ATE313549T1 - Bis-(n,n'-bis-(2-haloethyl)amino) phosphoramidate als antitumor-mittel - Google Patents

Bis-(n,n'-bis-(2-haloethyl)amino) phosphoramidate als antitumor-mittel

Info

Publication number: ATE313549T1
Authority: AT; Austria
Prior art keywords: bis; haloethyl; phosphoramidate; amino; antitumor agent
Prior art date: 2000-05-02

Application number

AT01935025T

Other languages

English (en)

Inventor

Jason R Herr

Robert T Lum

Steven R Schow

Fanying Meng

Michael R Kozlowski

Pavel Zhichkin

Original Assignee

Telik Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-05-02

Filing date

2001-05-02

Publication date

2006-01-15

2001-05-02 Application filed by Telik Inc filed Critical Telik Inc

2006-01-15 Application granted granted Critical

2006-01-15 Publication of ATE313549T1 publication Critical patent/ATE313549T1/de

Links

239000002246 antineoplastic agent Substances 0.000 title 1
PTMHPRAIXMAOOB-UHFFFAOYSA-L phosphoramidate Chemical compound NP([O-])([O-])=O PTMHPRAIXMAOOB-UHFFFAOYSA-L 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/22—Amides of acids of phosphorus
- C07F9/24—Esteramides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/22—Amides of acids of phosphorus
- C07F9/24—Esteramides
- C07F9/2454—Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic
- C07F9/2458—Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic of aliphatic amines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/22—Amides of acids of phosphorus
- C07F9/24—Esteramides
- C07F9/2404—Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic
- C07F9/2408—Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic of hydroxyalkyl compounds

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Tropical Medicine & Parasitology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AT01935025T 2000-05-02 2001-05-02 Bis-(n,n'-bis-(2-haloethyl)amino) phosphoramidate als antitumor-mittel ATE313549T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US56318100A	2000-05-02	2000-05-02
PCT/US2001/014290 WO2001083496A1 (en)	2000-05-02	2001-05-02	Bis-(n,n'-bis-(2-haloethyl)amino) phosphoramidates as antitumor agents

Publications (1)

Publication Number	Publication Date
ATE313549T1 true ATE313549T1 (de)	2006-01-15

Family

ID=24249433

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT01935025T ATE313549T1 (de)	2000-05-02	2001-05-02	Bis-(n,n'-bis-(2-haloethyl)amino) phosphoramidate als antitumor-mittel
AT05020467T ATE455779T1 (de)	2000-05-02	2001-05-02	Bis-(n,n'-bis-(2-haloethyl)amino)-phosphoramida e als anti-tumormittel

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
AT05020467T ATE455779T1 (de)	2000-05-02	2001-05-02	Bis-(n,n'-bis-(2-haloethyl)amino)-phosphoramida e als anti-tumormittel

Country Status (25)

Country	Link
EP (2)	EP1607399B1 (de)
JP (1)	JP4249928B2 (de)
KR (1)	KR100729980B1 (de)
CN (1)	CN1182143C (de)
AR (1)	AR029072A1 (de)
AT (2)	ATE313549T1 (de)
AU (2)	AU2001261153B2 (de)
BR (1)	BR0110553A (de)
CA (1)	CA2407606C (de)
CZ (1)	CZ20023615A3 (de)
DE (2)	DE60141181D1 (de)
DK (2)	DK1607399T3 (de)
EA (1)	EA006852B1 (de)
ES (2)	ES2253380T3 (de)
HU (1)	HUP0300688A3 (de)
IL (2)	IL152325A0 (de)
MX (1)	MXPA02010813A (de)
NO (2)	NO328854B1 (de)
NZ (1)	NZ522189A (de)
PL (1)	PL207005B1 (de)
PT (1)	PT1607399E (de)
TW (1)	TWI308569B (de)
UA (1)	UA74574C2 (de)
WO (1)	WO2001083496A1 (de)
ZA (1)	ZA200208591B (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TW200600091A (en)	2004-05-21	2006-01-01	Telik Inc	Sulfonylethyl phosphorodiamidates
US8198247B2 (en)	2004-12-21	2012-06-12	Telik, Inc.	Process for and intermediates in the preparation of canfosfamide and its salts
US7655799B2 (en)	2006-11-29	2010-02-02	Telik, Inc.	2{[2-(substituted amino)ethyl]sulfonyl}ethyl N,N,N',N'-tetrakis(2-chloroethyl)phosphorodiamidates
US7872134B2 (en)	2007-12-12	2011-01-18	Telik, Inc.	2-{[2-(substituted amino)ethyl]sulfonyl}ethyl N,N-bis(2-chloroethyl)phosphorodiamidates
JP2011517555A (ja)	2008-03-14	2011-06-16	ジェネンテック，インコーポレイテッド	薬剤耐性に関連する遺伝的変異
WO2020228685A1 (zh)	2019-05-13	2020-11-19	深圳艾欣达伟医药科技有限公司	含氟化合物及抗癌医药用途

