DK0680323T3 - Synergistisk kombination med antagonistvirkning ved NK1- og Nk2-receptorer. - Google Patents

Synergistisk kombination med antagonistvirkning ved NK1- og Nk2-receptorer.

Info

Publication number
DK0680323T3
DK0680323T3 DK94904685.8T DK94904685T DK0680323T3 DK 0680323 T3 DK0680323 T3 DK 0680323T3 DK 94904685 T DK94904685 T DK 94904685T DK 0680323 T3 DK0680323 T3 DK 0680323T3
Authority
DK
Denmark
Prior art keywords
receptors
antagonist activity
synergistic combination
product
associations
Prior art date
Application number
DK94904685.8T
Other languages
English (en)
Inventor
Claude Garret
Francois Montier
Original Assignee
Rhone Poulenc Rorer Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Rorer Sa filed Critical Rhone Poulenc Rorer Sa
Application granted granted Critical
Publication of DK0680323T3 publication Critical patent/DK0680323T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
  • Soil Working Implements (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Electrotherapy Devices (AREA)
  • Cosmetics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK94904685.8T 1993-01-19 1994-01-18 Synergistisk kombination med antagonistvirkning ved NK1- og Nk2-receptorer. DK0680323T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9300451A FR2700472B1 (fr) 1993-01-19 1993-01-19 Association synergisante ayant un effet antagoniste des récepteurs NK1 et NK2.

Publications (1)

Publication Number Publication Date
DK0680323T3 true DK0680323T3 (da) 1997-10-20

Family

ID=9443143

Family Applications (1)

Application Number Title Priority Date Filing Date
DK94904685.8T DK0680323T3 (da) 1993-01-19 1994-01-18 Synergistisk kombination med antagonistvirkning ved NK1- og Nk2-receptorer.

Country Status (25)

Country Link
US (1) US6177450B1 (da)
EP (1) EP0680323B1 (da)
JP (1) JP4341783B2 (da)
KR (1) KR100342152B1 (da)
AT (1) ATE150972T1 (da)
AU (1) AU682166B2 (da)
BE (1) BE1006705A3 (da)
CA (1) CA2152401C (da)
CH (1) CH687503A5 (da)
DE (1) DE69402411T2 (da)
DK (1) DK0680323T3 (da)
ES (2) ES2100689T3 (da)
FR (1) FR2700472B1 (da)
GB (1) GB2274777B (da)
GR (1) GR3023021T3 (da)
IE (1) IE940035A1 (da)
IL (1) IL108356A (da)
IT (1) IT1269185B (da)
LU (1) LU88442A1 (da)
NO (1) NO315077B1 (da)
NZ (1) NZ259728A (da)
PT (1) PT101444A (da)
TW (1) TW381021B (da)
WO (1) WO1994016697A1 (da)
ZA (1) ZA94333B (da)

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GB2287404A (en) * 1994-03-15 1995-09-20 Pfizer Antiinflammatory and analgesic compositions
WO1996014845A1 (en) * 1994-11-10 1996-05-23 Pfizer Inc. Nk-1 receptor antagonists for the treatment of eye disorders
US5696267A (en) * 1995-05-02 1997-12-09 Schering Corporation Substituted oximes, hydrazones and olefins as neurokinin antagonists
US5688960A (en) * 1995-05-02 1997-11-18 Schering Corporation Substituted oximes, hydrazones and olefins useful as neurokinin antagonists
FR2738245B1 (fr) * 1995-08-28 1997-11-21 Sanofi Sa Nouveaux derives de piperidine, procede pour leur obtention et compositions pharmaceutiques les contenant
US5691362A (en) * 1996-06-05 1997-11-25 Schering-Plough Corporation Substituted benzene-fused hetero- and carbocyclics as nuerokinin antagonists
US5789422A (en) * 1996-10-28 1998-08-04 Schering Corporation Substituted arylalkylamines as neurokinin antagonists
WO1998024446A1 (en) * 1996-12-02 1998-06-11 Merck Sharp & Dohme Limited Use of nk-1 receptor antagonists for treating movement disorders
US6156749A (en) * 1997-12-01 2000-12-05 Merck Sharp & Dohme Limited Use of NK-1 receptor antagonists for treating movement disorders
GB9816897D0 (en) * 1998-08-04 1998-09-30 Merck Sharp & Dohme Therapeutic use
FR2792835B3 (fr) * 1999-04-27 2001-05-25 Sanofi Sa Utilisation du saredutant pour la preparation de medicaments utiles dans le traitement ou la prevention de l'ensemble des troubles de l'humeur, des troubles de l'adaptation ou des troubles mixtes anxiete-depression
US20100189797A1 (en) 2002-06-10 2010-07-29 Julien Mendlewicz Oral antidepressant formulation
AU2004283038B9 (en) * 2003-10-27 2008-04-24 Novartis Ag Use of neurokinin antagonists in the treatment of urinary incontinence
US20060069086A1 (en) * 2004-09-23 2006-03-30 Alexander Michalow Methods for regulating neurotransmitter systems by inducing counteradaptations
US20080045610A1 (en) * 2004-09-23 2008-02-21 Alexander Michalow Methods for regulating neurotransmitter systems by inducing counteradaptations

Family Cites Families (35)

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US5164372A (en) 1989-04-28 1992-11-17 Fujisawa Pharmaceutical Company, Ltd. Peptide compounds having substance p antagonism, processes for preparation thereof and pharmaceutical composition comprising the same
FI97540C (fi) 1989-11-06 1997-01-10 Sanofi Sa Menetelmä terapeuttisesti käyttökelpoisten, aromaattisesti substituoitujen piperidiini- ja piperatsiinijohdannaisten valmistamiseksi
GB8929070D0 (en) 1989-12-22 1990-02-28 Fujisawa Pharmaceutical Co Peptide compounds,processes for preparation thereof and pharmaceutical composition comprising the same
US5232929A (en) 1990-11-28 1993-08-03 Pfizer Inc. 3-aminopiperidine derivatives and related nitrogen containing heterocycles and pharmaceutical compositions and use
IL99320A (en) 1990-09-05 1995-07-31 Sanofi Sa Arylalkylamines, their preparation and pharmaceutical compositions containing them
FR2678267B1 (fr) 1991-06-25 1994-02-04 Elf Sanofi Arylalkylamines, procede pour leur preparation et compositions pharmaceutiques les contenant.
GB9023116D0 (en) 1990-10-24 1990-12-05 Fujisawa Pharmaceutical Co Peptide compounds,processes for preparation thereof and pharmaceutical composition comprising the same
US5242930A (en) 1991-02-11 1993-09-07 Merck Sharp & Dohme Ltd. Azabicyclic compounds, pharmaceutical compositions containing them and their use in therapy
FR2677361A1 (fr) * 1991-06-04 1992-12-11 Adir Nouveaux peptides et pseudopeptides, derives de tachykinines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
EP0668770A1 (en) 1991-04-24 1995-08-30 Warner-Lambert Company $g(a)-SUBSTITUTED POLYPEPTIDES HAVING THERAPEUTIC ACTIVITY
FR2676054B1 (fr) 1991-05-03 1993-09-03 Sanofi Elf Nouveaux composes n-alkylenepiperidino et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant.
FR2676055B1 (fr) 1991-05-03 1993-09-03 Sanofi Elf Composes polycycliques amines et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant.
FR2676053B1 (fr) 1991-05-03 1993-08-27 Sanofi Elf Nouveaux composes dialkylenepiperidino et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant.
SK282203B6 (sk) 1991-06-20 2001-12-03 Pfizer Inc. Fluoroalkoxybenzylamínové deriváty heterocyklov obsahujúcich dusík, spôsob ich prípravy, medziprodukty, spôsob prípravy medziproduktov, použitie a farmaceutický prostriedok
TW202432B (da) 1991-06-21 1993-03-21 Pfizer
US5288730A (en) 1991-06-24 1994-02-22 Merck Sharp & Dohme Limited Azabicyclic compounds, pharmaceutical compositions containing them and their use in therapy
AU664188B2 (en) 1991-07-05 1995-11-09 Merck Sharp & Dohme Limited Aromatic compounds, pharmaceutical compositions containing them and their use in therapy
JPH06509087A (ja) 1991-07-05 1994-10-13 メルク　シヤープ　エンド　ドーム　リミテツド 芳香族化合物、それらを含む医薬組成物、及び治療におけるそれらの使用
EP0536817A1 (en) 1991-07-05 1993-04-14 MERCK SHARP & DOHME LTD. Azabicyclic compounds as tachykinin antagonists
WO1993001165A2 (en) 1991-07-10 1993-01-21 Merck Sharp & Dohme Limited Aromatic compounds, compositions containing them and their use in therapy
US5495047A (en) 1991-07-10 1996-02-27 Merck, Sharp & Dohme (Ltd.) Fused tricyclic compounds, pharmaceutical compositions containing them and their use in therapy
MY110227A (en) 1991-08-12 1998-03-31 Ciba Geigy Ag 1-acylpiperindine compounds.
CA2112397A1 (en) 1991-08-20 1993-03-04 Raymond Baker Azacyclic compounds, processes for their preparation and pharmaceutical compositions containing them
ES2149767T5 (es) 1991-09-20 2005-06-16 Glaxo Group Limited Nuevo uso medico para antagonistas de taquiquininas.
EP0607164B1 (en) 1991-09-26 2002-05-02 Pfizer Inc. Fused tricyclic nitrogen containing heterocycles as substance p receptor antagonists
JP2553020B2 (ja) 1991-11-07 1996-11-13 吉富製薬株式会社 キヌクリジン化合物およびその医薬用途
ES2111650T3 (es) 1991-11-12 1998-03-16 Pfizer Derivados aciclicos de etilenodiamina como antagonistas de receptores de la sustancia p.
EP0545478A1 (en) 1991-12-03 1993-06-09 MERCK SHARP & DOHME LTD. Heterocyclic compounds as tachykinin antagonists
GB9201179D0 (en) 1992-01-21 1992-03-11 Glaxo Group Ltd Chemical compounds
US5328927A (en) 1992-03-03 1994-07-12 Merck Sharpe & Dohme, Ltd. Hetercyclic compounds, processes for their preparation and pharmaceutical compositions containing them
FR2688219B1 (fr) 1992-03-03 1994-07-08 Sanofi Elf Sels d'ammonium quaternaires de composes aromatiques amines, leur preparation et compositions pharmaceutiques les contenant.
JP2656702B2 (ja) 1992-03-23 1997-09-24 ファイザー製薬株式会社 ペプチド性キヌクリジン
FR2689888B1 (fr) 1992-04-10 1994-06-10 Rhone Poulenc Rorer Sa Nouveaux derives de perhydroisoindole, leur preparation et les compositions pharmaceutiques qui les contiennent.
AU675786B2 (en) 1992-04-15 1997-02-20 Merck Sharp & Dohme Limited Azacyclic compounds
DE69331190T2 (de) 1992-05-18 2002-04-18 Pfizer Inc., New York Überbrückte azabicyclische derivate als substanz p antagonisten

