NO833778L - 1,3,4,6,7,11b-heksahydro-7-aryl-2h-pyrazino(2,1-alfa)isokinoliner og fremgangsmaate ved fremstilling derav - Google Patents

1,3,4,6,7,11b-heksahydro-7-aryl-2h-pyrazino(2,1-alfa)isokinoliner og fremgangsmaate ved fremstilling derav

Info

Publication number
NO833778L
NO833778L NO833778A NO833778A NO833778L NO 833778 L NO833778 L NO 833778L NO 833778 A NO833778 A NO 833778A NO 833778 A NO833778 A NO 833778A NO 833778 L NO833778 L NO 833778L
Authority
NO
Norway
Prior art keywords
pyrazino
hexahydro
cis
phenyl
hydrogen
Prior art date
Application number
NO833778A
Other languages
English (en)
Norwegian (no)
Inventor
Ronald C Griffith
Original Assignee
Pennwalt Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pennwalt Corp filed Critical Pennwalt Corp
Publication of NO833778L publication Critical patent/NO833778L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
NO833778A 1982-10-18 1983-10-17 1,3,4,6,7,11b-heksahydro-7-aryl-2h-pyrazino(2,1-alfa)isokinoliner og fremgangsmaate ved fremstilling derav NO833778L (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/435,132 US4517187A (en) 1982-10-18 1982-10-18 1,3,4,6,7-11b-Hexahydro-7-phenyl-2H-pyrazino[2,1-a]isoquinolines methods of preparation, and use as antidepressants

Publications (1)

Publication Number Publication Date
NO833778L true NO833778L (no) 1984-04-24

Family

ID=23727113

Family Applications (1)

Application Number Title Priority Date Filing Date
NO833778A NO833778L (no) 1982-10-18 1983-10-17 1,3,4,6,7,11b-heksahydro-7-aryl-2h-pyrazino(2,1-alfa)isokinoliner og fremgangsmaate ved fremstilling derav

Country Status (14)

Country Link
US (1) US4517187A (de)
EP (1) EP0107825B1 (de)
JP (1) JPS5989680A (de)
KR (1) KR870000622B1 (de)
AT (1) ATE32720T1 (de)
AU (1) AU1955583A (de)
CA (1) CA1219874A (de)
DE (1) DE3375784D1 (de)
DK (1) DK477783A (de)
FI (1) FI833784A7 (de)
IL (1) IL69586A (de)
NO (1) NO833778L (de)
NZ (1) NZ205425A (de)
ZA (1) ZA836448B (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4782058A (en) * 1985-04-26 1988-11-01 Pennwalt Corporation 1,3,4,6,7,11b-Hexahydro-6-phenyl-2H-pyrazino-(2,1-a)isoquinolines, for anti-histamine or anti-depression treatment
US4678791A (en) * 1985-05-07 1987-07-07 Pennwalt Corporation 6-phenyl-1,2-3,4,4a,5-6,10b-octahydrobenz(h)isoquinolines useful for treating depression
US4772705A (en) * 1985-07-25 1988-09-20 Pennwalt Corporation Processes for the preparation of trans 1,3,4,6,7,11b-hexahydro-7-aryl-2H-pyrazinol[2,1-a]isoquinolines
MX19222A (es) * 1989-01-23 1993-12-01 Pfizer Agentes ansioliticos bis-aza-biciclicos
PL180899B1 (pl) * 1994-09-30 2001-04-30 Pfizer Nowe pochodne 2,7-podstawionej oktahydro-1H-pirydo[1,2-a]pirazyny i środek farmaceutyczny je zawierający
CN106470994B (zh) * 2014-08-27 2019-09-24 豪夫迈·罗氏有限公司 用于治疗cns疾病的取代的吡嗪并[2,1-a]异喹啉衍生物
BR112022007998A2 (pt) * 2019-10-31 2022-07-05 Holosmedic Novo composto e composição farmacêutica para prevenção ou tratamento de câncer que compreende os mesmos

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1050901A (de) * 1964-02-06
US3684813A (en) * 1970-04-08 1972-08-15 Sterling Drug Inc Hexahydropyrazinoisoquinolines
US4162319A (en) * 1974-08-28 1979-07-24 Merck Patent Gesellschaft Mit Beschrankter Haftung Ring substituted pyrazino-isoquinoline derivatives and their preparation
DE2441261A1 (de) * 1974-08-28 1976-03-18 Merck Patent Gmbh Ringsubstituierte pyrazino-isochinolin-derivat und verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
JPS5989680A (ja) 1984-05-23
DE3375784D1 (en) 1988-04-07
EP0107825B1 (de) 1988-03-02
EP0107825A1 (de) 1984-05-09
ATE32720T1 (de) 1988-03-15
AU1955583A (en) 1984-05-03
ZA836448B (en) 1984-07-25
NZ205425A (en) 1986-05-09
DK477783D0 (da) 1983-10-17
FI833784A7 (fi) 1984-04-19
DK477783A (da) 1984-04-19
KR870000622B1 (ko) 1987-03-26
KR840006656A (ko) 1984-12-01
US4517187A (en) 1985-05-14
CA1219874A (en) 1987-03-31
FI833784A0 (fi) 1983-10-17
IL69586A0 (en) 1983-11-30
IL69586A (en) 1986-07-31

Similar Documents

Publication Publication Date Title
NO145382B (no) Analogifremgangsmaate til fremstilling av terapeutisk aktive 3-amino-indazolkarboksylsyrederivater
JPS6012350B2 (ja) 新規アリ−ルピペリジン誘導体の製造方法
Kim et al. Deoxygenative Amination of Azine-N-oxides with Acyl Azides via [3+ 2] Cycloaddition
UA100192C2 (en) 1-(arylsulfonyl)-4-(piperazin-1-yl)-1h-benzimidazoles as 5-hydroxytryptamine-6 ligands
EP1377578B1 (de) Beta-carbolinderivate und deren pharmazeutische verwendung gegen depression und angst
EP1446399B1 (de) Piperazin derivate mit sst1 antagonistischer wirkung
Zhang et al. Palladium Catalyzed Annulation of o-Iodo-Anilines with Propargyl Alcohols: Synthesis of Substituted Quinolines
GB2240104A (en) Arylvinylamide derivatives
US4517187A (en) 1,3,4,6,7-11b-Hexahydro-7-phenyl-2H-pyrazino[2,1-a]isoquinolines methods of preparation, and use as antidepressants
US6075018A (en) 1-[2-(substituted vinyl)]-3,4-dihydro-4-dihydro-5H-2,3-benzodiazepine derivatives
CA2166700C (en) Heterocyclic amines having central nervous system activity
US4649198A (en) Imidazo(1,5-a)pyrimidine derivatives and their use as antimycotic agents
NO783239L (no) Nye 7-azabenzimidazoler med basiske sidekjeder
Okuda et al. Polycyclic N-Heterocyclic Compounds. Part 63: Improved Synthesis of 5-Amino-1, 2-dihydrofuro [2, 3-c] isoquinolines via Truce–Smiles Rearrangement and Subsequent Formation to Furo [2, 3-c] isoquinoline
CA1107287A (en) Antidepressant carbazoles and intermediates thereto
US4518779A (en) 1,2,3,4-Tetrahydro-1-aminomethyl-4-phenyl isoquinolines
US4167638A (en) Process for production of 8-NHR quinolines
PL186055B1 (pl) Sposób wytwarzania pochodnych chinoliny i pochodne chinoliny
NZ205030A (en) Optically pure isomers of trans-1-n-propyl-6oxodecahydroquinoline
CN110172058B (zh) 7-氮杂螺[5.6]十二烷-10-酮类化合物及其制备方法与用途
NO792275L (no) Fremgangsmaate for fremstilling av farmakologisk aktive pyrazolo-pyridinderivater
Omar et al. Cyclization of 2, 4‐dinitronaphth‐1‐yl amino acids and their analogues to naphthimindazol‐N‐oxides: Kinetics and mechanism
KR20000049239A (ko) Ｎ-[2-(디메틸아미노)에틸]아크리딘-4-카복스아미드의 제조 방법
King et al. Antiplasmodial action and chemical constitution IX. Carbinolamines derived from 6: 7-dimethylquinoline
Ishii et al. Polymerisation of indole. Part 2. A new indole trimer