ATE320819T1 - Bestimmung von antigenen mittels oligonukleotid- antikörper-konjugaten - Google Patents

Bestimmung von antigenen mittels oligonukleotid- antikörper-konjugaten

Info

Publication number
ATE320819T1
ATE320819T1 AT97911864T AT97911864T ATE320819T1 AT E320819 T1 ATE320819 T1 AT E320819T1 AT 97911864 T AT97911864 T AT 97911864T AT 97911864 T AT97911864 T AT 97911864T AT E320819 T1 ATE320819 T1 AT E320819T1
Authority
AT
Austria
Prior art keywords
oligonucleotide
labeled
dendrimer
antigen
antigens
Prior art date
Application number
AT97911864T
Other languages
English (en)
Inventor
Thor W Nilsen
Original Assignee
Polyprobe Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Polyprobe Inc filed Critical Polyprobe Inc
Application granted granted Critical
Publication of ATE320819T1 publication Critical patent/ATE320819T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54306—Solid-phase reaction mechanisms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6804—Nucleic acid analysis using immunogens
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Cell Biology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AT97911864T 1996-10-29 1997-10-22 Bestimmung von antigenen mittels oligonukleotid- antikörper-konjugaten ATE320819T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/738,641 US6117631A (en) 1996-10-29 1996-10-29 Detection of antigens via oligonucleotide antibody conjugates

Publications (1)

Publication Number Publication Date
ATE320819T1 true ATE320819T1 (de) 2006-04-15

Family

ID=24968855

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97911864T ATE320819T1 (de) 1996-10-29 1997-10-22 Bestimmung von antigenen mittels oligonukleotid- antikörper-konjugaten

Country Status (9)

Country Link
US (2) US6117631A (de)
EP (1) EP0951297B1 (de)
JP (1) JP3786970B2 (de)
AT (1) ATE320819T1 (de)
AU (1) AU718804B2 (de)
CA (1) CA2270227C (de)
DE (1) DE69735532T2 (de)
ES (1) ES2260787T3 (de)
WO (1) WO1998018488A1 (de)

Families Citing this family (133)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6203989B1 (en) 1998-09-30 2001-03-20 Affymetrix, Inc. Methods and compositions for amplifying detectable signals in specific binding assays
GB9924351D0 (en) 1999-10-14 1999-12-15 Brennan Frank Immunomodulation methods and compositions
DE10013993A1 (de) * 2000-03-22 2001-10-25 Ruediger Benters Verfahren zur Erzeugung von aktivierten Sensoroberflächen zur hocheffizienten kovalenten Immobilisierung bioorganischer Makromoleküle
WO2001086296A2 (en) * 2000-05-05 2001-11-15 Agilix Corporation Highly multiplexed reporter carrier systems
US6511809B2 (en) * 2000-06-13 2003-01-28 E. I. Du Pont De Nemours And Company Method for the detection of an analyte by means of a nucleic acid reporter
US7601497B2 (en) 2000-06-15 2009-10-13 Qiagen Gaithersburg, Inc. Detection of nucleic acids by target-specific hybrid capture method
US7439016B1 (en) 2000-06-15 2008-10-21 Digene Corporation Detection of nucleic acids by type-specific hybrid capture method
WO2002014867A2 (en) * 2000-08-11 2002-02-21 Agilix Corporation Ultra-sensitive detection systems
US7011943B2 (en) * 2000-09-06 2006-03-14 Transnetyx, Inc. Method for detecting a designated genetic sequence in murine genomic DNA
US6803196B1 (en) * 2000-10-13 2004-10-12 Affymetrix, Inc. Methods and compositions for detecting signals in binding assays using microparticles
WO2002061129A2 (en) * 2000-11-15 2002-08-08 Minerva Biotechnologies Corporation Oligonucleotide identifiers
GB0029154D0 (en) * 2000-11-30 2001-01-17 Lee Helen Signal enhancement with multiple labelled-antibodies
GB0029617D0 (en) * 2000-12-05 2001-01-17 Norchip As Ligand detection method
DE10106654A1 (de) * 2001-02-12 2002-09-05 November Ag Molekulare Medizin Verfahren zum Nachweis und/oder zur Quantifizierung eines Analyten
WO2003012147A1 (en) * 2001-02-20 2003-02-13 Datascope Investment Corp. Method for reusing standard blots and microarrays utilizing dna dendrimer technology
WO2002080647A2 (en) * 2001-04-03 2002-10-17 Surromed, Inc. Methods and reagents for multiplexed analyte capture, surface array self-assembly, and analysis of complex biological samples
KR100436554B1 (ko) * 2001-04-17 2004-06-18 삼성전자주식회사 혼성화된 핵산의 검출감도를 증가시키는 방법
AU2002305478A1 (en) * 2001-06-20 2003-01-08 Molecular Staging, Inc. Conjugates of reduced antibodies and biomolecules
DE60230927D1 (de) * 2001-07-16 2009-03-05 Caprotec Bioanalytics Gmbh Fangverbindungen, ihre entnahme und verfahren zur analysierung des proteoms und von komplexen zusammensetzungen
EP1278061B1 (de) * 2001-07-19 2011-02-09 Sony Deutschland GmbH Chemische Sensoren aus Nanopartikel-Dendrimer-Komposit-Materialen
US9201067B2 (en) * 2003-03-05 2015-12-01 Posco Size-controlled macromolecule
AU2002360272A1 (en) * 2001-10-10 2003-04-22 Superarray Bioscience Corporation Detecting targets by unique identifier nucleotide tags
AU2002365271B2 (en) * 2001-11-06 2008-12-11 Agilix Corporation Sensitive coded detection systems
US20040009495A1 (en) * 2001-12-07 2004-01-15 Whitehead Institute For Biomedical Research Methods and products related to drug screening using gene expression patterns
US20040023248A1 (en) * 2001-12-07 2004-02-05 Whitehead Institiute For Biomedical Research Methods and reagents for improving nucleic acid detection
JP3897285B2 (ja) * 2002-02-05 2007-03-22 日立ソフトウエアエンジニアリング株式会社 生体高分子検出用試薬及び生体高分子検出方法
ATE421088T1 (de) * 2002-03-11 2009-01-15 Caprotec Bioanalytics Gmbh Verbindungen und verfahren für die analyse des proteoms
US20030175828A1 (en) * 2002-03-15 2003-09-18 Lazar James G. Signal amplification by Hybrid Capture
US20040022731A1 (en) * 2002-04-26 2004-02-05 Alexei Bogdanov In vivo imaging of apoptosis
AU2003267960A1 (en) * 2002-05-22 2004-01-06 Marshall University Methods, probes, and accessory molecules for detecting single nucleotide polymorphisms
DE602004030212D1 (de) * 2003-01-16 2011-01-05 Caprotec Bioanalytics Gmbh Verfahren zur identifizierung von auf arzneimittel nicht-zielgerichteten proteinen
AU2004209644A1 (en) * 2003-02-03 2004-08-19 Palo Alto Institute Of Molecular Medicine Cell-killing molecules and methods of use thereof
US9696298B2 (en) * 2003-04-03 2017-07-04 Enzo Life Sciences, Inc. Multisignal reagents for labeling analytes
US7229763B2 (en) * 2003-04-07 2007-06-12 Beckman Coulter, Inc. Assay system using labeled oligonucleotides
KR100571808B1 (ko) * 2003-04-16 2006-04-17 삼성전자주식회사 다층 박막 구조를 가진 dna 칩
DE60325107D1 (de) * 2003-08-25 2009-01-15 Marc Ramael Verfahren und kit zum quantitativen und/oder qualitativen nachweis von komponenten in einer probe
EP1685236A4 (de) * 2003-09-29 2008-01-23 Univ California Verfahren zur änderung der adhäsion, differenzierung und migration hämatopoetischer vorläuferzellen
WO2005047903A1 (en) * 2003-11-07 2005-05-26 Upstate Usa. Inc. A method for generating antibody conjugates that preserves antigen recognition
EP1531183A1 (de) * 2003-11-14 2005-05-18 bioMérieux BV Methode zur Vervielfältigung von RNA-Sequenzen
US8632994B2 (en) 2003-12-01 2014-01-21 Dako Denmark A/S Methods and compositions for immuno-histochemical detection
WO2005111242A2 (en) * 2004-05-10 2005-11-24 Parallele Bioscience, Inc. Digital profiling of polynucleotide populations
US20060094025A1 (en) * 2004-11-02 2006-05-04 Getts Robert C Methods for detection of microrna molecules
EP1851551A2 (de) * 2005-02-03 2007-11-07 Perkinelmer Las, Inc. Ultrasensitive detektionssysteme mit mehrdimensionalen signalen
WO2006096704A2 (en) 2005-03-07 2006-09-14 Invitrogen Corporation Isotopically-labeled proteome standards
US20060204999A1 (en) * 2005-03-14 2006-09-14 Stephen Macevicz Detecting molecular complexes
US7550264B2 (en) * 2005-06-10 2009-06-23 Datascope Investment Corporation Methods and kits for sense RNA synthesis
US7494776B2 (en) * 2005-07-07 2009-02-24 Beckman Coulter, Inc. Labeled complementary oligonucleotides to detect oligonucleotide-linked ligands
US20070048741A1 (en) * 2005-08-24 2007-03-01 Getts Robert C Methods and kits for sense RNA synthesis
US20070105124A1 (en) * 2005-11-08 2007-05-10 Getts Robert C Methods and kits for nucleic acid amplification
WO2007087312A2 (en) * 2006-01-23 2007-08-02 Population Genetics Technologies Ltd. Molecular counting
US20090002703A1 (en) * 2006-08-16 2009-01-01 Craig Edward Parman Methods and systems for quantifying isobaric labels and peptides
US8685899B2 (en) 2007-02-14 2014-04-01 Genisphere Inc. Methods, reagents and kits for detection of nucleic acid molecules
US20100190167A1 (en) * 2007-02-14 2010-07-29 Genisphere Inc. Methods, Reagents and Kits for Detection of Nucleic Acid Molecules
WO2009070742A2 (en) 2007-11-28 2009-06-04 Great Basin Scientific Methods and compositions for signal enhancement using multivalent interactions
WO2010017544A2 (en) 2008-08-08 2010-02-11 Genisphere, Inc. Long-acting dna dendrimers and methods thereof
TWI417389B (zh) * 2008-10-27 2013-12-01 Qiagen Gaithersburg Inc 於自動平台上之快速結果雜交捕捉法
DE102008062372B3 (de) * 2008-12-17 2010-06-17 Medizinische Hochschule Hannover Nachweiskonjugat und Verfahren zur Analyse
EP2370820B1 (de) * 2008-12-31 2016-02-24 Abbott Point Of Care, Inc. Verfahren und vorrichtung für einen immuntest unter verwendung von nukleotidkonjugaten
EP2385979B1 (de) * 2009-01-28 2017-08-16 QIAGEN Gaithersburg, Inc. Sequenzspezifisches verfahren zur vorbereitung grossvolumiger proben und assay
AU2010242867B2 (en) 2009-05-01 2016-05-12 Qiagen Gaithersburg, Inc. A non-target amplification method for detection of RNA splice-forms in a sample
JP5826752B2 (ja) 2009-09-14 2015-12-02 キアジェン ゲイサーズバーグ インコーポレイテッド 細胞学用培地に固定された組織サンプルから核酸またはタンパク質を回収するための組成物および方法
US8835358B2 (en) * 2009-12-15 2014-09-16 Cellular Research, Inc. Digital counting of individual molecules by stochastic attachment of diverse labels
US9315857B2 (en) 2009-12-15 2016-04-19 Cellular Research, Inc. Digital counting of individual molecules by stochastic attachment of diverse label-tags
CA2787781A1 (en) 2010-01-29 2011-08-04 Qiagen Gaithersburg, Inc. Method of determining and confirming the presence of an hpv in a sample
ES2615728T3 (es) 2010-01-29 2017-06-08 Qiagen Gaithersburg, Inc. Métodos y composiciones para una purificación y un análisis múltiple específico de secuencia de ácidos nucleicos
US20110206611A1 (en) 2010-02-24 2011-08-25 Genisphere, Llc DNA Dendrimers as Thermal Ablation Devices
US9422593B2 (en) 2010-05-19 2016-08-23 Qiagen Gaithresburg, Inc Methods and compositions for sequence-specific purification and multiplex analysis of nucleic acids
CA2799205A1 (en) 2010-05-25 2011-12-01 Qiagen Gaithersburg, Inc. Fast results hybrid capture assay and associated strategically-truncated probes
EP2619327B1 (de) 2010-09-21 2014-10-22 Population Genetics Technologies LTD. Erhöhung der verlässlichkeit von allel-aufrufen mit molekülzählung
WO2012071428A2 (en) 2010-11-22 2012-05-31 Solulink, Inc. Methods and/or use of oligonucleotide conjugates for assays and detections
AU2012220575B2 (en) 2011-02-24 2017-01-12 Qiagen Gaithersburg, Inc. Materials and methods for detection of HPV nucleic acid
ES2676027T3 (es) 2012-01-23 2018-07-16 Ventana Medical Systems, Inc. Estabilización de polímeros de soluciones de cromógeno
CA2865575C (en) 2012-02-27 2024-01-16 Cellular Research, Inc. Compositions and kits for molecular counting
US11177020B2 (en) 2012-02-27 2021-11-16 The University Of North Carolina At Chapel Hill Methods and uses for molecular tags
EP2820155B1 (de) 2012-02-28 2017-07-26 Population Genetics Technologies Ltd. Verfahren zur befestigung einer zählersequenz an einer nucleinsäureprobe
WO2013177046A1 (en) 2012-05-21 2013-11-28 Solulink, Inc. Methods and/or use of oligonucleotide conjugates for suppressing background due to cross-hybridization
US9651549B2 (en) 2012-07-13 2017-05-16 Genisphere, Llc Lateral flow assays using DNA dendrimers
DE202013012824U1 (de) 2012-09-04 2020-03-10 Guardant Health, Inc. Systeme zum Erfassen von seltenen Mutationen und einer Kopienzahlvariation
US10876152B2 (en) 2012-09-04 2020-12-29 Guardant Health, Inc. Systems and methods to detect rare mutations and copy number variation
US20160040229A1 (en) 2013-08-16 2016-02-11 Guardant Health, Inc. Systems and methods to detect rare mutations and copy number variation
US11913065B2 (en) 2012-09-04 2024-02-27 Guardent Health, Inc. Systems and methods to detect rare mutations and copy number variation
US20160051693A1 (en) 2013-03-21 2016-02-25 Genisphere, Llc Cellular Delivery of DNA Intercalating Agents
EP3027773B1 (de) * 2013-07-30 2020-03-25 President and Fellows of Harvard College Quantitative bildgebung auf dna-basis und hochauflösende bildgebung
US9567645B2 (en) 2013-08-28 2017-02-14 Cellular Research, Inc. Massively parallel single cell analysis
JP2017504307A (ja) 2013-10-07 2017-02-09 セルラー リサーチ, インコーポレイテッド アレイ上のフィーチャーをデジタルカウントするための方法およびシステム
ES2660989T3 (es) 2013-12-28 2018-03-27 Guardant Health, Inc. Métodos y sistemas para detectar variantes genéticas
US9909167B2 (en) * 2014-06-23 2018-03-06 The Board Of Trustees Of The Leland Stanford Junior University On-slide staining by primer extension
EP3259371B1 (de) 2015-02-19 2020-09-02 Becton, Dickinson and Company Hochdurchsatzeinzelzellenanalyse mit kombination von proteomischen und genomischen informationen
CN107208158B (zh) 2015-02-27 2022-01-28 贝克顿迪金森公司 空间上可寻址的分子条形编码
EP3835431B1 (de) 2015-03-30 2022-11-02 Becton, Dickinson and Company Verfahren für kombinatorische barcodierung
US11390914B2 (en) 2015-04-23 2022-07-19 Becton, Dickinson And Company Methods and compositions for whole transcriptome amplification
WO2016196229A1 (en) 2015-06-01 2016-12-08 Cellular Research, Inc. Methods for rna quantification
JP6940484B2 (ja) 2015-09-11 2021-09-29 セルラー リサーチ, インコーポレイテッド ライブラリー正規化のための方法および組成物
CA3038658A1 (en) 2015-12-14 2017-06-22 The Penn State Research Foundation Polymer-based signal amplification for protein and cell detection
CN117174167A (zh) 2015-12-17 2023-12-05 夸登特健康公司 通过分析无细胞dna确定肿瘤基因拷贝数的方法
IL260983B (en) * 2016-02-19 2022-07-01 Genisphere Llc Nucleic acid carriers and methods of medical use
EP3452614B1 (de) 2016-05-02 2023-06-28 Becton, Dickinson and Company Genaue molekulare barcodierung
US10301677B2 (en) 2016-05-25 2019-05-28 Cellular Research, Inc. Normalization of nucleic acid libraries
CN109074430B (zh) 2016-05-26 2022-03-29 贝克顿迪金森公司 分子标记计数调整方法
US10640763B2 (en) 2016-05-31 2020-05-05 Cellular Research, Inc. Molecular indexing of internal sequences
US10202641B2 (en) 2016-05-31 2019-02-12 Cellular Research, Inc. Error correction in amplification of samples
AU2017331459B2 (en) 2016-09-26 2023-04-13 Becton, Dickinson And Company Measurement of protein expression using reagents with barcoded oligonucleotide sequences
AU2017359048B2 (en) 2016-11-08 2022-07-21 Becton, Dickinson And Company Methods for expression profile classification
KR102790039B1 (ko) 2016-11-08 2025-04-04 벡톤 디킨슨 앤드 컴퍼니 세포 표지 분류 방법
ES2961580T3 (es) 2017-01-13 2024-03-12 Cellular Res Inc Revestimiento hidrófilo de canales de fluidos
CN110382708A (zh) 2017-02-01 2019-10-25 赛卢拉研究公司 使用阻断性寡核苷酸进行选择性扩增
EP3601339A4 (de) * 2017-03-31 2020-11-04 Ultivue, Inc. Dna-antigenaustausch und amplifikation
WO2018226293A1 (en) 2017-06-05 2018-12-13 Becton, Dickinson And Company Sample indexing for single cells
WO2019126209A1 (en) 2017-12-19 2019-06-27 Cellular Research, Inc. Particles associated with oligonucleotides
WO2019200326A1 (en) 2018-04-13 2019-10-17 Rarecyte, Inc. Kits for labeling of biomarkers and methods of using the same
EP3788170B1 (de) 2018-05-03 2025-01-01 Becton, Dickinson and Company Molekulare barcodierung auf gegenüberliegenden transkriptenden
EP3788171B1 (de) 2018-05-03 2023-04-05 Becton, Dickinson and Company Multiomics-probenanalyse mit hohem durchsatz
WO2020072380A1 (en) 2018-10-01 2020-04-09 Cellular Research, Inc. Determining 5' transcript sequences
EP3877520B1 (de) 2018-11-08 2025-03-19 Becton, Dickson And Company Ganze transkriptomanalyse von einzelzellen mittels random-priming
EP4745247A2 (de) 2018-12-13 2026-05-20 Becton Dickinson Co Selektive verlängerung in der einzelzellen-volltranskriptomanalyse
US20200209229A1 (en) * 2018-12-27 2020-07-02 Bio-Rad Laboratories, Inc. Sequential multiplex western blotting
WO2020150356A1 (en) 2019-01-16 2020-07-23 Becton, Dickinson And Company Polymerase chain reaction normalization through primer titration
CN113574178B (zh) 2019-01-23 2024-10-29 贝克顿迪金森公司 与抗体关联的寡核苷酸
CN120099139A (zh) 2019-02-14 2025-06-06 贝克顿迪金森公司 杂合体靶向和全转录物组扩增
US11965208B2 (en) 2019-04-19 2024-04-23 Becton, Dickinson And Company Methods of associating phenotypical data and single cell sequencing data
CN120099137A (zh) 2019-07-22 2025-06-06 贝克顿迪金森公司 单细胞染色质免疫沉淀测序测定
EP4055160B1 (de) 2019-11-08 2024-04-10 Becton Dickinson and Company Verwendung von random-rpiming zur gewinnung von v(d)j-informationen in voller länge für immunrepertoiresequenzierung
WO2021146219A1 (en) 2020-01-13 2021-07-22 Becton, Dickinson And Company Cell capture using du-containing oligonucleotides
EP4090763B1 (de) 2020-01-13 2024-12-04 Becton Dickinson and Company Verfahren und zusammensetzungen zur quantifizierung von proteinen und rna
ES2993319T3 (en) 2020-01-29 2024-12-27 Becton Dickinson Co Barcoded wells for spatial mapping of single cells through sequencing
CN115151810A (zh) 2020-02-25 2022-10-04 贝克顿迪金森公司 实现使用单细胞样品作为单色补偿对照的双特异性探针
US11661625B2 (en) 2020-05-14 2023-05-30 Becton, Dickinson And Company Primers for immune repertoire profiling
CN115803445A (zh) 2020-06-02 2023-03-14 贝克顿迪金森公司 用于5撇基因表达测定的寡核苷酸和珠
US11932901B2 (en) 2020-07-13 2024-03-19 Becton, Dickinson And Company Target enrichment using nucleic acid probes for scRNAseq
WO2022026909A1 (en) 2020-07-31 2022-02-03 Becton, Dickinson And Company Single cell assay for transposase-accessible chromatin
CN114544937B (zh) * 2020-11-11 2023-04-07 艾克发(北京)生物技术有限公司 一种多重信号放大系统及其在免疫吸附间接法检测中的应用
US11739443B2 (en) 2020-11-20 2023-08-29 Becton, Dickinson And Company Profiling of highly expressed and lowly expressed proteins
US12392771B2 (en) 2020-12-15 2025-08-19 Becton, Dickinson And Company Single cell secretome analysis

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5175270A (en) * 1986-09-10 1992-12-29 Polyprobe, Inc. Reagents for detecting and assaying nucleic acid sequences
US5656731A (en) * 1987-10-15 1997-08-12 Chiron Corporation Nucleic acid-amplified immunoassay probes
AU6267794A (en) * 1993-02-24 1994-09-14 Dade International Inc. Immobilization of specific binding assay reagents
US6121056A (en) * 1993-02-24 2000-09-19 Dade Behring Inc. Random detection of antigens with antibodies immobilized on soluble submicron particles
WO1994026932A1 (en) * 1993-05-13 1994-11-24 United States Of America, As Represented By The Secretary, Department Of Health And Human Services Nucleic acid tagged immunoassay
US5635602A (en) * 1993-08-13 1997-06-03 The Regents Of The University Of California Design and synthesis of bispecific DNA-antibody conjugates
US5912332A (en) * 1996-07-26 1999-06-15 Hybridon, Inc. Affinity-based purification of oligonucleotides using soluble multimeric oligonucleotides

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Publication number Publication date
AU4914097A (en) 1998-05-22
EP0951297A4 (de) 2002-01-02
WO1998018488A1 (en) 1998-05-07
JP3786970B2 (ja) 2006-06-21
EP0951297A1 (de) 1999-10-27
DE69735532D1 (de) 2006-05-11
CA2270227C (en) 2005-02-08
CA2270227A1 (en) 1998-05-07
AU718804B2 (en) 2000-04-20
DE69735532T2 (de) 2006-11-23
EP0951297B1 (de) 2006-03-22
ES2260787T3 (es) 2006-11-01
US6117631A (en) 2000-09-12
US6110687A (en) 2000-08-29
JP2001503517A (ja) 2001-03-13

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