ATE32720T1 - 1,3,4,6,7,11b-hexahydro-7-aryl-2h-pyrazino(2,1alpha)isochinoline als zwischenprodukte und als pharmazeutische verbindungen verwendbar und methode zu ihrer herstellung. - Google Patents

1,3,4,6,7,11b-hexahydro-7-aryl-2h-pyrazino(2,1alpha)isochinoline als zwischenprodukte und als pharmazeutische verbindungen verwendbar und methode zu ihrer herstellung.

Info

Publication number: ATE32720T1
Authority: AT; Austria
Prior art keywords: aryl; isochinolines; 1alpha; pyrazino; hexahydro
Prior art date: 1982-10-18

Application number

AT83110044T

Other languages

English (en)

Inventor

Ronald C Griffith

Original Assignee

Pennwalt Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1982-10-18

Filing date

1983-10-07

Publication date

1988-03-15

1983-10-07 Application filed by Pennwalt Corp filed Critical Pennwalt Corp

1988-03-15 Application granted granted Critical

1988-03-15 Publication of ATE32720T1 publication Critical patent/ATE32720T1/de

Links

150000001875 compounds Chemical class 0.000 title abstract 2
239000013067 intermediate product Substances 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 2
-1 aralkanoyl Chemical group 0.000 abstract 2
150000002431 hydrogen Chemical group 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
125000002252 acyl group Chemical group 0.000 abstract 1
125000004423 acyloxy group Chemical group 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000003282 alkyl amino group Chemical group 0.000 abstract 1
125000004103 aminoalkyl group Chemical group 0.000 abstract 1
230000001430 anti-depressive effect Effects 0.000 abstract 1
230000001387 anti-histamine Effects 0.000 abstract 1
239000000935 antidepressant agent Substances 0.000 abstract 1
229940005513 antidepressants Drugs 0.000 abstract 1
239000000739 antihistaminic agent Substances 0.000 abstract 1
125000003435 aroyl group Chemical group 0.000 abstract 1
125000003710 aryl alkyl group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
125000001589 carboacyl group Chemical group 0.000 abstract 1
230000001713 cholinergic effect Effects 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT83110044T 1982-10-18 1983-10-07 1,3,4,6,7,11b-hexahydro-7-aryl-2h-pyrazino(2,1alpha)isochinoline als zwischenprodukte und als pharmazeutische verbindungen verwendbar und methode zu ihrer herstellung. ATE32720T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US06/435,132 US4517187A (en)	1982-10-18	1982-10-18	1,3,4,6,7-11b-Hexahydro-7-phenyl-2H-pyrazino[2,1-a]isoquinolines methods of preparation, and use as antidepressants
EP83110044A EP0107825B1 (de)	1982-10-18	1983-10-07	1,3,4,6,7,11b-Hexahydro-7-aryl-2H-pyrazino(2,1-alpha)isochinoline als Zwischenprodukte und als pharmazeutische Verbindungen verwendbar und Methode zu ihrer Herstellung

Publications (1)

Publication Number	Publication Date
ATE32720T1 true ATE32720T1 (de)	1988-03-15

Family

ID=23727113

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT83110044T ATE32720T1 (de)	1982-10-18	1983-10-07	1,3,4,6,7,11b-hexahydro-7-aryl-2h-pyrazino(2,1alpha)isochinoline als zwischenprodukte und als pharmazeutische verbindungen verwendbar und methode zu ihrer herstellung.

Country Status (14)

