ATE318823T1 - Pharmazeutisch geeignete salze von 20(s)- camptothecinen - Google Patents

Pharmazeutisch geeignete salze von 20(s)- camptothecinen

Info

Publication number: ATE318823T1
Authority: AT; Austria
Prior art keywords: sub; acid; sup; alkylamino; substituent
Prior art date: 2001-09-25

Application number

AT02772643T

Other languages

English (en)

Inventor

Sairam Pothukuchi

Subrahmanyam Duvvuri

Sriram Rajagopal

Original Assignee

Reddys Lab Ltd Dr

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-09-25

Filing date

2002-09-25

Publication date

2006-03-15

2002-09-25 Application filed by Reddys Lab Ltd Dr filed Critical Reddys Lab Ltd Dr

2006-03-15 Application granted granted Critical

2006-03-15 Publication of ATE318823T1 publication Critical patent/ATE318823T1/de

Links

KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 abstract 3
150000001875 compounds Chemical class 0.000 abstract 3
CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 abstract 2
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 2
AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 abstract 2
NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 abstract 2
239000002253 acid Substances 0.000 abstract 2
125000003282 alkyl amino group Chemical group 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 2
WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
VLTRZXGMWDSKGL-UHFFFAOYSA-N perchloric acid Chemical compound OCl(=O)(=O)=O VLTRZXGMWDSKGL-UHFFFAOYSA-N 0.000 abstract 2
YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 abstract 2
125000001424 substituent group Chemical group 0.000 abstract 2
BMYNFMYTOJXKLE-UHFFFAOYSA-N 3-azaniumyl-2-hydroxypropanoate Chemical compound NCC(O)C(O)=O BMYNFMYTOJXKLE-UHFFFAOYSA-N 0.000 abstract 1
239000005711 Benzoic acid Substances 0.000 abstract 1
FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 abstract 1
OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 abstract 1
FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 abstract 1
PZAGQUOSOTUKEC-UHFFFAOYSA-N acetic acid;sulfuric acid Chemical compound CC(O)=O.OS(O)(=O)=O PZAGQUOSOTUKEC-UHFFFAOYSA-N 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
229910000147 aluminium phosphate Inorganic materials 0.000 abstract 1
239000011668 ascorbic acid Substances 0.000 abstract 1
235000010323 ascorbic acid Nutrition 0.000 abstract 1
229960005070 ascorbic acid Drugs 0.000 abstract 1
SRSXLGNVWSONIS-UHFFFAOYSA-N benzenesulfonic acid Chemical compound OS(=O)(=O)C1=CC=CC=C1 SRSXLGNVWSONIS-UHFFFAOYSA-N 0.000 abstract 1
229940092714 benzenesulfonic acid Drugs 0.000 abstract 1
235000010233 benzoic acid Nutrition 0.000 abstract 1
229960004365 benzoic acid Drugs 0.000 abstract 1
KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 abstract 1
239000004327 boric acid Substances 0.000 abstract 1
229960004106 citric acid Drugs 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
150000002431 hydrogen Chemical class 0.000 abstract 1
VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 abstract 1
239000011976 maleic acid Substances 0.000 abstract 1
229940098895 maleic acid Drugs 0.000 abstract 1
229940098779 methanesulfonic acid Drugs 0.000 abstract 1
229910017604 nitric acid Inorganic materials 0.000 abstract 1
FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 abstract 1
229960004889 salicylic acid Drugs 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000011975 tartaric acid Substances 0.000 abstract 1
229960001367 tartaric acid Drugs 0.000 abstract 1
235000002906 tartaric acid Nutrition 0.000 abstract 1
VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Oncology (AREA)
Hematology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicinal Preparation (AREA)
Cephalosporin Compounds (AREA)

AT02772643T 2001-09-25 2002-09-25 Pharmazeutisch geeignete salze von 20(s)- camptothecinen ATE318823T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IN798MA2001		2001-09-25

Publications (1)

Publication Number	Publication Date
ATE318823T1 true ATE318823T1 (de)	2006-03-15

Family

ID=33042623

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT02772643T ATE318823T1 (de)	2001-09-25	2002-09-25	Pharmazeutisch geeignete salze von 20(s)- camptothecinen

Country Status (18)

