ATE313324T1 - Verwendung von brefeldin a und deren derivate in der herstellung von arzneimittel zur behandlung von hyperplasie und verwandten erkrankungen - Google Patents
Verwendung von brefeldin a und deren derivate in der herstellung von arzneimittel zur behandlung von hyperplasie und verwandten erkrankungenInfo
- Publication number
- ATE313324T1 ATE313324T1 AT96918159T AT96918159T ATE313324T1 AT E313324 T1 ATE313324 T1 AT E313324T1 AT 96918159 T AT96918159 T AT 96918159T AT 96918159 T AT96918159 T AT 96918159T AT E313324 T1 ATE313324 T1 AT E313324T1
- Authority
- AT
- Austria
- Prior art keywords
- brefeldin
- derivatives
- hyperplasia
- intimal hyperplasia
- manufacturing
- Prior art date
Links
- KQNZDYYTLMIZCT-KQPMLPITSA-N brefeldin A Chemical compound O[C@@H]1\C=C\C(=O)O[C@@H](C)CCC\C=C\[C@@H]2C[C@H](O)C[C@H]21 KQNZDYYTLMIZCT-KQPMLPITSA-N 0.000 title abstract 4
- 206010020718 hyperplasia Diseases 0.000 title abstract 4
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 229940126601 medicinal product Drugs 0.000 title 1
- 238000000034 method Methods 0.000 abstract 3
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 abstract 2
- 241000124008 Mammalia Species 0.000 abstract 2
- 239000005557 antagonist Substances 0.000 abstract 2
- JUMGSHROWPPKFX-UHFFFAOYSA-N brefeldin-A Natural products CC1CCCC=CC2(C)CC(O)CC2(C)C(O)C=CC(=O)O1 JUMGSHROWPPKFX-UHFFFAOYSA-N 0.000 abstract 2
- 229960002897 heparin Drugs 0.000 abstract 2
- 229920000669 heparin Polymers 0.000 abstract 2
- 230000002401 inhibitory effect Effects 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 241000288906 Primates Species 0.000 abstract 1
- 208000024248 Vascular System injury Diseases 0.000 abstract 1
- 208000012339 Vascular injury Diseases 0.000 abstract 1
- 230000003872 anastomosis Effects 0.000 abstract 1
- 238000002399 angioplasty Methods 0.000 abstract 1
- 238000013171 endarterectomy Methods 0.000 abstract 1
- 238000006722 reduction reaction Methods 0.000 abstract 1
- 230000002792 vascular Effects 0.000 abstract 1
- 210000005166 vasculature Anatomy 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/483,216 US5618837A (en) | 1995-06-07 | 1995-06-07 | PDGF antagonists III |
| PCT/US1996/009061 WO1996040112A1 (en) | 1995-06-07 | 1996-06-04 | Use of brefeldin a and derivatives thereof in the treatment of hyperplasia and related disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE313324T1 true ATE313324T1 (de) | 2006-01-15 |
Family
ID=23919165
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT96918159T ATE313324T1 (de) | 1995-06-07 | 1996-06-04 | Verwendung von brefeldin a und deren derivate in der herstellung von arzneimittel zur behandlung von hyperplasie und verwandten erkrankungen |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5618837A (de) |
| EP (1) | EP0831807B1 (de) |
| JP (1) | JP3190684B2 (de) |
| AT (1) | ATE313324T1 (de) |
| AU (1) | AU6048396A (de) |
| DE (1) | DE69635614T2 (de) |
| DK (1) | DK0831807T3 (de) |
| ES (1) | ES2253750T3 (de) |
| WO (1) | WO1996040112A1 (de) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR9807980A (pt) * | 1997-02-05 | 2000-03-28 | Allelix Pharm Eco L P | Uso de um composto e composto para tratar um mamìfero com disfunção cognitiva |
