ATE360029T1 - Verfahren zur herstellung von glycopeptidderivaten - Google Patents

Verfahren zur herstellung von glycopeptidderivaten

Info

Publication number: ATE360029T1
Authority: AT; Austria
Prior art keywords: glycopeptide derivatives; producing glycopeptide; producing; derivatives; isolation
Prior art date: 2001-08-24

Application number

AT02759433T

Other languages

English (en)

Inventor

Junning Lee

Jyanwei Liu

Original Assignee

Theravance Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-08-24

Filing date

2002-08-23

Publication date

2007-05-15

2002-08-23 Application filed by Theravance Inc filed Critical Theravance Inc

2007-05-15 Application granted granted Critical

2007-05-15 Publication of ATE360029T1 publication Critical patent/ATE360029T1/de

Links

DQJCDTNMLBYVAY-ZXXIYAEKSA-N (2S,5R,10R,13R)-16-{[(2R,3S,4R,5R)-3-{[(2S,3R,4R,5S,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-5-(ethylamino)-6-hydroxy-2-(hydroxymethyl)oxan-4-yl]oxy}-5-(4-aminobutyl)-10-carbamoyl-2,13-dimethyl-4,7,12,15-tetraoxo-3,6,11,14-tetraazaheptadecan-1-oic acid Chemical class NCCCC[C@H](C(=O)N[C@@H](C)C(O)=O)NC(=O)CC[C@H](C(N)=O)NC(=O)[C@@H](C)NC(=O)C(C)O[C@@H]1[C@@H](NCC)C(O)O[C@H](CO)[C@H]1O[C@H]1[C@H](NC(C)=O)[C@@H](O)[C@H](O)[C@@H](CO)O1 DQJCDTNMLBYVAY-ZXXIYAEKSA-N 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
238000000034 method Methods 0.000 abstract 2
239000007795 chemical reaction product Substances 0.000 abstract 1
238000002955 isolation Methods 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
MYPYJXKWCTUITO-LYRMYLQWSA-N vancomycin Chemical class O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)NC)[C@H]1C[C@](C)(N)[C@H](O)[C@H](C)O1 MYPYJXKWCTUITO-LYRMYLQWSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
- C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
- C07K9/008—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT02759433T 2001-08-24 2002-08-23 Verfahren zur herstellung von glycopeptidderivaten ATE360029T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US31471101P	2001-08-24	2001-08-24

Publications (1)

Publication Number	Publication Date
ATE360029T1 true ATE360029T1 (de)	2007-05-15

Family

ID=23221113

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT02759433T ATE360029T1 (de)	2001-08-24	2002-08-23	Verfahren zur herstellung von glycopeptidderivaten

Country Status (14)

