NO20093371L - Bis-(N,N'-bis(2-halogenetyl)amino)fosforamidater som antitumormiddel - Google Patents

Bis-(N,N'-bis(2-halogenetyl)amino)fosforamidater som antitumormiddel

Info

Publication number
NO20093371L
NO20093371L NO20093371A NO20093371A NO20093371L NO 20093371 L NO20093371 L NO 20093371L NO 20093371 A NO20093371 A NO 20093371A NO 20093371 A NO20093371 A NO 20093371A NO 20093371 L NO20093371 L NO 20093371L
Authority
NO
Norway
Prior art keywords
bis
haloethyl
phosphoramidates
amino
antitumor agent
Prior art date
Application number
NO20093371A
Other languages
English (en)
Other versions
NO331833B1 (no
Inventor
Robert T Lum
Steven R Schow
Fanying Meng
Pavel Zhichkin
Jason R Herr
Michael Kozlowski
Original Assignee
Telik Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Publication of NO20093371L publication Critical patent/NO20093371L/no
Application filed by Telik Inc filed Critical Telik Inc
Publication of NO331833B1 publication Critical patent/NO331833B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/22—Amides of acids of phosphorus
    • C07F9/24—Esteramides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/22—Amides of acids of phosphorus
    • C07F9/24—Esteramides
    • C07F9/2454—Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/2458—Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic of aliphatic amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/22—Amides of acids of phosphorus
    • C07F9/24—Esteramides
    • C07F9/2404—Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/2408—Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic of hydroxyalkyl compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Forbindelse dom har antitumor-aktivitet eller er i stand til å bli modifisert til å ha antitumor-aktivitet er særlig egnet for anvendelse ved fremgangsmåter for behandling av tumorer, og spesielt behandling av cancer. Det beskrives også farmasøytiske preparater og fremgangsmåte for fremstilling av den kjemiske forbindelse.
NO20093371A 2000-05-02 2009-11-18 Bis-(N'N'-bis-(2-halogenetyl)amino)-fosforamidat-forbindelser, farmasoytisk preparat omfattende slike forbindelser, anvendelse av forbindelsene som antitumormiddel, og fremgangsmate for fremstilling av forbindelsene NO331833B1 (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US56318100A 2000-05-02 2000-05-02

Publications (2)

Publication Number Publication Date
NO20093371L true NO20093371L (no) 2002-12-04
NO331833B1 NO331833B1 (no) 2012-04-16

Family

ID=24249433

Family Applications (2)

Application Number Title Priority Date Filing Date
NO20025240A NO328854B1 (no) 2000-05-02 2002-11-01 Bis-(N',N'-bis-(2-halogenetyl)amino)-fosforamidat, farmasoytisk preparat omfattende forbindelsen, fremgangsmate for fremstilling og anvendelse av forbindelsen.
NO20093371A NO331833B1 (no) 2000-05-02 2009-11-18 Bis-(N'N'-bis-(2-halogenetyl)amino)-fosforamidat-forbindelser, farmasoytisk preparat omfattende slike forbindelser, anvendelse av forbindelsene som antitumormiddel, og fremgangsmate for fremstilling av forbindelsene

Family Applications Before (1)

Application Number Title Priority Date Filing Date
NO20025240A NO328854B1 (no) 2000-05-02 2002-11-01 Bis-(N',N'-bis-(2-halogenetyl)amino)-fosforamidat, farmasoytisk preparat omfattende forbindelsen, fremgangsmate for fremstilling og anvendelse av forbindelsen.

