ATE323709T1 - Androgenrezeptor-modulatorverbindungen und verfahren - Google Patents
Androgenrezeptor-modulatorverbindungen und verfahrenInfo
- Publication number
- ATE323709T1 ATE323709T1 AT00957854T AT00957854T ATE323709T1 AT E323709 T1 ATE323709 T1 AT E323709T1 AT 00957854 T AT00957854 T AT 00957854T AT 00957854 T AT00957854 T AT 00957854T AT E323709 T1 ATE323709 T1 AT E323709T1
- Authority
- AT
- Austria
- Prior art keywords
- methods
- androgen receptor
- receptor modulator
- modulator compounds
- compounds
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 5
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 239000000849 selective androgen receptor modulator Substances 0.000 title 1
- 102000001307 androgen receptors Human genes 0.000 abstract 3
- 108010080146 androgen receptors Proteins 0.000 abstract 3
- 239000000543 intermediate Substances 0.000 abstract 2
- 108010085012 Steroid Receptors Proteins 0.000 abstract 1
- 239000000556 agonist Substances 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000004031 partial agonist Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000000707 stereoselective effect Effects 0.000 abstract 1
- 102000005969 steroid hormone receptors Human genes 0.000 abstract 1
- 230000003637 steroidlike Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/16—Masculine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/26—Androgens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/28—Antiandrogens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Reproductive Health (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Gynecology & Obstetrics (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Hematology (AREA)
- Pregnancy & Childbirth (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15098899P | 1999-08-27 | 1999-08-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE323709T1 true ATE323709T1 (de) | 2006-05-15 |
Family
ID=22536855
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00957854T ATE323709T1 (de) | 1999-08-27 | 2000-08-25 | Androgenrezeptor-modulatorverbindungen und verfahren |
Country Status (21)
| Country | Link |
|---|---|
| US (3) | US6462038B1 (de) |
| EP (1) | EP1212330B1 (de) |
| JP (1) | JP2003508402A (de) |
| KR (1) | KR20020038741A (de) |
| CN (1) | CN1391576A (de) |
| AT (1) | ATE323709T1 (de) |
| AU (1) | AU778655B2 (de) |
| BG (1) | BG106550A (de) |
| BR (1) | BR0013597A (de) |
| CA (1) | CA2383077A1 (de) |
| CZ (1) | CZ2002711A3 (de) |
| DE (1) | DE60027443D1 (de) |
| HU (1) | HUP0202814A3 (de) |
| IL (1) | IL148045A0 (de) |
| MX (1) | MXPA02002032A (de) |
| NO (1) | NO20020913L (de) |
| PL (1) | PL353792A1 (de) |
| SK (1) | SK2732002A3 (de) |
| TR (1) | TR200200507T2 (de) |
| WO (1) | WO2001016139A1 (de) |
| ZA (1) | ZA200201056B (de) |
Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL353792A1 (en) * | 1999-08-27 | 2003-12-01 | Ligand Pharmaceuticals Incorporatedligand Pharmaceuticals Incorporated | Androgen receptor modulator compounds and methods |
| US6566372B1 (en) | 1999-08-27 | 2003-05-20 | Ligand Pharmaceuticals Incorporated | Bicyclic androgen and progesterone receptor modulator compounds and methods |
