ATE318922T1 - Zielgerichtete integration in chromosomen mittels retroviraler vektoren - Google Patents

Zielgerichtete integration in chromosomen mittels retroviraler vektoren

Info

Publication number
ATE318922T1
ATE318922T1 AT99932760T AT99932760T ATE318922T1 AT E318922 T1 ATE318922 T1 AT E318922T1 AT 99932760 T AT99932760 T AT 99932760T AT 99932760 T AT99932760 T AT 99932760T AT E318922 T1 ATE318922 T1 AT E318922T1
Authority
AT
Austria
Prior art keywords
chromosomes
retroviral vectors
targeted integration
gene therapy
relates
Prior art date
Application number
AT99932760T
Other languages
English (en)
Inventor
Walter Guenzburg
Brian Salmons
Sabine Strauss-Goller
Dieter Klein
Original Assignee
Inst Virologie Teilrechtsfaehi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inst Virologie Teilrechtsfaehi filed Critical Inst Virologie Teilrechtsfaehi
Application granted granted Critical
Publication of ATE318922T1 publication Critical patent/ATE318922T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/13011—Gammaretrovirus, e.g. murine leukeamia virus
    • C12N2740/13041—Use of virus, viral particle or viral elements as a vector
    • C12N2740/13043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Feedback Control In General (AREA)
  • Complex Calculations (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Electrotherapy Devices (AREA)
  • Compression Or Coding Systems Of Tv Signals (AREA)
AT99932760T 1998-07-01 1999-06-30 Zielgerichtete integration in chromosomen mittels retroviraler vektoren ATE318922T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DKPA199801016 1998-07-01

Publications (1)

Publication Number Publication Date
ATE318922T1 true ATE318922T1 (de) 2006-03-15

Family

ID=8100053

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99932760T ATE318922T1 (de) 1998-07-01 1999-06-30 Zielgerichtete integration in chromosomen mittels retroviraler vektoren

Country Status (7)

Country Link
US (1) US6656727B2 (de)
EP (1) EP1092035B1 (de)
JP (1) JP2002519069A (de)
AT (1) ATE318922T1 (de)
AU (1) AU4903099A (de)
DE (1) DE69930123T2 (de)
WO (1) WO2000001835A2 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030224415A1 (en) * 2001-06-29 2003-12-04 Gala Design, Inc. Selection free growth of host cells containing multiple integrating vectors
KR100545945B1 (ko) * 2000-07-03 2006-01-25 갈라 디자인, 인크. 발현 벡터
US20040235173A1 (en) * 2000-07-03 2004-11-25 Gala Design, Inc. Production of host cells containing multiple integrating vectors by serial transduction
AU2001271614B2 (en) * 2000-07-03 2007-05-31 Catalent Pharma Solutions, Llc Host cells containing multiple integrating vectors
US7384738B2 (en) * 2002-03-28 2008-06-10 Bremel Robert D Retrovirus-based genomic screening
US20040038304A1 (en) * 2002-03-28 2004-02-26 Gala Design, Inc. Antibody libraries
US20050221429A1 (en) * 2004-01-16 2005-10-06 Cardinal Health Pts, Llc Host cells containing multiple integrating vectors comprising an amplifiable marker
US20060233757A1 (en) * 2004-08-27 2006-10-19 Wendy Maury Vectors with viral insulators
AU2005282746A1 (en) * 2004-09-02 2006-03-16 Wyeth Systems and methods for protein production
US7470777B2 (en) * 2004-12-22 2008-12-30 Iowa State University Research Foundation, Inc. Compositions and methods related to modified retroviral vectors for restricted, site specific integration

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5856152A (en) * 1994-10-28 1999-01-05 The Trustees Of The University Of Pennsylvania Hybrid adenovirus-AAV vector and methods of use therefor
US5650309A (en) 1995-05-16 1997-07-22 The Regents Of The University Of California Viral vectors
US5801030A (en) * 1995-09-01 1998-09-01 Genvec, Inc. Methods and vectors for site-specific recombination
JP2001518804A (ja) * 1997-03-21 2001-10-16 エンゾー セラピューティクス インコーポレイテッド ベクターおよびウイルスベクター、およびこれらを増殖するためのパッケージング細胞株
US6251677B1 (en) * 1997-08-25 2001-06-26 The Trustees Of The University Of Pennsylvania Hybrid adenovirus-AAV virus and methods of use thereof

Also Published As

Publication number Publication date
DE69930123D1 (de) 2006-04-27
EP1092035A2 (de) 2001-04-18
WO2000001835A2 (en) 2000-01-13
WO2000001835A3 (en) 2000-04-06
DE69930123T2 (de) 2006-10-12
JP2002519069A (ja) 2002-07-02
AU4903099A (en) 2000-01-24
EP1092035B1 (de) 2006-03-01
US20010043921A1 (en) 2001-11-22
US6656727B2 (en) 2003-12-02

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