ATE321849T1 - Verfahren zur erkennung von nucleinsäuremolekülen codierend für (poly)peptide, welche mit zielmolekülen interagieren - Google Patents
Verfahren zur erkennung von nucleinsäuremolekülen codierend für (poly)peptide, welche mit zielmolekülen interagierenInfo
- Publication number
- ATE321849T1 ATE321849T1 AT98924190T AT98924190T ATE321849T1 AT E321849 T1 ATE321849 T1 AT E321849T1 AT 98924190 T AT98924190 T AT 98924190T AT 98924190 T AT98924190 T AT 98924190T AT E321849 T1 ATE321849 T1 AT E321849T1
- Authority
- AT
- Austria
- Prior art keywords
- peptides
- interact
- poly
- nucleic acid
- acid molecules
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1041—Ribosome/Polysome display, e.g. SPERT, ARM
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Immunology (AREA)
- Plant Pathology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP97106753 | 1997-04-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE321849T1 true ATE321849T1 (de) | 2006-04-15 |
Family
ID=8226724
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98924190T ATE321849T1 (de) | 1997-04-23 | 1998-04-23 | Verfahren zur erkennung von nucleinsäuremolekülen codierend für (poly)peptide, welche mit zielmolekülen interagieren |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US6348315B1 (de) |
| EP (1) | EP0975748B1 (de) |
| JP (1) | JP4086325B2 (de) |
| AT (1) | ATE321849T1 (de) |
| CA (1) | CA2289691C (de) |
| DE (1) | DE69834032T2 (de) |
| WO (1) | WO1998048008A1 (de) |
Families Citing this family (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69834032T2 (de) * | 1997-04-23 | 2006-12-07 | Universität Zürich | Verfahren zur erkennung von nucleinsäuremolekülen codierend für (poly)peptide, welche mit zielmolekülen interagieren |
| US6927025B1 (en) | 1997-09-03 | 2005-08-09 | Biovation Limited | Methods for protein screening |
| JP4524445B2 (ja) * | 1997-09-03 | 2010-08-18 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング | タンパク質のスクリーニング方法 |
| US20070166741A1 (en) | 1998-12-14 | 2007-07-19 | Somalogic, Incorporated | Multiplexed analyses of test samples |
| AU4427100A (en) | 1999-05-14 | 2000-12-05 | Enterprise Ireland Trading As Bioresearch Ireland | Nucleic acid probe-based diagnostic assays for prokaryotic and eukaryotic organisms |
| WO2001075097A2 (en) * | 2000-03-31 | 2001-10-11 | Cambridge Antibody Technology Limited | Improvements to ribosome display |
| EP1332209B1 (de) | 2000-09-08 | 2009-11-11 | Universität Zürich | Sammlung von proteinen mit sich wiederholenden sequenzen (repeat proteins), die repetitive sequenzmodule enthalten |
| EP1348034B1 (de) * | 2000-11-15 | 2016-07-20 | Minerva Biotechnologies Corporation | Oligonukleotididentifikatoren |
| DE10060959A1 (de) * | 2000-12-06 | 2002-06-20 | Aventis Res & Tech Gmbh & Co | Verfahren zur Isolierung und Identifizierung von Effektoren |
| US20040023256A1 (en) * | 2002-01-25 | 2004-02-05 | Puglisi Joseph D. | Translation profiling |
| US20050123973A1 (en) * | 2002-02-08 | 2005-06-09 | Shaobing Hua | Methods for generating monoclonal antibody against fusion protein containing peptide fragment derived from membrane protein |
| US20040067532A1 (en) * | 2002-08-12 | 2004-04-08 | Genetastix Corporation | High throughput generation and affinity maturation of humanized antibody |
| EP2048159B1 (de) | 2002-11-09 | 2014-01-01 | Immunocore Ltd. | T-Zellrezeptorpresentation |
| GB0316314D0 (en) * | 2003-07-12 | 2003-08-13 | Univ Belfast | Method |
| GB0411771D0 (en) * | 2004-05-26 | 2004-06-30 | Avidex Ltd | Nucleoproteins displaying native T cell receptor libraries |
| MX2007012569A (es) | 2005-04-18 | 2007-12-06 | Micromet Ag | Neutralizadores de anticuerpos del factor estimulante de la colonia de macrofagos-granulocitos humanos. |
| US20070111237A1 (en) * | 2005-09-14 | 2007-05-17 | Maurizio Zanetti | Process for identifying antigenized antibodies using ribosome cell free expression system |