| US7001911B2 (en) | 2000-06-28 | 2006-02-21 | Bristol-Myers Squibb Company | Fused cyclic modulators of nuclear hormone receptor function |
| JP2004509072A (ja) | 2000-06-28 | 2004-03-25 | ブリストル−マイヤーズ スクイブ カンパニー | 選択的アンドロゲン受容体モジュレーター並びにその同定、設計及び使用方法 |
| US20040077605A1 (en) | 2001-06-20 | 2004-04-22 | Salvati Mark E. | Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function |
| US6953679B2 (en) | 2000-09-19 | 2005-10-11 | Bristol-Myers Squibb Company | Method for the preparation of fused heterocyclic succinimide compounds and analogs thereof |
| US7026484B2 (en) * | 2001-02-23 | 2006-04-11 | Ligand Pharmaceuticals Incorporated | Tricyclic androgen receptor modulator compounds and methods |
| US7214690B2 (en) * | 2001-02-23 | 2007-05-08 | Ligand Pharmaceuticals Incorporated | Tricyclic quinolinone and tricyclic quinoline androgen receptor modulator compounds and methods |
| WO2003011824A1 (en) | 2001-07-31 | 2003-02-13 | Bristol-Myers Squibb Company | Bicyclic modulators of androgen receptor function |
| AU2002364082A1 (en) | 2001-12-19 | 2003-07-09 | Bristol-Myers Squibb Company | Fused heterocyclic compounds and analogs thereof: modulators of nuclear hormone receptor function |
| AU2003230869B2 (en) * | 2002-04-26 | 2010-02-25 | Ortho-Mcneil Pharmaceutical, Inc. | 2-(quinolonyl)-fused heterocycles as androgen receptor modulators |
| US7405234B2 (en) | 2002-05-17 | 2008-07-29 | Bristol-Myers Squibb Company | Bicyclic modulators of androgen receptor function |
| CN1665510A (zh) * | 2002-06-25 | 2005-09-07 | 惠氏公司 | 作为pr调节剂的环硫代氨基甲酸酯衍生物的衍生物和其用于治疗皮肤病的用途 |
| EP1567487A4 (de) | 2002-11-15 | 2005-11-16 | Bristol Myers Squibb Co | Offenkettige, mit prolylharnstoff verwandtemodulatoren der androgenrezeptorfunktion |
| WO2004065379A1 (en) | 2003-01-17 | 2004-08-05 | Warner-Lambert Company Llc | Androgen receptor antagonists |
| EP1587509A2 (de) | 2003-01-17 | 2005-10-26 | Warner-Lambert Company LLC | Antagonisten des androgenrezeptors |
| WO2004072044A2 (en) | 2003-02-11 | 2004-08-26 | Warner-Lambert Company Llc | Urea and thiourea derivatives |
| WO2004072043A1 (en) | 2003-02-11 | 2004-08-26 | Warner-Lambert Company Llc | Benzyl urea and thiourea derivatives useful as androgen antagonists |
| US7009052B2 (en) | 2003-03-20 | 2006-03-07 | Warner Lambert Company Llc | Sulfonamide derivatives |
| US7098340B2 (en) | 2003-05-14 | 2006-08-29 | Warner Lambert Company Llc | Benzyl sulfonamide derivatives |
| JP2007500245A (ja) * | 2003-06-10 | 2007-01-11 | スミスクライン ビーチャム コーポレーション | 化合物 |
| JP4709759B2 (ja) * | 2003-08-22 | 2011-06-22 | リガンド・ファーマシューティカルズ・インコーポレイテッド | アンドロゲン受容体モジュレーター化合物としての6−シクロアミノ−2−キノリノン誘導体 |
| EP1689383B1 (de) | 2003-11-19 | 2012-10-31 | Metabasis Therapeutics, Inc. | Neue phosphor enthaltende thyromimetika |
| CN1902057A (zh) * | 2003-12-26 | 2007-01-24 | 三菱化学株式会社 | 光学记录介质和染料 |
| US7820702B2 (en) | 2004-02-04 | 2010-10-26 | Bristol-Myers Squibb Company | Sulfonylpyrrolidine modulators of androgen receptor function and method |
| US7625923B2 (en) | 2004-03-04 | 2009-12-01 | Bristol-Myers Squibb Company | Bicyclic modulators of androgen receptor function |
| US7696241B2 (en) | 2004-03-04 | 2010-04-13 | Bristol-Myers Squibb Company | Bicyclic compounds as modulators of androgen receptor function and method |
