ATE117437T1 - Test von einer körperflüssigkeit zur messung von knochenresorption. - Google Patents

Test von einer körperflüssigkeit zur messung von knochenresorption.

Info

Publication number
ATE117437T1
ATE117437T1 AT88909905T AT88909905T ATE117437T1 AT E117437 T1 ATE117437 T1 AT E117437T1 AT 88909905 T AT88909905 T AT 88909905T AT 88909905 T AT88909905 T AT 88909905T AT E117437 T1 ATE117437 T1 AT E117437T1
Authority
AT
Austria
Prior art keywords
body fluid
bone resorption
test
measure bone
peptide fragments
Prior art date
Application number
AT88909905T
Other languages
English (en)
Inventor
David R Eyre
Original Assignee
Washington Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22377335&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE117437(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Washington Res Found filed Critical Washington Res Found
Application granted granted Critical
Publication of ATE117437T1 publication Critical patent/ATE117437T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6887—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids from muscle, cartilage or connective tissue
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4712—Muscle proteins, e.g. myosin, actin, protein
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/10—Musculoskeletal or connective tissue disorders
    • G01N2800/101—Diffuse connective tissue disease, e.g. Sjögren, Wegener's granulomatosis
    • G01N2800/102—Arthritis; Rheumatoid arthritis, i.e. inflammation of peripheral joints
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/10—Musculoskeletal or connective tissue disorders
    • G01N2800/105—Osteoarthritis, e.g. cartilage alteration, hypertrophy of bone
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/10—Musculoskeletal or connective tissue disorders
    • G01N2800/108—Osteoporosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/975—Kit
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/811—Test for named disease, body condition or organ function
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/822—Identified hapten
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/834—Urine; urinary system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Toxicology (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Apparatus For Radiation Diagnosis (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AT88909905T 1987-11-06 1988-10-21 Test von einer körperflüssigkeit zur messung von knochenresorption. ATE117437T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/118,234 US4973666A (en) 1987-11-06 1987-11-06 Peptide fragments containing HP and LP cross-links

Publications (1)

Publication Number Publication Date
ATE117437T1 true ATE117437T1 (de) 1995-02-15

Family

ID=22377335

Family Applications (1)

Application Number Title Priority Date Filing Date
AT88909905T ATE117437T1 (de) 1987-11-06 1988-10-21 Test von einer körperflüssigkeit zur messung von knochenresorption.

Country Status (8)

Country Link
US (16) US4973666A (de)
EP (1) EP0394296B2 (de)
JP (2) JP2780097B2 (de)
AT (1) ATE117437T1 (de)
DE (2) DE3852827T3 (de)
ES (1) ES2014540A6 (de)
HK (1) HK101395A (de)
WO (1) WO1989004491A1 (de)

