ATE317454T1 - Verfahren zur aktivitätsbestimmung einer substanz mittels eines funktionellen in vitro tests - Google Patents

Verfahren zur aktivitätsbestimmung einer substanz mittels eines funktionellen in vitro tests

Info

Publication number
ATE317454T1
ATE317454T1 AT99957374T AT99957374T ATE317454T1 AT E317454 T1 ATE317454 T1 AT E317454T1 AT 99957374 T AT99957374 T AT 99957374T AT 99957374 T AT99957374 T AT 99957374T AT E317454 T1 ATE317454 T1 AT E317454T1
Authority
AT
Austria
Prior art keywords
substance
activity
determining
functional
vitro test
Prior art date
Application number
AT99957374T
Other languages
English (en)
Inventor
Jean-Francois Bloch
Sandrine Dautel
Daniel Dupret
Jean-Michel Masson
Fabrice Lefevre
Original Assignee
Proteus Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Proteus Sa filed Critical Proteus Sa
Application granted granted Critical
Publication of ATE317454T1 publication Critical patent/ATE317454T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AT99957374T 1998-12-08 1999-12-08 Verfahren zur aktivitätsbestimmung einer substanz mittels eines funktionellen in vitro tests ATE317454T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9815488A FR2786788B1 (fr) 1998-12-08 1998-12-08 Procede de criblage de substances capables de modifier l'activite d'une ou plusieurs proteines cibles ou d'un ensemble cible de proteines exprimees in vitro

Publications (1)

Publication Number Publication Date
ATE317454T1 true ATE317454T1 (de) 2006-02-15

Family

ID=9533725

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99957374T ATE317454T1 (de) 1998-12-08 1999-12-08 Verfahren zur aktivitätsbestimmung einer substanz mittels eines funktionellen in vitro tests

Country Status (9)

Country Link
EP (2) EP1137802B1 (de)
JP (1) JP2002531851A (de)
AT (1) ATE317454T1 (de)
AU (1) AU779179B2 (de)
CA (1) CA2354572A1 (de)
DE (1) DE69929817T2 (de)
FR (1) FR2786788B1 (de)
IL (2) IL143639A0 (de)
WO (1) WO2000034514A1 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1160332A1 (de) * 2000-05-30 2001-12-05 Amsterdam Support Diagnostics B.V. Verfahren zum Nachweis von enzymatischer Aktivität oder von Resistenz gegen enzymatiche Inhibitoren
WO2002008766A1 (fr) * 2000-07-26 2002-01-31 Japan Science And Technology Corporation Sonde permettant d'analyser une interaction protéine/protéine et méthode d'analyse utilisant cette sonde
DE10158904A1 (de) * 2001-11-30 2003-06-12 Roche Diagnostics Gmbh Verfahren zur Herstellung von linearen DNA Fragmenten für die in vitro Expression von Proteinen

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4557862A (en) * 1983-10-28 1985-12-10 University Patents, Inc. Rhodamine derivatives as fluorogenic substrates for proteinases
AU1322692A (en) * 1990-11-05 1992-05-26 United States Of America, As Represented By The Secretary Of The Army, The Method for the in vitro production of protein from a dna sequence without cloning
US5235039A (en) * 1991-06-10 1993-08-10 Eli Lilly And Company Substrates for hiv protease
JPH07184648A (ja) * 1992-02-07 1995-07-25 Kunitada Shimotoono Ｈｃｖプロテイナーゼ活性物質、その製造法並びに同プロテイナーゼおよび同プロテイナーゼ阻害剤のアッセイ法
AU4843893A (en) * 1992-09-02 1994-03-29 Scripps Research Institute, The Coupled isothermal polynucleotide amplification and translation system
US5436131A (en) * 1993-04-02 1995-07-25 Merck & Co., Inc. Color screening assay for identifying inhibitor resistant HIV protease mutants
AU693443B2 (en) * 1993-04-08 1998-07-02 Research Development Foundation Cell free system for protein synthesis and use of chaperone proteins therein
GB9320562D0 (en) * 1993-10-06 1993-11-24 Zeneca Ltd Novel assay and applications
US5763198A (en) * 1994-07-22 1998-06-09 Sugen, Inc. Screening assays for compounds
US6063562A (en) * 1994-09-16 2000-05-16 Sepracor, Inc. In vitro method for predicting the evolutionary response of HIV protease to a drug targeted thereagainst
DE19710159A1 (de) * 1997-03-12 1998-10-01 Hoechst Ag In vitro Transkriptionsverfahren zum Screening von Naturstoffen und anderen chemischen Substanzen

Also Published As

Publication number Publication date
JP2002531851A (ja) 2002-09-24
EP1666612A2 (de) 2006-06-07
EP1666612A3 (de) 2006-06-21
CA2354572A1 (fr) 2000-06-15
DE69929817D1 (de) 2006-04-20
FR2786788A1 (fr) 2000-06-09
FR2786788B1 (fr) 2002-04-19
AU1510000A (en) 2000-06-26
IL143639A0 (en) 2002-04-21
AU779179B2 (en) 2005-01-13
WO2000034514A1 (fr) 2000-06-15
EP1137802B1 (de) 2006-02-08
DE69929817T2 (de) 2006-12-28
EP1137802A1 (de) 2001-10-04
IL143639A (en) 2007-08-19

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