| AU2088399A (en) | 1997-12-18 | 1999-07-05 | Purdue Research Foundation | Brefeldin a derivatives |
| US8236048B2 (en) | 2000-05-12 | 2012-08-07 | Cordis Corporation | Drug/drug delivery systems for the prevention and treatment of vascular disease |
| US20050002986A1 (en) * | 2000-05-12 | 2005-01-06 | Robert Falotico | Drug/drug delivery systems for the prevention and treatment of vascular disease |
| WO2002026139A1 (en) | 2000-09-29 | 2002-04-04 | Cordis Corporation | Coated medical devices |
| WO2002028387A1 (en) * | 2000-10-03 | 2002-04-11 | Oncopharmaceutical, Inc. | Inhibitors of angiogenesis and tumor growth for local and systemic administration |
| NZ592039A (en) | 2003-08-27 | 2013-03-28 | Ophthotech Corp | Combination therapy for the treatment of ocular neovascular disorders |
| US20120189641A1 (en) | 2009-02-25 | 2012-07-26 | OSI Pharmaceuticals, LLC | Combination anti-cancer therapy |
| JP2012519282A (ja) | 2009-02-27 | 2012-08-23 | オーエスアイ・ファーマシューティカルズ，エルエルシー | 間葉様腫瘍細胞またはその生成を阻害する薬剤を同定するための方法 |
| WO2010099138A2 (en) | 2009-02-27 | 2010-09-02 | Osi Pharmaceuticals, Inc. | Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation |
| US8642834B2 (en) | 2009-02-27 | 2014-02-04 | OSI Pharmaceuticals, LLC | Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation |
| JP2014519813A (ja) | 2011-04-25 | 2014-08-21 | オーエスアイ・ファーマシューティカルズ，エルエルシー | 癌薬剤発見、診断、および治療におけるｅｍｔ遺伝子シグネチャーの使用 |
| WO2013152252A1 (en) | 2012-04-06 | 2013-10-10 | OSI Pharmaceuticals, LLC | Combination anti-cancer therapy |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5250519A (en) * | 1991-03-29 | 1993-10-05 | Glycomed Incorporated | Non-anticoagulant heparin derivatives |
| CA2094858C (en) * | 1992-04-28 | 2004-06-15 | Robert D. Mitchell | Method of treating hyperproliferative vascular disease |
| WO1995021614A1 (en) * | 1994-02-09 | 1995-08-17 | Ariad Pharmaceuticals, Inc. | New protein trafficking inhibitors |
-
1995
- 1995-06-07 US US08/483,216 patent/US5618837A/en not_active Expired - Fee Related
-
1996
- 1996-06-04 WO PCT/US1996/009061 patent/WO1996040112A1/en not_active Ceased
- 1996-06-04 DK DK96918159T patent/DK0831807T3/da active
- 1996-06-04 AU AU60483/96A patent/AU6048396A/en not_active Abandoned
- 1996-06-04 JP JP50147297A patent/JP3190684B2/ja not_active Expired - Fee Related
- 1996-06-04 EP EP96918159A patent/EP0831807B1/de not_active Expired - Lifetime
- 1996-06-04 ES ES96918159T patent/ES2253750T3/es not_active Expired - Lifetime
- 1996-06-04 DE DE69635614T patent/DE69635614T2/de not_active Expired - Fee Related
- 1996-06-04 AT AT96918159T patent/ATE313324T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| JP2000513703A (ja) | 2000-10-17 |
| ES2253750T3 (es) | 2006-06-01 |
| EP0831807B1 (de) | 2005-12-21 |
| DE69635614D1 (de) | 2006-01-26 |
| US5618837A (en) | 1997-04-08 |
| EP0831807A1 (de) | 1998-04-01 |
| DE69635614T2 (de) | 2006-07-27 |
| WO1996040112A1 (en) | 1996-12-19 |
| AU6048396A (en) | 1996-12-30 |
| JP3190684B2 (ja) | 2001-07-23 |
| DK0831807T3 (da) | 2006-05-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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| REN | Ceased due to non-payment of the annual fee |