Families Citing this family (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5300434A (en) * 1987-11-06 1994-04-05 Washington Research Foundation Hybridoma cell line producing an antibody to type-I collagen amino-terminal telopeptide
US5320970A (en) * 1987-11-06 1994-06-14 Washington Research Foundation Detection of collagen degradation in vivo
US6153732A (en) * 1987-11-06 2000-11-28 Washington Research Foundation Kit for detecting analyte indicative of type II collagen resorption in vivo
US4973666A (en) * 1987-11-06 1990-11-27 Washington Research Foundation Peptide fragments containing HP and LP cross-links
US5702909A (en) * 1987-11-06 1997-12-30 Washington Research Foundation Methods of detecting collagen type II degradation in vivo
US5962639A (en) * 1987-11-06 1999-10-05 Washington Research Foundation Synthetic peptides corresponding to telopeptide sequences of cross-linked type I collagen metabolites
US6027903A (en) * 1987-11-06 2000-02-22 Washington Research Foundation Kit for detecting analyte indicative of type I collagen resorption in vivo
GB8815174D0 (en) * 1988-06-25 1988-08-03 Rowett Research Inst Method of monitoring collagen degradation
US5283197A (en) * 1988-06-25 1994-02-01 The Rowett Research Institute Method of monitoring collagen degradation
GB8929366D0 (en) * 1989-12-30 1990-02-28 Rowett Research Inst Method to detect connective tissue disorder in humans and animals
US5217903A (en) * 1990-05-15 1993-06-08 Trustees Of Boston University Measuring connective tissue breakdown products in body fluids
US5176655A (en) * 1990-11-08 1993-01-05 Mbo Laboratories, Inc. Disposable medical needle and catheter placement assembly having full safety enclosure means
US6121002A (en) * 1990-12-26 2000-09-19 The Rowett Research Institute Method to detect bone and other connective tissue disorders in humans and animals
GB9105893D0 (en) * 1991-03-20 1991-05-08 Orion Yhtymae Oy Bone resorption assay based on a peptide liberated during collagen degradation
US5362852A (en) * 1991-09-27 1994-11-08 Pfizer Inc. Modified peptide derivatives conjugated at 2-hydroxyethylamine moieties
GB9202139D0 (en) * 1992-01-31 1992-03-18 Sandoz Ltd Improvements in or relating to organic compounds
US6175016B1 (en) * 1992-01-31 2001-01-16 Novartis Ag Pyridine derivatives
JP3113440B2 (ja) * 1992-03-25 2000-11-27 日本臓器製薬株式会社 ピリジニウム誘導体
WO1994003814A2 (en) * 1992-07-31 1994-02-17 Metra Biosystems, Inc. Method and kit for pyridinium crosslink assay
US5620861A (en) * 1992-07-31 1997-04-15 Metra Biosystems, Inc. Method and kit for pyridinium crosslink assay
AU2481992A (en) * 1992-08-28 1994-03-29 Rowett Research Institute, The Method to monitor drug therapy and assess metastasis
US5350855A (en) * 1992-09-30 1994-09-27 Metra Biosystems, Inc. Derivatized D-acyl pyridinium reagent
US6132976A (en) * 1992-12-04 2000-10-17 Shriners Hospitals For Children Immunoassays for the measurement of collagen denaturation and cleavage in cartilage
US5736344A (en) * 1992-12-17 1998-04-07 Metra Biosystems, Inc. Serum pyridinium crosslinks assay
JPH08505149A (ja) * 1992-12-28 1996-06-04 ジェイ． ベイリンク，デビッド 骨再吸収検定法
US5541295A (en) * 1993-02-12 1996-07-30 The Board Of Governors For Higher Education State Of Rhode Island And Providence Plantations Detection of type II collagen and its peptides
DK104093D0 (da) * 1993-09-17 1993-09-17 Osteometer A S Fremgangsmaade til bestemmelse af collagen-fragmenter i legemsvaesker, test-kit og midler til udoevelse af fremgangsmaaden og anvendelse af fremgangsmaaden til diagnosticering af lidelser associeret til collagen-metabolismen
US6110689A (en) 1994-01-21 2000-08-29 Osteometer A/S Method of assaying collagen fragments in body fluids, a test kit and means for carrying out the method and use of the method to diagnose the presence of disorders associated with the metabolism of collagen
US5516699A (en) * 1994-02-16 1996-05-14 Institute Of Molecular Biology, Inc. Pyridinoline crosslinks as markers of periodontal and peri-implant disease activity
GB9506050D0 (en) * 1995-03-24 1995-05-10 Osteometer A S Assaying collagen fragments in body fluids
US5589346A (en) * 1994-06-21 1996-12-31 Bioquant, Inc. Method of monitoring markers of bone metabolism
JP3242792B2 (ja) * 1994-08-05 2001-12-25 日本臓器製薬株式会社 ナフチリジニウム誘導体
JPH10507266A (ja) 1994-10-17 1998-07-14 オステオミーター・ビオ・テク・エー／エス 体液中のコラーゲンの断片化パターンの評価とコラーゲンの代謝に関連する疾患の診断
US5763272A (en) * 1994-12-23 1998-06-09 Boehringer Mannheim Gmbh Hybridoma for producing antibody for collagen I
US5661039A (en) * 1995-03-01 1997-08-26 Metra Biosystems, Inc. Perspiration assay for bone resorption
US5750647A (en) * 1995-05-19 1998-05-12 Washington Research Foundation Synthetic peptide analogs of NTx
US6107047A (en) * 1996-03-21 2000-08-22 Osteometer Biotech A/S Assaying protein fragments in body fluids
GB9617616D0 (en) 1996-08-22 1996-10-02 Osteometer Biotech As Assaying protein fragments in body fluids
EP0829724A1 (de) * 1996-09-17 1998-03-18 Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek Tno Verfahren zum Nachweis von Kollagenabbau
ES2160985T3 (es) 1996-12-09 2001-11-16 Osteometer Biotech As Ensayos de tipo sandwich para fragmentos de colageno.
US5834610A (en) * 1997-05-06 1998-11-10 Johnson; Gary M. Conversion of pyridinoline to deoxypyridinoline
US5989925A (en) * 1997-06-27 1999-11-23 Serex, Inc. Antibody to and assay for peptide linked-pyridinoline as indicator of bone resorption level
US5972623A (en) * 1997-07-31 1999-10-26 Metra Biosystems, Inc. Collagen-peptide assay method
US6117646A (en) * 1997-09-22 2000-09-12 Osteometer Biotech A/S Assaying protein fragments in body fluids
US6780609B1 (en) 1998-10-23 2004-08-24 Genome Therapeutics Corporation High bone mass gene of 1.1q13.3
US6916903B2 (en) * 1998-06-19 2005-07-12 Washington Research Foundation Collagen type III synthetic peptides for collagen resorption assays
US6602980B1 (en) 1998-06-19 2003-08-05 Washington Research Foundation Collagen type III synthetic peptides for collagen resorption assays
US6348320B1 (en) 1998-06-19 2002-02-19 Washington Research Foundation Cartilage resorption assays measuring type II collagen fragments
ATE302949T1 (de) 1998-06-19 2005-09-15 Washington Res Found Knorpelresorptionsassays
US6642007B1 (en) * 1998-11-02 2003-11-04 Pfizer Inc. Assays for measurement of type II collagen fragments in urine
FR2795823B1 (fr) * 1999-07-01 2001-11-23 Inst Nat Sante Rech Med Methodes et kits pour le diagnostic ou le suivi d'une pathologie synoviale ou osteoarticulaire comprenant l'utilisation d'un marqueur specifique de la degradation du tissu synovial
EP1130021A3 (de) 2000-02-29 2004-03-03 Nippon Zoki Pharmaceutical Co., Ltd. Pyrrolopyridinium-Derivate
WO2002029409A2 (en) 2000-10-03 2002-04-11 Rowett Research Institute Method of assaying pyrrole-containing biological compounds
WO2003009758A1 (en) 2001-07-24 2003-02-06 Sunlight Medical, Ltd. Bone age assessment using ultrasound
WO2003009762A1 (en) * 2001-07-24 2003-02-06 Sunlight Medical, Ltd. Joint analysis using ultrasound
US20030054426A1 (en) * 2001-08-31 2003-03-20 Welsch Dean J. Peptide biomarker and method of identification
CA2469568A1 (en) * 2001-12-03 2003-06-12 Seroptix, Inc. A method for identifying markers
KR100924051B1 (ko) * 2002-03-08 2009-10-27 소니 가부시끼 가이샤 기록 매체 및 그 재생 장치, 재생 방법, 기록 매체 제조 장치 및 기록 장치
EP1485718B1 (de) * 2002-03-13 2008-08-06 Université de Liège Verfahren zur überwachung der typ-ii-kollagenabbau in knorpeln
US7110400B2 (en) * 2002-04-10 2006-09-19 Integrated Device Technology, Inc. Random access memory architecture and serial interface with continuous packet handling capability
DE10239479A1 (de) * 2002-08-28 2004-03-04 Bayer Cropscience Ag Substituierte spirocyclische Ketoenole
EP1584114A1 (de) * 2003-01-17 2005-10-12 Diode Solutions, Inc. Display mit einem organischen material
US20060030538A1 (en) * 2004-07-21 2006-02-09 Medtronic, Inc. Methods for reducing or preventing localized fibrosis using SiRNA
CA2574086A1 (en) * 2004-07-21 2006-02-23 Medtronic, Inc. Medical devices and methods for reducing localized fibrosis
EP2238455A4 (de) * 2008-01-18 2011-03-02 Vatrix Medical Inc Diagnostische biomarker für gefässaneurysma
US9012160B2 (en) * 2008-06-16 2015-04-21 Abraham Amir Monitoring skin metabolism products for evaluating burn injury
ES2679918T3 (es) 2010-02-18 2018-08-31 Vtv Therapeutics Llc Derivados de imidazol condensados sustituidos, composiciones farmacéuticas y métodos de uso de los mismos
US8759535B2 (en) 2010-02-18 2014-06-24 High Point Pharmaceuticals, Llc Substituted fused imidazole derivatives, pharmaceutical compositions, and methods of use thereof
US20110294142A1 (en) 2010-05-27 2011-12-01 Joydeep Lahiri Multiply Fluorescently Labeled Calcium Phosphate-Protein Surfaces
US20110294151A1 (en) 2010-05-27 2011-12-01 Hongwei Hanna Rao Fluorescently Labeled Calcium Phosphate Surfaces
USRE49477E1 (en) 2012-04-20 2023-03-28 Thomas Jefferson University Engineered antibody for inhibition of fibrosis
JP7161177B2 (ja) * 2017-07-19 2022-10-26 学校法人明治大学 コラーゲン産生促進剤
US20250172570A1 (en) * 2021-10-20 2025-05-29 Sekisui Medical Co., Ltd. Immunoassay method for cross-linked n-telopeptide of type i collagen, immunoassay kit, and antibody or antibody fragment thereof