Country Status (25)

Country Link
EP (2) EP1607399B1 (no)
JP (1) JP4249928B2 (no)
KR (1) KR100729980B1 (no)
CN (1) CN1182143C (no)
AR (1) AR029072A1 (no)
AT (2) ATE455779T1 (no)
AU (2) AU6115301A (no)
BR (1) BR0110553A (no)
CA (1) CA2407606C (no)
CZ (1) CZ20023615A3 (no)
DE (2) DE60116081T2 (no)
DK (2) DK1278759T3 (no)
EA (1) EA006852B1 (no)
ES (2) ES2337154T3 (no)
HU (1) HUP0300688A3 (no)
IL (2) IL152325A0 (no)
MX (1) MXPA02010813A (no)
NO (2) NO328854B1 (no)
NZ (1) NZ522189A (no)
PL (1) PL207005B1 (no)
PT (1) PT1607399E (no)
TW (1) TWI308569B (no)
UA (1) UA74574C2 (no)
WO (1) WO2001083496A1 (no)
ZA (1) ZA200208591B (no)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200600091A (en) * 2004-05-21 2006-01-01 Telik Inc Sulfonylethyl phosphorodiamidates
US8198247B2 (en) 2004-12-21 2012-06-12 Telik, Inc. Process for and intermediates in the preparation of canfosfamide and its salts
US7655799B2 (en) 2006-11-29 2010-02-02 Telik, Inc. 2{[2-(substituted amino)ethyl]sulfonyl}ethyl N,N,N',N'-tetrakis(2-chloroethyl)phosphorodiamidates
US7872134B2 (en) 2007-12-12 2011-01-18 Telik, Inc. 2-{[2-(substituted amino)ethyl]sulfonyl}ethyl N,N-bis(2-chloroethyl)phosphorodiamidates
SI2260111T1 (sl) * 2008-03-14 2015-10-30 Genentech, Inc. Genetske variante, povezane z odpornostjo proti zdravilom
KR20250052506A (ko) 2019-05-13 2025-04-18 아센타위츠 파마슈티컬즈 리미티드 플루오린 함유 화합물 및 이의 항암 의학적 용도

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5556942A (en) * 1991-04-29 1996-09-17 Terrapin Technologies, Inc. Glutathione S-transferase-activated compounds

Also Published As

Publication number Publication date
EA006852B1 (ru) 2006-04-28
DE60116081T2 (de) 2006-08-03
TWI308569B (en) 2009-04-11
HK1050368A1 (en) 2003-06-20
WO2001083496A1 (en) 2001-11-08
PL207005B1 (pl) 2010-10-29
KR100729980B1 (ko) 2007-06-20
NO20025240L (no) 2002-12-04
CA2407606C (en) 2008-07-15
EA200201154A1 (ru) 2003-04-24
MXPA02010813A (es) 2004-02-26
EP1607399B1 (en) 2010-01-20
PT1607399E (pt) 2010-02-02
CN1427844A (zh) 2003-07-02
AU2001261153B2 (en) 2005-04-07
KR20020094000A (ko) 2002-12-16
CN1182143C (zh) 2004-12-29
AR029072A1 (es) 2003-06-04
EP1278759B1 (en) 2005-12-21
NO20025240D0 (no) 2002-11-01
IL152325A0 (en) 2003-05-29
DK1607399T3 (da) 2010-05-10
UA74574C2 (en) 2006-01-16
IL152325A (en) 2011-04-28
CZ20023615A3 (cs) 2003-04-16
ES2337154T3 (es) 2010-04-21
JP2003531913A (ja) 2003-10-28
ATE455779T1 (de) 2010-02-15
AU6115301A (en) 2001-11-12
NZ522189A (en) 2004-04-30
EP1607399A2 (en) 2005-12-21
HK1084119A1 (en) 2006-07-21
ATE313549T1 (de) 2006-01-15
DK1278759T3 (da) 2006-02-13
BR0110553A (pt) 2003-04-01
EP1278759A1 (en) 2003-01-29
ZA200208591B (en) 2004-03-04
DE60116081D1 (en) 2006-01-26
PL358155A1 (en) 2004-08-09
NO328854B1 (no) 2010-05-31
NO331833B1 (no) 2012-04-16
CA2407606A1 (en) 2001-11-08
HUP0300688A3 (en) 2005-02-28
DE60141181D1 (de) 2010-03-11
EP1607399A3 (en) 2006-01-04
HUP0300688A2 (hu) 2003-07-28
JP4249928B2 (ja) 2009-04-08
ES2253380T3 (es) 2006-06-01

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