| US8519158B2 (en) | 2004-03-12 | 2013-08-27 | Ligand Pharmaceuticals Incorporated | Androgen receptor modulator compounds and methods |
| JP5070042B2 (ja) * | 2004-05-03 | 2012-11-07 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 選択的アンドローゲン受容体モジュレーター(sarms)としての新規インドール化合物 |
| WO2005111042A1 (en) * | 2004-05-03 | 2005-11-24 | Janssen Pharmaceutica N.V. | Novel indole derivatives as selective androgen receptor modulators (sarms) |
| CA2570047C (en) * | 2004-07-08 | 2010-09-28 | Warner-Lambert Company Llc | 4-cycloalkoxy benzonitriles as androgen modulators |
| US7280723B2 (en) * | 2005-05-06 | 2007-10-09 | Schott Corporation | Illumination assembly including a rigid light-guiding element incorporating a numerical-aperture alteration taper |
| BRPI0609191B8 (pt) | 2005-06-17 | 2021-05-25 | Ligand Pharm Inc | métodos e compostos moduladores de receptor de androgênio |
| JP2009506069A (ja) | 2005-08-26 | 2009-02-12 | ブレインセルス,インコーポレイティド | ムスカリン性受容体調節による神経発生 |
| EP2258359A3 (de) | 2005-08-26 | 2011-04-06 | Braincells, Inc. | Neurogenese durch Modulation des Muscarinrezeptors mit Sabcomelin |
| WO2007025303A2 (en) * | 2005-08-26 | 2007-03-01 | The Regents Of The University Of California | Non-steroidal antiandrogens |
| US7985756B2 (en) | 2005-10-21 | 2011-07-26 | Braincells Inc. | Modulation of neurogenesis by PDE inhibition |
| US7741317B2 (en) | 2005-10-21 | 2010-06-22 | Bristol-Myers Squibb Company | LXR modulators |
| US7790745B2 (en) | 2005-10-21 | 2010-09-07 | Bristol-Myers Squibb Company | Tetrahydroisoquinoline LXR Modulators |
| WO2007053596A1 (en) | 2005-10-31 | 2007-05-10 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
| US7888376B2 (en) | 2005-11-23 | 2011-02-15 | Bristol-Myers Squibb Company | Heterocyclic CETP inhibitors |
| US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
| WO2007134136A2 (en) | 2006-05-09 | 2007-11-22 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
| US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
| JP5498168B2 (ja) | 2006-12-01 | 2014-05-21 | ブリストル−マイヤーズ スクイブ カンパニー | アテローム性動脈硬化および循環器疾患の治療のためのcetp阻害剤としてのn−((3−ベンジル)−2,2−(ビス−フェニル)−プロパン−1−アミン誘導体 |
| JP5539221B2 (ja) | 2007-12-21 | 2014-07-02 | リガンド・ファーマシューティカルズ・インコーポレイテッド | 選択的アンドロゲン受容体モジュレーター(sarm)およびその使用 |
| EP2130831A1 (de) | 2008-06-06 | 2009-12-09 | InterMed Discovery GmbH | CDC25-Hemmer |
| US20120046364A1 (en) | 2009-02-10 | 2012-02-23 | Metabasis Therapeutics, Inc. | Novel Sulfonic Acid-Containing Thyromimetics, and Methods for Their Use |
| WO2010099217A1 (en) | 2009-02-25 | 2010-09-02 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
| SG11202011135WA (en) | 2018-05-14 | 2020-12-30 | Nuvation Bio Inc | Anti-cancer nuclear hormone receptor-targeting compounds |
| CN108659219B (zh) * | 2018-06-08 | 2021-02-09 | 扬州大学 | 一种聚苯胺的制备方法 |
| KR20220003554A (ko) | 2019-04-19 | 2022-01-10 | 리간드 파마슈티칼스 인코포레이티드 | 화합물의 결정질 형태 및 결정질 형태를 제조하는 방법 |
| US11826430B2 (en) | 2019-05-14 | 2023-11-28 | Nuvation Bio Inc. | Anti-cancer nuclear hormone receptor-targeting compounds |
| US11952349B2 (en) | 2019-11-13 | 2024-04-09 | Nuvation Bio Inc. | Anti-cancer nuclear hormone receptor-targeting compounds |
