ATE312828T1 - Acylaminothiazolderivate, deren herstellung und deren therapeutische verwendung - Google Patents
Acylaminothiazolderivate, deren herstellung und deren therapeutische verwendungInfo
- Publication number
- ATE312828T1 ATE312828T1 AT02794623T AT02794623T ATE312828T1 AT E312828 T1 ATE312828 T1 AT E312828T1 AT 02794623 T AT02794623 T AT 02794623T AT 02794623 T AT02794623 T AT 02794623T AT E312828 T1 ATE312828 T1 AT E312828T1
- Authority
- AT
- Austria
- Prior art keywords
- preparation
- therapeutic use
- acylaminothiazole derivatives
- acylaminothiazole
- derivatives
- Prior art date
Links
- 230000001225 therapeutic effect Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/40—Unsubstituted amino or imino radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0110504 | 2001-08-06 | ||
| FR0207222A FR2840899B1 (fr) | 2002-06-12 | 2002-06-12 | Derives d'acylaminothiazole, leur preparation et leur utilisation en therapeutique |
| PCT/FR2002/002802 WO2003014095A1 (fr) | 2001-08-06 | 2002-08-05 | Derives d'acylaminothiazole, leur preparation et leur utilisation en therapeutique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE312828T1 true ATE312828T1 (de) | 2005-12-15 |
Family
ID=26213132
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02794623T ATE312828T1 (de) | 2001-08-06 | 2002-08-05 | Acylaminothiazolderivate, deren herstellung und deren therapeutische verwendung |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US7288659B2 (de) |
| EP (1) | EP1417189B1 (de) |
| JP (1) | JP2005500370A (de) |
| AR (1) | AR039059A1 (de) |
| AT (1) | ATE312828T1 (de) |
| DE (1) | DE60208044T2 (de) |
| DK (1) | DK1417189T3 (de) |
| ES (1) | ES2254773T3 (de) |
| TW (1) | TWI318974B (de) |
| WO (1) | WO2003014095A1 (de) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR038703A1 (es) | 2002-02-28 | 2005-01-26 | Novartis Ag | Derivados de 5-feniltiazol y uso como inhibidor de quinasa p i 3 |
| AU2003265068A1 (en) * | 2002-10-09 | 2004-05-04 | Pfizer Products Inc. | Thiazole compounds for the treatment of neurodegenerative disorders |
| FR2850380B1 (fr) | 2003-01-23 | 2006-07-07 | Sanofi Synthelabo | Derives d'acylaminothiazole, leur preparation et leur utilisation en therapeutique |
| CA2524511A1 (en) * | 2003-05-12 | 2004-11-18 | Pfizer Products Inc. | Isoxazole and isothiazole compounds for the treatment of neurodegenerative disorders |
| CA2534529A1 (en) * | 2003-08-06 | 2005-02-24 | Pfizer Products Inc. | Oxazole compounds for the treatment of neurodegenerative disorders |
| FR2865206B1 (fr) * | 2004-01-16 | 2009-02-06 | Sanofi Synthelabo | Derives d'acylaminothiazole, leur preparation et leur application en therapeutique |
| FR2873374B1 (fr) * | 2004-07-22 | 2006-10-20 | Sanofi Synthelabo | Derives d'acylaminothiazole, leur preparation et leur application en therapeutique |
| FR2865207B1 (fr) * | 2004-01-16 | 2008-10-17 | Sanofi Synthelabo | Derives d'acylaminothiazole, leur preparation et leur application en therapeutique |
| PT1709018E (pt) | 2004-01-16 | 2011-10-24 | Sanofi Sa | Derivados de acilaminotiazole e sua aplicação como inibidores |
| RU2401262C2 (ru) * | 2004-01-16 | 2010-10-10 | Санофи-Авентис | Производные алкиламинотиазола, их получение и их применение в терапии |
| US7220865B2 (en) * | 2004-04-01 | 2007-05-22 | Pfizer Inc | Isoxazole-and isothiazole-amine compounds for the treatment of neurodegenerative disorders |
| US7232820B2 (en) | 2004-04-01 | 2007-06-19 | Pfizer Inc | Thiadiazole-amine compounds for the treatment of neurodegenerative disorders |
| CN101421265A (zh) * | 2006-01-18 | 2009-04-29 | 安姆根有限公司 | 作为蛋白激酶b(pkb)抑制剂的噻唑化合物 |
| AU2008276521B2 (en) | 2007-07-17 | 2011-11-03 | Amgen Inc. | Heterocyclic modulators of PKB |
| WO2009011871A2 (en) | 2007-07-17 | 2009-01-22 | Amgen Inc. | Thiadiazole modulators of pkb |
| US20170283425A1 (en) * | 2016-03-31 | 2017-10-05 | Merck Patent Gmbh | Compounds for the inhibition of cyclophilins and uses thereof |
| SG11202006837XA (en) | 2018-01-18 | 2020-08-28 | Daiichi Sankyo Co Ltd | Dihydroindolizinone derivative |
| TWI858093B (zh) | 2019-07-08 | 2024-10-11 | 國立大學法人東京工業大學 | 使用二氫吲哚啉酮衍生物之胰島素產生細胞之製作方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001504498A (ja) | 1996-11-22 | 2001-04-03 | エラン・ファーマシューティカルズ・インコーポレイテッド | Ｎ―（アリール／ヘテロアリール／アルキルアセチル）アミノ酸アミドおよびその医薬組成物、並びに該化合物を用いたβ―アミロイドペプチドの放出および／またはその合成を阻害する方法 |
| AR016751A1 (es) * | 1996-11-22 | 2001-08-01 | Athena Neurosciences Inc | Metodo para inhibir la liberacion del peptido beta-amiloide en una celula, composicion farmaceutica y compuestos utiles en dicho metodo |
| TR199901343T2 (xx) | 1996-12-23 | 1999-09-21 | Elan Pharmaceuticals, Inc. | Sikloalkil, laktam, lakton ve ilgili bile�ikler, bunlar� i�eren farmas�tik bile�imler ve b�yle bile�ikler kullan�larak �-amiloid peptidinin sal�nmas�n� ve/veya sentezini inhibe etmek i�in y�ntemler. |
| HRP980093A2 (en) * | 1997-02-28 | 1998-12-31 | Lilly Co Eli | Heterocyclic compounds, pharmaceutical compositions comprising same, and methods for inhibiting "beta"-amyloid peptide release and/or its synthesis by use of such compounds |
| US6486350B1 (en) * | 1998-09-30 | 2002-11-26 | Elan Pharmaceuticals Inc. | Biological reagents and methods for determining the mechanism in the generation of β-amyloid peptide |
| AU6229699A (en) | 1998-10-26 | 2000-05-15 | Sumitomo Pharmaceuticals Company, Limited | Beta-amyloid formation inhibitors |
-
2002
- 2002-08-02 AR ARP020102935A patent/AR039059A1/es active IP Right Grant
- 2002-08-05 TW TW091117569A patent/TWI318974B/zh not_active IP Right Cessation
- 2002-08-05 EP EP02794623A patent/EP1417189B1/de not_active Expired - Lifetime
- 2002-08-05 DK DK02794623T patent/DK1417189T3/da active
- 2002-08-05 JP JP2003519045A patent/JP2005500370A/ja active Pending
- 2002-08-05 WO PCT/FR2002/002802 patent/WO2003014095A1/fr not_active Ceased
- 2002-08-05 DE DE60208044T patent/DE60208044T2/de not_active Expired - Lifetime
- 2002-08-05 AT AT02794623T patent/ATE312828T1/de active
- 2002-08-05 ES ES02794623T patent/ES2254773T3/es not_active Expired - Lifetime
- 2002-08-05 US US10/485,837 patent/US7288659B2/en not_active Expired - Lifetime
-
2007
- 2007-09-20 US US11/858,454 patent/US20080058380A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AR039059A1 (es) | 2005-02-09 |
| JP2005500370A (ja) | 2005-01-06 |
| US7288659B2 (en) | 2007-10-30 |
| TWI318974B (en) | 2010-01-01 |
| US20080058380A1 (en) | 2008-03-06 |
| DE60208044D1 (de) | 2006-01-19 |
| EP1417189B1 (de) | 2005-12-14 |
| EP1417189A1 (de) | 2004-05-12 |
| DK1417189T3 (da) | 2006-05-08 |
| ES2254773T3 (es) | 2006-06-16 |
| WO2003014095A1 (fr) | 2003-02-20 |
| DE60208044T2 (de) | 2006-08-17 |
| US20040171643A1 (en) | 2004-09-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE60203917D1 (de) | Phenylsulfonyl-1,3-dihydro-2h-indol-2-on derivate, deren herstellung und deren therapeutische verwendung | |
| DE50312295D1 (de) | 8-ä3-amino-piperidin-1-ylü -xanthine, deren herstellung und deren verwendung als arzneimittel | |
| DE60107859D1 (de) | Benzimidazolderivate, ihre herstellung und therapeutische verwendung | |
| DE50209483D1 (de) | Xanthinderivate, deren herstellung und deren verwendung als arzneimittel | |
| DE60336907D1 (de) | Spirobifluorenderivate, deren herstellung und deren verwendung | |
| DE60209779D1 (de) | Sulfonamidderivate, deren herstellung und deren verwendung als medikamente | |
| DE60323754D1 (de) | Dioxan-2-alkylkarbamaten derivaten, deren herstellung und deren therapeutischen verwendung | |
| DE60208351D1 (de) | Glukopyranosyloxybenzylbenzolderivate und deren medizinische verwendung | |
| DE60230591D1 (de) | Glykopyranosyloxypyrazolderivate und deren medizinische verwendung | |
| DE60237580D1 (de) | Glykopyranosyloxypyrazolderivate und deren medizinische verwendung | |
| ATE395342T1 (de) | 2-carbamid-4-phenylthiazol-derivate, deren herstellung und therapeutische verwendung | |
| ATE231869T1 (de) | Pyridopyranoazepinderivate, ihre herstellung und therapeutische verwendung | |
| DE602005002470D1 (de) | 1-aminophthalazinderivate, deren herstellung und deren therapeutische verwendung | |
| EE200300311A (et) | Ftalasinoon-piperidinoderivaadid, nende kasutamine ja ravim | |
| DE60307632D1 (de) | Piperazinylacylpiperidinderivate, deren herstellung und deren therapeutische anwendung | |
| DE60235547D1 (de) | En daraus, deren herstellung und verwendung | |
| DE60130834D1 (de) | Zusammensetzungen gegen schlechte Gerüche, deren Herstellung und Verwendung | |
| DE60208044D1 (de) | Acylaminothiazolderivate, deren herstellung und deren therapeutische verwendung | |
| ATE357448T1 (de) | Benzoxazinonderivative, deren herstellung und verwendung | |
| DE602004017463D1 (de) | Diphenylpyridinderivate, deren herstellung und deren therapeutische anwendung | |
| DE50002417D1 (de) | 3-Amino-3-arylpropan-1-ol-Derivate, deren Herstellung und Verwendung | |
| ATE261959T1 (de) | Substituierte phenyl-piperazin-derivate, deren herstellung und verwendung | |
| DE60103054D1 (de) | Phenyloxazol-1,4-diazabicyclo[3.2.2]nonanderivate, ihre herstellung und ihre therapeutische verwendung | |
| DE60005690D1 (de) | Titanverbindungen, deren herstellung und verwendung | |
| DE60321372D1 (de) | 3-phenylpyridoindolderivate, ihre herstellung und verwendung |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1417189 Country of ref document: EP |