ATE321849T1 - Verfahren zur erkennung von nucleinsäuremolekülen codierend für (poly)peptide, welche mit zielmolekülen interagieren - Google Patents

Verfahren zur erkennung von nucleinsäuremolekülen codierend für (poly)peptide, welche mit zielmolekülen interagieren

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Publication number
ATE321849T1
ATE321849T1 AT98924190T AT98924190T ATE321849T1 AT E321849 T1 ATE321849 T1 AT E321849T1 AT 98924190 T AT98924190 T AT 98924190T AT 98924190 T AT98924190 T AT 98924190T AT E321849 T1 ATE321849 T1 AT E321849T1
Authority
AT
Austria
Prior art keywords
peptides
interact
poly
nucleic acid
acid molecules
Prior art date
Application number
AT98924190T
Other languages
English (en)
Inventor
Andreas Plueckthun
Jozef Hanes
Lutz Jermutus
Original Assignee
Univ Zuerich
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Zuerich filed Critical Univ Zuerich
Application granted granted Critical
Publication of ATE321849T1 publication Critical patent/ATE321849T1/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1041—Ribosome/Polysome display, e.g. SPERT, ARM
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Immunology (AREA)
  • Plant Pathology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
AT98924190T 1997-04-23 1998-04-23 Verfahren zur erkennung von nucleinsäuremolekülen codierend für (poly)peptide, welche mit zielmolekülen interagieren ATE321849T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP97106753 1997-04-23

Publications (1)

Publication Number Publication Date
ATE321849T1 true ATE321849T1 (de) 2006-04-15

Family

ID=8226724

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98924190T ATE321849T1 (de) 1997-04-23 1998-04-23 Verfahren zur erkennung von nucleinsäuremolekülen codierend für (poly)peptide, welche mit zielmolekülen interagieren

Country Status (7)

Country Link
US (2) US6348315B1 (de)
EP (1) EP0975748B1 (de)
JP (1) JP4086325B2 (de)
AT (1) ATE321849T1 (de)
CA (1) CA2289691C (de)
DE (1) DE69834032T2 (de)
WO (1) WO1998048008A1 (de)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998048008A1 (en) * 1997-04-23 1998-10-29 Plueckthun Andreas Methods for identifying nucleic acid molecules encoding (poly)peptides that interact with target molecules
CA2302147C (en) * 1997-09-03 2008-05-13 Biovation Limited Methods for protein screening
US6927025B1 (en) 1997-09-03 2005-08-09 Biovation Limited Methods for protein screening
US20070166741A1 (en) 1998-12-14 2007-07-19 Somalogic, Incorporated Multiplexed analyses of test samples
EP1179090B1 (de) 1999-05-14 2010-04-28 Enterprise Ireland (trading as Bioresearch Ireland) Diagnostische tests auf prokaryotische und eukaryotische organismen, basierend auf nukleinsäuresonden
DK1268766T3 (da) * 2000-03-31 2006-04-10 Cambridge Antibody Tech Forbedringer af ribosom-display
AU2002218166A1 (en) 2000-09-08 2002-03-22 Universitat Zurich Collections of repeat proteins comprising repeat modules
EP1348034B1 (de) * 2000-11-15 2016-07-20 Minerva Biotechnologies Corporation Oligonukleotididentifikatoren
DE10060959A1 (de) * 2000-12-06 2002-06-20 Aventis Res & Tech Gmbh & Co Verfahren zur Isolierung und Identifizierung von Effektoren
WO2003064604A2 (en) * 2002-01-25 2003-08-07 The Board Of Trustees Of The Leland Stanford Junior University Translation profiling
US20050123973A1 (en) * 2002-02-08 2005-06-09 Shaobing Hua Methods for generating monoclonal antibody against fusion protein containing peptide fragment derived from membrane protein
US20040067532A1 (en) * 2002-08-12 2004-04-08 Genetastix Corporation High throughput generation and affinity maturation of humanized antibody
ES2327229T3 (es) * 2002-11-09 2009-10-27 Immunocore Ltd. Presentacion del receptor de linfocitos t.
GB0316314D0 (en) * 2003-07-12 2003-08-13 Univ Belfast Method
GB0411771D0 (en) * 2004-05-26 2004-06-30 Avidex Ltd Nucleoproteins displaying native T cell receptor libraries
EA017420B9 (ru) 2005-04-18 2013-03-29 Микромет Аг Антитела-нейтрализаторы гранулоцитарно-макрофагального колониестимулирующего фактора человека
US20070111237A1 (en) * 2005-09-14 2007-05-17 Maurizio Zanetti Process for identifying antigenized antibodies using ribosome cell free expression system
WO2007059312A2 (en) 2005-11-16 2007-05-24 Ambrx, Inc. Methods and compositions comprising non-natural amino acids
WO2007084886A2 (en) * 2006-01-17 2007-07-26 Somalogic, Incorporated Multiplexed analyses of test samples
AR059448A1 (es) 2006-02-13 2008-04-09 Divergence Inc Polipeptidos quimericos vegetales de union para el reconocimiento molecular universal
EP1894939A1 (de) * 2006-09-01 2008-03-05 GSF-Forschungszentrum für Umwelt und Gesundheit GmbH Neues Supertag und seine Verwendung
JP5360997B2 (ja) * 2006-10-20 2013-12-04 アリーア・スカボロー・インコーポレイテツド 病原体を同定するためのアッセイ及び装置
EP2222846B1 (de) * 2007-08-10 2017-05-03 Protelix, Inc. Universelle fibronectin-typ iii-bindungsdomäne-bibliotheken
US8680019B2 (en) * 2007-08-10 2014-03-25 Protelica, Inc. Universal fibronectin Type III binding-domain libraries
US8470966B2 (en) 2007-08-10 2013-06-25 Protelica, Inc. Universal fibronectin type III binding-domain libraries
US12529164B2 (en) 2007-09-14 2026-01-20 Adimab, Llc Rationally designed, synthetic antibody libraries and uses therefor
US8877688B2 (en) 2007-09-14 2014-11-04 Adimab, Llc Rationally designed, synthetic antibody libraries and uses therefor
EP2193146B1 (de) 2007-09-14 2016-05-25 Adimab, LLC Synthetische antikörperbibliotheken mit rationalem design und ihre verwendung
RU2396336C2 (ru) 2007-09-27 2010-08-10 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) СПОСОБ ПОЛУЧЕНИЯ АМИНОКИСЛОТ С ИСПОЛЬЗОВАНИЕМ БАКТЕРИИ, ПРИНАДЛЕЖАЩЕЙ К РОДУ Escherichia
SG10201604258YA (en) 2007-11-30 2016-07-28 Abbvie Biotechnology Ltd Anti-tnf antibody formulations
US8883146B2 (en) 2007-11-30 2014-11-11 Abbvie Inc. Protein formulations and methods of making same
US8865179B2 (en) * 2008-01-26 2014-10-21 Swey-Shen Alexchen Aptameric IgE peptides in a protein scaffold as an allergy vaccine
EP2088432A1 (de) * 2008-02-11 2009-08-12 MorphoSys AG Verfahren zur Identifikation eines Antikörpers oder eines Targets
CN102177438A (zh) 2008-07-25 2011-09-07 理查德·W·瓦格纳 蛋白筛选方法
BRPI0921469B1 (pt) 2008-11-03 2022-01-18 Molecular Partners Ag Proteínas de ligação que inibem a interação com o receptor de vegf-a, composição farmacêutica
WO2011051333A1 (en) 2009-10-30 2011-05-05 Novartis Ag Universal fibronectin type iii bottom-side binding domain libraries
JP5863045B2 (ja) 2010-03-11 2016-02-16 国立研究開発法人理化学研究所 ポリペプチド配列の選択方法、並びに金属酸化物または含珪素化合物結合ペプチドおよびその利用
TWI510246B (zh) 2010-04-30 2015-12-01 Molecular Partners Ag 抑制ｖｅｇｆ－ａ受體交互作用的經修飾結合性蛋白質
EP3741883B1 (de) 2010-07-16 2022-12-14 Adimab, LLC Antikörperbibliotheken
RU2013108962A (ru) 2010-07-30 2014-09-10 Новартис Аг Молекулы фибронектина, содержащие карман, и их библиотеки
CN103459415B (zh) 2010-11-26 2021-04-09 分子组合公司 设计的与血清白蛋白结合的重复蛋白
JP5948673B2 (ja) 2011-03-10 2016-07-06 ジーンフロンティア株式会社 リポ多糖混入量を低減した蛋白質合成用組成物、該組成物を用いた蛋白質製造方法
ES2873375T3 (es) 2011-03-15 2021-11-03 X Body Inc Métodos de cribado de anticuerpos
ES2716013T3 (es) 2011-04-28 2019-06-07 Univ Leland Stanford Junior Identificación de polinucleótidos asociados a una muestra
KR20140039203A (ko) 2011-04-29 2014-04-01 얀센 바이오테크 인코포레이티드 Il4/il13 결합 반복 단백질 및 용도
WO2012161227A1 (ja) 2011-05-23 2012-11-29 独立行政法人理化学研究所 核酸構築物、核酸－蛋白質複合体、及びその利用
JP6483442B2 (ja) 2011-12-05 2019-03-13 エックス−ボディ インコーポレイテッド Ｐｄｇｆ受容体ベータ結合ポリペプチド
US20150231220A1 (en) 2012-03-27 2015-08-20 Mogam Biotechnology Research Institute Epitopes of epidermal growth factor receptor surface antigen and use thereof
RU2014150224A (ru) 2012-06-28 2016-08-20 Молекьюлар Партнерс Аг Сконструированный белок с анкириновым повтором, связывающийся с фактором роста тромбоцитов
EP2738180A1 (de) 2012-11-30 2014-06-04 Molecular Partners AG Bindeproteine mit mindestens zwei Bindedomänen gegen HER2
EP2989202B1 (de) 2013-04-25 2019-04-10 Sutro Biopharma, Inc. Die verwendung des lambda-gam proteins in der ribosomen-display-technologie
DK2989239T4 (da) 2013-04-25 2025-04-07 Sutro Biopharma Inc Selektion af Fab-fragmenter ved anvendelse af ribosomfremvisningsteknologi
NZ716126A (en) 2013-06-28 2021-12-24 X Body Inc Target antigen discovery, phenotypic screens and use thereof for identification of target cell specific target epitopes
WO2015042528A1 (en) 2013-09-23 2015-03-26 X-Body Biosciences, Inc. Methods and compositions for generation of binding agents against cell surface antigens
WO2015089080A2 (en) 2013-12-09 2015-06-18 Adimab, Llc Polyclonal mixtures of antibodies, and methods of making and using them
US10787500B2 (en) 2015-04-10 2020-09-29 Adimab, Llc Methods for purifying heterodimeric multispecific antibodies from parental homodimeric antibody species
WO2026060324A1 (en) 2024-09-13 2026-03-19 Ormoni Biosciences, Inc. Peptide libraries having improved functional pharmacokinetic parameters and methods of synthesis and use thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0494955T3 (da) * 1989-10-05 1998-10-26 Optein Inc Cellefri syntese og isolering af hidtil ukendte gener og polypeptider
WO1993003172A1 (en) * 1991-08-01 1993-02-18 University Research Corporation Systematic polypeptide evolution by reverse translation
US5466580A (en) * 1993-09-22 1995-11-14 Xoma Corporation Method for quantifying BPI in body fluids
WO1995011922A1 (en) * 1993-10-29 1995-05-04 Affymax Technologies N.V. In vitro peptide and antibody display libraries
US5922545A (en) * 1993-10-29 1999-07-13 Affymax Technologies N.V. In vitro peptide and antibody display libraries
WO1998048008A1 (en) * 1997-04-23 1998-10-29 Plueckthun Andreas Methods for identifying nucleic acid molecules encoding (poly)peptides that interact with target molecules

Also Published As

Publication number Publication date
US6348315B1 (en) 2002-02-19
DE69834032T2 (de) 2006-12-07
EP0975748B1 (de) 2006-03-29
WO1998048008A1 (en) 1998-10-29
DE69834032D1 (de) 2006-05-18
JP2001521395A (ja) 2001-11-06
CA2289691C (en) 2008-01-15
US20020115083A1 (en) 2002-08-22
EP0975748A1 (de) 2000-02-02
US6589741B2 (en) 2003-07-08
JP4086325B2 (ja) 2008-05-14
CA2289691A1 (en) 1998-10-29

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