ATE455779T1 - Bis-(n,n'-bis-(2-haloethyl)amino)-phosphoramida e als anti-tumormittel - Google Patents

Bis-(n,n'-bis-(2-haloethyl)amino)-phosphoramida e als anti-tumormittel

Info

Publication number: ATE455779T1
Authority: AT; Austria
Prior art keywords: bis; phosphoramida; haloethyl; amino; tumor agent
Prior art date: 2000-05-02

Application number

AT05020467T

Other languages

English (en)

Inventor

Jason R Herr

Fanying Meng

Robert T Lum

Michael R Kozlowski

Steven R Schow

Pavel Zhichkin

Original Assignee

Telik Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-05-02

Filing date

2001-05-02

Publication date

2010-02-15

2001-05-02 Application filed by Telik Inc filed Critical Telik Inc

2010-02-15 Application granted granted Critical

2010-02-15 Publication of ATE455779T1 publication Critical patent/ATE455779T1/de

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/22—Amides of acids of phosphorus
- C07F9/24—Esteramides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/22—Amides of acids of phosphorus
- C07F9/24—Esteramides
- C07F9/2454—Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic
- C07F9/2458—Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic of aliphatic amines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/22—Amides of acids of phosphorus
- C07F9/24—Esteramides
- C07F9/2404—Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic
- C07F9/2408—Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic of hydroxyalkyl compounds

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Oncology (AREA)
Tropical Medicine & Parasitology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Communicable Diseases (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AT05020467T 2000-05-02 2001-05-02 Bis-(n,n'-bis-(2-haloethyl)amino)-phosphoramida e als anti-tumormittel ATE455779T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US56318100A	2000-05-02	2000-05-02

Publications (1)

Publication Number	Publication Date
ATE455779T1 true ATE455779T1 (de)	2010-02-15

Family

ID=24249433

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT01935025T ATE313549T1 (de)	2000-05-02	2001-05-02	Bis-(n,n'-bis-(2-haloethyl)amino) phosphoramidate als antitumor-mittel
AT05020467T ATE455779T1 (de)	2000-05-02	2001-05-02	Bis-(n,n'-bis-(2-haloethyl)amino)-phosphoramida e als anti-tumormittel

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
AT01935025T ATE313549T1 (de)	2000-05-02	2001-05-02	Bis-(n,n'-bis-(2-haloethyl)amino) phosphoramidate als antitumor-mittel

Country Status (25)

Country	Link
EP (2)	EP1278759B1 (de)
JP (1)	JP4249928B2 (de)
KR (1)	KR100729980B1 (de)
CN (1)	CN1182143C (de)
AR (1)	AR029072A1 (de)
AT (2)	ATE313549T1 (de)
AU (2)	AU6115301A (de)
BR (1)	BR0110553A (de)
CA (1)	CA2407606C (de)
CZ (1)	CZ20023615A3 (de)
DE (2)	DE60116081T2 (de)
DK (2)	DK1607399T3 (de)
EA (1)	EA006852B1 (de)
ES (2)	ES2337154T3 (de)
HU (1)	HUP0300688A3 (de)
IL (2)	IL152325A0 (de)
MX (1)	MXPA02010813A (de)
NO (2)	NO328854B1 (de)
NZ (1)	NZ522189A (de)
PL (1)	PL207005B1 (de)
PT (1)	PT1607399E (de)
TW (1)	TWI308569B (de)
UA (1)	UA74574C2 (de)
WO (1)	WO2001083496A1 (de)
ZA (1)	ZA200208591B (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TW200600091A (en)	2004-05-21	2006-01-01	Telik Inc	Sulfonylethyl phosphorodiamidates
US8198247B2 (en)	2004-12-21	2012-06-12	Telik, Inc.	Process for and intermediates in the preparation of canfosfamide and its salts
US7655799B2 (en)	2006-11-29	2010-02-02	Telik, Inc.	2{[2-(substituted amino)ethyl]sulfonyl}ethyl N,N,N',N'-tetrakis(2-chloroethyl)phosphorodiamidates
US7872134B2 (en)	2007-12-12	2011-01-18	Telik, Inc.	2-{[2-(substituted amino)ethyl]sulfonyl}ethyl N,N-bis(2-chloroethyl)phosphorodiamidates
US9879267B2 (en) *	2008-03-14	2018-01-30	Genentech, Inc.	Genetic variations associated with drug resistance
CN118834240A (zh)	2019-05-13	2024-10-25	深圳艾欣达伟医药科技有限公司	含氟化合物及抗癌医药用途

