NO833778L - 1,3,4,6,7,11b-heksahydro-7-aryl-2h-pyrazino(2,1-alfa)isokinoliner og fremgangsmaate ved fremstilling derav - Google Patents

1,3,4,6,7,11b-heksahydro-7-aryl-2h-pyrazino(2,1-alfa)isokinoliner og fremgangsmaate ved fremstilling derav

Info

Publication number
NO833778L
NO833778L NO833778A NO833778A NO833778L NO 833778 L NO833778 L NO 833778L NO 833778 A NO833778 A NO 833778A NO 833778 A NO833778 A NO 833778A NO 833778 L NO833778 L NO 833778L
Authority
NO
Norway
Prior art keywords
pyrazino
hexahydro
cis
phenyl
hydrogen
Prior art date
Application number
NO833778A
Other languages
English (en)
Norwegian (no)
Inventor
Ronald C Griffith
Original Assignee
Pennwalt Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pennwalt Corp filed Critical Pennwalt Corp
Publication of NO833778L publication Critical patent/NO833778L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
NO833778A 1982-10-18 1983-10-17 1,3,4,6,7,11b-heksahydro-7-aryl-2h-pyrazino(2,1-alfa)isokinoliner og fremgangsmaate ved fremstilling derav NO833778L (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/435,132 US4517187A (en) 1982-10-18 1982-10-18 1,3,4,6,7-11b-Hexahydro-7-phenyl-2H-pyrazino[2,1-a]isoquinolines methods of preparation, and use as antidepressants

Publications (1)

Publication Number Publication Date
NO833778L true NO833778L (no) 1984-04-24

Family

ID=23727113

Family Applications (1)

Application Number Title Priority Date Filing Date
NO833778A NO833778L (no) 1982-10-18 1983-10-17 1,3,4,6,7,11b-heksahydro-7-aryl-2h-pyrazino(2,1-alfa)isokinoliner og fremgangsmaate ved fremstilling derav

Country Status (14)

Country Link
US (1) US4517187A (de)
EP (1) EP0107825B1 (de)
JP (1) JPS5989680A (de)
KR (1) KR870000622B1 (de)
AT (1) ATE32720T1 (de)
AU (1) AU1955583A (de)
CA (1) CA1219874A (de)
DE (1) DE3375784D1 (de)
DK (1) DK477783A (de)
FI (1) FI833784A7 (de)
IL (1) IL69586A (de)
NO (1) NO833778L (de)
NZ (1) NZ205425A (de)
ZA (1) ZA836448B (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4782058A (en) * 1985-04-26 1988-11-01 Pennwalt Corporation 1,3,4,6,7,11b-Hexahydro-6-phenyl-2H-pyrazino-(2,1-a)isoquinolines, for anti-histamine or anti-depression treatment
US4678791A (en) * 1985-05-07 1987-07-07 Pennwalt Corporation 6-phenyl-1,2-3,4,4a,5-6,10b-octahydrobenz(h)isoquinolines useful for treating depression
US4772705A (en) * 1985-07-25 1988-09-20 Pennwalt Corporation Processes for the preparation of trans 1,3,4,6,7,11b-hexahydro-7-aryl-2H-pyrazinol[2,1-a]isoquinolines
MX19222A (es) * 1989-01-23 1993-12-01 Pfizer Agentes ansioliticos bis-aza-biciclicos
DE69524241T2 (de) * 1994-09-30 2002-06-13 Pfizer Inc., New York 2,7,-substituierte octahydro-1h-pyrido[1,2-a]pyrazin derivate
MX2016016190A (es) * 2014-08-27 2017-03-08 Hoffmann La Roche Derivados de pirazino[2,1-a]isoquinolina sustituida para el tratamiento de trastornos del sistema nervioso central.
KR102622152B1 (ko) * 2019-10-31 2024-01-08 홀로스메딕 주식회사 신규한 화합물 및 이를 포함하는 암 예방 또는 치료용 약학 조성물

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1050901A (de) * 1964-02-06
US3684813A (en) * 1970-04-08 1972-08-15 Sterling Drug Inc Hexahydropyrazinoisoquinolines
DE2441261A1 (de) * 1974-08-28 1976-03-18 Merck Patent Gmbh Ringsubstituierte pyrazino-isochinolin-derivat und verfahren zu ihrer herstellung
US4162319A (en) * 1974-08-28 1979-07-24 Merck Patent Gesellschaft Mit Beschrankter Haftung Ring substituted pyrazino-isoquinoline derivatives and their preparation