Also Published As

Publication number Publication date
PT101444A (pt) 1994-10-31
GB9400691D0 (en) 1994-03-09
CA2152401A1 (fr) 1994-08-04
US6177450B1 (en) 2001-01-23
IL108356A (en) 1998-09-24
DE69402411D1 (de) 1997-05-07
IL108356A0 (en) 1994-04-12
JP4341783B2 (ja) 2009-10-07
KR960700056A (ko) 1996-01-19
IE940035A1 (en) 1994-07-27
ITMI940039A0 (it) 1994-01-14
FR2700472A1 (fr) 1994-07-22
GB2274777B (en) 1996-10-02
NZ259728A (en) 1996-05-28
ES2091712A1 (es) 1996-11-01
NO952828D0 (no) 1995-07-17
JPH08505637A (ja) 1996-06-18
TW381021B (en) 2000-02-01
IT1269185B (it) 1997-03-21
ES2091712B1 (es) 1997-08-01
NO315077B1 (no) 2003-07-07
DE69402411T2 (de) 1997-10-30
GR3023021T3 (en) 1997-07-30
EP0680323A1 (fr) 1995-11-08
WO1994016697A1 (fr) 1994-08-04
ES2100689T3 (es) 1997-06-16
NO952828L (no) 1995-07-17
AU682166B2 (en) 1997-09-25
ITMI940039A1 (it) 1995-07-14
ATE150972T1 (de) 1997-04-15
LU88442A1 (fr) 1994-10-03
CH687503A5 (fr) 1996-12-31
EP0680323B1 (fr) 1997-04-02
CA2152401C (fr) 2008-08-26
GB2274777A (en) 1994-08-10
FR2700472B1 (fr) 1995-02-17
BE1006705A3 (fr) 1994-11-22
AU5862794A (en) 1994-08-15
KR100342152B1 (ko) 2003-02-26
ZA94333B (en) 1994-09-02

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