ATE320439T1 - Anti-(retro)virale konjugate von sacchariden und acetamidino- oder guanidinoverbindungen - Google Patents

Anti-(retro)virale konjugate von sacchariden und acetamidino- oder guanidinoverbindungen

Info

Publication number: ATE320439T1
Authority: AT; Austria
Prior art keywords: saccharide; aids; acetamidino; residue; conjugates
Prior art date: 1998-12-28

Application number

AT99961263T

Other languages

English (en)

Inventor

Aviva Lapidot

Alexander Litovchick

Artem Evdokimov

Original Assignee

Yeda Res & Dev

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-12-28

Filing date

1999-12-28

Publication date

2006-04-15

1999-12-28 Application filed by Yeda Res & Dev filed Critical Yeda Res & Dev

2006-04-15 Application granted granted Critical

2006-04-15 Publication of ATE320439T1 publication Critical patent/ATE320439T1/de

Links

150000001720 carbohydrates Chemical class 0.000 title abstract 3
ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical class NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 title 1
230000003612 virological effect Effects 0.000 title 1
208000030507 AIDS Diseases 0.000 abstract 3
150000001875 compounds Chemical class 0.000 abstract 2
150000002772 monosaccharides Chemical class 0.000 abstract 2
150000002482 oligosaccharides Polymers 0.000 abstract 2
125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 1
239000004475 Arginine Substances 0.000 abstract 1
229930182566 Gentamicin Natural products 0.000 abstract 1
CEAZRRDELHUEMR-URQXQFDESA-N Gentamicin Chemical compound O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N CEAZRRDELHUEMR-URQXQFDESA-N 0.000 abstract 1
208000031886 HIV Infections Diseases 0.000 abstract 1
208000037357 HIV infectious disease Diseases 0.000 abstract 1
208000007766 Kaposi sarcoma Diseases 0.000 abstract 1
229930193140 Neomycin Natural products 0.000 abstract 1
229940126574 aminoglycoside antibiotic Drugs 0.000 abstract 1
239000002647 aminoglycoside antibiotic agent Substances 0.000 abstract 1
230000000798 anti-retroviral effect Effects 0.000 abstract 1
230000000840 anti-viral effect Effects 0.000 abstract 1
125000000637 arginyl group Chemical group N[C@@H](CCCNC(N)=N)C(=O)* 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
229940042399 direct acting antivirals protease inhibitors Drugs 0.000 abstract 1
208000033519 human immunodeficiency virus infectious disease Diseases 0.000 abstract 1
-1 hydroxy, amino Chemical group 0.000 abstract 1
229960000318 kanamycin Drugs 0.000 abstract 1
229930027917 kanamycin Natural products 0.000 abstract 1
SBUJHOSQTJFQJX-NOAMYHISSA-N kanamycin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N SBUJHOSQTJFQJX-NOAMYHISSA-N 0.000 abstract 1
229930182823 kanamycin A Natural products 0.000 abstract 1
229960004927 neomycin Drugs 0.000 abstract 1
229920001542 oligosaccharide Polymers 0.000 abstract 1
125000004043 oxo group Chemical group O=* 0.000 abstract 1
239000000137 peptide hydrolase inhibitor Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
- C07H3/04—Disaccharides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
- C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Virology (AREA)
General Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Communicable Diseases (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Oncology (AREA)
Crystallography & Structural Chemistry (AREA)
AIDS & HIV (AREA)
Tropical Medicine & Parasitology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Saccharide Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Peptides Or Proteins (AREA)

AT99961263T 1998-12-28 1999-12-28 Anti-(retro)virale konjugate von sacchariden und acetamidino- oder guanidinoverbindungen ATE320439T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IL12777398A IL127773A0 (en)	1998-12-28	1998-12-28	Saccharide conjugates and pharmaceutical compositions comprising them

Publications (1)

Publication Number	Publication Date
ATE320439T1 true ATE320439T1 (de)	2006-04-15

Family

ID=11072308

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99961263T ATE320439T1 (de)	1998-12-28	1999-12-28	Anti-(retro)virale konjugate von sacchariden und acetamidino- oder guanidinoverbindungen

Country Status (9)

Country	Link
US (1)	US6642365B1 (de)
EP (1)	EP1140958B1 (de)
JP (1)	JP2003525859A (de)
AT (1)	ATE320439T1 (de)
AU (1)	AU1795600A (de)
DE (1)	DE69930412T2 (de)
HK (1)	HK1042904A1 (de)
IL (2)	IL127773A0 (de)
WO (1)	WO2000039139A1 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2829136B1 (fr) *	2001-08-29	2006-11-17	Aventis Pharma Sa	Derives lipidiques d'aminoglycosides
WO2003049772A2 (en) *	2001-12-11	2003-06-19	The Board Of Trustees Of The Leland Stanford Junior University	Guanidinium transport reagents and conjugates
US20050085432A1 (en) *	2001-12-26	2005-04-21	Aviva Lapidot	Methods of using conjugates of saccharides and acetamidino or guanidino compounds for treating bacterial infections
AU2002951247A0 (en) *	2002-09-06	2002-09-19	Alchemia Limited	Compounds that interact with kinases
WO2005060573A2 (en)	2003-12-15	2005-07-07	University Of Medicine And Dentistry Of New Jersey	Pna-neamine conjugates and methods for producing and using the same
CA2481491A1 (en)	2004-09-14	2006-03-14	Le Groupe Lysac Inc.	Amidinated or guanidinated polysaccharides, their use as absorbents and a process for producing same
CA2632968A1 (en)	2005-12-02	2007-06-07	Isis Pharmaceuticals, Inc.	Antibacterial 4,5-substituted aminoglycoside analogs having multiple substituents
FR2930942B1 (fr) *	2008-05-07	2011-03-04	Centre Nat Rech Scient	Nouvelles utilisations de derives de d-mannopyranose activateurs de l'angiogenese
WO2010030690A1 (en)	2008-09-10	2010-03-18	Isis Pharmaceuticals, Inc.	Antibacterial 4,6-substituted 6', 6" and 1 modified aminoglycoside analogs
WO2010030704A2 (en)	2008-09-10	2010-03-18	Achaogen, Inc.	Antibacterial aminoglycoside analogs
WO2010042851A1 (en)	2008-10-09	2010-04-15	Achaogen, Inc.	Antibacterial aminoglycoside analogs
WO2010042850A1 (en)	2008-10-09	2010-04-15	Achaogen, Inc.	Antibacterial aminoglycoside analogs
MX2012004036A (es)	2009-10-09	2012-06-27	Achaogen Inc	Analogos de aminoglicosidos antibacterianos.
US8774488B2 (en)	2010-03-11	2014-07-08	Cellscape Corporation	Method and device for identification of nucleated red blood cells from a maternal blood sample
AR083879A1 (es)	2010-11-17	2013-03-27	Achaogen Inc	Analogos de aminoglicosidos antibacterianos, metodos de preparacion y uso como agentes terapeuticos
US20200131231A1 (en)	2017-02-17	2020-04-30	Oxford University Innovation Limited	Cell penetrating peptides
GB201812980D0 (en)	2018-08-09	2018-09-26	Univ Oxford Innovation Ltd	Cell-penetrating peptides
GB201812972D0 (en)	2018-08-09	2018-09-26	Univ Oxford Innovation Ltd	Cell-penetrating peptides
EP3883943A4 (de) *	2018-11-22	2023-01-04	Technion Research & Development Foundation Limited	Modifizierte aminoglycosidverbindungen und ihre verwendungen zur deaktivierung von bakteriellen ribosomen
US12465646B2 (en)	2018-12-07	2025-11-11	Oxford University Innovation Limited	Linkers

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE79034T1 (de) *	1987-10-14	1992-08-15	Ueno Seiyaku Oyo Kenkyujo Kk	Behandlung von viruskrankheiten.
WO1995000177A1 (en) *	1993-06-17	1995-01-05	Dextran Products Limited	Pharmaceutical preparation and a method for inhibiting the replication of various viruses
US5593835A (en) *	1995-05-12	1997-01-14	President And Fellows Of Harvard College	Methods and kits for RNA binding compounds

1998
- 1998-12-28 IL IL12777398A patent/IL127773A0/xx unknown
1999
- 1999-12-28 HK HK02102642.6A patent/HK1042904A1/zh unknown
- 1999-12-28 DE DE69930412T patent/DE69930412T2/de not_active Expired - Fee Related
- 1999-12-28 JP JP2000591050A patent/JP2003525859A/ja active Pending
- 1999-12-28 US US09/869,437 patent/US6642365B1/en not_active Expired - Fee Related
- 1999-12-28 EP EP99961263A patent/EP1140958B1/de not_active Expired - Lifetime
- 1999-12-28 WO PCT/IL1999/000704 patent/WO2000039139A1/en not_active Ceased
- 1999-12-28 AT AT99961263T patent/ATE320439T1/de not_active IP Right Cessation
- 1999-12-28 AU AU17956/00A patent/AU1795600A/en not_active Abandoned
2001
- 2001-06-26 IL IL143995A patent/IL143995A/en unknown

Also Published As

Publication number	Publication date
IL143995A (en)	2006-12-31
DE69930412D1 (de)	2006-05-11
WO2000039139A1 (en)	2000-07-06
DE69930412T2 (de)	2006-08-24
US6642365B1 (en)	2003-11-04
AU1795600A (en)	2000-07-31
HK1042904A1 (zh)	2002-08-30
IL127773A0 (en)	1999-10-28
JP2003525859A (ja)	2003-09-02
EP1140958B1 (de)	2006-03-15
EP1140958A1 (de)	2001-10-10

Legal Events

Date	Code	Title	Description
2006-09-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE320439T1 (de)	2006-04-15	Anti-(retro)virale konjugate von sacchariden und acetamidino- oder guanidinoverbindungen
ATE409048T1 (de)	2008-10-15	Pharmazeutisch aktive oligosaccharid-conjugate
SE9703089L (sv)	1999-02-28	Katjoniska sockertensider från etoxilerade ammoniumföreningar och reducerande sackarider
FI974060A0 (fi)	1997-10-27	Sulfatoitujen oligosakkaridien valmistus ja käyttö
MX2009007415A (es)	2009-09-28	Sacaridos modificados.
ES2083500T3 (es)	1996-04-16	Una composicion de aminoglicosidos con una nefrotoxicidad sustancialmente reducida, inducida por el aminoglicosido.
DK0983335T3 (da)	2006-03-27	Alkylpolyglucosidholdige desinfektionssammensætninger, der er virksomme mod Pseudomonas-mikroorganismer
CA2080343A1 (en)	1991-10-13	5-benzyl barbiturate derivatives
EA200000843A1 (ru)	2001-02-26	Сульфированные сахариды
SE9300954L (sv)	1994-09-24	Alkylglykosid, dess användning för rengöring samt komposition för detta ändamål
ATE350443T1 (de)	2007-01-15	Biozid wirkendes reinigungsmittel
ES2055582T3 (es)	1994-08-16	Empleo de una combinacion de agentes tensioactivos no ionicos.
ATE388960T1 (de)	2008-03-15	Glykopeptidderivate mit carboxysacchariden
KR910004557A (ko)	1991-03-28	2,4,6-치환 페놀 유도체
DK0514515T3 (da)	1997-05-12	Anthracyclinkonjugat
DK0649312T3 (da)	2001-11-12	Anthracyclinkonjugater, deres fremstilling og deres anvendelse som antitumormidler
DE69624827D1 (de)	2002-12-19	5'-substitutierte-ribofuranosyl benzimidazolen als antivirale.
WO1998049998A3 (de)	1999-02-04	Verwendung von glykosidischen siliconverbindungen zur herstellung von kosmetischen und/oder pharmazeutischen zubereitungen
DK0502304T3 (da)	1993-11-29	Middel til permanentbølgning af menneskehår indeholdende alkylpolyglycosider
ES2169564T3 (es)	2002-07-01	Empleo de alquilpoliglicosidos en limpiadores para tintas de impresion.
IL93258A0 (en)	1990-11-29	Anthracycline glycoside derivatives,their preparation and pharmaceutical compositions containing them
KR950014110A (ko)	1995-06-15	사이클로프로판 유도체 및 이를 포함하는 항바이러스제
DE60006648D1 (de)	2003-12-24	Verwendung von oberflächenaktiven quarternären ammoniumglycosid-verbindungen als zusatz für düngemittel und pestizide
KR950028750A (ko)	1995-11-22	샴푸조성물
DE60208390D1 (de)	2006-02-02	Flüssige farbzusammensetzungen mit acylglycerinen als dispergiermitteln