ATE319700T1 - Verfahren zu herstellung von tocotrienolen - Google Patents
Verfahren zu herstellung von tocotrienolenInfo
- Publication number
- ATE319700T1 ATE319700T1 AT01996253T AT01996253T ATE319700T1 AT E319700 T1 ATE319700 T1 AT E319700T1 AT 01996253 T AT01996253 T AT 01996253T AT 01996253 T AT01996253 T AT 01996253T AT E319700 T1 ATE319700 T1 AT E319700T1
- Authority
- AT
- Austria
- Prior art keywords
- tocotrienols
- producing
- tocotrienol
- antiatherogenic
- hypocholesterolemic
- Prior art date
Links
- 229930003802 tocotrienol Natural products 0.000 title abstract 4
- 239000011731 tocotrienol Substances 0.000 title abstract 4
- 235000019148 tocotrienols Nutrition 0.000 title abstract 4
- GJJVAFUKOBZPCB-ZGRPYONQSA-N (r)-3,4-dihydro-2-methyl-2-(4,8,12-trimethyl-3,7,11-tridecatrienyl)-2h-1-benzopyran-6-ol Chemical class OC1=CC=C2OC(CC/C=C(C)/CC/C=C(C)/CCC=C(C)C)(C)CCC2=C1 GJJVAFUKOBZPCB-ZGRPYONQSA-N 0.000 title abstract 3
- 229940068778 tocotrienols Drugs 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 235000013339 cereals Nutrition 0.000 abstract 3
- GJJVAFUKOBZPCB-UHFFFAOYSA-N 2-methyl-2-(4,8,12-trimethyltrideca-3,7,11-trienyl)-3,4-dihydrochromen-6-ol Chemical compound OC1=CC=C2OC(CCC=C(C)CCC=C(C)CCC=C(C)C)(C)CCC2=C1 GJJVAFUKOBZPCB-UHFFFAOYSA-N 0.000 abstract 1
- 102000007330 LDL Lipoproteins Human genes 0.000 abstract 1
- 108010007622 LDL Lipoproteins Proteins 0.000 abstract 1
- 235000019482 Palm oil Nutrition 0.000 abstract 1
- 230000000489 anti-atherogenic effect Effects 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 230000003064 anti-oxidating effect Effects 0.000 abstract 1
- 230000002785 anti-thrombosis Effects 0.000 abstract 1
- 239000003146 anticoagulant agent Substances 0.000 abstract 1
- 235000015872 dietary supplement Nutrition 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000000871 hypocholesterolemic effect Effects 0.000 abstract 1
- 230000004957 immunoregulator effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000003921 oil Substances 0.000 abstract 1
- 235000019198 oils Nutrition 0.000 abstract 1
- 239000002540 palm oil Substances 0.000 abstract 1
- 239000000047 product Substances 0.000 abstract 1
- 150000003612 tocotrienol derivatives Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
- C07D311/72—3,4-Dihydro derivatives having in position 2 at least one methyl radical and in position 6 one oxygen atom, e.g. tocopherols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pain & Pain Management (AREA)
- Pharmacology & Pharmacy (AREA)
- Rheumatology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrane Compounds (AREA)
- Steroid Compounds (AREA)
- Fats And Perfumes (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25648700P | 2000-12-20 | 2000-12-20 | |
| US30917101P | 2001-08-02 | 2001-08-02 | |
| US10/012,047 US6838104B2 (en) | 2000-12-20 | 2001-12-11 | Process for the production of tocotrienols |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE319700T1 true ATE319700T1 (de) | 2006-03-15 |
Family
ID=27359562
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01996253T ATE319700T1 (de) | 2000-12-20 | 2001-12-20 | Verfahren zu herstellung von tocotrienolen |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US6838104B2 (de) |
| EP (1) | EP1363895B1 (de) |
| AT (1) | ATE319700T1 (de) |
| AU (1) | AU2002227402A1 (de) |
| DE (1) | DE60117869T2 (de) |
| ES (1) | ES2260333T3 (de) |
| WO (1) | WO2002050054A2 (de) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6867308B2 (en) | 2001-09-19 | 2005-03-15 | Archer-Daniels-Midland Company | Process for separation of tocopherols |
| US6673945B2 (en) | 2001-11-08 | 2004-01-06 | Archer-Daniels Midland Company | Process for production of high purity tocopherols |
| AT414082B (de) * | 2002-05-03 | 2006-09-15 | Vis Vitalis Lizenz & Handels | Verfahren zur herstellung von tocotrienol-angereicherten präparationen |
| MY142319A (en) * | 2002-08-20 | 2010-11-15 | Malaysian Palm Oil Board Mpob | Extraction of palm vitamin e, phytosterols and squalene from palm oil |
| US7416756B2 (en) | 2003-09-10 | 2008-08-26 | Eastman Chemical Company | Process for the recovery of a phytolipid composition |
| PT2471530T (pt) | 2005-06-01 | 2017-04-19 | Edison Pharmaceuticals Inc | Produtos terapêuticos com atividade redox para o tratamento de doenças mitocondriais e de outras condições e modulação de biomarcadores energéticos |
| EP1986636B1 (de) | 2006-02-22 | 2013-04-24 | Edison Pharmaceuticals, Inc. | Phenol- und 1,4-benzochinon-derivate zur verwendung in der behandlung von erkrankungen der mitochondrien |
| WO2008142433A1 (en) * | 2007-05-24 | 2008-11-27 | Loders Croklaan B.V. | Process for producing compositions comprising tocoherols and tocotrienols |
| US8314153B2 (en) | 2008-09-10 | 2012-11-20 | Edison Pharmaceuticals, Inc. | Treatment of pervasive developmental disorders with redox-active therapeutics |
| PT2963006T (pt) | 2008-10-28 | 2018-12-14 | Bioelectron Tech Corp | Composição contendo alfa-tocotrienol quinona e seus intermediários |
| PL2424495T3 (pl) | 2009-04-28 | 2018-06-29 | Bioelectron Technology Corporation | Leczenie dziedzicznej neuropatii nerwów wzrokowych lebera i dominującego zaniku nerwu wzrokowego chinonami tokotrienolu |
| MX2011013558A (es) | 2009-06-25 | 2012-04-30 | Ampere Life Sciences Inc | Tratamiento del trastorno pervasivo del desarrollo con tocotrienoles o extractos de tocotrienoles enriquecidos. |
| MY160111A (en) * | 2009-07-30 | 2017-02-28 | Chiang Mai Univ | System and method for extracting vitamin e from fatty acid distillates |
| WO2013013078A1 (en) | 2011-07-19 | 2013-01-24 | Edison Pharmeceuticals, Inc. | Methods for selective oxidation of alpha tocotrienol in the presence of non-alpha tocotrienols |
| GB2501519B (en) | 2012-04-27 | 2020-01-15 | N V Desmet Ballestra Eng Sa | Physical refining of triglyceride oils and fats |
| WO2017106786A1 (en) | 2015-12-16 | 2017-06-22 | Bioelectron Technology Corporation | Improved methods for enriching alpha-tocotrienol from mixed tocol compositions |
| WO2017106803A1 (en) | 2015-12-17 | 2017-06-22 | Bioelectron Technology Corporation | Flouroalkyl, flouroalkoxy, phenoxy, heteroaryloxy, alkoxy, and amine 1,4-benzoquinone derivatives for treatment of oxidative stress disorders |
| WO2025172861A2 (en) | 2024-02-14 | 2025-08-21 | Biosergen As | Compositions of a therapeutic polyene macrolide and methods of their use |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4480108A (en) * | 1983-08-01 | 1984-10-30 | Eastman Kodak Company | Process for separation of tocopherol homologues |
| US4603142A (en) * | 1984-06-01 | 1986-07-29 | Wisconsin Alumni Research Foundation | Cholesterol lowering method of use |
| JPS6193178A (ja) * | 1984-10-12 | 1986-05-12 | Agency Of Ind Science & Technol | トコトリエノ−ル類の分離方法 |
| US5660692A (en) * | 1988-02-24 | 1997-08-26 | Cedars-Sinai Medical Center | Method of crosslinking amino acid-containing polymers using photoactivatable chemical crosslinkers |
| AU618791B2 (en) * | 1988-03-16 | 1992-01-09 | Bioindustry Development Centre | Production of high concentration tocopherols and tocotrienols from palm oil by-product |
| JPH07504887A (ja) * | 1991-11-22 | 1995-06-01 | リポジェニックス,インコーポレイテッド | トコトリエノールおよびトコトリエノール様化合物ならびにこれらを使用する方法 |
| JPH06193178A (ja) | 1992-12-25 | 1994-07-12 | Kurosawa Kensetsu Kk | フラットスラブの構築工法 |
| US5487817A (en) * | 1993-02-11 | 1996-01-30 | Hoffmann-La Roche Inc. | Process for tocopherols and sterols from natural sources |
| ATE213239T1 (de) * | 1993-08-06 | 2002-02-15 | Henkel Corp | Wiedergewinnung von tocopherolen |
| US5512691A (en) * | 1994-11-07 | 1996-04-30 | Eastman Chemical Company | Process for the production of tocopherol concentrates |
| US5504220A (en) | 1995-08-17 | 1996-04-02 | Eastman Chemical Company | Preparation of α-tocopherol |
| US6177114B1 (en) * | 1996-10-31 | 2001-01-23 | Carotina Sdn. Bhd. | Refining of edible oil rich in natural carotenes and Vitamin E |
| MY127634A (en) * | 1996-10-31 | 2006-12-29 | Global Palm Products Sdn Bhd | Refining of edible oil rich in natural carotenes and vitamin e |
| US5786491A (en) * | 1996-12-06 | 1998-07-28 | Eastman Chemical Company | Process for crystallizing D-alpha-tocopheryl succinate |
| US6706898B2 (en) * | 1998-01-29 | 2004-03-16 | Archer-Daniels-Midland Company | Methods for separating a tocopherol from a tocopherol-containing mixture |
| EP1051412B1 (de) * | 1998-01-29 | 2003-09-24 | Eastman Chemical Company | Verfahren zur trennung von einem tocotrienol aus einer tocol enthaltende mischung und deren zusammenstellungen |
| US6197357B1 (en) * | 1998-05-28 | 2001-03-06 | University Of Massachusetts | Refined vegetable oils and extracts thereof |
| US6350453B1 (en) * | 1999-05-24 | 2002-02-26 | American River Nutrition, Inc. | Tocotrienols and geranylgeraniol from Bixa orellana byproducts |
-
2001
- 2001-12-11 US US10/012,047 patent/US6838104B2/en not_active Expired - Fee Related
- 2001-12-20 EP EP01996253A patent/EP1363895B1/de not_active Revoked
- 2001-12-20 ES ES01996253T patent/ES2260333T3/es not_active Expired - Lifetime
- 2001-12-20 WO PCT/US2001/048624 patent/WO2002050054A2/en not_active Ceased
- 2001-12-20 AT AT01996253T patent/ATE319700T1/de not_active IP Right Cessation
- 2001-12-20 DE DE60117869T patent/DE60117869T2/de not_active Expired - Fee Related
- 2001-12-20 AU AU2002227402A patent/AU2002227402A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| ES2260333T3 (es) | 2006-11-01 |
| DE60117869T2 (de) | 2006-07-27 |
| US6838104B2 (en) | 2005-01-04 |
| US20020142083A1 (en) | 2002-10-03 |
| EP1363895A2 (de) | 2003-11-26 |
| DE60117869D1 (de) | 2006-05-04 |
| WO2002050054A2 (en) | 2002-06-27 |
| WO2002050054A3 (en) | 2003-02-27 |
| EP1363895B1 (de) | 2006-03-08 |
| AU2002227402A1 (en) | 2002-07-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |