ATE316134T1 - Zusammensetzung mit alpha-glycosylceramid zur stärkung zellulärer immunogenität - Google Patents
Zusammensetzung mit alpha-glycosylceramid zur stärkung zellulärer immunogenitätInfo
- Publication number
- ATE316134T1 ATE316134T1 AT98943077T AT98943077T ATE316134T1 AT E316134 T1 ATE316134 T1 AT E316134T1 AT 98943077 T AT98943077 T AT 98943077T AT 98943077 T AT98943077 T AT 98943077T AT E316134 T1 ATE316134 T1 AT E316134T1
- Authority
- AT
- Austria
- Prior art keywords
- alpha
- composition
- glycosylceramid
- immunogenicity
- cellular immunogenicity
- Prior art date
Links
- 230000005847 immunogenicity Effects 0.000 title abstract 3
- 230000001413 cellular effect Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 210000004881 tumor cell Anatomy 0.000 abstract 2
- 229940022399 cancer vaccine Drugs 0.000 abstract 1
- 238000009566 cancer vaccine Methods 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Crystallography & Structural Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP25718897 | 1997-09-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE316134T1 true ATE316134T1 (de) | 2006-02-15 |
Family
ID=17302909
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98943077T ATE316134T1 (de) | 1997-09-22 | 1998-09-22 | Zusammensetzung mit alpha-glycosylceramid zur stärkung zellulärer immunogenität |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6555372B1 (de) |
| EP (1) | EP1018548B1 (de) |
| KR (1) | KR100734643B1 (de) |
| CN (1) | CN100352918C (de) |
| AT (1) | ATE316134T1 (de) |
| AU (1) | AU749277B2 (de) |
| CA (1) | CA2304378A1 (de) |
| DE (1) | DE69833260T2 (de) |
| ES (1) | ES2256955T3 (de) |
| TW (1) | TW575420B (de) |
| WO (1) | WO1999015627A1 (de) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2001268564A1 (en) * | 2000-06-22 | 2002-01-02 | The Brigham And Women's Hospital, Inc. | Alpha-glycosylceramides for treating bacterial and fungal infections |
| CA2441893C (en) | 2001-03-26 | 2015-01-20 | Dana-Farber Cancer Institute, Inc. | Method of attenuating reactions to skin irritants |
| JP2005500336A (ja) | 2001-07-25 | 2005-01-06 | ニューヨーク・ユニバーシティ | 感染および癌に対するワクチンのためのアジュバントとしてのグリコシルセラミドの使用 |
| CA2459482C (en) * | 2001-08-16 | 2010-09-28 | Daiichi Suntory Pharma Co., Ltd. | Novel glycolipid and medicine for autoimmune disease containing the same as active ingredient |
| US20040171522A1 (en) * | 2003-02-27 | 2004-09-02 | Yaron Ilan | Regulation of immune responses by manipulation of intermediary metabolite levels |
| US7771726B2 (en) | 2003-10-08 | 2010-08-10 | New York University | Use of synthetic glycolipids as universal adjuvants for vaccines against cancer and infectious diseases |
| US20080145931A1 (en) | 2004-10-07 | 2008-06-19 | Argos Therapeutics, Inc. | Mature Dendritic Cell Compositions and Methods of Culturing Same |
| US8513008B2 (en) | 2004-10-07 | 2013-08-20 | Argos Therapeutics, Inc. | Mature dendritic cell compositions and methods for culturing same |
| WO2006060117A2 (en) * | 2004-11-02 | 2006-06-08 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for inhibition of nkt cells |
| WO2006058243A2 (en) * | 2004-11-24 | 2006-06-01 | Yale University | Leishmania antigens and related compositions and uses |
| US20070231344A1 (en) * | 2005-10-28 | 2007-10-04 | The Brigham And Women's Hospital, Inc. | Conjugate vaccines for non-proteinaceous antigens |