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL6716836A (de) * 1967-12-11 1969-06-13
US4094646A (en) * 1977-06-02 1978-06-13 The Baltimore Spice Company Rapid method of assaying collagen in meat and meat products
DE2816841A1 (de) * 1978-04-18 1979-10-31 Max Planck Gesellschaft Radioimmunologische bestimmung von prokollagen (typ iii) und prokollagen- peptid (typ iii)
US4298593A (en) * 1979-08-21 1981-11-03 Abbott Laboratories Reagents and methods utilizing labeled Fab bound to antigens
US4371374A (en) * 1980-11-17 1983-02-01 The Rockefeller University Monitoring metabolic control in diabetic patients by measuring glycosylated amino acids and peptides in urine
DE3209149A1 (de) * 1982-03-13 1983-10-06 Hoechst Ag Verfahren zur gemeinsamen immunologischen bestimmung von prokollagen-peptid (typ iii) und prokollagen-peptid col 1 (typ iii) und verfahren zur herstellung von anti-prokollagen-peptid col 1 (typ iii)-serum
US4628027A (en) * 1982-05-19 1986-12-09 Molecular Engineering Associates, Ltd. Vitro diagnostic methods using monoclonal antibodies against connective tissue proteins
CA1229789A (en) * 1983-06-06 1987-12-01 David Baylink Polypeptides exhibiting skeletal growth factor activity
US4731326A (en) * 1984-06-04 1988-03-15 Ortho Diagnostic Systems Inc. Disease diagnosis by detection of shed normal tissue antigens
US4774227A (en) * 1986-02-14 1988-09-27 Collagen Corporation Collagen compositions for bone repair containing autogeneic marrow
JPH0638081B2 (ja) * 1986-09-04 1994-05-18 富士薬品工業株式会社 ヒトコラーゲンペプチドの酵素免疫測定法
DE3851776T2 (de) * 1987-04-28 1995-05-04 Boehringer Mannheim Gmbh Verwendung von IGF-II zur Behandlung von Knochenkrankheiten.
GB2205643B (en) * 1987-05-08 1991-03-13 Farmos Group Limited Type iii collagen degradation assay
US5300434A (en) * 1987-11-06 1994-04-05 Washington Research Foundation Hybridoma cell line producing an antibody to type-I collagen amino-terminal telopeptide
US4973666A (en) * 1987-11-06 1990-11-27 Washington Research Foundation Peptide fragments containing HP and LP cross-links
US5320970A (en) * 1987-11-06 1994-06-14 Washington Research Foundation Detection of collagen degradation in vivo
GB8815174D0 (en) † 1988-06-25 1988-08-03 Rowett Research Inst Method of monitoring collagen degradation
AU645742B2 (en) * 1988-10-24 1994-01-27 Bruce Caterson Methods of and compositions for diagnosing, monitoring and treating the early stages of osteoarthritis
WO1990008195A1 (en) * 1989-01-13 1990-07-26 President And Fellows Of Harvard College Monoclonal antibody to human type ix collagen
US5055382A (en) * 1989-02-01 1991-10-08 Long John J Bleach-fix regeneration kit and use thereof in photographic processing
US5340934A (en) * 1989-11-03 1994-08-23 The United States Of Americas As Represented By The Secretary Of Health & Human Services CDNA sequences of human bone matrix proteins
GB9105893D0 (en) † 1991-03-20 1991-05-08 Orion Yhtymae Oy Bone resorption assay based on a peptide liberated during collagen degradation

Also Published As

Publication number Publication date
EP0394296B1 (de) 1995-01-18
EP0394296B2 (de) 2005-07-13
DE3852827T2 (de) 1995-06-29
HK101395A (en) 1995-06-30
JP2780097B2 (ja) 1998-07-23
US5140103A (en) 1992-08-18
US6025144A (en) 2000-02-15
US5945274A (en) 1999-08-31
US5939274A (en) 1999-08-17
US6204367B1 (en) 2001-03-20
US5532169A (en) 1996-07-02
DE3852827D1 (de) 1995-03-02
US5834221A (en) 1998-11-10
ES2014540A6 (es) 1990-07-16
US5962236A (en) 1999-10-05
US5652112A (en) 1997-07-29
DE3852827T3 (de) 2006-02-23
US5607862A (en) 1997-03-04
JPH03500818A (ja) 1991-02-21
US5455179A (en) 1995-10-03
WO1989004491A1 (en) 1989-05-18
JP2802751B2 (ja) 1998-09-24
US20040009531A1 (en) 2004-01-15
US6887659B2 (en) 2005-05-03
US4973666A (en) 1990-11-27
US5641837A (en) 1997-06-24
JPH09218198A (ja) 1997-08-19
EP0394296A1 (de) 1990-10-31
US20010031476A1 (en) 2001-10-18
DE394296T1 (de) 1994-04-28
US5641687A (en) 1997-06-24
US6509450B2 (en) 2003-01-21

Similar Documents

Publication Publication Date Title
DE3852827D1 (de) Test von einer körperflüssigkeit zur messung von knochenresorption.
NO890071D0 (no) Nedbrytningsanalyse for kollagen type iii.
GR940300047T1 (en) Methods of detecting bone resorption in vivo
ATE297950T1 (de) Testverfahren und reagenzien zur quantifizierung von hbnp
DE3686061D1 (de) Verfahren zur diagnose von krankheiten mit einer arthritischen komponente.
LU91015I2 (fr) Recombinate (Rurioctocog alfa) dans toutes ses formes couvertes par le brevet de base
ATE328281T1 (de) Methode zur diagnose von abnormalem knochenstoffwechsel
ATE209356T1 (de) Ein verfahren zur bestimmung von kollagenfragmenten in körperflüssigkeiten, ein testkit und mittel zur durchführung des verfahrens, und seine verwendung zur feststellung von mit dem kollagenmetabolismus assoziierten störungen
KR860700136A (ko) 백혈구의 클라스와 서브클라스의 식별, 산출 그리고 검사를 위한 시약체계와 방법
ATE347697T1 (de) Methode zur bestimmung von proteinfragmenten in körperflüssigkeiten
ATE142646T1 (de) Verfahren zur immunologischen bestimmung des carboxyterminalen peptids von typ-i-prokollagen
DE3776525D1 (de) Immunochemisches verfahren zur bestimmung von stabilem glykosiliertem haemoglobin.
ATE197155T1 (de) Stannius- körperchen -protein, stanniocalcin
DE69034254D1 (de) A-pdgf-rezeptor und dessen verwendung
DE69123723D1 (de) Diagnostisches verfahren und reagenz für hiv
FR2722508B1 (fr) Cassette d'expression d'une proteine p30 de toxoplasma gondii
DE59305225D1 (de) Verfahren zur Bestimmung von Thrombose verursachenden Lupus-anticoagulant-Antikörpern
ATE209359T1 (de) Bestimmung von freiem und komplexiertem trypsinogen-2
RU93028213A (ru) Способ определения сахара в крови
CS555888A1 (en) Method of pure specific antibodies production for proteins concentration's quick quantitative determination
DE69128193D1 (de) Verfahren zur bestimmung von gesamtem kalzium unter verwendung eines verdünnungsmittels

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
UEP Publication of translation of european patent specification

Ref document number: 0394296

Country of ref document: EP

EELA Cancelled due to lapse of time