon University Degradable polymers
US7332477B2 (en) * 2003-07-10 2008-02-19 Nitto Denko Corporation Photocleavable DNA transfer agent
EP1667732B1 (de) * 2003-09-29 2010-04-21 Nitto Denko Corporation Biologisch abbaubare polyacetale für die in-vivo-abgabe von polynucleotiden
BRPI0508410B8 (pt) * 2004-03-03 2021-05-25 Revance Therapeutics Inc composições e métodos para a aplicação tópica e liberação transdérmica de toxinas botulínicas
US9211248B2 (en) 2004-03-03 2015-12-15 Revance Therapeutics, Inc. Compositions and methods for topical application and transdermal delivery of botulinum toxins
JP2007527431A (ja) * 2004-03-03 2007-09-27 ルバンス セラピュティックス 局所的診断及び治療用の輸送のための組成物及び方法
US7358223B2 (en) * 2004-10-04 2008-04-15 Nitto Denko Corporation Biodegradable cationic polymers
GB0422877D0 (en) * 2004-10-14 2004-11-17 Univ Glasgow Bioactive polymers
US8057821B2 (en) * 2004-11-03 2011-11-15 Egen, Inc. Biodegradable cross-linked cationic multi-block copolymers for gene delivery and methods of making thereof
EP1836293A2 (de) * 2004-12-17 2007-09-26 Nitto Denko Corporation Immobilisiertes abbaubares kationisches polymer zur transfektion eukaryontischer zellen
US20120269886A1 (en) 2004-12-22 2012-10-25 Nitto Denko Corporation Therapeutic agent for pulmonary fibrosis
HUE056941T2 (hu) 2004-12-22 2022-04-28 Nitto Denko Corp Gyógyszerhordozó és gyógyszerhordozó kit fibrózis gátlására
GB2422839B (en) * 2005-01-11 2009-06-24 Schlumberger Holdings Degradable polymers for wellbore fluids and processes
ZA200707352B (en) 2005-03-03 2009-04-29 Revance Therapeutics Inc Compositions and methods for topical application and transdermal delivery of botulinum toxins
MX2007010674A (es) * 2005-03-03 2007-11-08 Revance Therapeutics Inc Composiciones y metodos para la aplicacion topica y el suministro transdermico de un oligopeptido.
US8343710B1 (en) 2005-03-11 2013-01-01 The Regents Of The University Of Colorado, A Body Corporate Photodegradable groups for tunable polymeric materials
US9180196B2 (en) 2005-03-11 2015-11-10 The Regents Of The University Of Colorado, A Body Corporate Photodegradable groups for tunable polymeric materials
WO2006098463A1 (ja) * 2005-03-14 2006-09-21 Shinka Soyaku Inc. ポリ核酸結合物質
US7674452B2 (en) * 2005-03-16 2010-03-09 Nitto Denko Corporation Polymer coating of cells
JP5541861B2 (ja) * 2005-04-29 2014-07-09 エージェンシー フォー サイエンス， テクノロジー アンド リサーチ 超分岐ポリマーおよびそれらの適用
JP4870941B2 (ja) * 2005-05-09 2012-02-08 公立大学法人大阪府立大学 高分子化合物
US7588754B2 (en) * 2005-05-10 2009-09-15 Nitto Denko Corporation Biodegradable polyacetals and methods
US20060263328A1 (en) * 2005-05-19 2006-11-23 Sang Van Hydrophilic polymers with pendant functional groups and method thereof
WO2006138380A2 (en) 2005-06-15 2006-12-28 Massachusetts Institute Of Technology Amine-containing lipids and uses thereof
EP1922052B1 (de) * 2005-08-08 2010-11-03 Angstrom Medica, Inc. Zementprodukte sowie verfahren zu deren herstellung und verwendung
JP4962931B2 (ja) * 2005-11-16 2012-06-27 公立大学法人大阪府立大学 ポリアミドアミンデンドロン脂質を含む遺伝子等運搬媒体組成物
CN103126971A (zh) * 2005-11-17 2013-06-05 雷文斯治疗公司 减少非毒素蛋白质的肉毒杆菌毒素组合物和其局部施用及透皮递送方法
US9572886B2 (en) 2005-12-22 2017-02-21 Nitto Denko Corporation Agent for treating myelofibrosis
DE102006008701A1 (de) * 2006-02-23 2007-08-30 Qiagen Gmbh Ein Verfahren zur Herstellung einer transformierten Zelle
US7700541B2 (en) * 2006-04-06 2010-04-20 Nitto Denko Corporation Biodegradable cationic polymers
CN100549044C (zh) * 2006-11-16 2009-10-14 南京慧基生物技术有限公司 可生物降解的交联聚乙烯亚胺及其应用
CN102988995A (zh) * 2006-12-29 2013-03-27 雷文斯治疗公司 用源自hiv-tat的多肽片段稳定的肉毒杆菌毒素的组合物及其局部施用和透皮递送的方法
BRPI0720729A2 (pt) * 2006-12-29 2014-04-08 Revance Therapeutics Inc Moléculas de transporte que utilizam polipeptídeos hiv-tat de sequência inversa.
