ATE318833T1 - Verfahren zur herstellung von methylcobalamin - Google Patents
Verfahren zur herstellung von methylcobalaminInfo
- Publication number
- ATE318833T1 ATE318833T1 AT00979985T AT00979985T ATE318833T1 AT E318833 T1 ATE318833 T1 AT E318833T1 AT 00979985 T AT00979985 T AT 00979985T AT 00979985 T AT00979985 T AT 00979985T AT E318833 T1 ATE318833 T1 AT E318833T1
- Authority
- AT
- Austria
- Prior art keywords
- producing methylcobalamin
- methylcobalamin
- producing
- provides
- methylating
- Prior art date
Links
- 235000007672 methylcobalamin Nutrition 0.000 title abstract 3
- 239000011585 methylcobalamin Substances 0.000 title abstract 3
- JEWJRMKHSMTXPP-BYFNXCQMSA-M methylcobalamin Chemical compound C[Co+]N([C@]1([H])[C@H](CC(N)=O)[C@]\2(CCC(=O)NC[C@H](C)OP(O)(=O)OC3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)C)C/2=C(C)\C([C@H](C/2(C)C)CCC(N)=O)=N\C\2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O JEWJRMKHSMTXPP-BYFNXCQMSA-M 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title 1
- RMRCNWBMXRMIRW-BYFNXCQMSA-M cyanocobalamin Chemical compound N#C[Co+]N([C@]1([H])[C@H](CC(N)=O)[C@]\2(CCC(=O)NC[C@H](C)OP(O)(=O)OC3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)C)C/2=C(C)\C([C@H](C/2(C)C)CCC(N)=O)=N\C\2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O RMRCNWBMXRMIRW-BYFNXCQMSA-M 0.000 abstract 2
- YOZNUFWCRFCGIH-BYFNXCQMSA-L hydroxocobalamin Chemical compound O[Co+]N([C@]1([H])[C@H](CC(N)=O)[C@]\2(CCC(=O)NC[C@H](C)OP(O)(=O)OC3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)C)C/2=C(C)\C([C@H](C/2(C)C)CCC(N)=O)=N\C\2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O YOZNUFWCRFCGIH-BYFNXCQMSA-L 0.000 abstract 2
- 239000003638 chemical reducing agent Substances 0.000 abstract 1
- 235000000639 cyanocobalamin Nutrition 0.000 abstract 1
- 239000011666 cyanocobalamin Substances 0.000 abstract 1
- 229960002104 cyanocobalamin Drugs 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 235000004867 hydroxocobalamin Nutrition 0.000 abstract 1
- 239000011704 hydroxocobalamin Substances 0.000 abstract 1
- 229960001103 hydroxocobalamin Drugs 0.000 abstract 1
- 239000012022 methylating agents Substances 0.000 abstract 1
- 230000001035 methylating effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H23/00—Compounds containing boron, silicon or a metal, e.g. chelates or vitamin B12
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP35068399 | 1999-12-09 | ||
| JP2000188619 | 2000-06-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE318833T1 true ATE318833T1 (de) | 2006-03-15 |
Family
ID=26579251
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00979985T ATE318833T1 (de) | 1999-12-09 | 2000-12-07 | Verfahren zur herstellung von methylcobalamin |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6657057B2 (de) |
| EP (1) | EP1236737B1 (de) |
| JP (1) | JP3948958B2 (de) |
| KR (1) | KR100694688B1 (de) |
| CN (1) | CN1170841C (de) |
| AT (1) | ATE318833T1 (de) |
| CA (1) | CA2394155C (de) |
| DE (1) | DE60026354T2 (de) |
| DK (1) | DK1236737T3 (de) |
| ES (1) | ES2257339T3 (de) |
| TW (1) | TW581770B (de) |
| WO (1) | WO2001042271A1 (de) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2449480C (en) * | 2001-06-05 | 2009-07-21 | Eisai Co., Ltd. | Process for producing methylcobalamin |
| AU2003258100A1 (en) * | 2002-08-06 | 2004-02-23 | Intradigm Corporation | Methods of down regulating target gene expression in vivo by introduction of interfering rna |
| ES2264374B1 (es) * | 2005-03-23 | 2007-11-01 | Ferrer Internacional, S.A. | Procedimiento de fabricacion de la metilcobalamina. |
| CN100348201C (zh) * | 2005-09-29 | 2007-11-14 | 周卓和 | 甲钴胺分散片及其制备方法 |
| JP5779710B2 (ja) * | 2011-05-30 | 2015-09-16 | インターキム ソシエダッド アノニマ デ キャピタル バリアブレＩｎｔｅｒｑｕｉｍ， Ｓ．Ａ． Ｄｅ Ｃ．Ｖ． | メチルコバラミンの合成プロセス |
