ATE328281T1 - Methode zur diagnose von abnormalem knochenstoffwechsel - Google Patents

Methode zur diagnose von abnormalem knochenstoffwechsel

Info

Publication number
ATE328281T1
ATE328281T1 AT98935306T AT98935306T ATE328281T1 AT E328281 T1 ATE328281 T1 AT E328281T1 AT 98935306 T AT98935306 T AT 98935306T AT 98935306 T AT98935306 T AT 98935306T AT E328281 T1 ATE328281 T1 AT E328281T1
Authority
AT
Austria
Prior art keywords
ocif
antibodies recognizing
arthrosis
concentration
monoclonal antibodies
Prior art date
Application number
AT98935306T
Other languages
English (en)
Inventor
Kazuki Yano
Fumie Kobayashi
Masaaki Goto
Naohiro Washida
Eisuke Tsuda
Kanji Higashio
Yoshiji Yamada
Original Assignee
Sankyo Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co filed Critical Sankyo Co
Application granted granted Critical
Publication of ATE328281T1 publication Critical patent/ATE328281T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/10—Musculoskeletal or connective tissue disorders
    • G01N2800/108—Osteoporosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/811—Test for named disease, body condition or organ function
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/808—Materials and products related to genetic engineering or hybrid or fused cell technology, e.g. hybridoma, monoclonal products
    • Y10S530/809—Fused cells, e.g. hybridoma

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Wood Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Food Science & Technology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Apparatus For Radiation Diagnosis (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
AT98935306T 1997-09-24 1998-07-31 Methode zur diagnose von abnormalem knochenstoffwechsel ATE328281T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP27647597 1997-09-24

Publications (1)

Publication Number Publication Date
ATE328281T1 true ATE328281T1 (de) 2006-06-15

Family

ID=17569976

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98935306T ATE328281T1 (de) 1997-09-24 1998-07-31 Methode zur diagnose von abnormalem knochenstoffwechsel

Country Status (16)

Country Link
US (2) US6693175B2 (de)
EP (1) EP0974671B1 (de)
JP (1) JP4268684B2 (de)
KR (1) KR100547395B1 (de)
CN (1) CN1183159C (de)
AT (1) ATE328281T1 (de)
AU (1) AU739304B2 (de)
CA (1) CA2269114A1 (de)
DE (1) DE69834719D1 (de)
HU (1) HUP0002062A3 (de)
IL (1) IL129535A (de)
NO (1) NO992472D0 (de)
NZ (1) NZ335759A (de)
RU (1) RU2203497C2 (de)
WO (1) WO1999015691A1 (de)
ZA (1) ZA986974B (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL117175A (en) * 1995-02-20 2005-11-20 Sankyo Co Osteoclastogenesis inhibitory factor protein
TR200101146T2 (tr) 1998-10-28 2001-09-21 Sankyo Co., Ltd. Kemik-patobolizmasını tedavi edici madde.
JP3709332B2 (ja) * 2000-09-14 2005-10-26 株式会社エーシーバイオテクノロジーズ 骨粗鬆症の診断および／または骨粗鬆症骨折リスクの予測の方法
WO2002062990A1 (fr) * 2001-02-07 2002-08-15 Sankyo Company, Limited Anticorps et utilisation de cet anticorps
WO2002079256A1 (fr) * 2001-03-26 2002-10-10 Sankyo Company, Limited Anticorps et son utilisation
ES2337716T3 (es) * 2001-04-03 2010-04-28 Societe Des Produits Nestle S.A. Osteoprotegerina en la leche.
EP1270015A3 (de) * 2001-06-29 2004-02-25 Sankyo Company Limited Ein Komplex enthaltend OCIF und einem Polysaccharid
WO2003074084A1 (en) * 2002-03-01 2003-09-12 Sankyo Company, Limited A pharmaceutical composition
US7279451B2 (en) 2002-10-25 2007-10-09 Honeywell International Inc. Compositions containing fluorine substituted olefins
AU2002343870A1 (en) * 2002-11-07 2004-06-07 Kumamoto Technology And Industry Foundation Transgenic mammal carrying ganp and utilization thereof
KR100545064B1 (ko) * 2003-05-26 2006-01-24 김현기 인간 원암단백질에 특이적인 항체를 포함하는 간경변증진단 키트
RU2261661C1 (ru) * 2004-02-11 2005-10-10 Белых Елена Викторовна Способ прогнозирования переломов кости у женщин, больных ревматоидным артритом
RU2268655C2 (ru) * 2004-03-09 2006-01-27 Государственное учреждение "Нижегородский научно-исследовательский институт гигиены и профпатологии Министерства здравоохранения Российской Федерации" Способ оценки риска развития аллергодерматозов
RU2271007C2 (ru) * 2004-04-28 2006-02-27 Дмитрий Владимирович Пешехонов Способ исследования сыворотки крови для фармакологической коррекции при остеопорозе
KR101414064B1 (ko) * 2006-05-17 2014-07-01 더 리서치 파운데이션 포 더 스테이트 유니버시티 오브 뉴욕 세포 배양액 중의 세포의 운명에 영향을 미치는 방법
RU2358655C2 (ru) * 2007-08-20 2009-06-20 Федеральное государственное учреждение "Уральский научно-исследовательский институт травматологии и ортопедии им. В.Д. Чаклина" Федерального агентства по высокотехнологичной медицинской помощи" Способ диагностики иммобилизационного остеопороза
RU2429476C1 (ru) * 2010-04-22 2011-09-20 Государственное учреждение Московский областной научно-исследовательский клинический институт им. М.Ф. Владимирского (ГУ МОНИКИ им. М.Ф. Владимирского) Способ диагностики артроза
WO2012051495A2 (en) 2010-10-15 2012-04-19 The Research Foundation Of State University Of New York Compositions and methods for enhancing the biological response to chemical agents and physical stimuli
RU2524616C1 (ru) * 2013-01-21 2014-07-27 Государственное бюджетное образовательное учреждение высшего профессионального образования "Владивостокский государственный медицинский университет" Министерства здравоохранения Российской Федерации (ГОУ ВПО ВГМУ Минздрава России) Способ диагностики ранней стадии ревматоидного артрита
GB201302257D0 (en) 2013-02-08 2013-03-27 Nobel Biocare Services Ag Method for measuring bone loss rate
CN106405064B (zh) * 2016-08-30 2018-10-26 嘉兴行健生物科技有限公司 一种40岁以上女性骨转换率的评估方法
CN109540818A (zh) * 2018-12-21 2019-03-29 云南农业大学 一种基于钙、磷血液生化标记选育武定鸡的方法
CN113621060B (zh) * 2020-05-07 2023-07-04 浙江瑞硕生物技术有限公司 一种opg抗体对及其应用

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4179337A (en) 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
US4444879A (en) * 1981-01-29 1984-04-24 Science Research Center, Inc. Immunoassay with article having support film and immunological counterpart of analyte
WO1990004417A1 (en) * 1988-10-24 1990-05-03 Bruce Caterson Methods of and compositions for diagnosing, monitoring and treating the early stages of osteoarthritis
CA2071912C (en) 1990-11-30 2002-10-15 Hanne Bentz Use of a bone morphogenetic protein in synergistic combination with tgf-beta for bone repair
US5118667A (en) 1991-05-03 1992-06-02 Celtrix Pharmaceuticals, Inc. Bone growth factors and inhibitors of bone resorption for promoting bone formation
CA2068389A1 (en) 1991-05-13 1992-11-14 Masahiko Sato Method for inhibiting bone resorption
MX9204303A (es) 1991-07-23 1993-11-01 Rhone Poulenc Rorer Int Factor regulador del crecimiento de osteoclasto.
US5366859A (en) * 1991-10-31 1994-11-22 Mitsubishi Petrochemical Co., Ltd. Radioimmunoassay method
US5447851B1 (en) 1992-04-02 1999-07-06 Univ Texas System Board Of Dna encoding a chimeric polypeptide comprising the extracellular domain of tnf receptor fused to igg vectors and host cells
US5427954A (en) * 1992-04-29 1995-06-27 Shriner's Hospitals For Crippled Children Compositions and methods for detection and treatment of human osteoarthritis
RU2046600C1 (ru) * 1992-07-28 1995-10-27 Саратовский научно-исследовательский институт травматологии и ортопедии Способ диагностики травматических повреждений тазобедренного сустава
US5578569A (en) 1993-03-12 1996-11-26 Tam; Cherk S. Method of increasing bone growth
JPH09502614A (ja) 1993-09-14 1997-03-18 メルク エンド カンパニー インコーポレーテッド 新規ヒト蛋白質チロシンホスファターゼをコードするｃＤＮＡ
WO1996000240A1 (en) * 1994-06-27 1996-01-04 Snow Brand Milk Products Co., Ltd. Novel protein and process for producing the same
EP0727211A1 (de) 1995-02-10 1996-08-21 Smithkline Beecham Corporation Verwendung von src SH2-spezifische Verbindungen zur Behandlung von Knochenresorptionserkrankungen
IL117175A (en) * 1995-02-20 2005-11-20 Sankyo Co Osteoclastogenesis inhibitory factor protein
WO1996028546A1 (en) 1995-03-15 1996-09-19 Human Genome Sciences, Inc. Human tumor necrosis factor receptor
AU6090896A (en) * 1995-06-07 1997-01-15 Osteosa Inc. Osteoclast growth regulatory factor
WO1997000317A1 (en) 1995-06-07 1997-01-03 Osteosa Inc. Osteoclast growth regulatory factor
US6613544B1 (en) * 1995-12-22 2003-09-02 Amgen Inc. Osteoprotegerin
US6369027B1 (en) * 1995-12-22 2002-04-09 Amgen Inc. Osteoprotegerin
JPH1057071A (ja) 1996-08-19 1998-03-03 Snow Brand Milk Prod Co Ltd 新規ｄｎａ及びそれを用いた蛋白質の製造方法
US5830850A (en) * 1996-08-28 1998-11-03 Mount Sinai School Of Medicine Of The City Of New York Methods for the treatment of bone resorption disorders, including osteoporosis
WO1998028423A2 (en) 1996-12-20 1998-07-02 Board Of Regents, The University Of Texas System Compositions and methods of use for osteoclast inhibitory factors
EP2003203A1 (de) 1996-12-23 2008-12-17 Immunex Corporation Ligand für den Rezeptorauslöser von NF-kappa b, wobei der Ligand Mitglied der TNF-Überfamilie ist
US5843678A (en) 1997-04-16 1998-12-01 Amgen Inc. Osteoprotegerin binding proteins

Also Published As

Publication number Publication date
KR20000068916A (ko) 2000-11-25
EP0974671A4 (de) 2004-10-22
EP0974671A1 (de) 2000-01-26
CA2269114A1 (en) 1999-03-24
NO992472L (no) 1999-05-21
IL129535A0 (en) 2000-02-29
KR100547395B1 (ko) 2006-02-01
EP0974671A8 (de) 2002-07-03
NO992472D0 (no) 1999-05-21
US6693175B2 (en) 2004-02-17
CN1183159C (zh) 2005-01-05
US20040033533A1 (en) 2004-02-19
US6998242B2 (en) 2006-02-14
HUP0002062A2 (hu) 2000-10-28
IL129535A (en) 2003-07-06
AU739304B2 (en) 2001-10-11
CN1239515A (zh) 1999-12-22
US20020004207A1 (en) 2002-01-10
EP0974671B1 (de) 2006-05-31
AU8461798A (en) 1999-04-12
JP4268684B2 (ja) 2009-05-27
NZ335759A (en) 2002-02-01
HUP0002062A3 (en) 2002-09-30
WO1999015691A1 (en) 1999-04-01
RU2203497C2 (ru) 2003-04-27
DE69834719D1 (de) 2006-07-06
ZA986974B (en) 1999-02-04

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