ATE319723T1 - Wasserlösslische prodrugs von gehinderten phenolen - Google Patents

Wasserlösslische prodrugs von gehinderten phenolen

Info

Publication number: ATE319723T1
Authority: AT; Austria
Prior art keywords: water soluble; hindered phenols; soluble prodrugs; prodrugs; aliphatic
Prior art date: 1998-08-07

Application number

AT99939030T

Other languages

English (en)

Inventor

Valentino J Stella

Jan J Zygmunt

Ingrid Gunda Georg

Muhammed S Safadi

Original Assignee

Univ Kansas

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-08-07

Filing date

1999-08-06

Publication date

2006-03-15

1999-08-06 Application filed by Univ Kansas filed Critical Univ Kansas

2006-03-15 Application granted granted Critical

2006-03-15 Publication of ATE319723T1 publication Critical patent/ATE319723T1/de

Links

239000000651 prodrug Substances 0.000 title abstract 2
229940002612 prodrug Drugs 0.000 title abstract 2
150000002989 phenols Chemical class 0.000 title 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title 1
125000001931 aliphatic group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
- C07F9/6552—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a six-membered ring
- C07F9/65522—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a six-membered ring condensed with carbocyclic rings or carbocyclic ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
- C07K7/645—Cyclosporins; Related peptides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
General Chemical & Material Sciences (AREA)
Genetics & Genomics (AREA)
Chemical Kinetics & Catalysis (AREA)
Biotechnology (AREA)
Biophysics (AREA)
Gastroenterology & Hepatology (AREA)
Immunology (AREA)
Epidemiology (AREA)
Anesthesiology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicinal Preparation (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Saccharide Compounds (AREA)
Pyrane Compounds (AREA)
Steroid Compounds (AREA)
Compounds Of Unknown Constitution (AREA)
Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)

AT99939030T 1998-08-07 1999-08-06 Wasserlösslische prodrugs von gehinderten phenolen ATE319723T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US09/131,385 US6204257B1 (en)	1998-08-07	1998-08-07	Water soluble prodrugs of hindered alcohols

Publications (1)

Publication Number	Publication Date
ATE319723T1 true ATE319723T1 (de)	2006-03-15

Family

ID=22449234

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99939030T ATE319723T1 (de)	1998-08-07	1999-08-06	Wasserlösslische prodrugs von gehinderten phenolen

Country Status (27)

Country	Link
US (4)	US6204257B1 (de)
EP (2)	EP1683803A1 (de)
JP (1)	JP4554081B2 (de)
KR (1)	KR100662799B1 (de)
CN (2)	CN1198834C (de)
AT (1)	ATE319723T1 (de)
AU (1)	AU769755B2 (de)
BR (1)	BR9912853A (de)
CA (1)	CA2339834C (de)
CY (1)	CY1105043T1 (de)
CZ (1)	CZ304020B6 (de)
DE (1)	DE69930269T2 (de)
DK (1)	DK1102776T3 (de)
ES (1)	ES2268876T3 (de)
HK (1)	HK1047939B (de)
HU (1)	HU229401B1 (de)
IL (1)	IL141316A (de)
MX (1)	MXPA01001431A (de)
NO (1)	NO330357B1 (de)
NZ (1)	NZ509795A (de)
PL (1)	PL198141B1 (de)
PT (1)	PT1102776E (de)
RU (1)	RU2235727C2 (de)
TR (1)	TR200100772T2 (de)
UA (1)	UA73479C2 (de)
WO (1)	WO2000008033A1 (de)
ZA (1)	ZA200101039B (de)

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1998
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1999
- 1999-06-08 UA UA2001031520A patent/UA73479C2/uk unknown
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- 1999-08-06 CN CNB998114405A patent/CN1198834C/zh not_active Expired - Fee Related
- 1999-08-06 AU AU53394/99A patent/AU769755B2/en not_active Ceased
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Publication number	Publication date
CY1105043T1 (el)	2010-03-03
IL141316A (en)	2004-06-20
CZ2001479A3 (cs)	2001-09-12
HU229401B1 (en)	2013-12-30
DE69930269T2 (de)	2006-12-07
EP1102776B1 (de)	2006-03-08
BR9912853A (pt)	2001-10-30
PT1102776E (pt)	2007-02-28
RU2235727C2 (ru)	2004-09-10
AU5339499A (en)	2000-02-28
CN1357000A (zh)	2002-07-03
WO2000008033A1 (en)	2000-02-17
KR100662799B1 (ko)	2007-01-02
JP2002522443A (ja)	2002-07-23
CA2339834A1 (en)	2000-02-17
US20050090431A1 (en)	2005-04-28
HUP0200317A3 (en)	2004-07-28
PL347211A1 (en)	2002-03-25
US7244718B2 (en)	2007-07-17
CN1198834C (zh)	2005-04-27
EP1102776A1 (de)	2001-05-30
IL141316A0 (en)	2002-03-10
TR200100772T2 (tr)	2001-12-21
US6204257B1 (en)	2001-03-20
CZ304020B6 (cs)	2013-08-28
PL198141B1 (pl)	2008-05-30
CN1680402A (zh)	2005-10-12
NO20010659D0 (no)	2001-02-07
MXPA01001431A (es)	2002-11-29
NZ509795A (en)	2003-10-31
DK1102776T3 (da)	2006-07-10
ES2268876T3 (es)	2007-03-16
US20010025035A1 (en)	2001-09-27
HUP0200317A2 (en)	2002-06-29
NO20010659L (no)	2001-04-06
NO330357B1 (no)	2011-04-04
EP1683803A1 (de)	2006-07-26
ZA200101039B (en)	2002-02-05
HK1047939A1 (en)	2003-03-14
DE69930269D1 (de)	2006-05-04
JP4554081B2 (ja)	2010-09-29
US20030176324A1 (en)	2003-09-18
US6451776B2 (en)	2002-09-17
KR20010079627A (ko)	2001-08-22
CA2339834C (en)	2011-01-25
US6872838B2 (en)	2005-03-29
HK1047939B (zh)	2005-11-18
UA73479C2 (uk)	2005-08-15
AU769755B2 (en)	2004-02-05

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