Country	Link
US (1)	US4517187A (de)
EP (1)	EP0107825B1 (de)
JP (1)	JPS5989680A (de)
KR (1)	KR870000622B1 (de)
AT (1)	ATE32720T1 (de)
AU (1)	AU1955583A (de)
CA (1)	CA1219874A (de)
DE (1)	DE3375784D1 (de)
DK (1)	DK477783A (de)
FI (1)	FI833784A7 (de)
IL (1)	IL69586A (de)
NO (1)	NO833778L (de)
NZ (1)	NZ205425A (de)
ZA (1)	ZA836448B (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4782058A (en) *	1985-04-26	1988-11-01	Pennwalt Corporation	1,3,4,6,7,11b-Hexahydro-6-phenyl-2H-pyrazino-(2,1-a)isoquinolines, for anti-histamine or anti-depression treatment
US4678791A (en) *	1985-05-07	1987-07-07	Pennwalt Corporation	6-phenyl-1,2-3,4,4a,5-6,10b-octahydrobenz(h)isoquinolines useful for treating depression
US4772705A (en) *	1985-07-25	1988-09-20	Pennwalt Corporation	Processes for the preparation of trans 1,3,4,6,7,11b-hexahydro-7-aryl-2H-pyrazinol[2,1-a]isoquinolines
MX19222A (es) *	1989-01-23	1993-12-01	Pfizer	Agentes ansioliticos bis-aza-biciclicos
DE69524241T2 (de) *	1994-09-30	2002-06-13	Pfizer Inc., New York	2,7,-substituierte octahydro-1h-pyrido[1,2-a]pyrazin derivate
MX2016016190A (es) *	2014-08-27	2017-03-08	Hoffmann La Roche	Derivados de pirazino[2,1-a]isoquinolina sustituida para el tratamiento de trastornos del sistema nervioso central.
KR102622152B1 (ko) *	2019-10-31	2024-01-08	홀로스메딕 주식회사	신규한 화합물 및 이를 포함하는 암 예방 또는 치료용 약학 조성물

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1050901A (de) *	1964-02-06
US3684813A (en) *	1970-04-08	1972-08-15	Sterling Drug Inc	Hexahydropyrazinoisoquinolines
DE2441261A1 (de) *	1974-08-28	1976-03-18	Merck Patent Gmbh	Ringsubstituierte pyrazino-isochinolin-derivat und verfahren zu ihrer herstellung
US4162319A (en) *	1974-08-28	1979-07-24	Merck Patent Gesellschaft Mit Beschrankter Haftung	Ring substituted pyrazino-isoquinoline derivatives and their preparation

1982
- 1982-10-18 US US06/435,132 patent/US4517187A/en not_active Expired - Fee Related
1983
- 1983-08-26 CA CA000435430A patent/CA1219874A/en not_active Expired
- 1983-08-29 IL IL69586A patent/IL69586A/xx unknown
- 1983-08-30 NZ NZ205425A patent/NZ205425A/en unknown
- 1983-08-31 ZA ZA836448A patent/ZA836448B/xx unknown
- 1983-09-26 AU AU19555/83A patent/AU1955583A/en not_active Abandoned
- 1983-10-07 AT AT83110044T patent/ATE32720T1/de not_active IP Right Cessation
- 1983-10-07 EP EP83110044A patent/EP0107825B1/de not_active Expired
- 1983-10-07 DE DE8383110044T patent/DE3375784D1/de not_active Expired
- 1983-10-13 JP JP58190025A patent/JPS5989680A/ja active Pending
- 1983-10-17 NO NO833778A patent/NO833778L/no unknown
- 1983-10-17 DK DK477783A patent/DK477783A/da not_active Application Discontinuation
- 1983-10-17 FI FI833784A patent/FI833784A7/fi not_active Application Discontinuation
- 1983-10-18 KR KR1019830004928A patent/KR870000622B1/ko not_active Expired

Also Published As

Publication number	Publication date
EP0107825A1 (de)	1984-05-09
IL69586A0 (en)	1983-11-30
KR870000622B1 (ko)	1987-03-26
DE3375784D1 (en)	1988-04-07
ZA836448B (en)	1984-07-25
EP0107825B1 (de)	1988-03-02
IL69586A (en)	1986-07-31
AU1955583A (en)	1984-05-03
KR840006656A (ko)	1984-12-01
US4517187A (en)	1985-05-14
NO833778L (no)	1984-04-24
NZ205425A (en)	1986-05-09
DK477783D0 (da)	1983-10-17
FI833784A0 (fi)	1983-10-17
FI833784A7 (fi)	1984-04-19
JPS5989680A (ja)	1984-05-23
DK477783A (da)	1984-04-19
CA1219874A (en)	1987-03-31

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Legal Events

Date	Code	Title	Description
1988-06-15	UEP	Publication of translation of european patent specification
1990-07-15	REN	Ceased due to non-payment of the annual fee