TWI407971B (zh) 2007-03-30 2013-09-11 日東電工股份有限公司 Cancer cells and tumor-related fibroblasts
US20080312174A1 (en) * 2007-06-05 2008-12-18 Nitto Denko Corporation Water soluble crosslinked polymers
CA2694046C (en) * 2007-07-26 2023-09-12 Revance Therapeutics, Inc. Cationic peptides and compositions thereof
EP2192886B1 (de) * 2007-08-28 2017-12-20 Pioneer Surgical Technology, Inc. Zementprodukte sowie verfahren zu deren herstellung und verwendung
CN101970012A (zh) 2007-09-14 2011-02-09 日东电工株式会社 药物载体
US8703194B2 (en) 2007-11-02 2014-04-22 Agency For Science, Technology And Research Stimulus-responsive biodegradable polymers and methods of preparation
US20090130752A1 (en) * 2007-11-07 2009-05-21 University Of Utah Research Foundation Biodegradable poly(disulfide amine)s for gene delivery
CN101918473A (zh) * 2007-11-07 2010-12-15 犹他大学研究基金会 可还原聚(酰胺乙烯亚胺)的可切割修饰以增强核苷酸递送
JP5619341B2 (ja) * 2007-11-30 2014-11-05 エイジェンシー フォー サイエンス， テクノロジー アンド リサーチＡｇｅｎｃｙ Ｆｏｒ Ｓｃｉｅｎｃｅ，Ｔｅｃｈｎｏｌｏｇｙ Ａｎｄ Ｒｅｓｅａｒｃｈ 刺激応答型生分解性高分子及びその製造方法
WO2009114854A1 (en) * 2008-03-14 2009-09-17 Egen, Inc. Biodegradable cross-linked branched poly (alkylene imines)
KR100961280B1 (ko) * 2008-05-21 2010-06-03 한국생명공학연구원 형광특성이 향상된 풀러렌-실리카 나노입자, 이의 제조방법및 이의 용도
EP3269395A1 (de) 2008-11-07 2018-01-17 Massachusetts Institute Of Technology Aminoalkohol-lipoide und verwendungen davon
US20120196923A1 (en) * 2009-05-15 2012-08-02 Kaushal Rege Polymers for delivering a substance into a cell
EP3318248B1 (de) 2009-12-01 2019-04-10 Translate Bio, Inc. Ausgabe von mrna zur vermehrung von proteinen und enzymen bei humangenetischen erkrankungen
US9193827B2 (en) 2010-08-26 2015-11-24 Massachusetts Institute Of Technology Poly(beta-amino alcohols), their preparation, and uses thereof
CN102010508B (zh) * 2010-10-19 2012-10-03 北京大学 一种阳离子聚合物及其制备方法和应用
US9644042B2 (en) 2010-12-17 2017-05-09 Carnegie Mellon University Electrochemically mediated atom transfer radical polymerization
US20120202890A1 (en) 2011-02-08 2012-08-09 Nian Wu Polymer-carbohydrate-lipid conjugates
WO2012134135A2 (ko) * 2011-03-25 2012-10-04 서울대학교산학협력단 스페르민 공중합체 및 이를 핵산 전달체로 이용하는 유전자 치료
EP2691443B1 (de) 2011-03-28 2021-02-17 Massachusetts Institute of Technology Konjugierte lipomers und ihre verwendung
RU2013154295A (ru) 2011-06-08 2015-07-20 Шир Хьюман Дженетик Терапис, Инк. КОМПОЗИЦИИ ЛИПИДНЫХ НАНОЧАСТИЦ И СПОСОБЫ ДЛЯ ДОСТАВКИ мРНК
US8883177B2 (en) 2011-06-28 2014-11-11 Nian Wu Pharmaceutical compositions for parenteral administration
US20140275420A1 (en) 2011-08-22 2014-09-18 Carnegie Mellon University Atom transfer radical polymerization under biologically compatible conditions
PE20181541A1 (es) 2011-10-27 2018-09-26 Massachusetts Inst Technology Derivados de aminoacidos funcionalizados en la terminal n capaces de formar microesferas encapsuladoras de farmaco
WO2013185067A1 (en) 2012-06-08 2013-12-12 Shire Human Genetic Therapies, Inc. Nuclease resistant polynucleotides and uses thereof
WO2014028487A1 (en) 2012-08-13 2014-02-20 Massachusetts Institute Of Technology Amine-containing lipidoids and uses thereof
US9109087B2 (en) * 2012-09-13 2015-08-18 International Business Machines Corporation Low molecular weight branched polyamines for delivery of biologically active materials
MX370929B (es) 2012-10-28 2020-01-08 Revance Therapeutics Inc Composiciones y usos de las mismas para el tratamiento seguro de la rinitis.
KR101460204B1 (ko) * 2013-01-08 2014-11-10 한국과학기술원 친수성 핵산 유전자를 유기용매에 가용화시키고, 이를 소수성 미립자에 봉입한 제어방출형 유전자 전달용 복합체와 이의 제조방법
JP6586075B2 (ja) 2013-03-14 2019-10-02 トランスレイト バイオ， インコーポレイテッド メッセンジャーｒｎａの精製方法
RS57739B1 (sr) 2013-03-14 2018-12-31 Translate Bio Inc Kompozicije cftr irnk i postupci i upotrebe u vezi sa njima
WO2014179562A1 (en) 2013-05-01 2014-11-06 Massachusetts Institute Of Technology 1,3,5-triazinane-2,4,6-trione derivatives and uses thereof
JP6506749B2 (ja) 2013-10-22 2019-04-24 シャイアー ヒューマン ジェネティック セラピーズ インコーポレイテッド フェニルケトン尿症のためのｍＲＮＡ療法
ES3032935T3 (en) 2013-10-22 2025-07-29 Translate Bio Inc Lipid formulations for delivery of messenger rna
CN106413811A (zh) 2013-10-22 2017-02-15 夏尔人类遗传性治疗公司 精氨基琥珀酸合成酶缺乏症的mrna疗法
JP6466637B2 (ja) * 2013-11-28 2019-02-06 ソマール株式会社 糖鎖含有ポリマー、および、糖鎖含有ポリマー複合体
US9850269B2 (en) 2014-04-25 2017-12-26 Translate Bio, Inc. Methods for purification of messenger RNA
JP6557722B2 (ja) 2014-05-30 2019-08-07 シャイアー ヒューマン ジェネティック セラピーズ インコーポレイテッド 核酸の送達のための生分解性脂質
FR3022544B1 (fr) * 2014-06-23 2018-01-05 Arkema France Oligomeres acryles multifonctionnels de structure ramifiee, par polyaddition entre amines et acrylates multifonctionnels.
KR102559979B1 (ko) 2014-06-24 2023-07-25 샤이어 휴먼 지네틱 테라피즈 인크. 핵산의 전달용 입체화학적으로 풍부한 조성물
US9840479B2 (en) 2014-07-02 2017-12-12 Massachusetts Institute Of Technology Polyamine-fatty acid derived lipidoids and uses thereof
US11484580B2 (en) 2014-07-18 2022-11-01 Revance Therapeutics, Inc. Topical ocular preparation of botulinum toxin for use in ocular surface disease
EP3034539A1 (de) * 2014-12-19 2016-06-22 Ethris GmbH Zusammensetzungen zur Einführung von Nukleinsäure in Zellen
CN104561067A (zh) * 2014-12-24 2015-04-29 广东省人民医院 一种安全高效的蛋白质转染进入细胞的载体
US9982070B2 (en) 2015-01-12 2018-05-29 Carnegie Mellon University Aqueous ATRP in the presence of an activator regenerator
WO2016205691A1 (en) 2015-06-19 2016-12-22 Massachusetts Institute Of Technology Alkenyl substituted 2,5-piperazinediones and their use in compositions for delivering an agent to a subject or cell
CN107921030B (zh) 2015-08-14 2024-07-02 荣昌生物制药(烟台)股份有限公司 抗体-药物偶联物的共价连接子及其制备方法与应用
NZ747314A (en) 2016-04-14 2022-07-29 Benitec Ip Holdings Inc Reagents for treatment of oculopharyngeal muscular dystrophy (opmd) and use thereof
CN106146834B (zh) * 2016-06-24 2018-12-18 浙江大学 一种具有酯酶响应的阳离子聚合物
GB2551979A (en) 2016-06-30 2018-01-10 Rs Arastirma Egitim Danismanlik Llac Sanayi Ticaret Ltd Cleavable polymer drug conjugates
GB2556055B (en) 2016-11-16 2022-03-23 Rs Arastirma Egitim Danismanlik Ilac Sanayi Ticaret Ltd Sti Self-assembled diblock copolymers composed of pegmema and drug bearing polymeric segments
CN106755111A (zh) * 2017-01-11 2017-05-31 山东省肿瘤防治研究院 一种富含羟基的纳米基因载体及其制备方法与应用
WO2018132582A1 (en) 2017-01-12 2018-07-19 Carnegie Mellon University Surfactant assisted formation of a catalyst complex for emulsion atom transfer radical polymerization processes
EA201991747A1 (ru) 2017-02-27 2020-06-04 Транслейт Био, Инк. НОВАЯ КОДОН-ОПТИМИЗИРОВАННАЯ мРНК CFTR
MX2019013752A (es) 2017-05-16 2020-07-20 Translate Bio Inc Tratamiento de la fibrosis quística mediante el suministro de arnm que codifica cftr optimizado en codones.