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5556942A (en) *	1991-04-29	1996-09-17	Terrapin Technologies, Inc.	Glutathione S-transferase-activated compounds

2001
- 2001-02-05 UA UA2002119554A patent/UA74574C2/uk unknown
- 2001-05-01 TW TW090110381A patent/TWI308569B/zh not_active IP Right Cessation
- 2001-05-02 AT AT01935025T patent/ATE313549T1/de active
- 2001-05-02 EP EP05020467A patent/EP1607399B1/de not_active Expired - Lifetime
- 2001-05-02 AU AU2001261153A patent/AU2001261153B2/en not_active Ceased
- 2001-05-02 AT AT05020467T patent/ATE455779T1/de active
- 2001-05-02 ES ES01935025T patent/ES2253380T3/es not_active Expired - Lifetime
- 2001-05-02 KR KR1020027014577A patent/KR100729980B1/ko not_active Expired - Fee Related
- 2001-05-02 HU HU0300688A patent/HUP0300688A3/hu unknown
- 2001-05-02 WO PCT/US2001/014290 patent/WO2001083496A1/en not_active Ceased
- 2001-05-02 AR ARP010102067A patent/AR029072A1/es active IP Right Grant
- 2001-05-02 MX MXPA02010813A patent/MXPA02010813A/es active IP Right Grant
- 2001-05-02 CZ CZ20023615A patent/CZ20023615A3/cs unknown
- 2001-05-02 DE DE60141181T patent/DE60141181D1/de not_active Expired - Lifetime
- 2001-05-02 EA EA200201154A patent/EA006852B1/ru not_active IP Right Cessation
- 2001-05-02 PT PT05020467T patent/PT1607399E/pt unknown
- 2001-05-02 AU AU6115301A patent/AU6115301A/xx active Pending
- 2001-05-02 ES ES05020467T patent/ES2337154T3/es not_active Expired - Lifetime
- 2001-05-02 DK DK05020467.6T patent/DK1607399T3/da active
- 2001-05-02 DK DK01935025T patent/DK1278759T3/da active
- 2001-05-02 DE DE60116081T patent/DE60116081T2/de not_active Expired - Lifetime
- 2001-05-02 EP EP01935025A patent/EP1278759B1/de not_active Expired - Lifetime
- 2001-05-02 CA CA002407606A patent/CA2407606C/en not_active Expired - Fee Related
- 2001-05-02 BR BR0110553-1A patent/BR0110553A/pt active Search and Examination
- 2001-05-02 NZ NZ522189A patent/NZ522189A/en not_active IP Right Cessation
- 2001-05-02 CN CNB018089623A patent/CN1182143C/zh not_active Expired - Fee Related
- 2001-05-02 JP JP2001580921A patent/JP4249928B2/ja not_active Expired - Fee Related
- 2001-05-02 PL PL358155A patent/PL207005B1/pl not_active IP Right Cessation
- 2001-05-02 IL IL15232501A patent/IL152325A0/xx unknown
2002
- 2002-10-16 IL IL152325A patent/IL152325A/en not_active IP Right Cessation
- 2002-10-23 ZA ZA200208591A patent/ZA200208591B/en unknown
- 2002-11-01 NO NO20025240A patent/NO328854B1/no not_active IP Right Cessation
2009
- 2009-11-18 NO NO20093371A patent/NO331833B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
DE60116081T2 (de)	2006-08-03
KR20020094000A (ko)	2002-12-16
DK1278759T3 (da)	2006-02-13
PT1607399E (pt)	2010-02-02
JP2003531913A (ja)	2003-10-28
DE60116081D1 (en)	2006-01-26
WO2001083496A1 (en)	2001-11-08
AU6115301A (en)	2001-11-12
NO331833B1 (no)	2012-04-16
TWI308569B (en)	2009-04-11
NO20025240L (no)	2002-12-04
EP1607399A3 (de)	2006-01-04
EP1607399A2 (de)	2005-12-21
CN1182143C (zh)	2004-12-29
JP4249928B2 (ja)	2009-04-08
CA2407606C (en)	2008-07-15
ZA200208591B (en)	2004-03-04
CZ20023615A3 (cs)	2003-04-16
IL152325A0 (en)	2003-05-29
NO328854B1 (no)	2010-05-31
HK1084119A1 (en)	2006-07-21
DK1607399T3 (da)	2010-05-10
UA74574C2 (en)	2006-01-16
EP1607399B1 (de)	2010-01-20
BR0110553A (pt)	2003-04-01
NO20093371L (no)	2002-12-04
DE60141181D1 (de)	2010-03-11
NO20025240D0 (no)	2002-11-01
EA200201154A1 (ru)	2003-04-24
ATE455779T1 (de)	2010-02-15
PL358155A1 (en)	2004-08-09
ES2253380T3 (es)	2006-06-01
EA006852B1 (ru)	2006-04-28
AR029072A1 (es)	2003-06-04
CA2407606A1 (en)	2001-11-08
ES2337154T3 (es)	2010-04-21
EP1278759B1 (de)	2005-12-21
KR100729980B1 (ko)	2007-06-20
MXPA02010813A (es)	2004-02-26
EP1278759A1 (de)	2003-01-29
NZ522189A (en)	2004-04-30
HUP0300688A3 (en)	2005-02-28
HUP0300688A2 (hu)	2003-07-28
CN1427844A (zh)	2003-07-02
HK1050368A1 (en)	2003-06-20
AU2001261153B2 (en)	2005-04-07
IL152325A (en)	2011-04-28
PL207005B1 (pl)	2010-10-29

Legal Events

Date

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Title

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2006-08-15

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ATE289640T1 (de)	2005-03-15	Amidofunktionelle aminopolydiorganosiloxane
EP1417988A4 (de)	2008-05-07	Atemgerät
DE60216854D1 (de)	2007-02-01	Polyamid-Zusammensetzung
NO20015477L (no)	2002-01-11	4,5,6,7-tetrahydroindazolderivater som antitumormidler
DE60203635D1 (de)	2005-05-12	Knieschützer für sportkleidungsstück
DK1322654T3 (da)	2009-04-14	Platinkomplekser som antitumormidler
ATE455779T1 (de)	2010-02-15	Bis-(n,n'-bis-(2-haloethyl)amino)-phosphoramida e als anti-tumormittel
NO20014753L (no)	2001-11-29	C(10)-karbonatsubstituerte taxaner som antitumormidler
DE60102039D1 (de)	2004-03-25	Polyamidzusammensetzung
DE60107240D1 (de)	2004-12-23	Bicyclyl oder heterobicyclyl methanesulfonylamino-substituierte n-hydroxyformamide
NO20031239D0 (no)	2003-03-18	1-amino-alkylsykloheksaner som trypanocidale midler
ITMI20011758A1 (it)	2003-02-10	Ligandi
DK1177185T3 (da)	2005-06-06	4,5,6,7-tetrahydroindazolderivater som antitumormidler
ES1048305Y (es)	2001-12-01	Hebilla autoblocante.
ITRM20000389A0 (it)	2000-07-14	Torcia elettrica tascabile di novita'.
ES1049554Y (es)	2002-04-16	Agenda de bolsillo
UA4997S (uk)	2001-07-16	Етикетка «княжна. печиво мигдальне»
UA5696S (uk)	2002-02-15	Костюм чоловічий
PT1056744E (pt)	2004-03-31	2-¬trans-(4-aminociclo-hexil)amino\|purinas 6,9-dissubstituidas
ES1050241Y (es)	2002-07-01	Maquina de juego de habilidad-expendedora de premios.
FI20001995A0 (fi)	2000-09-11	Palovaroitinjärjestelmä
ES1046259Y (es)	2001-05-16	Tobogan infantil.
UA6263S (uk)	2002-08-15	Бойова машина
IT1315997B1 (it)	2003-03-26	Apparecchiatura per indossare guanti elastici.
ES1050442Y (es)	2002-07-16	Prenda protectora.