ATE411307T1 - Verfahren zur herstellung von alkenylierten hydroxylierten aromatischen verbindungen, von chromanverbindungen und deren acylierten derivaten - Google Patents
Verfahren zur herstellung von alkenylierten hydroxylierten aromatischen verbindungen, von chromanverbindungen und deren acylierten derivatenInfo
- Publication number
- ATE411307T1 ATE411307T1 AT04819653T AT04819653T ATE411307T1 AT E411307 T1 ATE411307 T1 AT E411307T1 AT 04819653 T AT04819653 T AT 04819653T AT 04819653 T AT04819653 T AT 04819653T AT E411307 T1 ATE411307 T1 AT E411307T1
- Authority
- AT
- Austria
- Prior art keywords
- compounds
- alkenylated
- aromatic compounds
- producing
- chrome
- Prior art date
Links
- 150000001491 aromatic compounds Chemical class 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title abstract 3
- VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical class [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 title 1
- 238000000034 method Methods 0.000 abstract 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 239000011732 tocopherol Substances 0.000 abstract 2
- DFUSDJMZWQVQSF-XLGIIRLISA-N (2r)-2-methyl-2-[(4r,8r)-4,8,12-trimethyltridecyl]-3,4-dihydrochromen-6-ol Chemical compound OC1=CC=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1 DFUSDJMZWQVQSF-XLGIIRLISA-N 0.000 abstract 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 abstract 1
- 230000010933 acylation Effects 0.000 abstract 1
- 238000005917 acylation reaction Methods 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- QZXCCPZJCKEPSA-UHFFFAOYSA-N chlorfenac Chemical compound OC(=O)CC1=C(Cl)C=CC(Cl)=C1Cl QZXCCPZJCKEPSA-UHFFFAOYSA-N 0.000 abstract 1
- VZWXIQHBIQLMPN-UHFFFAOYSA-N chromane Chemical class C1=CC=C2CCCOC2=C1 VZWXIQHBIQLMPN-UHFFFAOYSA-N 0.000 abstract 1
- 150000002471 indium Chemical class 0.000 abstract 1
- 238000007363 ring formation reaction Methods 0.000 abstract 1
- 229960001295 tocopherol Drugs 0.000 abstract 1
- 229930003799 tocopherol Natural products 0.000 abstract 1
- 235000019149 tocopherols Nutrition 0.000 abstract 1
- QUEDXNHFTDJVIY-UHFFFAOYSA-N γ-tocopherol Chemical class OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1 QUEDXNHFTDJVIY-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
- C07D311/72—3,4-Dihydro derivatives having in position 2 at least one methyl radical and in position 6 one oxygen atom, e.g. tocopherols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
- C07C37/11—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by reactions increasing the number of carbon atoms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/582—Recycling of unreacted starting or intermediate materials
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Obesity (AREA)
- Pharmacology & Pharmacy (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Nutrition Science (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pyrane Compounds (AREA)
- Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03027992 | 2003-12-05 | ||
| EP04013714 | 2004-06-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE411307T1 true ATE411307T1 (de) | 2008-10-15 |
Family
ID=34655105
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04819653T ATE411307T1 (de) | 2003-12-05 | 2004-12-03 | Verfahren zur herstellung von alkenylierten hydroxylierten aromatischen verbindungen, von chromanverbindungen und deren acylierten derivaten |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7696364B2 (de) |
| EP (1) | EP1689733B1 (de) |
| JP (2) | JP4917435B2 (de) |
| KR (1) | KR101143802B1 (de) |
| CN (1) | CN101704809B (de) |
| AT (1) | ATE411307T1 (de) |
| DE (1) | DE602004017217D1 (de) |
| WO (1) | WO2005054223A2 (de) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070049762A1 (en) * | 2003-12-15 | 2007-03-01 | Werner Bonrath | Process for the manufacture of trimethylydroquine dialkanoates |
| CN1968943B (zh) * | 2004-06-11 | 2011-08-10 | 帝斯曼知识产权资产管理有限公司 | 生产色满衍生物尤其是α-生育酚及其链烷酸酯的方法 |
| EP2522647B1 (de) * | 2011-05-10 | 2014-04-30 | DSM IP Assets B.V. | Verfahren zum Trennen von chiralen Isomeren von Chromverbindungen und ihre Derivate und Vorläufer |
| ES2606354T3 (es) | 2012-08-10 | 2017-03-23 | Dsm Ip Assets B.V. | Tocoferoles con estabilidad cromática incrementada |
| EP2882729B1 (de) | 2012-08-10 | 2016-09-21 | DSM IP Assets B.V. | Geschütztes tocopherol mit reduziertem anteil an freien tocopherolen |
| US20200131145A1 (en) | 2017-07-12 | 2020-04-30 | Dsm Ip Assets B.V. | Novel synthesis of intermediates for the preparation of alpha-tocopherol |
| CN111936483A (zh) * | 2018-03-29 | 2020-11-13 | 帝斯曼知识产权资产管理有限公司 | 具有短侧链的苯并二氢吡喃-6-醇的制备方法 |
| CA3108138A1 (en) * | 2018-08-17 | 2020-02-20 | Basf Se | Synthesis of chromanol and 2-methyl-1,4-naphthoquinone derivatives |
| WO2020035600A1 (en) * | 2018-08-17 | 2020-02-20 | Basf Se | Synthesis of chromanol derivatives |
| KR102846267B1 (ko) * | 2018-08-17 | 2025-08-13 | 바스프 에스이 | 크로마놀 유도체의 합성 |
| US20240209132A1 (en) * | 2021-04-28 | 2024-06-27 | Dsm Ip Assets B.V. | Coupling of 2,3,5-trimethylhydroquinone and unsaturated alcohols |
| EP4330242A1 (de) * | 2021-04-28 | 2024-03-06 | DSM IP Assets B.V. | Ringschluss von benzochinonen, die eine ungesättigte seitenkette enthalten, unter verwendung einer base in einem zweiphasensystem |
| US20240217941A1 (en) * | 2021-04-28 | 2024-07-04 | Dsm Ip Assets B.V. | Ring closure of benzoquinones containing an unsaturated side chain using a basic catalyst |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5089372A (de) * | 1973-12-18 | 1975-07-17 | ||
| DE2428691A1 (de) * | 1974-06-14 | 1976-01-08 | Merck Patent Gmbh | Hexahydro-diazepino-indolderivate und verfahren zu ihrer herstellung |
| DE4243464A1 (de) * | 1992-12-22 | 1994-06-23 | Basf Ag | Verfahren zur Herstellung von alpha-Tocopherol und alpha-Tocopherylacetat in flüssigem oder überkritischem Kohlendioxid |
| JP2644460B2 (ja) * | 1994-07-27 | 1997-08-25 | エーザイ株式会社 | α−トコフェロールの製造方法 |
| US5663376A (en) * | 1994-07-27 | 1997-09-02 | Eisai Co., Ltd. | Process for the preparation of α-tocopherol |
| JPH09241184A (ja) * | 1996-03-08 | 1997-09-16 | Central Glass Co Ltd | フリーデル−クラフト−アルキル化反応生成物の製造方法 |
| JPH09262479A (ja) * | 1996-03-29 | 1997-10-07 | Kuraray Co Ltd | ルイス酸触媒 |
| DE19826403A1 (de) * | 1998-06-15 | 1999-12-16 | Basf Ag | Übergangsmetallkomplexe |
| US6180557B1 (en) | 1998-08-13 | 2001-01-30 | Council Of Scientific & Industrial Research | Supported catalyst useful for Friedel-Crafts reactions and process for the preparation of aralkylated aromatic compounds using the catalyst |
| FR2784104B1 (fr) * | 1998-09-18 | 2002-12-27 | Rhone Poulenc Nutrition Animal | Procede de preparation de la vitamine e |
| EP1000940A1 (de) | 1998-11-11 | 2000-05-17 | F. Hoffmann-La Roche Ag | Verfahren zur Herstellung von d,l-alpha-Tocopherol |
| CA2288851A1 (en) * | 1998-11-11 | 2000-05-11 | F. Hoffmann-La Roche Ag | Process for manufacturing d,i-alpha-tocopherol |
| KR100288503B1 (ko) * | 1999-04-02 | 2001-04-16 | 박호군 | 인듐을 이용한 알킬 방향족 화합물의 제조방법 |
| KR100452291B1 (ko) * | 1999-12-14 | 2004-10-08 | 에스케이 주식회사 | 고수율 및 고순도로 ＤＬ-α-토코페롤를 제조하는 방법 |
| DE10011402A1 (de) * | 2000-03-09 | 2001-09-13 | Degussa | Verfahren zur Herstellung von alpha-Tocopherolestern |
| ATE296299T1 (de) * | 2000-07-10 | 2005-06-15 | Dsm Ip Assets Bv | Acylierungsverfahren |
| US6706931B2 (en) * | 2000-12-21 | 2004-03-16 | Shell Oil Company | Branched primary alcohol compositions and derivatives thereof |
| US6459000B1 (en) * | 2001-03-26 | 2002-10-01 | Council Of Scientific And Industrial Research | Process for the liquid phase acylation of aromatic compounds |
| GB0123597D0 (en) | 2001-10-02 | 2001-11-21 | Univ Belfast | Friedal-crafts reactions |
| CN1968943B (zh) | 2004-06-11 | 2011-08-10 | 帝斯曼知识产权资产管理有限公司 | 生产色满衍生物尤其是α-生育酚及其链烷酸酯的方法 |
-
2004
- 2004-12-03 DE DE602004017217T patent/DE602004017217D1/de not_active Expired - Lifetime
- 2004-12-03 JP JP2006541912A patent/JP4917435B2/ja not_active Expired - Fee Related
- 2004-12-03 WO PCT/EP2004/013788 patent/WO2005054223A2/en not_active Ceased
- 2004-12-03 AT AT04819653T patent/ATE411307T1/de not_active IP Right Cessation
- 2004-12-03 EP EP04819653A patent/EP1689733B1/de not_active Expired - Lifetime
- 2004-12-03 CN CN2009102610557A patent/CN101704809B/zh not_active Expired - Fee Related
- 2004-12-03 KR KR1020067010843A patent/KR101143802B1/ko not_active Expired - Fee Related
- 2004-12-06 US US11/005,402 patent/US7696364B2/en active Active
-
2011
- 2011-04-26 JP JP2011098558A patent/JP2011178801A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| DE602004017217D1 (de) | 2008-11-27 |
| WO2005054223A2 (en) | 2005-06-16 |
| KR20060117335A (ko) | 2006-11-16 |
| EP1689733B1 (de) | 2008-10-15 |
| EP1689733A2 (de) | 2006-08-16 |
| JP4917435B2 (ja) | 2012-04-18 |
| JP2011178801A (ja) | 2011-09-15 |
| CN101704809B (zh) | 2012-11-07 |
| US7696364B2 (en) | 2010-04-13 |
| KR101143802B1 (ko) | 2012-05-11 |
| US20050171362A1 (en) | 2005-08-04 |
| JP2007513121A (ja) | 2007-05-24 |
| WO2005054223A3 (en) | 2005-10-27 |
| CN101704809A (zh) | 2010-05-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |