ATE322479T1 - Benzamidinderivate - Google Patents

Benzamidinderivate

Info

Publication number: ATE322479T1
Authority: AT; Austria
Prior art keywords: group; optionally substituted; hydrogen atom; alkyl group; halogen atom
Prior art date: 1999-10-28

Application number

AT00970070T

Other languages

English (en)

Inventor

Koichi Fujimoto

Fumitoshi Asai

Hayao Matsuhashi

Original Assignee

Sankyo Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-10-28

Filing date

2000-10-25

Publication date

2006-04-15

2000-10-25 Application filed by Sankyo Co filed Critical Sankyo Co

2006-04-15 Application granted granted Critical

2006-04-15 Publication of ATE322479T1 publication Critical patent/ATE322479T1/de

Links

PXXJHWLDUBFPOL-UHFFFAOYSA-N benzamidine Chemical class NC(=N)C1=CC=CC=C1 PXXJHWLDUBFPOL-UHFFFAOYSA-N 0.000 title 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
125000005843 halogen group Chemical group 0.000 abstract 3
125000000217 alkyl group Chemical group 0.000 abstract 2
125000000547 substituted alkyl group Chemical group 0.000 abstract 2
108010074860 Factor Xa Proteins 0.000 abstract 1
125000002252 acyl group Chemical group 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
125000003710 aryl alkyl group Chemical group 0.000 abstract 1
150000003937 benzamidines Chemical class 0.000 abstract 1
208000015294 blood coagulation disease Diseases 0.000 abstract 1
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
125000003386 piperidinyl group Chemical group 0.000 abstract 1
125000000719 pyrrolidinyl group Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Heart & Thoracic Surgery (AREA)
Vascular Medicine (AREA)
Cardiology (AREA)
Urology & Nephrology (AREA)
Diabetes (AREA)
Hematology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Manufacture Of Alloys Or Alloy Compounds (AREA)

AT00970070T 1999-10-28 2000-10-25 Benzamidinderivate ATE322479T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP30719299		1999-10-28

Publications (1)

Publication Number	Publication Date
ATE322479T1 true ATE322479T1 (de)	2006-04-15

Family

ID=17966162

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT00970070T ATE322479T1 (de)	1999-10-28	2000-10-25	Benzamidinderivate

Country Status (26)

Country	Link
US (3)	US6555556B1 (de)
EP (1)	EP1245564B1 (de)
KR (1)	KR100642953B1 (de)
CN (2)	CN1572882A (de)
AT (1)	ATE322479T1 (de)
AU (1)	AU776193B2 (de)
BR (1)	BR0015120A (de)
CA (1)	CA2389156C (de)
CY (1)	CY1106116T1 (de)
CZ (1)	CZ20021432A3 (de)
DE (1)	DE60027204T2 (de)
DK (1)	DK1245564T3 (de)
ES (1)	ES2261248T3 (de)
HK (1)	HK1047431B (de)
HU (1)	HUP0203161A3 (de)
IL (2)	IL149306A0 (de)
MX (1)	MXPA02004218A (de)
NO (1)	NO323147B1 (de)
NZ (1)	NZ518581A (de)
PL (1)	PL354619A1 (de)
PT (1)	PT1245564E (de)
RU (1)	RU2222529C2 (de)
TR (1)	TR200201654T2 (de)
TW (1)	TWI226886B (de)
WO (1)	WO2001030756A1 (de)
ZA (1)	ZA200203278B (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR100642953B1 (ko) *	1999-10-28	2006-11-10	상꾜 가부시키가이샤	벤즈아미딘 유도체
MXPA03009097A (es)	2001-04-05	2004-02-12	Sankyo Co	Derivados de benzamidina.
WO2002089803A1 (fr) *	2001-05-07	2002-11-14	Sankyo Company, Limited	Composition d'ionophorese
EP1486485A4 (de) *	2002-03-15	2009-07-15	Kissei Pharmaceutical	Neue kristalle eines 5-hydroxycarbamimidoyl-2-hydroxybenzolsulfonamidderivats
CA2585003C (en) *	2004-11-23	2010-08-17	Dong Wha Pharm. Ind. Co., Ltd.	An oral preparation having improved bioavailability
CN103159620A (zh) *	2013-03-28	2013-06-19	广西师范大学	一种2-羟基间苯二甲酸的制备方法
KR20250112249A (ko)	2022-11-22	2025-07-23	키메드 바이오사이언시스 (청두) 컴퍼니 리미티드	융합된 고리 화합물, 이의 접합체 및 이의 용도

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS57209270A (en) *	1981-06-19	1982-12-22	Chugai Pharmaceut Co Ltd	Proline derivative
ZA928276B (en)	1991-10-31	1993-05-06	Daiichi Seiyaku Co	Aromatic amidine derivates and salts thereof.
US5731324A (en) *	1993-07-22	1998-03-24	Eli Lilly And Company	Glycoprotein IIb/IIIa antagonists
ZA951617B (en) *	1994-03-04	1997-02-27	Lilly Co Eli	Antithrombotic agents.
HUT77313A (hu)	1994-12-02	1998-03-30	Yamanouchi Pharmaceutical Co., Ltd.	Amidino-naftil-származékok és sóik, e vegyületeket tartalmazó gyógyászati készítmények és alkalmazásuk
DE4443390A1 (de) *	1994-12-06	1996-06-13	Basf Ag	Neue dipeptidische p-Amidinobenzylamide mit N-terminalen Sulfonyl- bzw. Aminosulfonylresten
DE69628856T2 (de) *	1996-01-02	2004-05-06	Aventis Pharmaceuticals Inc.	Substituierte n-[(aminoiminomethyl oder aminomethyl)phenyl]propylamide
WO1998011094A1 (en) *	1996-09-12	1998-03-19	Schering Aktiengesellschaft	Benzamidine derivatives substituted by cyclic amino acid or cycl ic hydroxy acid derivatives and their use as anti-coagulants
TW542822B (en) *	1997-01-17	2003-07-21	Ajinomoto Kk	Benzamidine derivatives
US6545054B1 (en) *	1999-02-11	2003-04-08	Millennium Pharmaceuticals, Inc.	Alkenyl and alkynyl compounds as inhibitors of factor Xa
US6350761B1 (en) *	1999-07-30	2002-02-26	Berlex Laboratories, Inc.	Benzenamine derivatives as anti-coagulants
KR100642953B1 (ko) *	1999-10-28	2006-11-10	상꾜 가부시키가이샤	벤즈아미딘 유도체

2000
- 2000-10-25 KR KR1020027005382A patent/KR100642953B1/ko not_active Expired - Fee Related
- 2000-10-25 WO PCT/JP2000/007469 patent/WO2001030756A1/ja not_active Ceased
- 2000-10-25 NZ NZ518581A patent/NZ518581A/en unknown
- 2000-10-25 CN CNA2004100634713A patent/CN1572882A/zh active Pending
- 2000-10-25 CZ CZ20021432A patent/CZ20021432A3/cs unknown
- 2000-10-25 RU RU2002111343/04A patent/RU2222529C2/ru not_active IP Right Cessation
- 2000-10-25 HK HK02108844.9A patent/HK1047431B/en not_active IP Right Cessation
- 2000-10-25 MX MXPA02004218A patent/MXPA02004218A/es active IP Right Grant
- 2000-10-25 TR TR2002/01654T patent/TR200201654T2/xx unknown
- 2000-10-25 CA CA002389156A patent/CA2389156C/en not_active Expired - Fee Related
- 2000-10-25 PT PT00970070T patent/PT1245564E/pt unknown
- 2000-10-25 CN CNB008178003A patent/CN1293052C/zh not_active Expired - Fee Related
- 2000-10-25 PL PL00354619A patent/PL354619A1/xx unknown
- 2000-10-25 AT AT00970070T patent/ATE322479T1/de not_active IP Right Cessation
- 2000-10-25 ES ES00970070T patent/ES2261248T3/es not_active Expired - Lifetime
- 2000-10-25 DK DK00970070T patent/DK1245564T3/da active
- 2000-10-25 BR BR0015120-3A patent/BR0015120A/pt not_active Application Discontinuation
- 2000-10-25 IL IL14930600A patent/IL149306A0/xx active IP Right Grant
- 2000-10-25 AU AU79574/00A patent/AU776193B2/en not_active Ceased
- 2000-10-25 DE DE60027204T patent/DE60027204T2/de not_active Expired - Lifetime
- 2000-10-25 HU HU0203161A patent/HUP0203161A3/hu unknown
- 2000-10-25 EP EP00970070A patent/EP1245564B1/de not_active Expired - Lifetime
- 2000-10-27 TW TW089122706A patent/TWI226886B/zh not_active IP Right Cessation
2002
- 2002-04-23 IL IL149306A patent/IL149306A/en not_active IP Right Cessation
- 2002-04-24 ZA ZA200203278A patent/ZA200203278B/en unknown
- 2002-04-25 US US10/132,042 patent/US6555556B1/en not_active Expired - Fee Related
- 2002-04-26 NO NO20021990A patent/NO323147B1/no not_active IP Right Cessation
- 2002-11-06 US US10/288,838 patent/US20040010009A1/en not_active Abandoned
2003
- 2003-11-07 US US10/704,355 patent/US20040248981A1/en not_active Abandoned
2006
- 2006-07-04 CY CY20061100927T patent/CY1106116T1/el unknown

Also Published As

Publication number	Publication date
AU776193B2 (en)	2004-09-02
TR200201654T2 (tr)	2002-12-23
NZ518581A (en)	2004-11-26
KR20020092347A (ko)	2002-12-11
HUP0203161A2 (hu)	2002-12-28
MXPA02004218A (es)	2002-10-17
BR0015120A (pt)	2002-06-25
CA2389156C (en)	2009-05-12
CA2389156A1 (en)	2001-05-03
RU2222529C2 (ru)	2004-01-27
CN1413189A (zh)	2003-04-23
DE60027204D1 (en)	2006-05-18
DE60027204T2 (de)	2006-11-23
DK1245564T3 (da)	2006-08-14
EP1245564A1 (de)	2002-10-02
US20040010009A1 (en)	2004-01-15
CN1293052C (zh)	2007-01-03
ZA200203278B (en)	2003-08-26
NO20021990L (no)	2002-06-25
US6555556B1 (en)	2003-04-29
WO2001030756A1 (en)	2001-05-03
KR100642953B1 (ko)	2006-11-10
HUP0203161A3 (en)	2003-12-29
PL354619A1 (en)	2004-02-09
AU7957400A (en)	2001-05-08
TWI226886B (en)	2005-01-21
HK1047431B (en)	2006-07-14
IL149306A (en)	2007-07-04
NO20021990D0 (no)	2002-04-26
CZ20021432A3 (cs)	2002-10-16
EP1245564B1 (de)	2006-04-05
EP1245564A4 (de)	2003-03-05
ES2261248T3 (es)	2006-11-16
IL149306A0 (en)	2002-11-10
HK1047431A1 (en)	2003-02-21
CN1572882A (zh)	2005-02-02
CY1106116T1 (el)	2011-06-08
NO323147B1 (no)	2007-01-08
US20040248981A1 (en)	2004-12-09
PT1245564E (pt)	2006-06-30

Legal Events

Date

Code

Title

Description

2007-02-15

UEP

Publication of translation of european patent specification

Ref document number: 1245564

Country of ref document: EP

2010-07-15

REN

Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
WO2002081448A1 (en)	2002-10-17	Benzamidine derivative
GB9801690D0 (en)	1998-03-25	Therapeutic agents
WO2000071510A3 (en)	2001-08-30	INHIBITORS OF FACTOR Xa
PT863875E (pt)	2003-10-31	Novos compostos 4-(oxialcoxifenil)-3-oxi-piperidina para o tratamento de insuficiencia cardiaca e renal
TR200200579T2 (tr)	2002-12-23	Amino-tirazolpiridin türevleri.
WO2001019798A3 (en)	2001-10-25	Inhibitors of factor xa
WO2000047554A3 (en)	2001-08-09	INHIBITORS OF FACTOR Xa
NO993706D0 (no)	1999-07-29	Pyrrolidinderivater med fosfolipase A2 inhiberende aktivitet
TR200201205T2 (tr)	2002-08-21	N-ikame edilmiş karbamoiloksialkil-azolyum türevleri.
ATE425139T1 (de)	2009-03-15	Benzamidinderivate
DE60121461D1 (de)	2006-08-24	Kondensierte pyridoindolderivate
WO2000071516A3 (en)	2001-01-18	INHIBITORS OF FACTOR Xa
TW200420545A (en)	2004-10-16	1-(4-benzyl-piperazin-1-yl)-3-phenyl-propenone derivatives
TR200001452T2 (tr)	2004-12-21	Bifenilamidin türevleri.
NO20052182L (no)	2005-05-03	Nye forbindelser
NO20060146L (no)	2006-03-07	Benzimidazolderivater, sammensetninger som inneholder slike, fremstilling derav og anvendelse derav
CY1105113T1 (el)	2010-03-03	Παραγωγα της αρυλικης (ή ετepοαρυλικης) αζολυλκαρβυνολης για την αντιμετωπιση της ακρατειας ουρων
DK1245564T3 (da)	2006-08-14	Benzamidinderivater
BR9813719A (pt)	2000-10-17	Agentes terapêuticos
NO20022123L (no)	2002-05-03	Osoksazolderivater for anvendelse som inhibitorer for fosfodiesterase VII
HRP20010885B1 (en)	2010-07-31	Ethanesulfonyl-piperidine derivatives
WO2002006280A3 (en)	2003-07-17	INHIBITORS OF FACTOR Xa
DK0896822T3 (da)	2003-06-02	4-aminopyrrol (3,2-d) pyrimidiner som neuropeptide Y receptorantagonister
ATE293961T1 (de)	2005-05-15	Verwendung von hydantoin und seinen derivaten gegen hypalbuminämie
NO20052994L (no)	2005-07-12	Nye fosforamidderivater.