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5556942A (en) *	1991-04-29	1996-09-17	Terrapin Technologies, Inc.	Glutathione S-transferase-activated compounds

2001
- 2001-02-05 UA UA2002119554A patent/UA74574C2/uk unknown
- 2001-05-01 TW TW090110381A patent/TWI308569B/zh not_active IP Right Cessation
- 2001-05-02 AT AT01935025T patent/ATE313549T1/de active
- 2001-05-02 CA CA002407606A patent/CA2407606C/en not_active Expired - Fee Related
- 2001-05-02 AR ARP010102067A patent/AR029072A1/es active IP Right Grant
- 2001-05-02 EP EP01935025A patent/EP1278759B1/de not_active Expired - Lifetime
- 2001-05-02 WO PCT/US2001/014290 patent/WO2001083496A1/en not_active Ceased
- 2001-05-02 KR KR1020027014577A patent/KR100729980B1/ko not_active Expired - Fee Related
- 2001-05-02 CZ CZ20023615A patent/CZ20023615A3/cs unknown
- 2001-05-02 ES ES05020467T patent/ES2337154T3/es not_active Expired - Lifetime
- 2001-05-02 DE DE60116081T patent/DE60116081T2/de not_active Expired - Lifetime
- 2001-05-02 AU AU6115301A patent/AU6115301A/xx active Pending
- 2001-05-02 MX MXPA02010813A patent/MXPA02010813A/es active IP Right Grant
- 2001-05-02 IL IL15232501A patent/IL152325A0/xx unknown
- 2001-05-02 JP JP2001580921A patent/JP4249928B2/ja not_active Expired - Fee Related
- 2001-05-02 PT PT05020467T patent/PT1607399E/pt unknown
- 2001-05-02 HU HU0300688A patent/HUP0300688A3/hu unknown
- 2001-05-02 AU AU2001261153A patent/AU2001261153B2/en not_active Ceased
- 2001-05-02 NZ NZ522189A patent/NZ522189A/en not_active IP Right Cessation
- 2001-05-02 EP EP05020467A patent/EP1607399B1/de not_active Expired - Lifetime
- 2001-05-02 DK DK05020467.6T patent/DK1607399T3/da active
- 2001-05-02 DK DK01935025T patent/DK1278759T3/da active
- 2001-05-02 DE DE60141181T patent/DE60141181D1/de not_active Expired - Lifetime
- 2001-05-02 ES ES01935025T patent/ES2253380T3/es not_active Expired - Lifetime
- 2001-05-02 BR BR0110553-1A patent/BR0110553A/pt active Search and Examination
- 2001-05-02 PL PL358155A patent/PL207005B1/pl not_active IP Right Cessation
- 2001-05-02 CN CNB018089623A patent/CN1182143C/zh not_active Expired - Fee Related
- 2001-05-02 AT AT05020467T patent/ATE455779T1/de active
- 2001-05-02 EA EA200201154A patent/EA006852B1/ru not_active IP Right Cessation
2002
- 2002-10-16 IL IL152325A patent/IL152325A/en not_active IP Right Cessation
- 2002-10-23 ZA ZA200208591A patent/ZA200208591B/en unknown
- 2002-11-01 NO NO20025240A patent/NO328854B1/no not_active IP Right Cessation
2009
- 2009-11-18 NO NO20093371A patent/NO331833B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
CA2407606C (en)	2008-07-15
DE60116081D1 (en)	2006-01-26
HUP0300688A3 (en)	2005-02-28
DK1278759T3 (da)	2006-02-13
ZA200208591B (en)	2004-03-04
JP4249928B2 (ja)	2009-04-08
NO331833B1 (no)	2012-04-16
EP1607399A3 (de)	2006-01-04
CN1182143C (zh)	2004-12-29
EP1607399B1 (de)	2010-01-20
PL207005B1 (pl)	2010-10-29
PT1607399E (pt)	2010-02-02
AR029072A1 (es)	2003-06-04
PL358155A1 (en)	2004-08-09
HK1050368A1 (en)	2003-06-20
EA006852B1 (ru)	2006-04-28
NO20025240L (no)	2002-12-04
AU6115301A (en)	2001-11-12
HK1084119A1 (en)	2006-07-21
NO20025240D0 (no)	2002-11-01
HUP0300688A2 (hu)	2003-07-28
WO2001083496A1 (en)	2001-11-08
DE60116081T2 (de)	2006-08-03
NO20093371L (no)	2002-12-04
IL152325A (en)	2011-04-28
DK1607399T3 (da)	2010-05-10
KR100729980B1 (ko)	2007-06-20
CA2407606A1 (en)	2001-11-08
IL152325A0 (en)	2003-05-29
NZ522189A (en)	2004-04-30
ES2253380T3 (es)	2006-06-01
AU2001261153B2 (en)	2005-04-07
MXPA02010813A (es)	2004-02-26
BR0110553A (pt)	2003-04-01
EP1607399A2 (de)	2005-12-21
ES2337154T3 (es)	2010-04-21
JP2003531913A (ja)	2003-10-28
EP1278759A1 (de)	2003-01-29
TWI308569B (en)	2009-04-11
UA74574C2 (en)	2006-01-16
ATE313549T1 (de)	2006-01-15
KR20020094000A (ko)	2002-12-16
CN1427844A (zh)	2003-07-02
NO328854B1 (no)	2010-05-31
EA200201154A1 (ru)	2003-04-24
CZ20023615A3 (cs)	2003-04-16
EP1278759B1 (de)	2005-12-21
DE60141181D1 (de)	2010-03-11