Country	Link
US (2)	US7015305B2 (de)
EP (1)	EP1419174B1 (de)
JP (1)	JP4116546B2 (de)
KR (1)	KR100909435B1 (de)
CN (1)	CN1281619C (de)
AT (1)	ATE360029T1 (de)
AU (1)	AU2002324768A1 (de)
CA (1)	CA2457215C (de)
DE (1)	DE60219638T2 (de)
DK (1)	DK1419174T3 (de)
ES (1)	ES2284907T3 (de)
NO (1)	NO335304B1 (de)
TW (1)	TWI312785B (de)
WO (1)	WO2003018607A2 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU2003243574A1 (en)	2002-06-17	2003-12-31	Theravance, Inc.	PROCESS FOR PREPARING N-PROTECTED Beta-AMINO ALDEHYDE COMPOUNDS
TWI342312B (en) *	2003-10-22	2011-05-21	Theravance Inc	Hydrochloride salts of a glycopeptide phosphonate derivative
EP1771456A2 (de) *	2004-07-30	2007-04-11	Palumed SA	Hybride qa-moleküle, in denen q ein aminochinolin und a ein antibiotikarückstand ist, ihre synthese und ihre verwendung als antibakterielles mittel
EP2753638A1 (de)	2011-09-09	2014-07-16	Sandoz AG	Verfahren zur synthese von telavancin und seinen pharmazeutisch akzeptablen salzen sowie n-geschützte derivate daraus
WO2013034676A1 (en)	2011-09-09	2013-03-14	Sandoz Ag	Process for the synthesis of telavancin, its pharmaceutically acceptable salts as well as an n-protected imine-derivative of telavancin
AU2016223090A1 (en)	2015-02-23	2017-08-24	Cumberland Pharmaceuticals Inc.	Doses and methods of administering telavancin
CN106467570B (zh) *	2015-08-14	2020-04-07	正大天晴药业集团股份有限公司	糖肽类抗生素的还原烷基化方法
CN106631902A (zh) *	2016-09-23	2017-05-10	上海步越化工科技有限公司	一种特拉万星侧链癸基(2‑氧代乙基)氨基甲酸9h‑芴‑9‑甲基酯的制备方法
GB2577420B (en) *	2017-05-22	2022-07-06	Insmed Inc	Glycopeptide derivative compounds and uses thereof
CN111233713A (zh) *	2020-01-20	2020-06-05	福建康鸿生物科技有限公司	一种特拉万星中间体合成方法
WO2022198009A1 (en) *	2021-03-18	2022-09-22	Insmed Incorporated	Dry powder compositions of glycopeptide derivative compounds and methods of use thereof

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3160632A (en) *	1961-01-30	1964-12-08	Stauffer Chemical Co	Aminomethylenephosphinic acids, salts thereof, and process for their production
US4698327A (en) *	1985-04-25	1987-10-06	Eli Lilly And Company	Novel glycopeptide derivatives
IL78597A0 (en)	1985-04-25	1986-08-31	Lilly Co Eli	Novel glycopeptide derivatives
US4643987A (en) *	1985-08-14	1987-02-17	Eli Lilly And Company	Modified glycopeptides
EP0273727A3 (de)	1986-12-30	1990-01-17	Smithkline Beecham Corporation	Glykosilierte Glycopeptide
ATE134646T1 (de)	1988-12-27	1996-03-15	Lepetit Spa	C63-amidderivate von 34-de(acetylglucosaminyl)-34-deoxy-teicoplanine
CA2031803C (en) *	1989-12-13	2001-05-29	Ramakrishnan Nagarajan	Improvements in or relating to glycopeptide deriveratives
CZ285703B6 (cs)	1991-07-29	1999-10-13	Biosearch Italia S. P. A.	Amidové deriváty antibiotika A 40926
US5750509A (en) *	1991-07-29	1998-05-12	Gruppo Lepetit S.P.A.	Amide derivatives of antibiotic A 40926
US5840684A (en) *	1994-01-28	1998-11-24	Eli Lilly And Company	Glycopeptide antibiotic derivatives
AU703106B2 (en)	1994-01-28	1999-03-18	Eli Lilly And Company	Glycopeptide antibiotic derivatives
US5918873A (en) *	1995-03-30	1999-07-06	Canon Kabushiki Kaisha	Sheet supplying apparatus which regulates tip end of sheet by first and second abutment means
US5919756A (en)	1996-06-28	1999-07-06	Eli Lilly And Company	Amides
US5952466A (en) *	1997-11-12	1999-09-14	Eli Lilly And Company	Reductive alkylation of glycopeptide antibiotics
US5939382A (en)	1996-11-21	1999-08-17	Eli Lilly And Company	Reducing agent for reductive alkylation of glycopeptide antibiotics
US5916873A (en)	1997-04-17	1999-06-29	Eli Lilly And Company	Teicoplanin derivatives
CA2318394A1 (en)	1998-02-20	1999-08-26	Advanced Medicine, Inc.	Novel antibacterial agents
US6518242B1 (en) *	1998-02-20	2003-02-11	Theravance, Inc.	Derivatives of glycopeptide antibacterial agents
US6392012B1 (en)	1998-12-23	2002-05-21	Advanced Medicine, Inc.	Glycopeptide derivatives and pharmaceutical compositions containing the same
AU4054900A (en)	1999-04-02	2000-10-23	Advanced Medicine East, Inc.	Desleucyl glycopeptide antibiotics and methods of making same
WO2001057071A2 (en) *	2000-02-04	2001-08-09	Advanced Medicine, Inc.	Glycopeptide derivatives having antibiotic activity
EP1278549B1 (de) *	2000-05-02	2008-12-10	Theravance, Inc.	Zusammensetzung die eine zyklodextrin und ein glykopeptid-antibiotikum enthält
SI1276759T1 (sl)	2000-05-02	2008-12-31	Theravance Inc	Postopek reduktivnega alkiliranja na glikopeptidih
UA75083C2 (uk) *	2000-06-22	2006-03-15	Тераванс, Інк.	Похідні глікопептидфосфонатів

2002
- 2002-08-20 TW TW091118799A patent/TWI312785B/zh not_active IP Right Cessation
- 2002-08-23 DK DK02759433T patent/DK1419174T3/da active
- 2002-08-23 KR KR1020047002617A patent/KR100909435B1/ko not_active Expired - Fee Related
- 2002-08-23 AU AU2002324768A patent/AU2002324768A1/en not_active Abandoned
- 2002-08-23 ES ES02759433T patent/ES2284907T3/es not_active Expired - Lifetime
- 2002-08-23 CN CNB028166140A patent/CN1281619C/zh not_active Expired - Fee Related
- 2002-08-23 EP EP02759433A patent/EP1419174B1/de not_active Expired - Lifetime
- 2002-08-23 JP JP2003523266A patent/JP4116546B2/ja not_active Expired - Fee Related
- 2002-08-23 AT AT02759433T patent/ATE360029T1/de not_active IP Right Cessation
- 2002-08-23 CA CA2457215A patent/CA2457215C/en not_active Expired - Fee Related
- 2002-08-23 DE DE60219638T patent/DE60219638T2/de not_active Expired - Lifetime
- 2002-08-23 WO PCT/US2002/026831 patent/WO2003018607A2/en not_active Ceased
- 2002-08-23 US US10/226,988 patent/US7015305B2/en not_active Expired - Lifetime
2004
- 2004-02-23 NO NO20040779A patent/NO335304B1/no not_active IP Right Cessation
2005
- 2005-11-08 US US11/268,913 patent/US7160984B2/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
EP1419174A2 (de)	2004-05-19
ES2284907T3 (es)	2007-11-16
CA2457215C (en)	2011-12-13
US20060058503A1 (en)	2006-03-16
US20030045457A1 (en)	2003-03-06
KR100909435B1 (ko)	2009-07-28
JP4116546B2 (ja)	2008-07-09
EP1419174B1 (de)	2007-04-18
JP2005525997A (ja)	2005-09-02
DK1419174T3 (da)	2007-07-02
EP1419174A4 (de)	2005-10-12
DE60219638D1 (de)	2007-05-31
DE60219638T2 (de)	2007-12-20
NO20040779L (no)	2004-02-23
WO2003018607A2 (en)	2003-03-06
US7160984B2 (en)	2007-01-09
CA2457215A1 (en)	2003-03-06
TWI312785B (en)	2009-08-01
CN1281619C (zh)	2006-10-25
CN1610692A (zh)	2005-04-27
NO335304B1 (no)	2014-11-10
KR20040028997A (ko)	2004-04-03
US7015305B2 (en)	2006-03-21
AU2002324768A1 (en)	2003-03-10
WO2003018607A3 (en)	2003-11-27

Legal Events

Date	Code	Title	Description
2007-10-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
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DE60219638D1 (de)	2007-05-31	Verfahren zur herstellung von glycopeptidderivaten
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