CN109134855B (zh) * 2018-07-23 2021-03-23 安徽大学 一种酸敏感的聚酰胺胺的阳离子聚合物poeamam及其制备方法和应用
KR102950141B1 (ko) 2018-08-24 2026-04-07 트랜슬레이트 바이오 인코포레이티드 전령 rna의 정제 방법
WO2020106946A1 (en) 2018-11-21 2020-05-28 Translate Bio, Inc. TREATMENT OF CYSTIC FIBROSIS BY DELIVERY OF NEBULIZED mRNA ENCODING CFTR
WO2020243647A1 (en) * 2019-05-31 2020-12-03 Children’S Hospital Medical Center Polymer based cellular labeling, barcoding and assembly
EP4031662A1 (de) 2019-09-20 2022-07-27 Translate Bio, Inc. Mrna-codierendes technisches cftr
EP3798250A1 (de) * 2019-09-25 2021-03-31 University College Dublin Hyperverzweigte kationische polymere, die als nukleinsäureabgabevektoren für die transfektion geeignet sind
CN111647166B (zh) * 2020-06-29 2022-08-02 苏州大学 可降解超支化聚合物
CN114904003B (zh) * 2021-02-09 2023-09-29 广州立得生物医药科技有限公司 可电离的阳离子脂质类似物材料在作为核酸药物递送载体或转染试剂中的应用
CN114874294B (zh) * 2022-03-25 2024-01-30 圣诺生物医药技术(苏州)有限公司 一种多肽化合物、多肽脂质纳米递送系统及其应用
CN116425973B (zh) * 2023-04-03 2024-01-26 深圳市华元生物技术股份有限公司 一种pH响应型的肝靶向的药物递送载体及其制备方法和应用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6509032B1 (en) * 1991-08-28 2003-01-21 Mcmaster University Cationic amphiphiles
US5919455A (en) * 1993-10-27 1999-07-06 Enzon, Inc. Non-antigenic branched polymer conjugates
DE69505398T2 (de) * 1994-08-12 1999-03-11 Kao Corp., Tokio/Tokyo Verfahren zur herstellung von verbesserten superabsorbierenden polymeren
WO1997045069A1 (en) * 1996-05-29 1997-12-04 Cell Genesys, Inc. Cationic polymer/lipid nucleic acid delivery vehicles
US6060534A (en) * 1996-07-11 2000-05-09 Scimed Life Systems, Inc. Medical devices comprising ionically and non-ionically crosslinked polymer hydrogels having improved mechanical properties
US5925379A (en) * 1997-03-27 1999-07-20 Geltex Pharmaceuticals, Inc. Interpenetrating polymer networks for sequestration of bile acids
DE19726186A1 (de) * 1997-06-20 1998-12-24 Boehringer Ingelheim Int Komplexe für den Transport von Nukleinsäure in höhere eukaryotische Zellen
KR100219918B1 (ko) * 1997-07-03 1999-09-01 김윤 대장선택적 약물전달용 조성물
US6290947B1 (en) * 1997-09-19 2001-09-18 Geltex Pharmaceuticals, Inc. Ionic polymers as toxin-binding agents
US6072101A (en) * 1997-11-19 2000-06-06 Amcol International Corporation Multicomponent superabsorbent gel particles
KR100520183B1 (ko) * 1999-08-23 2005-10-10 주식회사 하이닉스반도체 두 개의 이중결합을 가지는 가교제를 단량체로 포함하는 포토레지스트용 공중합체
US6696038B1 (en) 2000-09-14 2004-02-24 Expression Genetics, Inc. Cationic lipopolymer as biocompatible gene delivery agent
US20030186916A1 (en) * 2002-03-12 2003-10-02 Lei Yu Vector for transfection of eukaryotic cells

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JP2005532323A (ja) 2005-10-27
EP1503802B1 (de) 2005-12-14
CN1646174B (zh) 2010-12-08
US20030215395A1 (en) 2003-11-20
CA2482458A1 (en) 2003-11-27
CN1646174A (zh) 2005-07-27
JP4425128B2 (ja) 2010-03-03
ES2257672T3 (es) 2006-08-01
KR20050006161A (ko) 2005-01-15
WO2003097107A3 (en) 2004-01-22
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