| KR20230160299A (ko) | 2021-03-23 | 2023-11-23 | 누베이션 바이오 인크. | 항암 핵 호르몬 수용체 표적화 화합물 |
| US12006314B2 (en) | 2021-05-03 | 2024-06-11 | Nuvation Bio Inc. | Anti-cancer nuclear hormone receptor-targeting compounds |
Family Cites Families (94)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH590274A5 (de) * | 1970-03-16 | 1977-07-29 | Hoffmann La Roche | |
| US3979394A (en) | 1970-12-11 | 1976-09-07 | Agfa-Gevaert N.V. | Duplo quinoline compounds |
| GB1379387A (en) | 1970-12-11 | 1975-01-02 | Agfa Gevaert | Photoconductive recording materials |
| US3755332A (en) | 1971-07-01 | 1973-08-28 | Ciba Geigy Corp | Substituted 4 indazolaminoquinolines |
| GB1400993A (en) | 1971-11-10 | 1975-07-16 | Agfa Gevaert | Electrophotographic material |
| BE795696A (nl) | 1972-02-28 | 1973-08-21 | Agfa Gevaert Nv | Voor warmte gevoelige materialen |
| US3936461A (en) * | 1973-09-24 | 1976-02-03 | Warner-Lambert Company | Substituted 4-benzylquinolines |
| US3993656A (en) | 1974-11-19 | 1976-11-23 | Merck & Co., Inc. | 1,8-Naphthyridine compounds |
| US4138490A (en) * | 1975-03-20 | 1979-02-06 | Imperial Chemical Industries Limited | Analgesic compositions containing 1,2-dihydro-2-oxoquinol-4-ylpropionic acid derivatives |
| IE43079B1 (en) * | 1975-03-20 | 1980-12-17 | Ici Ltd | Quinolone derivatives |
| SU555119A1 (ru) | 1975-05-19 | 1977-04-25 | Предприятие П/Я Г-4913 | Вулканизуема резинова смесь на основе полиизопренового каучука |
| LU77254A1 (de) | 1977-05-04 | 1979-01-18 | ||
| US4579134A (en) * | 1977-09-08 | 1986-04-01 | The Bridgeport Metal Goods Manufacturing Co. | Lipstick container |
| US4326055A (en) | 1977-12-22 | 1982-04-20 | Hoffmann-La Roche Inc. | Stilbene derivatives |
| JPS54154797A (en) * | 1978-05-25 | 1979-12-06 | Eisai Co Ltd | Benzimidazoquinolizine derivative and antibacterials comprising it |
| US4234589A (en) * | 1979-09-24 | 1980-11-18 | E. R. Squibb & Sons, Inc. | Imidazolylethoxymethyl derivatives of 1,3-dioxolo quinolines |
| JPS5777676A (en) | 1980-10-31 | 1982-05-15 | Otsuka Pharmaceut Co Ltd | Carbostyril derivative |
| DE3202100A1 (de) | 1982-01-23 | 1983-08-04 | Basf Ag, 6700 Ludwigshafen | Substituierte benzoesaeure-4-hydroxyanilide, ihre herstellung und diese enthaltende pharmazeutische zubereitungen |
| US4534979A (en) | 1982-06-28 | 1985-08-13 | Usv Pharmaceutical Corp. | Polyene compounds useful in the treatment of psoriasis and allergic responses |
| US4427654A (en) | 1982-07-27 | 1984-01-24 | University Of Delaware | Wound healing compositions and formulations |
| US4505852A (en) | 1982-11-29 | 1985-03-19 | Enzyme Systems Products | 7-Amino-4-trifluoromethylquinolone derived substrates and method for determining enzymes and inhibitors |
| US4539134A (en) | 1982-12-02 | 1985-09-03 | Halliburton Company | Methods and cleaning compositions for removing organic materials from metallic surfaces |
| JPS6056985A (ja) * | 1983-09-08 | 1985-04-02 | Sankyo Co Ltd | クマリン誘導体 |
| PT79699B (en) | 1983-12-22 | 1986-12-10 | Pfizer | Process for preparing quinolone inotropic agents |
| NZ212209A (en) | 1984-05-29 | 1988-08-30 | Pfizer | Quinolone derivatives and pharmaceutical compositions |
| US4783549A (en) | 1984-09-05 | 1988-11-08 | L'oreal | Benzonorbornene derivatives, processes for their preparation and medicinal and cosmetic compositions containing them |
| DE3434944A1 (de) | 1984-09-22 | 1986-04-03 | Basf Ag, 6700 Ludwigshafen | L-substituierte tetralinderivate, ihre herstellung und verwendung |
| FR2580277B1 (fr) | 1985-04-15 | 1988-06-10 | Oreal | Nouveaux derives naphtaleniques a action retinoique, le ur procede de preparation et compositions medicamenteuse et cosmetique les contenant |
| LU86022A1 (fr) | 1985-07-25 | 1987-02-04 | Cird | Derives aromatiques polycyliques,leur procede de preparation et leur application dans les domaines pharmaceutique et cosmetique |
| JPS62215581A (ja) | 1986-03-18 | 1987-09-22 | Koichi Shiyudo | フラボンカルボン酸誘導体 |
| FR2601670B1 (fr) | 1986-07-17 | 1988-10-07 | Cird | Nouveaux derives bicycliques aromatiques, leur procede de preparation et leur utilisation en medecine humaine et veterinaire et en cosmetique |
| US5071773A (en) | 1986-10-24 | 1991-12-10 | The Salk Institute For Biological Studies | Hormone receptor-related bioassays |
| FR2605626B1 (fr) | 1986-10-27 | 1989-06-02 | Oreal | Nouveaux derives aromatiques bicycliques, leur procede de preparation et leur utilisation en cosmetique et en medecine humaine et veterinaire |
| US5081242A (en) | 1986-12-22 | 1992-01-14 | Ortho Pharmaceutical Corporation | 6-benzoxazinyl- and 6-benzothiazinyl 2,3,4,5-tetrahydropyridazin-3-ones |
| GB8630702D0 (en) | 1986-12-23 | 1987-02-04 | Wellcome Found | Quinoline compound |
| FR2614618B1 (fr) | 1987-04-30 | 1989-07-07 | Cird | Derives heterocycliques polycycliques, leur procede de preparation et leur utilisation en medecine humaine et veterinaire |
| EP0303418A3 (de) | 1987-08-11 | 1990-11-07 | Smithkline Beecham Laboratoires Pharmaceutiques | Substituierte Indolone, verwendbar in der Behandlung von Herz- oder Asthmakrankheiten |
| LU87040A1 (fr) | 1987-11-04 | 1989-06-14 | Oreal | Esters aromatiques polycycliques d'antibiotiques macrolidiques et lincosamidiques,leur procede de preparation et compositions pharmaceutiques et cosmetiques les contenant |
| US4981784A (en) | 1987-12-02 | 1991-01-01 | The Salk Institute For Biological Studies | Retinoic acid receptor method |
| WO1989007441A1 (en) | 1988-02-10 | 1989-08-24 | The Regents Of The University Of California | 6-amino-1,2-benzopyrone antitumorigenic agents and method |
| DE3810706A1 (de) | 1988-03-25 | 1989-10-05 | Schering Ag | Substituierte cumarinderivate, verfahren zu ihrer herstellung und ihre verwendung als mittel mit herbizider wirkung |
| EP0347960B1 (de) | 1988-06-23 | 1994-07-06 | Agfa-Gevaert N.V. | Für elektrophotographische Zwecke geeignetes photoempfindliches Aufzeichnungsmaterial |
| GB8820174D0 (en) | 1988-08-25 | 1988-09-28 | Wellcome Found | Quinoline compound |
| US5108486A (en) * | 1990-02-09 | 1992-04-28 | Kanagawa Chemical Laboratory, Ltd. | Herbicidal substituted-phenyl-1,2,4-triazol-5(1H)-thiones and -ones |
| US5091528A (en) | 1990-09-12 | 1992-02-25 | Allergan, Inc. | 6- or 7- (2-imino-2-imidazolidine)-1,4-benzoxazines as α adrenergic agents |
| DE4036779A1 (de) | 1990-11-17 | 1992-05-21 | Basf Ag | Verwendung von arylpolyencarbonsaeuren und ihren derivaten als lichtschutzmittel in kosmetischen zubereitungen |