Also Published As

Publication number Publication date
EP0107825A1 (de) 1984-05-09
IL69586A0 (en) 1983-11-30
KR870000622B1 (ko) 1987-03-26
DE3375784D1 (en) 1988-04-07
ZA836448B (en) 1984-07-25
ATE32720T1 (de) 1988-03-15
EP0107825B1 (de) 1988-03-02
IL69586A (en) 1986-07-31
AU1955583A (en) 1984-05-03
KR840006656A (ko) 1984-12-01
US4517187A (en) 1985-05-14
NZ205425A (en) 1986-05-09
DK477783D0 (da) 1983-10-17
FI833784A0 (fi) 1983-10-17
FI833784A7 (fi) 1984-04-19
JPS5989680A (ja) 1984-05-23
DK477783A (da) 1984-04-19
CA1219874A (en) 1987-03-31

Similar Documents

Publication Publication Date Title
NO145382B (no) Analogifremgangsmaate til fremstilling av terapeutisk aktive 3-amino-indazolkarboksylsyrederivater
JPS6012350B2 (ja) 新規アリ−ルピペリジン誘導体の製造方法
Kim et al. Deoxygenative Amination of Azine-N-oxides with Acyl Azides via [3+ 2] Cycloaddition
EP1377578B1 (de) Beta-carbolinderivate und deren pharmazeutische verwendung gegen depression und angst
EP1446399B1 (de) Piperazin derivate mit sst1 antagonistischer wirkung
Zhang et al. Palladium Catalyzed Annulation of o-Iodo-Anilines with Propargyl Alcohols: Synthesis of Substituted Quinolines
NO833778L (no) 1,3,4,6,7,11b-heksahydro-7-aryl-2h-pyrazino(2,1-alfa)isokinoliner og fremgangsmaate ved fremstilling derav
GB2240104A (en) Arylvinylamide derivatives
US6075018A (en) 1-[2-(substituted vinyl)]-3,4-dihydro-4-dihydro-5H-2,3-benzodiazepine derivatives
CA2166700C (en) Heterocyclic amines having central nervous system activity
US4649198A (en) Imidazo(1,5-a)pyrimidine derivatives and their use as antimycotic agents
NO783239L (no) Nye 7-azabenzimidazoler med basiske sidekjeder
Okuda et al. Polycyclic N-Heterocyclic Compounds. Part 63: Improved Synthesis of 5-Amino-1, 2-dihydrofuro [2, 3-c] isoquinolines via Truce–Smiles Rearrangement and Subsequent Formation to Furo [2, 3-c] isoquinoline
EP0260642A2 (de) Thiazolo [f]-kondensierte Hexahydrochinolin Derivate, als dopaminergische Mittel
US4518779A (en) 1,2,3,4-Tetrahydro-1-aminomethyl-4-phenyl isoquinolines
US4167638A (en) Process for production of 8-NHR quinolines
PL186055B1 (pl) Sposób wytwarzania pochodnych chinoliny i pochodne chinoliny
RU2178785C2 (ru) Способ получения n-[2-(диметиламино)-этил]акридин-4-карбоксамида и его производных
NO792275L (no) Fremgangsmaate for fremstilling av farmakologisk aktive pyrazolo-pyridinderivater
Omar et al. Cyclization of 2, 4‐dinitronaphth‐1‐yl amino acids and their analogues to naphthimindazol‐N‐oxides: Kinetics and mechanism
King et al. Antiplasmodial action and chemical constitution IX. Carbinolamines derived from 6: 7-dimethylquinoline
Ishii et al. Polymerisation of indole. Part 2. A new indole trimer
US5512566A (en) Tricyclic compounds having affinity for the 5-HT1A receptor
CA1153371A (en) Process for the preparation of 9-hydrazono- 6,7,8,9-tetrahydro-4h-pyro[1,2-alpyrimidine -4-one compounds, the salts and hydrates thereof, certain representatives of the compound prepared and pharmaceutical compositions containing them
KR20010075326A (ko) 일산화질소 생성효소 억제제로서아미노알킬-3,4-디하이드로퀴놀린 유도체