ATE319734T1 - Steroidale verbindungen zur inhibierung von steroidsulfatasen - Google Patents

Steroidale verbindungen zur inhibierung von steroidsulfatasen

Info

Publication number
ATE319734T1
ATE319734T1 AT02801418T AT02801418T ATE319734T1 AT E319734 T1 ATE319734 T1 AT E319734T1 AT 02801418 T AT02801418 T AT 02801418T AT 02801418 T AT02801418 T AT 02801418T AT E319734 T1 ATE319734 T1 AT E319734T1
Authority
AT
Austria
Prior art keywords
group
steroidal compounds
inhibiting steroid
sulfatases
steroid sulfatases
Prior art date
Application number
AT02801418T
Other languages
English (en)
Inventor
Barry V L Potter
Michael J Reed
Lok Wai L Woo
Original Assignee
Sterix Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/GB2001/004645 external-priority patent/WO2002032409A2/en
Priority claimed from GB0125073A external-priority patent/GB0125073D0/en
Priority claimed from GB0209274A external-priority patent/GB0209274D0/en
Application filed by Sterix Ltd filed Critical Sterix Ltd
Application granted granted Critical
Publication of ATE319734T1 publication Critical patent/ATE319734T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT02801418T 2001-10-18 2002-10-17 Steroidale verbindungen zur inhibierung von steroidsulfatasen ATE319734T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/GB2001/004645 WO2002032409A2 (en) 2000-10-20 2001-10-18 Use of compound in the manufacture of a pharmaceutical for inhibiting steroid sulphatase and steroid dehydrogenase activity
GB0125073A GB0125073D0 (en) 2001-10-18 2001-10-18 Compound
GB0209274A GB0209274D0 (en) 2002-04-23 2002-04-23 Compound

Publications (1)

Publication Number Publication Date
ATE319734T1 true ATE319734T1 (de) 2006-03-15

Family

ID=27256082

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02801418T ATE319734T1 (de) 2001-10-18 2002-10-17 Steroidale verbindungen zur inhibierung von steroidsulfatasen

Country Status (6)

Country Link
EP (1) EP1448592B1 (de)
JP (1) JP4553586B2 (de)
AT (1) ATE319734T1 (de)
DE (1) DE60209811T2 (de)
PT (1) PT1448592E (de)
WO (1) WO2003033518A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1989218B1 (de) * 2006-02-17 2009-12-30 Janssen Pharmaceutica, N.V. 17-phosphor-steroid-derivate als progesteron-rezeptormodulatoren
AU2007217094A1 (en) * 2006-02-17 2007-08-30 Janssen Pharmaceutica N.V. 11-phosphorous steroid derivatives useful as progesterone receptor modulators
GB0604142D0 (en) * 2006-03-01 2006-04-12 Sterix Ltd Compound
KR20100068287A (ko) 2007-09-17 2010-06-22 쁘레글렘 에스.아. 폐경기 전 여성의 에스트로겐 의존성 질환의 치료
EP2149371A1 (de) 2008-07-28 2010-02-03 PregLem S.A. Verwendung von Steroid-Sulfatase-Hemmern zur Behandlung von Frühgeburtsleiden
CN104557602B (zh) * 2015-01-07 2016-08-17 华东师范大学 三环二萜衍生物及其制备方法、及其在制备抗肿瘤药物中的应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT314746B (de) * 1970-06-18 1974-04-25 Richter Gedeon Vegyeszet Verfahren zur Herstellung von neuen D-Homo-imid-Derivaten mit Sterangerüst
GB9118478D0 (en) * 1991-08-29 1991-10-16 Imperial College Steroid sulphatase inhibitors
US5755964A (en) * 1996-02-02 1998-05-26 The Dow Chemical Company Method of treating polyamide membranes to increase flux
GB0025788D0 (en) * 2000-10-20 2000-12-06 Sterix Ltd Use

Also Published As

Publication number Publication date
WO2003033518A1 (en) 2003-04-24
DE60209811D1 (de) 2006-05-04
EP1448592A1 (de) 2004-08-25
PT1448592E (pt) 2006-07-31
JP4553586B2 (ja) 2010-09-29
DE60209811T2 (de) 2006-10-12
EP1448592B1 (de) 2006-03-08
JP2005506359A (ja) 2005-03-03

Similar Documents

Publication Publication Date Title
CY1109130T1 (el) Οιστρογονου-17-σουλφαμικα ως αναστολεις σουλφατασης στεροειδους
DE69233053D1 (de) Steroid-sulfatase hemmende Verbindungen
MXPA05010339A (es) Derivados de estrogeno como inhibidores de la esteroide sulfatasa.
KR950702960A (ko) 레트로바이러스 프로테아제 저해제로서 유용한 히드록시에틸아미노 술폰아미드(hydroxyethylamino sulfonamides useful as retroviral protease inhibitors)
TR200101893T2 (tr) Antiviral maddeler olarak 4-okso-1,4 dihidro -3- kuinolinkarboksamitler.
KR970700181A (ko) 레트로바이러스성 프로테아제 억제 화합물 제조용 합성 중간체(Synthetic intermediates for preparing retroviral protease inhibiting compounds)
CY1107710T1 (el) Εκκριματαγωγa αυξητικhς ορμoνης
BR0111780A (pt) Agente herbicida
MXPA02004440A (es) Derivados de pirrol como inhibidores de la fosfodiesterasa vii.
DK0918776T3 (da) Totalsyntese af antitumor acylfulvener
ES2177058T3 (es) Compuestos eter piperidinilaminometil trifluorometil ciclicos como antagonistas de la sustancia p.
NO20002676L (no) Androgene steroidforbindelser og en fremgangsmÕte for fremstilling og anvendelse av samme
ATE319734T1 (de) Steroidale verbindungen zur inhibierung von steroidsulfatasen
DE60001979D1 (de) Neue Substrate zur Detektion von mikrobiellen Metaboliten
MX2008011292A (es) Compuestos esteroidales como inhibidores de esteroide sulfatasa.
YU34799A (sh) Efikasna sinteza furan sulfonamid jedinjenja primenljivih u sintezi novih il-1 inhibitora
ATE408615T1 (de) Steroidale verbindungen zur hemmung von steroid sulfotase
DE60124519D1 (de) Trihydroxybenzen zur verhinderung der korrosion von titan
DE60023740D1 (de) Halogenierte sulphamat-, phosphonat-, thiophosphonat-, sulphonat- und sulphonamid- verbindungen als inhibitoren von steroidsulfatase
CA2419463A1 (en) Primary intermediates for oxidative coloration of hair
BR0214422A (pt) Isomerização do ácido fosfórico de um esteróide 5(10),9(11)dieno ao esteróide 4,9-dieno correspondente
MY120189A (en) Sultam and sultone derived oxazolidinones
ECSP982576A (es) Derivados de epotilona
ES2187987T3 (es) Procedimiento para la preparacion de derivados 1,3-diaza-espirol(4,4)n0n-1-en-4-onicos y de intermedios 1-ciano-1-acilamino-ciclopentanicos.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1448592

Country of ref document: EP