| JPH0570464A (ja) * | 1991-02-18 | 1993-03-23 | Yamanouchi Pharmaceut Co Ltd | オキサジノベンズアゾール化合物 |
| US5147844A (en) | 1991-06-14 | 1992-09-15 | Eastman Kodak Company | Mixture on cyan and yellow dyes to form a green hue for color filter array element |
| FR2683818B1 (fr) | 1991-11-14 | 1993-12-31 | Adir Cie | Nouveaux derives de 3-sulfonylamino-2-(1h)-quinoleinone, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| WO1994015902A1 (en) | 1993-01-11 | 1994-07-21 | Ligand Pharmaceuticals Inc. | Compounds having selectivity for retinoid x receptors |
| BR9306284A (pt) | 1992-04-22 | 1998-01-13 | Ligand Pharm Inc | Compostos tendo seletividade pra receptores de retinóides x |
| CA2093577C (en) | 1992-05-07 | 2006-01-03 | Michael Klaus | Alkyl or alkoxy substituted s-heterocyclic retinoids |
| AU658331B2 (en) | 1992-09-29 | 1995-04-06 | Les Laboratoires Servier | New chromene compounds having a triene side chain, process for the preparation thereof, and pharmaceutical compositions containing them |
| AU700706B2 (en) | 1992-11-25 | 1999-01-14 | Ligand Pharmaceuticals, Inc. | RXR homodimer formation and bridged bicyclic aromatic compounds and their use in modulating gene expression |
| WO1994015901A1 (en) | 1993-01-11 | 1994-07-21 | Ligand Pharmaceuticals Inc. | Compounds having selectivity for retinoid x receptors |
| US5455265A (en) | 1993-02-11 | 1995-10-03 | Allergan, Inc. | Method of treatment with compounds having selective agonist-like activity on RXR retinoid receptors |
| US5399586A (en) | 1993-03-11 | 1995-03-21 | Allergan, Inc. | Treatment of mammals afflicted with tumors with compounds having RXR retinoid receptor agonist activity |
| US5677336A (en) * | 1993-10-21 | 1997-10-14 | Ligand Pharmaceuticals Incorporated | Non-steroid androgen receptor antagonist compounds and methods |
| AU1860995A (en) | 1994-03-08 | 1995-09-25 | Takeda Chemical Industries Ltd. | Quinoline or quinazoline derivatives as anti-inflammatory agents, in particular for treating arthritis |
| FR2719041B1 (fr) | 1994-04-26 | 1996-05-31 | Cird Galderma | Nouveaux composés polyéniques, compositions pharmaceutiques et cosmétiques les contenant et utilisations. |
| CN1091092C (zh) | 1994-08-10 | 2002-09-18 | 霍夫曼-拉罗奇有限公司 | 视黄酸x-受体配位体、组合物及其用途 |
| US5977125A (en) | 1994-10-31 | 1999-11-02 | Eisai Co., Ltd. | Mono-or polyenic carboxylic acid derivatives |
| US5968908A (en) | 1994-12-19 | 1999-10-19 | American Cyanamid Company | Restricted 9-cis retinoids |
| IL116259A (en) | 1994-12-19 | 2000-07-16 | American Cyanamid Co | Analogs of 9-cis retinoic acid and their use |
| US5696130A (en) * | 1994-12-22 | 1997-12-09 | Ligand Pharmaceuticals Incorporated | Tricyclic steroid receptor modulator compounds and methods |
| WO1996019458A2 (en) | 1994-12-22 | 1996-06-27 | Ligand Pharmaceuticals Incorporated | Steroid receptor modulator compounds and methods |
| US6696459B1 (en) * | 1994-12-22 | 2004-02-24 | Ligand Pharmaceuticals Inc. | Steroid receptor modulator compounds and methods |
| US5721103A (en) | 1994-12-30 | 1998-02-24 | Ligand Pharmaceuticals Incorporated | Trienoic retinoid compounds and methods |