Legal Events

Date

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Title

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2010-07-15

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Publication of translation of european patent specification

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Publication	Publication Date	Title
PL368370A1 (pl)	2005-03-21	Kompozycja glifosatu
EP1417988A4 (de)	2008-05-07	Atemgerät
ATE289640T1 (de)	2005-03-15	Amidofunktionelle aminopolydiorganosiloxane
DE60216854D1 (de)	2007-02-01	Polyamid-Zusammensetzung
DE60210598D1 (de)	2006-05-24	3,7-DIAZABICYCLOc3.3.1Ü-FORMULIERUNGEN ALS ANTIARRHYTHMIKA
DK1322654T3 (da)	2009-04-14	Platinkomplekser som antitumormidler
DE60100771D1 (de)	2003-10-23	Lederbeschichtungszusammensetzung
NO20030868L (no)	2003-04-04	N-(3,5-diklor-2-metoksyfenyl)-4-metoksy-3-piperazin-1-yl- benzensulfonamid
ATE313549T1 (de)	2006-01-15	Bis-(n,n'-bis-(2-haloethyl)amino) phosphoramidate als antitumor-mittel
BR0112600A (pt)	2003-06-24	Compostos calcilìticos
ATE468751T1 (de)	2010-06-15	Verbesserte herbizidzusammensetzung
DE60213084D1 (de)	2006-08-24	3,7-DIAZABICYCLOc3.3.1Ü-FORMULIERUNGEN ALS ANTIARRHYTHMIKA
IS7131A (is)	2004-01-29	Nýjar 2,4-díamínóþíasól afleiður
ATE470655T1 (de)	2010-06-15	Substituierte 1,5-diaminopentan-3-ol-verbindungen
ITRM20000389A0 (it)	2000-07-14	Torcia elettrica tascabile di novita'.
UA5728S (uk)	2002-03-15	Диван «шпех - комфорт»
UA6053S (uk)	2002-06-17	Пляшка «фреш»
PT1056744E (pt)	2004-03-31	2-¬trans-(4-aminociclo-hexil)amino\|purinas 6,9-dissubstituidas
UA4997S (uk)	2001-07-16	Етикетка «княжна. печиво мигдальне»
IS7299A (is)	2004-06-03	3,4-díhýdró-1H-ísókínólóín-2-ýl-afleiður
UA5696S (uk)	2002-02-15	Костюм чоловічий
ES1049554Y (es)	2002-04-16	Agenda de bolsillo
ITRM20010662A0 (it)	2001-11-07	Indumento per attivita' ginnica e relativo metodo di allenamento.
DK1177185T3 (da)	2005-06-06	4,5,6,7-tetrahydroindazolderivater som antitumormidler
ITMC20020043A0 (it)	2002-05-23	"macchina per la bricchettatura".