ATE232559T1 - Verfahren zur signalverstärkung - Google Patents
Verfahren zur signalverstärkungInfo
- Publication number
- ATE232559T1 ATE232559T1 AT97937967T AT97937967T ATE232559T1 AT E232559 T1 ATE232559 T1 AT E232559T1 AT 97937967 T AT97937967 T AT 97937967T AT 97937967 T AT97937967 T AT 97937967T AT E232559 T1 ATE232559 T1 AT E232559T1
- Authority
- AT
- Austria
- Prior art keywords
- signal amplification
- disclosed
- methods
- analyte
- kits
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 230000003321 amplification Effects 0.000 title 1
- 238000003199 nucleic acid amplification method Methods 0.000 title 1
- 239000012491 analyte Substances 0.000 abstract 1
- 238000004458 analytical method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6804—Nucleic acid analysis using immunogens
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
- C12Q1/682—Signal amplification
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2458/00—Labels used in chemical analysis of biological material
- G01N2458/10—Oligonucleotides as tagging agents for labelling antibodies
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Control Of Motors That Do Not Use Commutators (AREA)
- Arrangements For Transmission Of Measured Signals (AREA)
- Oscillators With Electromechanical Resonators (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Amplifiers (AREA)
- Tone Control, Compression And Expansion, Limiting Amplitude (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2271896P | 1996-07-12 | 1996-07-12 | |
| PCT/US1997/012118 WO1998002580A2 (en) | 1996-07-12 | 1997-07-11 | Signal amplification method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE232559T1 true ATE232559T1 (de) | 2003-02-15 |
Family
ID=21811080
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97937967T ATE232559T1 (de) | 1996-07-12 | 1997-07-11 | Verfahren zur signalverstärkung |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US5902724A (de) |
| EP (1) | EP0938588B1 (de) |
| JP (1) | JP2000515367A (de) |
| AT (1) | ATE232559T1 (de) |
| AU (1) | AU4040097A (de) |
| CA (1) | CA2259918A1 (de) |
| DE (1) | DE69719057T2 (de) |
| WO (1) | WO1998002580A2 (de) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9805935D0 (en) * | 1998-03-19 | 1998-05-13 | Ciba Geigy Ag | Organic compounds |
| GB9905580D0 (en) | 1999-03-12 | 1999-05-05 | Tepnel Medical Ltd | Enyzymatically catalysed signal amplification |
| US6472153B1 (en) | 1999-10-26 | 2002-10-29 | Epoch Biosciences, Inc. | Hybridization-triggered fluorescent detection of nucleic acids |
| US20020051981A1 (en) * | 2000-03-08 | 2002-05-02 | Robert Getts | Methods for assay and detection on a microarray |
| US6803196B1 (en) * | 2000-10-13 | 2004-10-12 | Affymetrix, Inc. | Methods and compositions for detecting signals in binding assays using microparticles |
| US20030109067A1 (en) | 2001-12-06 | 2003-06-12 | Immunetech, Inc. | Homogeneous immunoassays for multiple allergens |
| US20040002095A1 (en) * | 2002-03-22 | 2004-01-01 | Bio-Rad Laboratories, Inc. | Universal signal amplification tail |
| CN101410530B (zh) | 2003-04-18 | 2013-03-27 | 贝克顿·迪金森公司 | 免疫-扩增 |
| ATE501277T1 (de) * | 2005-07-01 | 2011-03-15 | Dako Denmark As | Monomere und polymere linker zur konjugierung von biologischen molekülen und anderen stoffen |
| WO2009005552A2 (en) * | 2007-03-29 | 2009-01-08 | Epitype Corporation | Methods and compositions for multivalent binding and methods for manufacture of rapid diagnostic tests |
| WO2008154085A1 (en) * | 2007-06-06 | 2008-12-18 | Bio-Rad Laboratories, Inc. | Signal amplification using circular hairpin probes |
| US20090298805A1 (en) | 2008-06-03 | 2009-12-03 | Polson George A | Topical pyrithione compositions and methods for treatment of nail fungus |
| JP2010048566A (ja) * | 2008-08-19 | 2010-03-04 | Sumitomo Chemical Co Ltd | Ｄｎａを定量又は検出する方法 |
| US8900850B2 (en) * | 2009-09-17 | 2014-12-02 | Michael J. Lane | Lateral flow based methods and assays for rapid and inexpensive diagnostic tests |
| ES2606012T3 (es) * | 2010-02-26 | 2017-03-17 | Ventana Medical Systems, Inc. | Hibridación in situ con sondas PolyTag |
| WO2012071428A2 (en) | 2010-11-22 | 2012-05-31 | Solulink, Inc. | Methods and/or use of oligonucleotide conjugates for assays and detections |
| JP6430253B2 (ja) * | 2011-11-05 | 2018-11-28 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 相互作用を検出および測定するための核酸ベースのリンカー |
| WO2013177046A1 (en) | 2012-05-21 | 2013-11-28 | Solulink, Inc. | Methods and/or use of oligonucleotide conjugates for suppressing background due to cross-hybridization |
| RU2016106961A (ru) * | 2013-08-22 | 2017-09-27 | Аптон Биосистемс, Инк. | Цифровой анализ молекулярных анализируемых веществ с помощью электрических способов |
| WO2016089588A1 (en) | 2014-12-06 | 2016-06-09 | Children's Medical Center Corporation | Nucleic acid-based linkers for detecting and measuring interactions |
| US10036066B2 (en) | 2015-03-17 | 2018-07-31 | Dako Denmark A/S | In situ hybridization detection method |
| WO2016196824A1 (en) | 2015-06-02 | 2016-12-08 | Children's Medical Center Corporation | Nucleic acid complexes for screening barcoded compounds |
| WO2017003950A2 (en) | 2015-06-27 | 2017-01-05 | Children's Medical Center Corporation | Compositions and methods for analyte detection using nanoswitches |
| US11713483B2 (en) | 2016-02-09 | 2023-08-01 | Children's Medical Center Corporation | Method for detection of analytes via polymer complexes |
| WO2017165585A1 (en) | 2016-03-23 | 2017-09-28 | Children's Medical Center Corporation | Systems and apparatus for detecting compounds in human biological samples |
| WO2017165647A1 (en) | 2016-03-23 | 2017-09-28 | Children's Medical Center Corporation | Rapid and sensitive detection and quantification of analytes in complex samples using polymer-based methods |
| WO2018009463A2 (en) | 2016-07-05 | 2018-01-11 | California Institute Of Technology | Fractional initiator hybridization chain reaction |
| CN110300806B (zh) * | 2016-12-16 | 2024-03-19 | 艾瑞特姆有限责任公司 | 使用连接扩增的分子检测 |
| US11591636B2 (en) | 2017-11-20 | 2023-02-28 | Children's Medical Center Corporation | Force-controlled nanoswitch assays for single-molecule detection in complex biological fluids |
| WO2019200326A1 (en) | 2018-04-13 | 2019-10-17 | Rarecyte, Inc. | Kits for labeling of biomarkers and methods of using the same |
| EP3754028A1 (de) * | 2019-06-18 | 2020-12-23 | Apollo Life Sciences GmbH | Verfahren zur signalcodierung von analyten in einer probe |
| US12571802B2 (en) | 2020-02-29 | 2026-03-10 | President And Fellows Of Harvard College | Nanoswitch caliper trains for high-throughput, high-resolution structural analysis of biomolecules |
| US11873485B2 (en) | 2021-01-26 | 2024-01-16 | California Institute Of Technology | Allosteric conditional guide RNAs for cell-selective regulation of CRISPR/Cas |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4994373A (en) * | 1983-01-27 | 1991-02-19 | Enzo Biochem, Inc. | Method and structures employing chemically-labelled polynucleotide probes |
| GB8306426D0 (en) * | 1983-03-09 | 1983-04-13 | Malcolm A D B | Detecting polynucleotide sequence |
| CA1228811A (en) * | 1983-05-05 | 1987-11-03 | Robert G. Pergolizzi | Assay method utilizing polynucleotide sequences |
| GB8405437D0 (en) * | 1984-03-01 | 1984-04-04 | Amersham Int Plc | Detecting polynucleotide sequences |
| ATE65092T1 (de) * | 1985-05-31 | 1991-07-15 | Amoco Corp | Verstaerkung von hybridisierungssignalen durch verwendung von komplementarischen dns-straengen. |
| US4882269A (en) * | 1985-12-13 | 1989-11-21 | Princeton University | Amplified hybridization assay |
| US5124246A (en) * | 1987-10-15 | 1992-06-23 | Chiron Corporation | Nucleic acid multimers and amplified nucleic acid hybridization assays using same |
| CA2039517C (en) * | 1990-04-03 | 2006-11-07 | David Segev | Dna probe signal amplification |
| EP0529070A1 (de) * | 1991-02-27 | 1993-03-03 | Amoco Corporation | Verfahren zur verbesserung der empfindlichkeit von hybridisierungsassays |
| US5567591A (en) * | 1991-06-24 | 1996-10-22 | Becton Dickinson And Company | Amplified assay for analyte |
| US5681697A (en) * | 1993-12-08 | 1997-10-28 | Chiron Corporation | Solution phase nucleic acid sandwich assays having reduced background noise and kits therefor |
| CA2126952C (en) * | 1994-06-28 | 2010-12-14 | Sithian Pandian | Probe, kit, and method of amplification for increasing the sensitivity of nucleic acid hybridization assays |
| US5681702A (en) * | 1994-08-30 | 1997-10-28 | Chiron Corporation | Reduction of nonspecific hybridization by using novel base-pairing schemes |
| US5770365A (en) * | 1995-08-25 | 1998-06-23 | Tm Technologies, Inc. | Nucleic acid capture moieties |
-
1997
- 1997-07-11 AU AU40400/97A patent/AU4040097A/en not_active Abandoned
- 1997-07-11 JP JP10504560A patent/JP2000515367A/ja not_active Ceased
- 1997-07-11 CA CA002259918A patent/CA2259918A1/en not_active Abandoned
- 1997-07-11 DE DE69719057T patent/DE69719057T2/de not_active Expired - Lifetime
- 1997-07-11 WO PCT/US1997/012118 patent/WO1998002580A2/en not_active Ceased
- 1997-07-11 US US08/893,535 patent/US5902724A/en not_active Expired - Lifetime
- 1997-07-11 AT AT97937967T patent/ATE232559T1/de not_active IP Right Cessation
- 1997-07-11 EP EP97937967A patent/EP0938588B1/de not_active Expired - Lifetime
-
1999
- 1999-04-16 US US09/293,362 patent/US6245513B1/en not_active Expired - Lifetime
-
2001
- 2001-02-27 US US09/796,725 patent/US20040005552A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| DE69719057T2 (de) | 2003-12-04 |
| WO1998002580A3 (en) | 1998-05-14 |
| EP0938588B1 (de) | 2003-02-12 |
| US6245513B1 (en) | 2001-06-12 |
| JP2000515367A (ja) | 2000-11-21 |
| US5902724A (en) | 1999-05-11 |
| CA2259918A1 (en) | 1998-01-22 |
| AU4040097A (en) | 1998-02-09 |
| US20040005552A1 (en) | 2004-01-08 |
| EP0938588A2 (de) | 1999-09-01 |
| WO1998002580A2 (en) | 1998-01-22 |
| DE69719057D1 (de) | 2003-03-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |