ATE321773T1 - Semisynthetisches verfahren zur herstellung von didemninanalogen - Google Patents

Semisynthetisches verfahren zur herstellung von didemninanalogen

Info

Publication number: ATE321773T1
Authority: AT; Austria
Prior art keywords: didemnine; analogues; producing; semisynthetic process; semisynthetic
Prior art date: 1996-10-24

Application number

AT97911896T

Other languages

English (en)

Inventor

Kenneth L Rinehart

Alexandra J Sanborn

Original Assignee

Univ Illinois

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-10-24

Filing date

1997-10-24

Publication date

2006-04-15

1997-10-24 Application filed by Univ Illinois filed Critical Univ Illinois

2006-04-15 Application granted granted Critical

2006-04-15 Publication of ATE321773T1 publication Critical patent/ATE321773T1/de

Links

KYHUYMLIVQFXRI-XYUQHQMCSA-N (2s)-n-[(2r)-1-[[(3s,6s,8s,12s,13r,16s,17r,20s,23s)-13-[(2s)-butan-2-yl]-12-hydroxy-20-[(4-methoxyphenyl)methyl]-6,17,21-trimethyl-3-(2-methylpropyl)-2,5,7,10,15,19,22-heptaoxo-8-propan-2-yl-9,18-dioxa-1,4,14,21-tetrazabicyclo[21.3.0]hexacosan-16-yl]amino Chemical class CN([C@H](CC(C)C)C(=O)N[C@@H]1C(=O)N[C@@H]([C@H](CC(=O)O[C@H](C(=O)[C@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N2CCC[C@H]2C(=O)N(C)[C@@H](CC=2C=CC(OC)=CC=2)C(=O)O[C@@H]1C)C(C)C)O)[C@@H](C)CC)C(=O)[C@@H]1CCCN1C(=O)C(C)O KYHUYMLIVQFXRI-XYUQHQMCSA-N 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
238000002360 preparation method Methods 0.000 abstract 1
238000010189 synthetic method Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K11/02—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof cyclic, e.g. valinomycins ; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Virology (AREA)
Oncology (AREA)
Genetics & Genomics (AREA)
Communicable Diseases (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biochemistry (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Bioinformatics & Cheminformatics (AREA)
Transplantation (AREA)
Biotechnology (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Steroid Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

AT97911896T 1996-10-24 1997-10-24 Semisynthetisches verfahren zur herstellung von didemninanalogen ATE321773T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US2911296P	1996-10-24	1996-10-24

Publications (1)

Publication Number	Publication Date
ATE321773T1 true ATE321773T1 (de)	2006-04-15

Family

ID=21847298

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT97911896T ATE321773T1 (de)	1996-10-24	1997-10-24	Semisynthetisches verfahren zur herstellung von didemninanalogen

Country Status (9)

Country	Link
US (1)	US6841530B2 (de)
EP (1)	EP0973518B1 (de)
JP (1)	JP2001503746A (de)
AT (1)	ATE321773T1 (de)
AU (1)	AU731757B2 (de)
CA (1)	CA2269881A1 (de)
DE (1)	DE69735583T2 (de)
ES (1)	ES2262175T3 (de)
WO (1)	WO1998017275A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20030148933A1 (en)	1990-10-01	2003-08-07	Pharma Mar S.A.	Derivatives of dehydrodidemnin B
GB9803448D0 (en)	1998-02-18	1998-04-15	Pharma Mar Sa	Pharmaceutical formulation
ES2272462T3 (es)	2000-04-07	2007-05-01	The Trustees Of The University Of Pennsylvania	Analogos de tamadarina y didemnina y procedimiento de fabricacion y uso.
US6509315B1 (en)	2000-04-07	2003-01-21	The Trustees Of The University Of Pennsylvania	Didemnin analogs and fragments and methods of making and using them
GB0103750D0 (en) *	2001-02-15	2001-04-04	Pharma Mar Sa	Synthetic methods for aplidine and new antitumoral derivatives methods of making and using them
UA76718C2 (uk)	2000-06-30	2006-09-15	Фарма Мар, С.А.	Протипухлинні похідні аплідину
GB0016148D0 (en) *	2000-06-30	2000-08-23	Pharma Mar Sa	Synthetic methods for aplidine and new antitiumoral derivatives
BR0114604A (pt)	2000-10-12	2003-10-14	Pharma Mar Sa	Tratamento de cnceres
KR20060002778A (ko)	2003-03-12	2006-01-09	파르마 마르, 에스.에이.	개선된 항종양 치료
JP4584245B2 (ja)	2003-03-12	2010-11-17	ダナ−ファーバーキャンサーインスティテュート，インコーポレイテッド	多発性骨髄腫治療用のアプリジン
AU2004224418A1 (en)	2003-03-21	2004-10-07	Madeleine M. Joullie	Tamandarin analogs and fragments thereof and methods of making and using
HUE028055T2 (en)	2006-02-28	2016-11-28	Pharma Mar Sa	Improved treatment of myeloma multiplex
WO2013041969A2 (en)	2011-09-21	2013-03-28	King Abdullah University Of Science And Technology	Didemnin biosynthetic gene cluster in tistrella mobilis
LT3615544T (lt)	2017-04-27	2023-05-10	Pharma Mar S.A.	Priešnavikiniai junginiai
CN115594739B (zh) *	2021-06-28	2025-02-14	浙江珲达生物科技有限公司	一种dehydrodidemnin B类化合物的制备方法
CN116284222A (zh) *	2021-12-14	2023-06-23	浙江珲达生物科技有限公司	一种Didemnin B的分离纯化方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4950649A (en) *	1980-09-12	1990-08-21	University Of Illinois	Didemnins and nordidemnins
US4493796A (en) *	1980-09-12	1985-01-15	Board Of Trustees, Univ. Of Ill.	Didemnins A, B, C, and derivatives thereof, as antiviral agents
US4948791A (en) *	1989-04-10	1990-08-14	The Board Of Trustees Of The University Of Illinois	Novel Cytotoxic cyclic depsipeptides from the tunicate trididemnum solidum

1997
- 1997-10-24 JP JP51964898A patent/JP2001503746A/ja not_active Ceased
- 1997-10-24 DE DE69735583T patent/DE69735583T2/de not_active Expired - Fee Related
- 1997-10-24 WO PCT/US1997/019210 patent/WO1998017275A1/en not_active Ceased
- 1997-10-24 CA CA002269881A patent/CA2269881A1/en not_active Abandoned
- 1997-10-24 AU AU49165/97A patent/AU731757B2/en not_active Ceased
- 1997-10-24 EP EP97911896A patent/EP0973518B1/de not_active Expired - Lifetime
- 1997-10-24 ES ES97911896T patent/ES2262175T3/es not_active Expired - Lifetime
- 1997-10-24 AT AT97911896T patent/ATE321773T1/de not_active IP Right Cessation
2001
- 2001-09-10 US US09/949,947 patent/US6841530B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
DE69735583T2 (de)	2007-04-05
EP0973518B1 (de)	2006-03-29
WO1998017275A1 (en)	1998-04-30
EP0973518A1 (de)	2000-01-26
DE69735583D1 (de)	2006-05-18
AU731757B2 (en)	2001-04-05
US6841530B2 (en)	2005-01-11
JP2001503746A (ja)	2001-03-21
US20020037835A1 (en)	2002-03-28
AU4916597A (en)	1998-05-15
CA2269881A1 (en)	1998-04-30
ES2262175T3 (es)	2006-11-16
EP0973518A4 (de)	2004-05-26

Legal Events

Date	Code	Title	Description
2006-09-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE69020175D1 (de)	1995-07-27	Verfahren zur Herstellung von Organosiliciumverbindungen.
DE69012535D1 (de)	1994-10-20	Verfahren zur Herstellung von Hydrogensiloxanen.
DE69735583D1 (de)	2006-05-18	Semisynthetisches verfahren zur herstellung von didemninanalogen
DE3784123D1 (de)	1993-03-25	Verfahren zur herstellung keramischer verbundwerkstoffe.
DE19781729T1 (de)	1999-03-25	Verfahren zur Herstellung von Monoestern von 1,3-Diolen
DE69013710D1 (de)	1994-12-08	Verfahren zur Herstellung von Organosiliciumverbindungen.
DE69113695D1 (de)	1995-11-16	Verfahren zur Herstellung von Perfluoralkoxysulfonverbindungen.
DE69707215D1 (de)	2001-11-15	Verfahren zur Herstellung von Perfluoropolyethern
DE59005420D1 (de)	1994-05-26	Verfahren zur Herstellung von Dialkylcarbonaten.
DE69009614D1 (de)	1994-07-14	Verfahren zur Herstellung von (S)-gamma-Hydroxymethyl-alpha,beta-Butenolid.
DE59104845D1 (de)	1995-04-13	Verfahren zur Herstellung von 2-Chlor-5-methyl-pyridin.
DE59004274D1 (de)	1994-03-03	Verfahren zur Herstellung von Alkylhalogensilanen.
DE69020830D1 (de)	1995-08-17	Verfahren zur Herstellung von (S)-4-Hydroxymethyl-gamma-lacton.
DE68911571D1 (de)	1994-02-03	Verfahren zur Herstellung von Silikonschaum-Zusammensetzungen.
DE69313556D1 (de)	1997-10-09	Verfahren zur Herstellung von zyklischen Depsipeptiden
DE59105577D1 (de)	1995-06-29	Verfahren zur Herstellung von Arylcarbonaten.
DE59300777D1 (de)	1995-11-23	Verfahren zur Herstellung von Perfluorpolyethern.
DE69006864D1 (de)	1994-04-07	Verfahren zur Herstellung von Organosiliciumverbindungen.
DE59407675D1 (de)	1999-03-04	Verfahren zur Herstellung von 6H-Dibenz-(c,e)(1,2)-oxaphosphorin-6-on
DE68912809D1 (de)	1994-03-17	Verfahren zur Herstellung von Bis(2,2,6,6-tetramethyl-4-piperidyl)amin.
DE59101444D1 (de)	1994-05-26	Verfahren zur Herstellung von p-Amino-phenolen.
DE69006820D1 (de)	1994-03-31	Verfahren zur Herstellung von 1,1-Dichlorotetrafluorethan.
DE69109510D1 (de)	1995-06-14	Verfahren zur Herstellung von Glycin.
DE59105908D1 (de)	1995-08-10	Verfahren zur Herstellung von Bis(hydroxymethyl)phosphinaten.
DE69010526D1 (de)	1994-08-18	Verfahren zur Herstellung von L-Alanin.