| EP1951890A4 (de) | 2005-11-16 | 2009-06-24 | Ambrx Inc | Verfahren und zusammensetzungen mit nichtnatürlichen aminosäuren |
| HUE025489T2 (en) * | 2006-01-17 | 2016-04-28 | Somalogic Inc | Multiplexed analysis of test samples |
| AR059448A1 (es) | 2006-02-13 | 2008-04-09 | Divergence Inc | Polipeptidos quimericos vegetales de union para el reconocimiento molecular universal |
| EP1894939A1 (de) * | 2006-09-01 | 2008-03-05 | GSF-Forschungszentrum für Umwelt und Gesundheit GmbH | Neues Supertag und seine Verwendung |
| EP2084528B1 (de) * | 2006-10-20 | 2012-08-29 | Alere Scarborough, Inc. | Tests und vorrichtungen zur identifizierung von krankheitserregern |
| US8680019B2 (en) * | 2007-08-10 | 2014-03-25 | Protelica, Inc. | Universal fibronectin Type III binding-domain libraries |
| US8470966B2 (en) | 2007-08-10 | 2013-06-25 | Protelica, Inc. | Universal fibronectin type III binding-domain libraries |
| US20090176654A1 (en) * | 2007-08-10 | 2009-07-09 | Protelix, Inc. | Universal fibronectin type III binding-domain libraries |
| US8877688B2 (en) * | 2007-09-14 | 2014-11-04 | Adimab, Llc | Rationally designed, synthetic antibody libraries and uses therefor |
| WO2009036379A2 (en) | 2007-09-14 | 2009-03-19 | Adimab, Inc. | Rationally designed, synthetic antibody libraries and uses therefor |
| US12529164B2 (en) | 2007-09-14 | 2026-01-20 | Adimab, Llc | Rationally designed, synthetic antibody libraries and uses therefor |
| RU2396336C2 (ru) * | 2007-09-27 | 2010-08-10 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) | СПОСОБ ПОЛУЧЕНИЯ АМИНОКИСЛОТ С ИСПОЛЬЗОВАНИЕМ БАКТЕРИИ, ПРИНАДЛЕЖАЩЕЙ К РОДУ Escherichia |
| US8883146B2 (en) | 2007-11-30 | 2014-11-11 | Abbvie Inc. | Protein formulations and methods of making same |
| US8420081B2 (en) | 2007-11-30 | 2013-04-16 | Abbvie, Inc. | Antibody formulations and methods of making same |
| US8865179B2 (en) * | 2008-01-26 | 2014-10-21 | Swey-Shen Alexchen | Aptameric IgE peptides in a protein scaffold as an allergy vaccine |
| EP2088432A1 (de) * | 2008-02-11 | 2009-08-12 | MorphoSys AG | Verfahren zur Identifikation eines Antikörpers oder eines Targets |
| KR20110036638A (ko) | 2008-07-25 | 2011-04-07 | 리차드 더블유. 와그너 | 단백질 스크리닝 방법 |
| NZ592591A (en) | 2008-11-03 | 2012-04-27 | Molecular Partners Ag | Binding proteins comprising ankyrin repeast domains that inhibit the vegf-a receptor interaction |
| US9139825B2 (en) | 2009-10-30 | 2015-09-22 | Novartis Ag | Universal fibronectin type III bottom-side binding domain libraries |
| WO2011111832A1 (ja) | 2010-03-11 | 2011-09-15 | 独立行政法人理化学研究所 | ポリペプチド配列の選択方法、並びに金属酸化物または含珪素化合物結合ペプチドおよびその利用 |
| TWI510246B (zh) | 2010-04-30 | 2015-12-01 | Molecular Partners Ag | 抑制vegf-a受體交互作用的經修飾結合性蛋白質 |
| MX381912B (es) | 2010-07-16 | 2025-03-13 | Adimab Llc | Colecciones de anticuerpos. |
| AU2011283646B2 (en) | 2010-07-30 | 2015-07-09 | Novartis Ag | Fibronectin cradle molecules and libraries thereof |
| EP3514169B1 (de) | 2010-11-26 | 2024-03-06 | Molecular Partners AG | Repeat-protein, die sich an serumalbumin binden |
| PH12013501201A1 (en) * | 2010-12-09 | 2013-07-29 | Univ Pennsylvania | Use of chimeric antigen receptor-modified t cells to treat cancer |
| JP5948673B2 (ja) | 2011-03-10 | 2016-07-06 | ジーンフロンティア株式会社 | リポ多糖混入量を低減した蛋白質合成用組成物、該組成物を用いた蛋白質製造方法 |
| EP3798236B1 (de) | 2011-03-15 | 2022-08-10 | X-Body, Inc. | Antikörper-screening-verfahren |
| SG10201900183VA (en) | 2011-04-28 | 2019-05-30 | Univ Leland Stanford Junior | Identification of polynucleotides associated with a sample |
| WO2012149439A2 (en) | 2011-04-29 | 2012-11-01 | Janssen Biotech, Inc. | Il4/il13 binding repeat proteins and uses |
| WO2012161227A1 (ja) | 2011-05-23 | 2012-11-29 | 独立行政法人理化学研究所 | 核酸構築物、核酸-蛋白質複合体、及びその利用 |
| CN107353342B (zh) | 2011-12-05 | 2021-08-10 | X 博迪生物科学公司 | PDGF受体β结合多肽 |
| KR101930019B1 (ko) | 2012-03-27 | 2018-12-17 | 주식회사 녹십자 | 표피 성장 인자 수용체 표면 항원상의 에피토프 및 이의 용도 |
| SG11201408196RA (en) | 2012-06-28 | 2015-03-30 | Molecular Partners Ag | Designed ankyrin repeat proteins binding to platelet-derived growth factor |
| EP2738180A1 (de) | 2012-11-30 | 2014-06-04 | Molecular Partners AG | Bindeproteine mit mindestens zwei Bindedomänen gegen HER2 |
| EP2989202B1 (de) | 2013-04-25 | 2019-04-10 | Sutro Biopharma, Inc. | Die verwendung des lambda-gam proteins in der ribosomen-display-technologie |
| US20160069897A1 (en) | 2013-04-25 | 2016-03-10 | Suthro Biopharma, Inc. | Selection of fab fragments using ribosomal display technology |
| US10370651B2 (en) | 2013-06-28 | 2019-08-06 | X-Body, Inc. | Target antigen discovery, phenotypic screens and use thereof for identification of target cell specific target epitopes |
| AU2014321251B2 (en) | 2013-09-23 | 2020-04-16 | X-Body, Inc. | Methods and compositions for generation of binding agents against cell surface antigens |
| WO2015089080A2 (en) | 2013-12-09 | 2015-06-18 | Adimab, Llc | Polyclonal mixtures of antibodies, and methods of making and using them |
| EP3280444B1 (de) | 2015-04-10 | 2024-05-08 | Adimab, LLC | Verfahren zur reinigung heterodimerer multispezifischer antikörper aus elterlichen homodimeren antikörperarten |
| AU2022293680A1 (en) * | 2021-06-15 | 2024-01-18 | Protillion Biosciences, Inc. | Methods, systems, and compositions of generating and analyzing polypeptide libraries |
| WO2026060324A1 (en) | 2024-09-13 | 2026-03-19 | Ormoni Biosciences, Inc. | Peptide libraries having improved functional pharmacokinetic parameters and methods of synthesis and use thereof |
| WO2026097015A1 (en) | 2024-11-01 | 2026-05-07 | Eindura Therapeutics, Inc. | Targeted therapeutics with an electrophilic group for covalent attachment and methods of use and manufacture thereof |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2118066T3 (es) * | 1989-10-05 | 1998-09-16 | Optein Inc | Sintesis y aislamiento, exentos de celulas, de nuevos genes y polipeptidos. |
| WO1993003172A1 (en) * | 1991-08-01 | 1993-02-18 | University Research Corporation | Systematic polypeptide evolution by reverse translation |
| US5466580A (en) * | 1993-09-22 | 1995-11-14 | Xoma Corporation | Method for quantifying BPI in body fluids |
| US5922545A (en) * | 1993-10-29 | 1999-07-13 | Affymax Technologies N.V. | In vitro peptide and antibody display libraries |
| WO1995011922A1 (en) * | 1993-10-29 | 1995-05-04 | Affymax Technologies N.V. | In vitro peptide and antibody display libraries |
| DE69834032T2 (de) * | 1997-04-23 | 2006-12-07 | Universität Zürich | Verfahren zur erkennung von nucleinsäuremolekülen codierend für (poly)peptide, welche mit zielmolekülen interagieren |
-
1998
- 1998-04-23 DE DE69834032T patent/DE69834032T2/de not_active Expired - Lifetime
- 1998-04-23 JP JP54503898A patent/JP4086325B2/ja not_active Expired - Fee Related
- 1998-04-23 WO PCT/EP1998/002420 patent/WO1998048008A1/en not_active Ceased
- 1998-04-23 EP EP98924190A patent/EP0975748B1/de not_active Expired - Lifetime
- 1998-04-23 AT AT98924190T patent/ATE321849T1/de active
- 1998-04-23 CA CA002289691A patent/CA2289691C/en not_active Expired - Fee Related
-
1999
- 1999-10-22 US US09/425,585 patent/US6348315B1/en not_active Expired - Lifetime
-
2001
- 2001-09-14 US US09/953,321 patent/US6589741B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CA2289691A1 (en) | 1998-10-29 |
| WO1998048008A1 (en) | 1998-10-29 |
| DE69834032T2 (de) | 2006-12-07 |
| EP0975748A1 (de) | 2000-02-02 |
| JP2001521395A (ja) | 2001-11-06 |
| JP4086325B2 (ja) | 2008-05-14 |
| US6348315B1 (en) | 2002-02-19 |
| US6589741B2 (en) | 2003-07-08 |
| DE69834032D1 (de) | 2006-05-18 |
| EP0975748B1 (de) | 2006-03-29 |
| CA2289691C (en) | 2008-01-15 |
| US20020115083A1 (en) | 2002-08-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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