NO20093371L - Bis-(N,N'-bis(2-halogenetyl)amino)fosforamidater som antitumormiddel - Google Patents

Bis-(N,N'-bis(2-halogenetyl)amino)fosforamidater som antitumormiddel

Info

Publication number
NO20093371L
NO20093371L NO20093371A NO20093371A NO20093371L NO 20093371 L NO20093371 L NO 20093371L NO 20093371 A NO20093371 A NO 20093371A NO 20093371 A NO20093371 A NO 20093371A NO 20093371 L NO20093371 L NO 20093371L
Authority
NO
Norway
Prior art keywords
bis
haloethyl
phosphoramidates
amino
antitumor agent
Prior art date
Application number
NO20093371A
Other languages
English (en)
Other versions
NO331833B1 (no
Inventor
Robert T Lum
Steven R Schow
Fanying Meng
Pavel Zhichkin
Jason R Herr
Michael Kozlowski
Original Assignee
Telik Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Publication of NO20093371L publication Critical patent/NO20093371L/no
Application filed by Telik Inc filed Critical Telik Inc
Publication of NO331833B1 publication Critical patent/NO331833B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/22—Amides of acids of phosphorus
    • C07F9/24—Esteramides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/22—Amides of acids of phosphorus
    • C07F9/24—Esteramides
    • C07F9/2454—Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/2458—Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic of aliphatic amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/22—Amides of acids of phosphorus
    • C07F9/24—Esteramides
    • C07F9/2404—Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/2408—Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic of hydroxyalkyl compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Forbindelse dom har antitumor-aktivitet eller er i stand til å bli modifisert til å ha antitumor-aktivitet er særlig egnet for anvendelse ved fremgangsmåter for behandling av tumorer, og spesielt behandling av cancer. Det beskrives også farmasøytiske preparater og fremgangsmåte for fremstilling av den kjemiske forbindelse.
NO20093371A 2000-05-02 2009-11-18 Bis-(N'N'-bis-(2-halogenetyl)amino)-fosforamidat-forbindelser, farmasoytisk preparat omfattende slike forbindelser, anvendelse av forbindelsene som antitumormiddel, og fremgangsmate for fremstilling av forbindelsene NO331833B1 (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US56318100A 2000-05-02 2000-05-02

Publications (2)

Publication Number Publication Date
NO20093371L true NO20093371L (no) 2002-12-04
NO331833B1 NO331833B1 (no) 2012-04-16

Family

ID=24249433

Family Applications (2)

Application Number Title Priority Date Filing Date
NO20025240A NO328854B1 (no) 2000-05-02 2002-11-01 Bis-(N',N'-bis-(2-halogenetyl)amino)-fosforamidat, farmasoytisk preparat omfattende forbindelsen, fremgangsmate for fremstilling og anvendelse av forbindelsen.
NO20093371A NO331833B1 (no) 2000-05-02 2009-11-18 Bis-(N'N'-bis-(2-halogenetyl)amino)-fosforamidat-forbindelser, farmasoytisk preparat omfattende slike forbindelser, anvendelse av forbindelsene som antitumormiddel, og fremgangsmate for fremstilling av forbindelsene

Family Applications Before (1)

Application Number Title Priority Date Filing Date
NO20025240A NO328854B1 (no) 2000-05-02 2002-11-01 Bis-(N',N'-bis-(2-halogenetyl)amino)-fosforamidat, farmasoytisk preparat omfattende forbindelsen, fremgangsmate for fremstilling og anvendelse av forbindelsen.

Country Status (25)

Country Link
EP (2) EP1607399B1 (no)
JP (1) JP4249928B2 (no)
KR (1) KR100729980B1 (no)
CN (1) CN1182143C (no)
AR (1) AR029072A1 (no)
AT (2) ATE313549T1 (no)
AU (2) AU2001261153B2 (no)
BR (1) BR0110553A (no)
CA (1) CA2407606C (no)
CZ (1) CZ20023615A3 (no)
DE (2) DE60141181D1 (no)
DK (2) DK1607399T3 (no)
EA (1) EA006852B1 (no)
ES (2) ES2253380T3 (no)
HU (1) HUP0300688A3 (no)
IL (2) IL152325A0 (no)
MX (1) MXPA02010813A (no)
NO (2) NO328854B1 (no)
NZ (1) NZ522189A (no)
PL (1) PL207005B1 (no)
PT (1) PT1607399E (no)
TW (1) TWI308569B (no)
UA (1) UA74574C2 (no)
WO (1) WO2001083496A1 (no)
ZA (1) ZA200208591B (no)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200600091A (en) 2004-05-21 2006-01-01 Telik Inc Sulfonylethyl phosphorodiamidates
US8198247B2 (en) 2004-12-21 2012-06-12 Telik, Inc. Process for and intermediates in the preparation of canfosfamide and its salts
US7655799B2 (en) 2006-11-29 2010-02-02 Telik, Inc. 2{[2-(substituted amino)ethyl]sulfonyl}ethyl N,N,N',N'-tetrakis(2-chloroethyl)phosphorodiamidates
US7872134B2 (en) 2007-12-12 2011-01-18 Telik, Inc. 2-{[2-(substituted amino)ethyl]sulfonyl}ethyl N,N-bis(2-chloroethyl)phosphorodiamidates
JP2011517555A (ja) 2008-03-14 2011-06-16 ジェネンテック， インコーポレイテッド 薬剤耐性に関連する遺伝的変異
WO2020228685A1 (zh) 2019-05-13 2020-11-19 深圳艾欣达伟医药科技有限公司 含氟化合物及抗癌医药用途