| CN102391340A (zh) * | 2011-10-31 | 2012-03-28 | 河北玉星生物工程有限公司 | 一种甲钴胺的制备方法 |
| CN105218608A (zh) * | 2015-10-29 | 2016-01-06 | 无锡福祈制药有限公司 | 一种甲钴胺的制备方法 |
| HUE063127T2 (hu) | 2016-07-08 | 2024-01-28 | Healthtech Bio Actives S L U | Eljárás metilkobalamin tisztítására |
| CN106349313B (zh) * | 2016-08-23 | 2019-05-14 | 宁夏泰瑞制药股份有限公司 | 一种利用氰钴胺合成甲钴胺粗品的方法 |
| CN108546278A (zh) * | 2018-03-17 | 2018-09-18 | 山东辰龙药业有限公司 | 甲钴胺的精制方法 |
| DE102018005078A1 (de) | 2018-06-26 | 2020-01-02 | Ilma biochem GmbH | Verfahren zur Herstellung und Zusammensetzung von stabilisierten Cob(II)alamin- und Cob(II)inamide-Lösungen als Ausgangszubereitungen zur Herstellung von Arzneimitteln, Medizinprodukten, Nahrungsergänzungsmitteln und Kosmetika |
| CN108948116A (zh) * | 2018-08-30 | 2018-12-07 | 上海应用技术大学 | 一种甲钴胺的绿色合成工艺 |
| CN111808158B (zh) * | 2020-07-23 | 2022-12-06 | 宁夏金维制药股份有限公司 | 一种维生素b12粗品的制备方法 |
| CN114874274B (zh) * | 2022-04-21 | 2024-05-14 | 南京工业大学 | 一种改进的合成甲钴胺的方法 |
| CN114874276B (zh) * | 2022-04-21 | 2024-06-21 | 南京工业大学 | 一种改进的合成甲钴胺的方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS4538059B1 (de) * | 1967-07-27 | 1970-12-02 | ||
| BE759614A (fr) * | 1969-12-01 | 1971-06-01 | Glaxo Lab Ltd | Elimination d'ions cyanure de solutions de corrinoides |
| GB1306958A (en) | 1970-09-30 | 1973-02-14 | Pierrel Spa | Process for the preparation of substituted cobamides |
| FR2108794B1 (de) | 1970-10-06 | 1974-04-12 | Roussel Uclaf | |
| FR2240232A1 (en) | 1973-08-08 | 1975-03-07 | Boige Jean | Methylcobalamine prepn from cyanocobalamine - by reduction and methylation using methyl acid oxalate and a metal |
| US3928320A (en) | 1971-11-10 | 1975-12-23 | Jean Boige | Process for the preparation of methylcobalamine |
| BE789252A (fr) | 1971-11-10 | 1973-03-26 | Boige Jean | Procede de fabrication de la methylcobalamine |
| US3789211A (en) | 1972-07-14 | 1974-01-29 | Marvin Glass & Associates | Decorative lighting system |
| JPS4947899A (de) | 1972-09-18 | 1974-05-09 | ||
| JPS5729587B2 (de) | 1973-06-14 | 1982-06-23 | ||
| JPS5038120A (de) | 1973-08-09 | 1975-04-09 | ||
| JPH08143590A (ja) | 1994-11-24 | 1996-06-04 | Meiji Seika Kaisha Ltd | 高純度メチルコバラミンの製造方法 |
-
2000
- 2000-12-07 CN CNB008168857A patent/CN1170841C/zh not_active Expired - Lifetime
- 2000-12-07 DE DE60026354T patent/DE60026354T2/de not_active Expired - Lifetime
- 2000-12-07 ES ES00979985T patent/ES2257339T3/es not_active Expired - Lifetime
- 2000-12-07 DK DK00979985T patent/DK1236737T3/da active
- 2000-12-07 AT AT00979985T patent/ATE318833T1/de active
- 2000-12-07 EP EP00979985A patent/EP1236737B1/de not_active Expired - Lifetime
- 2000-12-07 WO PCT/JP2000/008675 patent/WO2001042271A1/ja not_active Ceased
- 2000-12-07 CA CA002394155A patent/CA2394155C/en not_active Expired - Fee Related
- 2000-12-07 US US10/130,797 patent/US6657057B2/en not_active Expired - Fee Related
- 2000-12-07 KR KR1020027006442A patent/KR100694688B1/ko not_active Expired - Fee Related
- 2000-12-07 JP JP2001543568A patent/JP3948958B2/ja not_active Expired - Fee Related
- 2000-12-08 TW TW089126254A patent/TW581770B/zh not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE60026354D1 (de) | 2006-04-27 |
| CN1409723A (zh) | 2003-04-09 |
| US20020183511A1 (en) | 2002-12-05 |
| US6657057B2 (en) | 2003-12-02 |
| DE60026354T2 (de) | 2006-11-09 |
| ES2257339T3 (es) | 2006-08-01 |
| WO2001042271A1 (en) | 2001-06-14 |
| CA2394155C (en) | 2008-01-15 |
| EP1236737B1 (de) | 2006-03-01 |
| DK1236737T3 (da) | 2006-06-19 |
| EP1236737A4 (de) | 2003-02-26 |
| EP1236737A1 (de) | 2002-09-04 |
| TW581770B (en) | 2004-04-01 |
| KR100694688B1 (ko) | 2007-03-13 |
| KR20030022767A (ko) | 2003-03-17 |
| JP3948958B2 (ja) | 2007-07-25 |
| CA2394155A1 (en) | 2001-06-14 |
| CN1170841C (zh) | 2004-10-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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