EA200401423A1 - Пиперазинбензотиазолы, используемые в качестве средств для лечения церебральных ишемических расстройств или расстройств цнс - Google Patents

Пиперазинбензотиазолы, используемые в качестве средств для лечения церебральных ишемических расстройств или расстройств цнс

Info

Publication number
EA200401423A1
EA200401423A1 EA200401423A EA200401423A EA200401423A1 EA 200401423 A1 EA200401423 A1 EA 200401423A1 EA 200401423 A EA200401423 A EA 200401423A EA 200401423 A EA200401423 A EA 200401423A EA 200401423 A1 EA200401423 A1 EA 200401423A1
Authority
EA
Eurasian Patent Office
Prior art keywords
disorders
piperizinbenzothiazoles
cerebral ischemic
treat cerebral
cns
Prior art date
Application number
EA200401423A
Other languages
English (en)
Other versions
EA009682B1 (ru
Inventor
Паскаль Гайяр
Жан-Пьер Готтелан
Пьер-Ален Витте
Original Assignee
Апплайд Резеч Системз Арс Холдинг Н. В.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Апплайд Резеч Системз Арс Холдинг Н. В. filed Critical Апплайд Резеч Системз Арс Холдинг Н. В.
Publication of EA200401423A1 publication Critical patent/EA200401423A1/ru
Publication of EA009682B1 publication Critical patent/EA009682B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Настоящее изобретение относится к пиперазинбензотиазоловым производным, а в частности, к их применению для лечения и/или профилактики церебральных ишемических расстройств или расстройств ЦНС. Настоящее изобретение также относится к способам получения указанных соединений.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200401423A 2002-04-25 2003-04-25 Пиперазинбензотиазолы, используемые в качестве средств для лечения церебральных ишемических расстройств или расстройств цнс EA009682B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02100417 2002-04-25
PCT/EP2003/004323 WO2003091249A1 (en) 2002-04-25 2003-04-25 Piperazine benzothiazoles as agents for the treatment of cerebral ischemic disorders or cns disorders

Publications (2)

Publication Number Publication Date
EA200401423A1 true EA200401423A1 (ru) 2005-04-28
EA009682B1 EA009682B1 (ru) 2008-02-28

Family

ID=29265991

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200401423A EA009682B1 (ru) 2002-04-25 2003-04-25 Пиперазинбензотиазолы, используемые в качестве средств для лечения церебральных ишемических расстройств или расстройств цнс

Country Status (22)

Country Link
US (1) US7314878B2 (ru)
EP (1) EP1501828B1 (ru)
JP (1) JP4523289B2 (ru)
KR (1) KR100948469B1 (ru)
CN (1) CN1310911C (ru)
AT (1) ATE383356T1 (ru)
AU (1) AU2003233067B2 (ru)
BR (1) BRPI0309594A8 (ru)
CA (1) CA2481763C (ru)
CY (1) CY1107204T1 (ru)
DE (1) DE60318567T2 (ru)
DK (1) DK1501828T3 (ru)
EA (1) EA009682B1 (ru)
ES (1) ES2297165T3 (ru)
IL (2) IL164796A (ru)
MX (1) MXPA04010474A (ru)
PT (1) PT1501828E (ru)
RS (1) RS51407B (ru)
SI (1) SI1501828T1 (ru)
UA (1) UA78035C2 (ru)
WO (1) WO2003091249A1 (ru)
ZA (1) ZA200408023B (ru)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4523289B2 (ja) 2002-04-25 2010-08-11 メルク セローノ ソシエテ アノニム 脳虚血障害又はｃｎｓ障害の処置のための薬剤としてのピペラジンベンゾチアゾール
JP5021307B2 (ja) * 2003-09-12 2012-09-05 メルク セローノ ソシエテ アノニム 糖尿病治療のためのベンゾチアゾール誘導体
WO2005118543A1 (ja) * 2004-06-03 2005-12-15 Ono Pharmaceutical Co., Ltd. キナーゼ阻害薬およびその用途
ATE411817T1 (de) * 2004-11-17 2008-11-15 Ares Trading Sa Benzothiazolformulierungen und ihre verwendung
US7838522B2 (en) 2004-11-17 2010-11-23 Ares Trading S.A. Benzothiazole formulations and use thereof
KR20080044836A (ko) 2005-07-15 2008-05-21 라보라뚜와르 세로노 에스. 에이. 자궁내막증 치료용 ｊｎｋ 억제제
BRPI0613042A2 (pt) * 2005-07-15 2010-12-14 Serono Lab inibidores de jnk para o tratamento de endometriose
WO2008125518A2 (en) * 2007-04-17 2008-10-23 Merck Serono S.A. Process for the preparation of piperazine benzothiazoles
ES2392788T3 (es) * 2008-05-16 2012-12-13 F. Hoffmann-La Roche Ag Inhibidores de las JNK
EP2576537B1 (en) * 2010-06-04 2016-03-16 F.Hoffmann-La Roche Ag 2-amino-pyrimidine derivatives useful as inhibitors of jnk
US8471027B2 (en) * 2011-04-06 2013-06-25 Hoffmann-La Roche Inc. Adamantyl compounds
CN104903331A (zh) * 2013-01-24 2015-09-09 山东亨利医药科技有限责任公司 Jnk抑制剂

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4153574B2 (ja) 1997-09-10 2008-09-24 トーアエイヨー株式会社 新規なピペリジン誘導体、その製造法およびそれを含有する循環器官用剤
EP1110957A1 (en) * 1999-12-24 2001-06-27 Applied Research Systems ARS Holding N.V. Benzazole derivatives and their use as JNK modulators
EP1193256A1 (en) 2000-09-27 2002-04-03 Applied Research Systems ARS Holding N.V. Pharmaceutically active benzsulfonamide derivatives as inhibitors of JNK proteins
JP4523289B2 (ja) 2002-04-25 2010-08-11 メルク セローノ ソシエテ アノニム 脳虚血障害又はｃｎｓ障害の処置のための薬剤としてのピペラジンベンゾチアゾール

Also Published As

Publication number Publication date
EP1501828B1 (en) 2008-01-09
IL164796A0 (en) 2005-12-18
ES2297165T3 (es) 2008-05-01
ZA200408023B (en) 2005-11-30
AU2003233067B2 (en) 2009-01-08
RS51407B (sr) 2011-02-28
EP1501828A1 (en) 2005-02-02
BRPI0309594A8 (pt) 2017-04-11
CY1107204T1 (el) 2012-11-21
WO2003091249A1 (en) 2003-11-06
RS92804A (sr) 2006-12-15
KR100948469B1 (ko) 2010-03-17
US20050261304A1 (en) 2005-11-24
KR20040104572A (ko) 2004-12-10
CA2481763A1 (en) 2003-11-06
UA78035C2 (en) 2007-02-15
MXPA04010474A (es) 2004-12-13
IL164796A (en) 2013-02-28
JP2006504631A (ja) 2006-02-09
AU2003233067A1 (en) 2003-11-10
PT1501828E (pt) 2008-02-11
CN1310911C (zh) 2007-04-18
DE60318567T2 (de) 2009-02-19
HK1075664A1 (en) 2005-12-23
EA009682B1 (ru) 2008-02-28
CN1662528A (zh) 2005-08-31
JP4523289B2 (ja) 2010-08-11
CA2481763C (en) 2011-06-14
US7314878B2 (en) 2008-01-01
DK1501828T3 (da) 2008-03-10
BRPI0309594A2 (pt) 2016-11-16
ATE383356T1 (de) 2008-01-15
SI1501828T1 (sl) 2008-04-30
DE60318567D1 (de) 2008-02-21

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Legal Events

Date Code Title Description
PC4A Registration of transfer of a eurasian patent by assignment
PD4A Registration of transfer of a eurasian patent in accordance with the succession in title
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU