ATE313324T1 - Verwendung von brefeldin a und deren derivate in der herstellung von arzneimittel zur behandlung von hyperplasie und verwandten erkrankungen - Google Patents
Verwendung von brefeldin a und deren derivate in der herstellung von arzneimittel zur behandlung von hyperplasie und verwandten erkrankungenInfo
- Publication number
- ATE313324T1 ATE313324T1 AT96918159T AT96918159T ATE313324T1 AT E313324 T1 ATE313324 T1 AT E313324T1 AT 96918159 T AT96918159 T AT 96918159T AT 96918159 T AT96918159 T AT 96918159T AT E313324 T1 ATE313324 T1 AT E313324T1
- Authority
- AT
- Austria
- Prior art keywords
- brefeldin
- derivatives
- hyperplasia
- intimal hyperplasia
- manufacturing
- Prior art date
Links
- KQNZDYYTLMIZCT-KQPMLPITSA-N brefeldin A Chemical compound O[C@@H]1\C=C\C(=O)O[C@@H](C)CCC\C=C\[C@@H]2C[C@H](O)C[C@H]21 KQNZDYYTLMIZCT-KQPMLPITSA-N 0.000 title abstract 4
- 206010020718 hyperplasia Diseases 0.000 title abstract 4
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 229940126601 medicinal product Drugs 0.000 title 1
- 238000000034 method Methods 0.000 abstract 3
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 abstract 2
- 241000124008 Mammalia Species 0.000 abstract 2
- 239000005557 antagonist Substances 0.000 abstract 2
- JUMGSHROWPPKFX-UHFFFAOYSA-N brefeldin-A Natural products CC1CCCC=CC2(C)CC(O)CC2(C)C(O)C=CC(=O)O1 JUMGSHROWPPKFX-UHFFFAOYSA-N 0.000 abstract 2
- 229960002897 heparin Drugs 0.000 abstract 2
- 229920000669 heparin Polymers 0.000 abstract 2
- 230000002401 inhibitory effect Effects 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 241000288906 Primates Species 0.000 abstract 1
- 208000024248 Vascular System injury Diseases 0.000 abstract 1
- 208000012339 Vascular injury Diseases 0.000 abstract 1
- 230000003872 anastomosis Effects 0.000 abstract 1
- 238000002399 angioplasty Methods 0.000 abstract 1
- 238000013171 endarterectomy Methods 0.000 abstract 1
- 238000006722 reduction reaction Methods 0.000 abstract 1
- 230000002792 vascular Effects 0.000 abstract 1
- 210000005166 vasculature Anatomy 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/483,216 US5618837A (en) | 1995-06-07 | 1995-06-07 | PDGF antagonists III |
| PCT/US1996/009061 WO1996040112A1 (en) | 1995-06-07 | 1996-06-04 | Use of brefeldin a and derivatives thereof in the treatment of hyperplasia and related disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE313324T1 true ATE313324T1 (de) | 2006-01-15 |
Family
ID=23919165
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT96918159T ATE313324T1 (de) | 1995-06-07 | 1996-06-04 | Verwendung von brefeldin a und deren derivate in der herstellung von arzneimittel zur behandlung von hyperplasie und verwandten erkrankungen |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5618837A (de) |
| EP (1) | EP0831807B1 (de) |
| JP (1) | JP3190684B2 (de) |
| AT (1) | ATE313324T1 (de) |
| AU (1) | AU6048396A (de) |
| DE (1) | DE69635614T2 (de) |
| DK (1) | DK0831807T3 (de) |
| ES (1) | ES2253750T3 (de) |
| WO (1) | WO1996040112A1 (de) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001512422A (ja) * | 1997-02-05 | 2001-08-21 | アレリツクス・フアーム−エコ・エル・ピー | 記憶増強のための薬剤 |
| WO1999031084A1 (en) | 1997-12-18 | 1999-06-24 | Purdue Research Foundation | Brefeldin a derivatives |
| US8236048B2 (en) | 2000-05-12 | 2012-08-07 | Cordis Corporation | Drug/drug delivery systems for the prevention and treatment of vascular disease |
| US20050002986A1 (en) * | 2000-05-12 | 2005-01-06 | Robert Falotico | Drug/drug delivery systems for the prevention and treatment of vascular disease |
| CA2424029C (en) | 2000-09-29 | 2008-01-29 | Cordis Corporation | Coated medical devices |
| AU2001296558A1 (en) | 2000-10-03 | 2002-04-15 | Oncopharmaceutical, Inc. | Inhibitors of angiogenesis and tumor growth for local and systemic administration |
| NZ592039A (en) | 2003-08-27 | 2013-03-28 | Ophthotech Corp | Combination therapy for the treatment of ocular neovascular disorders |
| WO2010099139A2 (en) | 2009-02-25 | 2010-09-02 | Osi Pharmaceuticals, Inc. | Combination anti-cancer therapy |
| WO2010099138A2 (en) | 2009-02-27 | 2010-09-02 | Osi Pharmaceuticals, Inc. | Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation |
| WO2010099363A1 (en) | 2009-02-27 | 2010-09-02 | Osi Pharmaceuticals, Inc. | Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation |
| WO2010099364A2 (en) | 2009-02-27 | 2010-09-02 | Osi Pharmaceuticals, Inc. | Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation |
| WO2012149014A1 (en) | 2011-04-25 | 2012-11-01 | OSI Pharmaceuticals, LLC | Use of emt gene signatures in cancer drug discovery, diagnostics, and treatment |
| WO2013152252A1 (en) | 2012-04-06 | 2013-10-10 | OSI Pharmaceuticals, LLC | Combination anti-cancer therapy |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5250519A (en) * | 1991-03-29 | 1993-10-05 | Glycomed Incorporated | Non-anticoagulant heparin derivatives |
| CA2094858C (en) * | 1992-04-28 | 2004-06-15 | Robert D. Mitchell | Method of treating hyperproliferative vascular disease |
| WO1995021614A1 (en) * | 1994-02-09 | 1995-08-17 | Ariad Pharmaceuticals, Inc. | New protein trafficking inhibitors |
-
1995
- 1995-06-07 US US08/483,216 patent/US5618837A/en not_active Expired - Fee Related
-
1996
- 1996-06-04 AU AU60483/96A patent/AU6048396A/en not_active Abandoned
- 1996-06-04 WO PCT/US1996/009061 patent/WO1996040112A1/en not_active Ceased
- 1996-06-04 DK DK96918159T patent/DK0831807T3/da active
- 1996-06-04 ES ES96918159T patent/ES2253750T3/es not_active Expired - Lifetime
- 1996-06-04 DE DE69635614T patent/DE69635614T2/de not_active Expired - Fee Related
- 1996-06-04 EP EP96918159A patent/EP0831807B1/de not_active Expired - Lifetime
- 1996-06-04 JP JP50147297A patent/JP3190684B2/ja not_active Expired - Fee Related
- 1996-06-04 AT AT96918159T patent/ATE313324T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP0831807A1 (de) | 1998-04-01 |
| DK0831807T3 (da) | 2006-05-08 |
| WO1996040112A1 (en) | 1996-12-19 |
| DE69635614D1 (de) | 2006-01-26 |
| EP0831807B1 (de) | 2005-12-21 |
| US5618837A (en) | 1997-04-08 |
| JP2000513703A (ja) | 2000-10-17 |
| DE69635614T2 (de) | 2006-07-27 |
| AU6048396A (en) | 1996-12-30 |
| JP3190684B2 (ja) | 2001-07-23 |
| ES2253750T3 (es) | 2006-06-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 0831807 Country of ref document: EP |
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| REN | Ceased due to non-payment of the annual fee |