Country	Link
US (1)	US7071203B2 (de)
EP (1)	EP1430059B1 (de)
JP (1)	JP2005507893A (de)
KR (1)	KR20040039404A (de)
CN (1)	CN1575292A (de)
AT (1)	ATE318823T1 (de)
BR (1)	BR0212990A (de)
CA (1)	CA2461089A1 (de)
DE (1)	DE60209517D1 (de)
HU (1)	HUP0401912A3 (de)
IL (1)	IL160982A0 (de)
MX (1)	MXPA04002784A (de)
NO (1)	NO20041643L (de)
NZ (1)	NZ531878A (de)
PL (1)	PL368229A1 (de)
RU (1)	RU2004109163A (de)
WO (1)	WO2003027118A1 (de)
ZA (1)	ZA200402321B (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU2003207369A1 (en) *	2002-02-18	2003-09-04	Dr. Reddy's Laboratories Limited	A process for the preparation of 10-hydroxy-9-n,n-dimethylaminomethyl-5-(2'-fluoroethoxy)-20(s)-camptothecin hydrochloride
TWI333492B (en)	2003-11-12	2010-11-21	Smithkline Beecham Cork Ltd	Crystalline topotecan hydrochloride product and preparation thereof
US7897772B2 (en) *	2004-10-01	2011-03-01	Kabushiki Kaisha Yakult Honsha	Acid addition salt of irinotecan
ITMI20061473A1 (it) *	2006-07-26	2008-01-27	Indena Spa	Derivati della camptotecina ad attivita antitumorale

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN1025029C (zh) *	1988-10-22	1994-06-15	沈阳药学院	喜树硷精氨酸盐制剂的制备方法
US6177439B1 (en) *	1995-06-06	2001-01-23	Reddy's Research Foundation	Water soluble analogues of 20(S)-camptothecin
JP4094710B2 (ja) *	1997-11-06	2008-06-04	株式会社ヤクルト本社	新規なカンプトテシン誘導体

2002
- 2002-09-25 EP EP02772643A patent/EP1430059B1/de not_active Expired - Lifetime
- 2002-09-25 IL IL16098202A patent/IL160982A0/xx unknown
- 2002-09-25 WO PCT/IB2002/003950 patent/WO2003027118A1/en not_active Ceased
- 2002-09-25 RU RU2004109163/04A patent/RU2004109163A/ru not_active Application Discontinuation
- 2002-09-25 CN CNA028210840A patent/CN1575292A/zh active Pending
- 2002-09-25 DE DE60209517T patent/DE60209517D1/de not_active Expired - Lifetime
- 2002-09-25 JP JP2003530706A patent/JP2005507893A/ja not_active Withdrawn
- 2002-09-25 PL PL02368229A patent/PL368229A1/xx not_active Application Discontinuation
- 2002-09-25 US US10/490,552 patent/US7071203B2/en not_active Expired - Fee Related
- 2002-09-25 BR BR0212990-6A patent/BR0212990A/pt not_active IP Right Cessation
- 2002-09-25 AT AT02772643T patent/ATE318823T1/de not_active IP Right Cessation
- 2002-09-25 KR KR10-2004-7004255A patent/KR20040039404A/ko not_active Withdrawn
- 2002-09-25 CA CA002461089A patent/CA2461089A1/en not_active Abandoned
- 2002-09-25 NZ NZ531878A patent/NZ531878A/en unknown
- 2002-09-25 HU HU0401912A patent/HUP0401912A3/hu unknown
- 2002-09-25 MX MXPA04002784A patent/MXPA04002784A/es unknown
2004
- 2004-03-24 ZA ZA200402321A patent/ZA200402321B/xx unknown
- 2004-04-22 NO NO20041643A patent/NO20041643L/no unknown

Also Published As

Publication number	Publication date
NO20041643L (no)	2004-04-22
MXPA04002784A (es)	2004-07-29
WO2003027118A1 (en)	2003-04-03
US20040198760A1 (en)	2004-10-07
CN1575292A (zh)	2005-02-02
US7071203B2 (en)	2006-07-04
IL160982A0 (en)	2004-08-31
BR0212990A (pt)	2004-09-21
NZ531878A (en)	2006-04-28
HUP0401912A3 (en)	2007-02-28
CA2461089A1 (en)	2003-04-03
EP1430059B1 (de)	2006-03-01
DE60209517D1 (de)	2006-04-27
RU2004109163A (ru)	2005-10-10
EP1430059A1 (de)	2004-06-23
PL368229A1 (en)	2005-03-21
HUP0401912A2 (hu)	2005-01-28
KR20040039404A (ko)	2004-05-10
ZA200402321B (en)	2005-01-13
JP2005507893A (ja)	2005-03-24

Legal Events

Date	Code	Title	Description
2006-09-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

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