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5556942A (en) * 1991-04-29 1996-09-17 Terrapin Technologies, Inc. Glutathione S-transferase-activated compounds

Also Published As

Publication number Publication date
DE60116081T2 (de) 2006-08-03
KR20020094000A (ko) 2002-12-16
DK1278759T3 (da) 2006-02-13
PT1607399E (pt) 2010-02-02
JP2003531913A (ja) 2003-10-28
DE60116081D1 (en) 2006-01-26
WO2001083496A1 (en) 2001-11-08
AU6115301A (en) 2001-11-12
NO331833B1 (no) 2012-04-16
TWI308569B (en) 2009-04-11
NO20025240L (no) 2002-12-04
EP1607399A3 (en) 2006-01-04
EP1607399A2 (en) 2005-12-21
CN1182143C (zh) 2004-12-29
JP4249928B2 (ja) 2009-04-08
CA2407606C (en) 2008-07-15
ZA200208591B (en) 2004-03-04
CZ20023615A3 (cs) 2003-04-16
IL152325A0 (en) 2003-05-29
NO328854B1 (no) 2010-05-31
HK1084119A1 (en) 2006-07-21
DK1607399T3 (da) 2010-05-10
UA74574C2 (en) 2006-01-16
EP1607399B1 (en) 2010-01-20
BR0110553A (pt) 2003-04-01
DE60141181D1 (de) 2010-03-11
NO20025240D0 (no) 2002-11-01
EA200201154A1 (ru) 2003-04-24
ATE455779T1 (de) 2010-02-15
PL358155A1 (en) 2004-08-09
ES2253380T3 (es) 2006-06-01
EA006852B1 (ru) 2006-04-28
ATE313549T1 (de) 2006-01-15
AR029072A1 (es) 2003-06-04
CA2407606A1 (en) 2001-11-08
ES2337154T3 (es) 2010-04-21
EP1278759B1 (en) 2005-12-21
KR100729980B1 (ko) 2007-06-20
MXPA02010813A (es) 2004-02-26
EP1278759A1 (en) 2003-01-29
NZ522189A (en) 2004-04-30
HUP0300688A3 (en) 2005-02-28
HUP0300688A2 (hu) 2003-07-28
CN1427844A (zh) 2003-07-02
HK1050368A1 (en) 2003-06-20
AU2001261153B2 (en) 2005-04-07
IL152325A (en) 2011-04-28
PL207005B1 (pl) 2010-10-29

Similar Documents

Publication Publication Date Title
BR0312464A (pt) Inibidores de tirosina quinases
BR0200782A (pt) Compostos para o tratamento da isquemia
TR200200068T2 (tr) Nematisital triflüorobütenler
IS6658A (is) Ný efnasambönd
PH12013500123A1 (en) Hemiasterlin derivatives and uses thereof
IS2376B (is) Þíenópýrimidíndíón og notkun þeirra í breytingu ásjálfsnæmissjúkdómi
DK0923570T3 (da) Pyridylalken- og pyridylalkynsyreamider som cytostatiske og immunosuppresive midler
IS6520A (is) Ný efnasambönd
BRPI0409969A (pt) composto, composição farmacêutica, uso de um composto, e, processo para preparar um composto
BR0113838A (pt) Derivados de n-fenil-2-pirimidina-amina
EE9900217A (et) Sulfiinhappe derivaadid, nende valmistamine ja kasutamine
ATE433447T1 (de) Pyrimiidinverbindungen
DK1519724T3 (da) Fredericamycin-derivater som lægemidler til behandling af tumorer
DE60226729D1 (de) Hydroxyalkylaminderivate als beta-secretase-inhibitoren und deren verwendung zur behandlung der alzheimerschen krankheit oder ähnlicher krankheiten
BR0007589A (pt) Inibidores da proliferação de células
ATE300541T1 (de) Pyrazolopyridinderivate
ATE302203T1 (de) Pyrazolopyrimidin- und pyrazolotriazinderivate und diese enthaltende pharmazeutische zubereitungen
WO2003106384A3 (en) Novel boronic chalcone derivatives and uses thereof
BR9908125A (pt) Composto, composto dimérico, composição farmacêutica, uso do composto, processo compreendendo inibir células de câncer, e, processo terapêutico
DK0823903T3 (da) Heterocykliske biarylforbindelser, farmaceutiske præparater og kosmetiske sammensætninger, der indeholder dem, og anvendelser
BR0311491A (pt) Composto, composição farmacêutica, uso de um composto, e, método terapêutico para tratar câncer em um mamìfero
SE9804212D0 (sv) Compounds
TR200402070T4 (tr) Siklobüten-dion türevleri ve bunların damar sertliği tedavisinde kullanımı
ATE267816T1 (de) Tan-1057 derivate
BR0312470A (pt) Composto, uso do mesmo, composição farmacêutica, método de tratar e/ou prevenir câncer, e, processo para preparar o composto

Legal Events

Date Code Title Description
MM1K Lapsed by not paying the annual fees