| JP4001913B2 (ja) | 1994-12-30 | 2007-10-31 | リガンド・ファーマシューティカルズ・インコーポレイテッド | 新規なトリエンレチノイド化合物および方法 |
| MX9710228A (es) | 1995-06-21 | 1998-03-31 | Sod Conseils Rech Applic | Nuevos analogos de camptotecina, procedimientos de preparacion, su aplicacion como medicinas y las composiciones farmaceuticas que los comprenden. |
| JP3964478B2 (ja) | 1995-06-30 | 2007-08-22 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | ヘテロ環含有カルボン酸誘導体及びそれを含有する医薬 |
| JPH11511156A (ja) * | 1995-08-11 | 1999-09-28 | スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー | ビフェニル(チオ)アミドおよびビフェニルエタン(チオ)オン誘導体、その製造方法ならびに5−ht▲下1d▼ 受容体拮抗薬としてのその使用 |
| US5776699A (en) | 1995-09-01 | 1998-07-07 | Allergan, Inc. | Method of identifying negative hormone and/or antagonist activities |
| BR9610875A (pt) | 1995-10-06 | 1999-07-13 | Ligand Pharm Inc | Modulares rxr seletivos - dimeros e processos para seu uso |
| US6017924A (en) * | 1996-06-27 | 2000-01-25 | Ligand Pharmaceuticals Incorporated | Androgen receptor modulator compounds and methods |
| AU728178B2 (en) | 1996-06-27 | 2001-01-04 | Ligand Pharmaceuticals Incorporated | Androgen receptor modulator compounds and methods |
| FR2752837B1 (fr) | 1996-09-02 | 1999-11-12 | Cird Galderma | Nouveaux composes modulateurs des recepteurs hormonaux, les compositions les comprenant et leur utilisation en therapie |
| JP2858002B2 (ja) * | 1997-01-06 | 1999-02-17 | 大塚製薬株式会社 | 医薬組成物 |
| CN1511519A (zh) | 1997-11-12 | 2004-07-14 | - | 2型t辅助细胞介导的免疫病的治疗 |
| US6001846A (en) * | 1998-02-17 | 1999-12-14 | Ligand Pharmaceuticals Incorporated | Process for the preparation of 1,2-dihydroquinolines |
| JPH11242304A (ja) * | 1998-02-26 | 1999-09-07 | Konica Corp | 熱現像感光材料 |
| WO1999043708A1 (en) | 1998-02-27 | 1999-09-02 | Novo Nordisk A/S | Glp-1 derivatives of glp-1 and exendin with protracted profile of action |
| WO1999058486A1 (en) | 1998-05-11 | 1999-11-18 | Novo Nordisk A/S | New compounds, their preparation and use |
| US6093826A (en) * | 1998-06-08 | 2000-07-25 | Ligand Pharmaceuticals Incorporated | Process for the preparation of C(5)-substituted 1,2-dihydro-5H-chromeno[3,4-f] quinolines |
| US6147224A (en) | 1998-10-01 | 2000-11-14 | Allergan Sales, Inc. | 2,4-pentadienoic acid derivatives having selective activity for retinoid X (RXR) receptors |
| WO2000053562A1 (en) | 1999-03-08 | 2000-09-14 | Basilea Pharmaceutica Ag | Retinoid antagonists and use thereof |
| AT407876B (de) * | 1999-04-30 | 2001-07-25 | Georg Dr Uray | Lumineszierende 4-trifluormethyl-2-chinolinone mit langwelliger uv-absorption und ihre verwendung |
| US6566372B1 (en) * | 1999-08-27 | 2003-05-20 | Ligand Pharmaceuticals Incorporated | Bicyclic androgen and progesterone receptor modulator compounds and methods |
| PL353792A1 (en) * | 1999-08-27 | 2003-12-01 | Ligand Pharmaceuticals Incorporatedligand Pharmaceuticals Incorporated | Androgen receptor modulator compounds and methods |
| US6667313B1 (en) * | 1999-08-27 | 2003-12-23 | Ligand Pharmaceuticals Inc. | 8-substituted-6-triflouromethyl-9-pyrido [3,2-G] quinoline compounds as androgen receptor modulators |
| US6172241B1 (en) * | 1999-10-15 | 2001-01-09 | Ligand Pharmaceuticals Incorporated | Process for the preparation of 1,2-dihydroquinolines |
| US7026484B2 (en) * | 2001-02-23 | 2006-04-11 | Ligand Pharmaceuticals Incorporated | Tricyclic androgen receptor modulator compounds and methods |
| US7214690B2 (en) * | 2001-02-23 | 2007-05-08 | Ligand Pharmaceuticals Incorporated | Tricyclic quinolinone and tricyclic quinoline androgen receptor modulator compounds and methods |
| WO2003011824A1 (en) * | 2001-07-31 | 2003-02-13 | Bristol-Myers Squibb Company | Bicyclic modulators of androgen receptor function |
-
2000
- 2000-08-25 PL PL00353792A patent/PL353792A1/xx not_active Application Discontinuation
- 2000-08-25 DE DE60027443T patent/DE60027443D1/de not_active Expired - Lifetime
- 2000-08-25 CZ CZ2002711A patent/CZ2002711A3/cs unknown
- 2000-08-25 MX MXPA02002032A patent/MXPA02002032A/es active IP Right Grant
- 2000-08-25 WO PCT/US2000/023520 patent/WO2001016139A1/en not_active Ceased
- 2000-08-25 BR BR0013597-6A patent/BR0013597A/pt not_active Application Discontinuation
- 2000-08-25 KR KR1020027002613A patent/KR20020038741A/ko not_active Withdrawn
- 2000-08-25 CN CN00814951A patent/CN1391576A/zh active Pending
- 2000-08-25 SK SK273-2002A patent/SK2732002A3/sk unknown
- 2000-08-25 HU HU0202814A patent/HUP0202814A3/hu unknown
- 2000-08-25 JP JP2001519705A patent/JP2003508402A/ja active Pending
- 2000-08-25 US US09/648,684 patent/US6462038B1/en not_active Expired - Lifetime
- 2000-08-25 CA CA002383077A patent/CA2383077A1/en not_active Abandoned
- 2000-08-25 AU AU69414/00A patent/AU778655B2/en not_active Ceased
- 2000-08-25 EP EP00957854A patent/EP1212330B1/de not_active Expired - Lifetime
- 2000-08-25 TR TR2002/00507T patent/TR200200507T2/xx unknown
- 2000-08-25 AT AT00957854T patent/ATE323709T1/de not_active IP Right Cessation
- 2000-08-25 IL IL14804500A patent/IL148045A0/xx unknown
-
2002
- 2002-02-06 ZA ZA200201056A patent/ZA200201056B/xx unknown
- 2002-02-25 NO NO20020913A patent/NO20020913L/no unknown
- 2002-03-25 BG BG106550A patent/BG106550A/xx unknown
- 2002-09-09 US US10/238,363 patent/US20030186970A1/en not_active Abandoned
-
2006
- 2006-01-25 US US11/340,282 patent/US20070167445A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU778655B2 (en) | 2004-12-16 |
| NO20020913D0 (no) | 2002-02-25 |
| US20070167445A1 (en) | 2007-07-19 |
| EP1212330A1 (de) | 2002-06-12 |
| US20030186970A1 (en) | 2003-10-02 |
| DE60027443D1 (de) | 2006-05-24 |
| IL148045A0 (en) | 2002-09-12 |
| CN1391576A (zh) | 2003-01-15 |
| NO20020913L (no) | 2002-04-29 |
| TR200200507T2 (tr) | 2002-10-21 |
| WO2001016139A1 (en) | 2001-03-08 |
| PL353792A1 (en) | 2003-12-01 |
| KR20020038741A (ko) | 2002-05-23 |
| BR0013597A (pt) | 2002-07-16 |
| HUP0202814A3 (en) | 2003-11-28 |
| CZ2002711A3 (cs) | 2003-11-12 |
| EP1212330B1 (de) | 2006-04-19 |
| HUP0202814A2 (hu) | 2002-12-28 |
| SK2732002A3 (en) | 2002-07-02 |
| JP2003508402A (ja) | 2003-03-04 |
| CA2383077A1 (en) | 2001-03-08 |
| WO2001016139A9 (en) | 2002-09-19 |
| US6462038B1 (en) | 2002-10-08 |
| ZA200201056B (en) | 2003-07-30 |
| BG106550A (en) | 2002-10-31 |
| AU6941400A (en) | 2001-03-26 |
| MXPA02002032A (es) | 2003-05-19 |
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| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |