ATE328888T1 - Radicicol und monocillin und ihre analogen und ihre anwendungen - Google Patents

Radicicol und monocillin und ihre analogen und ihre anwendungen

Info

Publication number: ATE328888T1
Authority: AT; Austria
Prior art keywords: monocillin; radicicol; analogues; applications; sub
Prior art date: 2000-08-25

Application number

AT01966236T

Other languages

English (en)

Inventor

Samuel J Danishefsky

Robert M Garbaccio

Daniel K Baeschlin

Shawn J Stachel

David Solit

Neil Rosen

Original Assignee

Sloan Kettering Inst Cancer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-08-25

Filing date

2001-08-24

Publication date

2006-06-15

2001-08-24 Application filed by Sloan Kettering Inst Cancer filed Critical Sloan Kettering Inst Cancer

2006-06-15 Application granted granted Critical

2006-06-15 Publication of ATE328888T1 publication Critical patent/ATE328888T1/de

Links

229930190086 Monocillin Natural products 0.000 title 1
XTUZVEOWUSGCSV-HKCOAVLJSA-N Monocillin I Natural products CC1CC2OC2C=C/C=C/C(=O)Cc3cc(O)cc(O)c3C(=O)O1 XTUZVEOWUSGCSV-HKCOAVLJSA-N 0.000 title 1
FCPVYOBCFFNJFS-LQDWTQKMSA-M benzylpenicillin sodium Chemical compound [Na+].N([C@H]1[C@H]2SC([C@@H](N2C1=O)C([O-])=O)(C)C)C(=O)CC1=CC=CC=C1 FCPVYOBCFFNJFS-LQDWTQKMSA-M 0.000 title 1
VYGYNVZNSSTDLJ-HKCOAVLJSA-N monorden Natural products CC1CC2OC2C=C/C=C/C(=O)CC3C(C(=CC(=C3Cl)O)O)C(=O)O1 VYGYNVZNSSTDLJ-HKCOAVLJSA-N 0.000 title 1
WYZWZEOGROVVHK-GTMNPGAYSA-N radicicol Chemical compound C/1=C/C=C/C(=O)CC2=C(Cl)C(O)=CC(O)=C2C(=O)O[C@H](C)C[C@H]2O[C@@H]2\1 WYZWZEOGROVVHK-GTMNPGAYSA-N 0.000 title 1
229930192524 radicicol Natural products 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 2
230000015572 biosynthetic process Effects 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1
229940124597 therapeutic agent Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D225/00—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom
- C07D225/04—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D225/06—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Diabetes (AREA)
Hematology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Steroid Compounds (AREA)
Circuits Of Receivers In General (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Saccharide Compounds (AREA)

AT01966236T 2000-08-25 2001-08-24 Radicicol und monocillin und ihre analogen und ihre anwendungen ATE328888T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US22827700P	2000-08-25	2000-08-25
US30455301P	2001-07-11	2001-07-11
US09/938,754 US7115651B2 (en)	2000-08-25	2001-08-24	Macrocycles and uses thereof

Publications (1)

Publication Number	Publication Date
ATE328888T1 true ATE328888T1 (de)	2006-06-15

Family

ID=27397829

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT01966236T ATE328888T1 (de)	2000-08-25	2001-08-24	Radicicol und monocillin und ihre analogen und ihre anwendungen

Country Status (6)

Country	Link
US (1)	US7115651B2 (de)
EP (1)	EP1315732B1 (de)
AT (1)	ATE328888T1 (de)
AU (1)	AU2001286768A1 (de)
DE (1)	DE60120427D1 (de)
WO (1)	WO2002016369A2 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7705120B2 (en)	2001-06-21	2010-04-27	Millennium Pharmaceuticals, Inc.	Compositions, kits, and methods for identification, assessment, prevention, and therapy of breast cancer
US20050182129A1 (en) *	2002-04-17	2005-08-18	Akiko Ikeda	Hair growth tonic
EP1633774B1 (de)	2003-06-18	2010-02-17	Tranzyme Pharma Inc.	Makrozyklische motilin rezeptorantagonisten
JP4575294B2 (ja)	2003-06-27	2010-11-04	協和発酵キリン株式会社	Ｈｓｐ９０ファミリー蛋白質阻害剤
US20070004674A1 (en) *	2003-08-22	2007-01-04	Kyowa Hakko Kogyo Co. Ltd.	Remedy for diseases associated with immunoglobulin gene translocation
US8329683B2 (en)	2006-06-02	2012-12-11	Nexgenix Pharmaceuticals, Llc	Treatment of neurofibromatosis with radicicol and its derivatives
WO2008150302A1 (en) *	2007-06-04	2008-12-11	Nexgenix Pharmaceuticals	Treatment of neurofibromatosis with radicicol and its derivatives
WO2008021213A1 (en) *	2006-08-11	2008-02-21	Nicolas Winssinger	Macrocyclic compounds useful as inhibitors of kinases and hsp90
AU2008287542C1 (en)	2007-06-01	2015-01-22	The Trustees Of Princeton University	Treatment of viral infections by modulation of host cell metabolic pathways
EP2173733A2 (de) *	2007-06-05	2010-04-14	WINSSINGER, Nicolas	Zusammensetzungen und verfahren mit analogen von radicicol a
EP2200653A2 (de) *	2007-09-10	2010-06-30	University of Massachusetts	Antitumorale mittel gegen mitochondrien
US20110190237A1 (en) *	2008-01-15	2011-08-04	Nexgenix Pharmaceuticals	Macrocyclic Prodrug Compounds Useful as Therapeutics
MX2010007755A (es)	2008-01-15	2010-12-21	Univ Strasbourg	Sintesis de lactonas de acido resorcilico utiles como agentes terapeuticos.
US20090258869A1 (en) *	2008-02-08	2009-10-15	The Regents Of The University Of California	Methods and compounds for treatment or prevention of substance-related disorders
EP2254880B8 (de)	2008-02-21	2016-09-21	OncoSynergy, Inc.	Als Therapeutika geeignete makrocyclische Prodrugverbindungen
US8663210B2 (en)	2009-05-13	2014-03-04	Novian Health, Inc.	Methods and apparatus for performing interstitial laser therapy and interstitial brachytherapy
WO2016196256A2 (en)	2015-06-04	2016-12-08	University Of North Carolina At Greensboro	Non-aromatic difluoro analogues of resorcylic acid lactones
PT3658148T (pt)	2017-07-28	2024-08-26	Turning Point Therapeutics Inc	Compostos macrocíclicos e utilizações dos mesmos
US20230390416A1 (en) *	2020-10-16	2023-12-07	The Brigham And Women's Hospital, Inc.	Compositions for inducing tumor immunity and reducing drug tolerance

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FR96046E (fr) *	1966-06-29	1972-05-19	Commercial Solvents Corp	Composé utilisable comme supplément alimentaire pour les animaux.
FR96016E (fr)	1966-06-29	1972-05-19	Commercial Solvents Corp	Composé utilisable comme supplément alimentaire pour les animaux.
US3621036A (en) *	1969-02-27	1971-11-16	Merck & Co Inc	Derivatives of zearalane
BE757083A (fr) *	1970-02-16	1971-03-16	Commercial Solvents Corp	Nouveaux produits a activite antibacterienne
BE757082A (fr) *	1970-02-16	1971-03-16	Commercial Solvents Corp	Procede de preparation de nouveaux produits a activite antibacterienne
US3901921A (en) *	1972-04-25	1975-08-26	Commercial Solvents Corp	Synthesis of zearalanes and related compounds and intermediates useful in the syntheses thereof
US4035504A (en) *	1975-05-12	1977-07-12	Imc Chemical Group, Inc.	Method for treating cholesterolemia by administering resorcylic acid lactone derivatives
US4088658A (en) *	1976-11-04	1978-05-09	Imc Chemical Group, Inc.	Synthesis of dideoxyzearalane and related compounds
US4166764A (en) *	1978-02-01	1979-09-04	W. R. Grace & Co.	Production of monorden
US4228079A (en)	1978-10-30	1980-10-14	W. R. Grace & Co.	Dialkoxy monorden derivatives
IE911915A1 (en)	1990-06-06	1991-12-18	Sankyo Co	Radicicol derivatives, their preparation and their¹anti-tumor activity
US5650430A (en)	1990-06-06	1997-07-22	Sankyo Company, Limited	Radicicol derivatives, their preparation and their anti-tumor activity
GB9225396D0 (en)	1992-12-04	1993-01-27	Sandoz Ltd	Improvements in or relating to organic compounds
US5731343A (en)	1995-02-24	1998-03-24	The Scripps Research Institute	Method of use of radicicol for treatment of immunopathological disorders
JP3938936B2 (ja) *	1995-04-26	2007-06-27	協和醗酵工業株式会社	ラディシコール誘導体
JPH09202781A (ja) *	1996-01-25	1997-08-05	Sankyo Co Ltd	ラディシコール誘導体
ATE266017T1 (de)	1996-10-25	2004-05-15	Kyowa Hakko Kogyo Kk	Radicicolderivate
AU3534499A (en)	1998-04-24	1999-11-16	Kyowa Hakko Kogyo Co. Ltd.	Radicicol derivatives
CA2356622A1 (en) *	1998-12-24	2000-07-06	Novation Pharmaceuticals Inc.	Compounds which affect mrna stability and uses therefor
WO2000061578A1 (en)	1999-04-09	2000-10-19	Sloan-Kettering Institute For Cancer Research	Methods and compositions for degradation and/or inhibition of her-family tyrosine kinases
CA2395136A1 (en)	1999-12-22	2001-06-28	The Scripps Research Institute	Angiogenesis and vascular permeability modulators and inhibitors

2001
- 2001-08-24 EP EP01966236A patent/EP1315732B1/de not_active Expired - Lifetime
- 2001-08-24 WO PCT/US2001/026577 patent/WO2002016369A2/en not_active Ceased
- 2001-08-24 DE DE60120427T patent/DE60120427D1/de not_active Expired - Lifetime
- 2001-08-24 AU AU2001286768A patent/AU2001286768A1/en not_active Abandoned
- 2001-08-24 AT AT01966236T patent/ATE328888T1/de not_active IP Right Cessation
- 2001-08-24 US US09/938,754 patent/US7115651B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
AU2001286768A1 (en)	2002-03-04
EP1315732B1 (de)	2006-06-07
WO2002016369A3 (en)	2002-08-29
EP1315732A2 (de)	2003-06-04
DE60120427D1 (de)	2006-07-20
US20020091151A1 (en)	2002-07-11
US7115651B2 (en)	2006-10-03
WO2002016369A2 (en)	2002-02-28

Legal Events

Date	Code	Title	Description
2006-12-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE328888T1 (de)	2006-06-15	Radicicol und monocillin und ihre analogen und ihre anwendungen
ATE297203T1 (de)	2005-06-15	Antithrombotische mitteln
EP1442016A4 (de)	2005-05-25	1h-indolderivate als hochselektive cyclooxygenase-2-inhibitoren
CY1108522T1 (el)	2014-04-09	Μεθοδος συνθεσης της περινδοπριλης και των φαρμακευτικως αποδεκτων αλατων της
SE0302760D0 (sv)	2003-10-20	New compounds
DE602004008098D1 (de)	2007-09-20	Substituierte 2h-ä1,2,4ütriazoloä4,3-aüpyrazine als gsk-3-inhibitoren
MXPA04004674A (es)	2004-08-12	Ligados de los receptors de los canabinodies.
TR200200579T2 (tr)	2002-12-23	Amino-tirazolpiridin türevleri.
EA199900937A1 (ru)	2000-08-28	Фармацевтические композиции, содержащие вориконазол
WO2003053359A3 (en)	2004-04-15	1,3-bis-(substituted-phenyl)-2-propyn-1-ones and their use to treat disorders
DE60324544D1 (de)	2008-12-18	Muskarin antagonisten
SE0101932D0 (sv)	2001-05-31	Pharmaceutical combinations
BR0105563A (pt)	2002-04-02	Derivados e análogos de galantamina
SE9901077D0 (sv)	1999-03-23	Novel use
ATE380174T1 (de)	2007-12-15	Arginin-mimetika als faktor xa-inhibitoren
ATE272617T1 (de)	2004-08-15	Sulfonamid-derivate
ATE479657T1 (de)	2010-09-15	N-(aryl)-2-arylethensulfonamide und ihre therapeutischen anwendungen
CY1108224T1 (el)	2014-02-12	Καινοτομες κρυσταλλικες μορφες ενος αναστολεα του παραγοντα χα
MXPA03010766A (es)	2005-03-07	Nuevos compuestos y composiciones como inhibicores de las catepsinas.
SE9801494D0 (sv)	1998-04-28	Novel use
ATE308540T1 (de)	2005-11-15	Antithrombosemittel
ATE266029T1 (de)	2004-05-15	Substituierte pyrrolobenzimidazolderivate zur entzündungshemmung
NO20051282L (no)	2005-05-11	Antitumorale analoger av lamellariner.
DE60107832D1 (en)	2005-01-20	Chromenylmethylpyrimidindiamine als antibakterielle wirkstoffe
WO2004048381A3 (en)	2004-08-05	Pyrazoloazepine compounds as pharmaceutical agents