ATE321773T1 - Semisynthetisches verfahren zur herstellung von didemninanalogen - Google Patents

Semisynthetisches verfahren zur herstellung von didemninanalogen

Info

Publication number: ATE321773T1
Authority: AT; Austria
Prior art keywords: didemnine; analogues; producing; semisynthetic process; semisynthetic
Prior art date: 1996-10-24

Application number

AT97911896T

Other languages

English (en)

Inventor

Kenneth L Rinehart

Alexandra J Sanborn

Original Assignee

Univ Illinois

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-10-24

Filing date

1997-10-24

Publication date

2006-04-15

1997-10-24 Application filed by Univ Illinois filed Critical Univ Illinois

2006-04-15 Application granted granted Critical

2006-04-15 Publication of ATE321773T1 publication Critical patent/ATE321773T1/de

Links

KYHUYMLIVQFXRI-XYUQHQMCSA-N (2s)-n-[(2r)-1-[[(3s,6s,8s,12s,13r,16s,17r,20s,23s)-13-[(2s)-butan-2-yl]-12-hydroxy-20-[(4-methoxyphenyl)methyl]-6,17,21-trimethyl-3-(2-methylpropyl)-2,5,7,10,15,19,22-heptaoxo-8-propan-2-yl-9,18-dioxa-1,4,14,21-tetrazabicyclo[21.3.0]hexacosan-16-yl]amino Chemical class CN([C@H](CC(C)C)C(=O)N[C@@H]1C(=O)N[C@@H]([C@H](CC(=O)O[C@H](C(=O)[C@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N2CCC[C@H]2C(=O)N(C)[C@@H](CC=2C=CC(OC)=CC=2)C(=O)O[C@@H]1C)C(C)C)O)[C@@H](C)CC)C(=O)[C@@H]1CCCN1C(=O)C(C)O KYHUYMLIVQFXRI-XYUQHQMCSA-N 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
238000002360 preparation method Methods 0.000 abstract 1
238000010189 synthetic method Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K11/02—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof cyclic, e.g. valinomycins ; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Molecular Biology (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Communicable Diseases (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Genetics & Genomics (AREA)
Virology (AREA)
Oncology (AREA)
Immunology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Transplantation (AREA)
Biotechnology (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Steroid Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

AT97911896T 1996-10-24 1997-10-24 Semisynthetisches verfahren zur herstellung von didemninanalogen ATE321773T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US2911296P	1996-10-24	1996-10-24

Publications (1)

Publication Number	Publication Date
ATE321773T1 true ATE321773T1 (de)	2006-04-15

Family

ID=21847298

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT97911896T ATE321773T1 (de)	1996-10-24	1997-10-24	Semisynthetisches verfahren zur herstellung von didemninanalogen

Country Status (9)

Country	Link
US (1)	US6841530B2 (de)
EP (1)	EP0973518B1 (de)
JP (1)	JP2001503746A (de)
AT (1)	ATE321773T1 (de)
AU (1)	AU731757B2 (de)
CA (1)	CA2269881A1 (de)
DE (1)	DE69735583T2 (de)
ES (1)	ES2262175T3 (de)
WO (1)	WO1998017275A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20030148933A1 (en)	1990-10-01	2003-08-07	Pharma Mar S.A.	Derivatives of dehydrodidemnin B
GB9803448D0 (en)	1998-02-18	1998-04-15	Pharma Mar Sa	Pharmaceutical formulation
US6509315B1 (en)	2000-04-07	2003-01-21	The Trustees Of The University Of Pennsylvania	Didemnin analogs and fragments and methods of making and using them
CA2405779A1 (en)	2000-04-07	2001-10-18	The Trustees Of The University Of Pennsylvania	Tamandarin and didemnin analogs and methods of making and using them
GB0103750D0 (en) *	2001-02-15	2001-04-04	Pharma Mar Sa	Synthetic methods for aplidine and new antitumoral derivatives methods of making and using them
GB0016148D0 (en) *	2000-06-30	2000-08-23	Pharma Mar Sa	Synthetic methods for aplidine and new antitiumoral derivatives
UA76718C2 (uk) *	2000-06-30	2006-09-15	Фарма Мар, С.А.	Протипухлинні похідні аплідину
IL155273A0 (en)	2000-10-12	2003-11-23	Pharma Mar Sa	Pharmaceutical compositions comprising an aplidine compound
AU2004218883B2 (en)	2003-03-12	2009-10-01	Dana-Farber Cancer Institute, Inc.	Aplidine for multiple myeloma treatment
EP1620117A4 (de)	2003-03-12	2009-07-29	Pharma Mar Sa	Verbesserte antitumorale behandlungen
JP2006523214A (ja)	2003-03-21	2006-10-12	ジユーリー，マデレーン・エム	タマンダリン類似物およびこれらのフラグメントそして製造方法および使用方法
WO2007101235A2 (en)	2006-02-28	2007-09-07	Pharma Mar, S.A.	Improved antitumoral treatments
EP2758519B1 (de)	2011-09-21	2017-03-29	King Abdullah University Of Science And Technology	Biosynthetisches didemnin-gencluster in tistrella mobilis
KR102491180B1 (ko)	2017-04-27	2023-01-20	파르마 마르 에스.에이.	항종양 화합물
CN115594739B (zh) *	2021-06-28	2025-02-14	浙江珲达生物科技有限公司	一种dehydrodidemnin B类化合物的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4950649A (en) *	1980-09-12	1990-08-21	University Of Illinois	Didemnins and nordidemnins
US4493796A (en) *	1980-09-12	1985-01-15	Board Of Trustees, Univ. Of Ill.	Didemnins A, B, C, and derivatives thereof, as antiviral agents
US4948791A (en) *	1989-04-10	1990-08-14	The Board Of Trustees Of The University Of Illinois	Novel Cytotoxic cyclic depsipeptides from the tunicate trididemnum solidum

1997
- 1997-10-24 DE DE69735583T patent/DE69735583T2/de not_active Expired - Fee Related
- 1997-10-24 ES ES97911896T patent/ES2262175T3/es not_active Expired - Lifetime
- 1997-10-24 JP JP51964898A patent/JP2001503746A/ja not_active Ceased
- 1997-10-24 CA CA002269881A patent/CA2269881A1/en not_active Abandoned
- 1997-10-24 EP EP97911896A patent/EP0973518B1/de not_active Expired - Lifetime
- 1997-10-24 AT AT97911896T patent/ATE321773T1/de not_active IP Right Cessation
- 1997-10-24 WO PCT/US1997/019210 patent/WO1998017275A1/en not_active Ceased
- 1997-10-24 AU AU49165/97A patent/AU731757B2/en not_active Ceased
2001
- 2001-09-10 US US09/949,947 patent/US6841530B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
CA2269881A1 (en)	1998-04-30
JP2001503746A (ja)	2001-03-21
EP0973518A1 (de)	2000-01-26
US20020037835A1 (en)	2002-03-28
WO1998017275A1 (en)	1998-04-30
EP0973518A4 (de)	2004-05-26
AU731757B2 (en)	2001-04-05
DE69735583D1 (de)	2006-05-18
ES2262175T3 (es)	2006-11-16
US6841530B2 (en)	2005-01-11
DE69735583T2 (de)	2007-04-05
AU4916597A (en)	1998-05-15
EP0973518B1 (de)	2006-03-29

Legal Events

Date	Code	Title	Description
2006-09-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE69020175D1 (de)	1995-07-27	Verfahren zur Herstellung von Organosiliciumverbindungen.
DE69012535D1 (de)	1994-10-20	Verfahren zur Herstellung von Hydrogensiloxanen.
ATE321773T1 (de)	2006-04-15	Semisynthetisches verfahren zur herstellung von didemninanalogen
DE69016521D1 (de)	1995-03-16	Verfahren zur Herstellung von Dialkylethern.
DE3784123D1 (de)	1993-03-25	Verfahren zur herstellung keramischer verbundwerkstoffe.
DE69013710D1 (de)	1994-12-08	Verfahren zur Herstellung von Organosiliciumverbindungen.
DE69113695D1 (de)	1995-11-16	Verfahren zur Herstellung von Perfluoralkoxysulfonverbindungen.
DE69707215D1 (de)	2001-11-15	Verfahren zur Herstellung von Perfluoropolyethern
DE19781729T1 (de)	1999-03-25	Verfahren zur Herstellung von Monoestern von 1,3-Diolen
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DE69313556D1 (de)	1997-10-09	Verfahren zur Herstellung von zyklischen Depsipeptiden
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DE69634809D1 (de)	2005-07-07	Verfahren zur Herstellung von Platin Verbindungen
DE59300777D1 (de)	1995-11-23	Verfahren zur Herstellung von Perfluorpolyethern.
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