| WO2007074788A1 (ja) | 2005-12-27 | 2007-07-05 | University Of The Ryukyus | 抗腫瘍剤及び免疫賦活剤 |
| EP2060252A1 (de) | 2007-11-19 | 2009-05-20 | Wittycell | Neue Formulierung von Galactosylceramid-Derivaten |
| JP5561700B2 (ja) * | 2008-03-25 | 2014-07-30 | 独立行政法人理化学研究所 | 新規糖脂質及びその用途 |
| JP5025692B2 (ja) * | 2009-07-06 | 2012-09-12 | 壽製薬株式会社 | 糖脂質誘導体の製造方法 |
| JP5095683B2 (ja) * | 2009-07-06 | 2012-12-12 | 壽製薬株式会社 | 新規糖脂質誘導体及びこれを有効成分とする製剤 |
| BR112012002963A2 (pt) | 2009-08-12 | 2017-10-24 | Sigmoid Pharma Ltd | composições imunomoduladoras compreendendo uma matriz de polímero e uma fase oleosa |
| GB201212010D0 (en) * | 2012-07-05 | 2012-08-22 | Sigmoid Pharma Ltd | Formulations |
| CN104497065B (zh) * | 2014-11-24 | 2017-10-24 | 浙江大学 | α‑半乳糖神经酰胺新异构体及其用途 |
| CN104497064B (zh) * | 2014-11-24 | 2017-10-24 | 浙江大学 | α‑半乳糖神经酰胺新异构体及其合成方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3806565A1 (de) * | 1988-03-01 | 1989-09-14 | Deutsches Krebsforsch | Virusmodifizierte tumorvakzinen fuer die immuntherapie von tumormetastasen |
| JPH0559081A (ja) * | 1991-08-29 | 1993-03-09 | Kirin Brewery Co Ltd | 新規スフインゴ糖脂質、その製造法および使用 |
| TW261533B (de) * | 1992-07-16 | 1995-11-01 | Kirin Brewery | |
| JP4020958B2 (ja) | 1993-04-15 | 2007-12-12 | キリンファーマ株式会社 | 新規スフィンゴ糖脂質およびその使用 |
| US5858776A (en) * | 1993-11-03 | 1999-01-12 | Repligen Corporation | Tumor cells with increased immunogenicity and uses therefor |
| TW555562B (en) | 1996-12-27 | 2003-10-01 | Kirin Brewery | Method for activation of human antigen-presenting cells, activated human antigen-presenting cells and use thereof |
| DE69840528D1 (de) * | 1997-04-10 | 2009-03-19 | Kyowa Hakko Kirin Co Ltd | NKT-Zellenaktivatoren, die Alpha-Glycosylceramide enthalten |
-
1998
- 1998-09-21 TW TW87115682A patent/TW575420B/zh not_active IP Right Cessation
- 1998-09-22 EP EP98943077A patent/EP1018548B1/de not_active Expired - Lifetime
- 1998-09-22 CN CNB988114003A patent/CN100352918C/zh not_active Expired - Fee Related
- 1998-09-22 ES ES98943077T patent/ES2256955T3/es not_active Expired - Lifetime
- 1998-09-22 US US09/509,087 patent/US6555372B1/en not_active Expired - Fee Related
- 1998-09-22 AT AT98943077T patent/ATE316134T1/de not_active IP Right Cessation
- 1998-09-22 CA CA002304378A patent/CA2304378A1/en not_active Abandoned
- 1998-09-22 WO PCT/JP1998/004249 patent/WO1999015627A1/ja not_active Ceased
- 1998-09-22 KR KR1020007002999A patent/KR100734643B1/ko not_active Expired - Fee Related
- 1998-09-22 DE DE69833260T patent/DE69833260T2/de not_active Expired - Fee Related
- 1998-09-22 AU AU90960/98A patent/AU749277B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| KR20010030649A (ko) | 2001-04-16 |
| EP1018548B1 (de) | 2006-01-18 |
| ES2256955T3 (es) | 2006-07-16 |
| CN1279713A (zh) | 2001-01-10 |
| CA2304378A1 (en) | 1999-04-01 |
| DE69833260T2 (de) | 2006-09-28 |
| TW575420B (en) | 2004-02-11 |
| US6555372B1 (en) | 2003-04-29 |
| CN100352918C (zh) | 2007-12-05 |
| DE69833260D1 (de) | 2006-04-06 |
| WO1999015627A1 (en) | 1999-04-01 |
| AU749277B2 (en) | 2002-06-20 |
| EP1018548A4 (de) | 2001-03-21 |
| EP1018548A1 (de) | 2000-07-12 |
| AU9096098A (en) | 1999-04-12 |
| KR100734643B1 (ko) | 2007-07-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |