ATE328888T1 - Radicicol und monocillin und ihre analogen und ihre anwendungen - Google Patents

Radicicol und monocillin und ihre analogen und ihre anwendungen

Info

Publication number: ATE328888T1
Authority: AT; Austria
Prior art keywords: monocillin; radicicol; analogues; applications; sub
Prior art date: 2000-08-25

Application number

AT01966236T

Other languages

English (en)

Inventor

Samuel J Danishefsky

Robert M Garbaccio

Daniel K Baeschlin

Shawn J Stachel

David Solit

Neil Rosen

Original Assignee

Sloan Kettering Inst Cancer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-08-25

Filing date

2001-08-24

Publication date

2006-06-15

2001-08-24 Application filed by Sloan Kettering Inst Cancer filed Critical Sloan Kettering Inst Cancer

2006-06-15 Application granted granted Critical

2006-06-15 Publication of ATE328888T1 publication Critical patent/ATE328888T1/de

Links

229930190086 Monocillin Natural products 0.000 title 1
XTUZVEOWUSGCSV-HKCOAVLJSA-N Monocillin I Natural products CC1CC2OC2C=C/C=C/C(=O)Cc3cc(O)cc(O)c3C(=O)O1 XTUZVEOWUSGCSV-HKCOAVLJSA-N 0.000 title 1
FCPVYOBCFFNJFS-LQDWTQKMSA-M benzylpenicillin sodium Chemical compound [Na+].N([C@H]1[C@H]2SC([C@@H](N2C1=O)C([O-])=O)(C)C)C(=O)CC1=CC=CC=C1 FCPVYOBCFFNJFS-LQDWTQKMSA-M 0.000 title 1
VYGYNVZNSSTDLJ-HKCOAVLJSA-N monorden Natural products CC1CC2OC2C=C/C=C/C(=O)CC3C(C(=CC(=C3Cl)O)O)C(=O)O1 VYGYNVZNSSTDLJ-HKCOAVLJSA-N 0.000 title 1
WYZWZEOGROVVHK-GTMNPGAYSA-N radicicol Chemical compound C/1=C/C=C/C(=O)CC2=C(Cl)C(O)=CC(O)=C2C(=O)O[C@H](C)C[C@H]2O[C@@H]2\1 WYZWZEOGROVVHK-GTMNPGAYSA-N 0.000 title 1
229930192524 radicicol Natural products 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 2
230000015572 biosynthetic process Effects 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1
229940124597 therapeutic agent Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D225/00—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom
- C07D225/04—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D225/06—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Diabetes (AREA)
Hematology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Steroid Compounds (AREA)
Circuits Of Receivers In General (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Saccharide Compounds (AREA)

AT01966236T 2000-08-25 2001-08-24 Radicicol und monocillin und ihre analogen und ihre anwendungen ATE328888T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US22827700P	2000-08-25	2000-08-25
US30455301P	2001-07-11	2001-07-11
US09/938,754 US7115651B2 (en)	2000-08-25	2001-08-24	Macrocycles and uses thereof

Publications (1)

Publication Number	Publication Date
ATE328888T1 true ATE328888T1 (de)	2006-06-15

Family

ID=27397829

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT01966236T ATE328888T1 (de)	2000-08-25	2001-08-24	Radicicol und monocillin und ihre analogen und ihre anwendungen

Country Status (6)

Country	Link
US (1)	US7115651B2 (de)
EP (1)	EP1315732B1 (de)
AT (1)	ATE328888T1 (de)
AU (1)	AU2001286768A1 (de)
DE (1)	DE60120427D1 (de)
WO (1)	WO2002016369A2 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU2002322280A1 (en)	2001-06-21	2003-01-21	Millennium Pharmaceuticals, Inc.	Compositions, kits, and methods for identification, assessment, prevention, and therapy of breast cancer
CN1652743A (zh) *	2002-04-17	2005-08-10	大正制药株式会社	毛发生长补剂
CA2528375C (en)	2003-06-18	2013-11-19	Tranzyme Pharma, Inc.	Macrocyclic antagonists of the motilin receptor
ES2432747T3 (es)	2003-06-27	2013-12-05	Kyowa Hakko Kirin Co., Ltd.	Inhibidores de proteínas de la familia HSP90
WO2005018674A1 (ja) *	2003-08-22	2005-03-03	Kyowa Hakko Kogyo Co., Ltd.	イムノグロブリン遺伝子の転座を伴う疾患の治療薬
WO2008150302A1 (en) *	2007-06-04	2008-12-11	Nexgenix Pharmaceuticals	Treatment of neurofibromatosis with radicicol and its derivatives
US8329683B2 (en)	2006-06-02	2012-12-11	Nexgenix Pharmaceuticals, Llc	Treatment of neurofibromatosis with radicicol and its derivatives
EP2136799B1 (de) *	2006-08-11	2017-10-04	Universite De Strasbourg	Makrocyclische verbindungen als hemmer von kinase und hsp90
KR20100031528A (ko)	2007-06-01	2010-03-22	더 트러스티즈 오브 프린스턴 유니버시티	숙주세포 대사경로의 조절을 통한 바이러스 감염 치료
EP2173733A2 (de) *	2007-06-05	2010-04-14	WINSSINGER, Nicolas	Zusammensetzungen und verfahren mit analogen von radicicol a
CN101854955B (zh) *	2007-09-10	2012-07-18	马萨诸塞大学	靶向线粒体的抗肿瘤剂
MX2010007755A (es)	2008-01-15	2010-12-21	Univ Strasbourg	Sintesis de lactonas de acido resorcilico utiles como agentes terapeuticos.
US20110190237A1 (en) *	2008-01-15	2011-08-04	Nexgenix Pharmaceuticals	Macrocyclic Prodrug Compounds Useful as Therapeutics
WO2009105755A2 (en)	2008-02-21	2009-08-27	Nexgenix Pharmaceuticals	Macrocyclic prodrug compounds useful as therapeutics
US20090258869A1 (en) *	2008-02-08	2009-10-15	The Regents Of The University Of California	Methods and compounds for treatment or prevention of substance-related disorders
US8663210B2 (en)	2009-05-13	2014-03-04	Novian Health, Inc.	Methods and apparatus for performing interstitial laser therapy and interstitial brachytherapy
US10434085B2 (en)	2015-06-04	2019-10-08	University Of North Carolina At Greensboro	Non-aromatic difluoro analogues of resorcylic acid lactones
CA3069232A1 (en)	2017-07-28	2019-01-31	Turning Point Therapeutics, Inc.	Macrocyclic compounds and uses thereof
US20230390416A1 (en) *	2020-10-16	2023-12-07	The Brigham And Women's Hospital, Inc.	Compositions for inducing tumor immunity and reducing drug tolerance

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* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR96016E (fr)	1966-06-29	1972-05-19	Commercial Solvents Corp	Composé utilisable comme supplément alimentaire pour les animaux.
FR96046E (fr) *	1966-06-29	1972-05-19	Commercial Solvents Corp	Composé utilisable comme supplément alimentaire pour les animaux.
US3621036A (en) *	1969-02-27	1971-11-16	Merck & Co Inc	Derivatives of zearalane
BE757083A (fr) *	1970-02-16	1971-03-16	Commercial Solvents Corp	Nouveaux produits a activite antibacterienne
BE757082A (fr) *	1970-02-16	1971-03-16	Commercial Solvents Corp	Procede de preparation de nouveaux produits a activite antibacterienne
US3901921A (en) *	1972-04-25	1975-08-26	Commercial Solvents Corp	Synthesis of zearalanes and related compounds and intermediates useful in the syntheses thereof
US4035504A (en) *	1975-05-12	1977-07-12	Imc Chemical Group, Inc.	Method for treating cholesterolemia by administering resorcylic acid lactone derivatives
US4088658A (en) *	1976-11-04	1978-05-09	Imc Chemical Group, Inc.	Synthesis of dideoxyzearalane and related compounds
US4228079A (en)	1978-10-30	1980-10-14	W. R. Grace & Co.	Dialkoxy monorden derivatives
US4166764A (en) *	1978-02-01	1979-09-04	W. R. Grace & Co.	Production of monorden
US5650430A (en) *	1990-06-06	1997-07-22	Sankyo Company, Limited	Radicicol derivatives, their preparation and their anti-tumor activity
IE911915A1 (en)	1990-06-06	1991-12-18	Sankyo Co	Radicicol derivatives, their preparation and their¹anti-tumor activity
GB9225396D0 (en)	1992-12-04	1993-01-27	Sandoz Ltd	Improvements in or relating to organic compounds
US5731343A (en)	1995-02-24	1998-03-24	The Scripps Research Institute	Method of use of radicicol for treatment of immunopathological disorders
ES2149468T3 (es) *	1995-04-26	2000-11-01	Kyowa Hakko Kogyo Kk	Derivados de radicicol.
JPH09202781A (ja) *	1996-01-25	1997-08-05	Sankyo Co Ltd	ラディシコール誘導体
ATE266017T1 (de)	1996-10-25	2004-05-15	Kyowa Hakko Kogyo Kk	Radicicolderivate
WO1999055689A1 (en)	1998-04-24	1999-11-04	Kyowa Hakko Kogyo Co., Ltd.	Radicicol derivatives
JP2002533389A (ja) *	1998-12-24	2002-10-08	ノーベーションファーマシューティカルズインコーポレーテッド	ｍＲＮＡ安定性に影響する化合物およびそのための使用
AU769235B2 (en)	1999-04-09	2004-01-22	Sloan-Kettering Institute For Cancer Research	Methods and compositions for degradation and/or inhibition of her-family tyrosine kinases
HU229628B1 (en)	1999-12-22	2014-03-28	Scripps Research Inst	Angiogenesis and vascular permeability modulators and inhibitors

2001
- 2001-08-24 EP EP01966236A patent/EP1315732B1/de not_active Expired - Lifetime
- 2001-08-24 DE DE60120427T patent/DE60120427D1/de not_active Expired - Lifetime
- 2001-08-24 WO PCT/US2001/026577 patent/WO2002016369A2/en not_active Ceased
- 2001-08-24 AT AT01966236T patent/ATE328888T1/de not_active IP Right Cessation
- 2001-08-24 AU AU2001286768A patent/AU2001286768A1/en not_active Abandoned
- 2001-08-24 US US09/938,754 patent/US7115651B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP1315732B1 (de)	2006-06-07
AU2001286768A1 (en)	2002-03-04
WO2002016369A3 (en)	2002-08-29
DE60120427D1 (de)	2006-07-20
WO2002016369A2 (en)	2002-02-28
EP1315732A2 (de)	2003-06-04
US7115651B2 (en)	2006-10-03
US20020091151A1 (en)	2002-07-11

Legal Events

Date	Code	Title	Description
2006-12-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE60120427D1 (de)	2006-07-20	Radicicol und monocillin und ihre analogen und ihre anwendungen
ATE297203T1 (de)	2005-06-15	Antithrombotische mitteln
EP1442016A4 (de)	2005-05-25	1h-indolderivate als hochselektive cyclooxygenase-2-inhibitoren
CY1108522T1 (el)	2014-04-09	Μεθοδος συνθεσης της περινδοπριλης και των φαρμακευτικως αποδεκτων αλατων της
SE0302760D0 (sv)	2003-10-20	New compounds
DE602004008098D1 (de)	2007-09-20	Substituierte 2h-ä1,2,4ütriazoloä4,3-aüpyrazine als gsk-3-inhibitoren
PT1263730E (pt)	2008-02-11	Derivados amina para o tratamento de apoptose
TR200200579T2 (tr)	2002-12-23	Amino-tirazolpiridin türevleri.
ATE306261T1 (de)	2005-10-15	Antithrombosemittel
DK1353911T3 (da)	2011-07-18	Antivirale midler
WO2003053359A3 (en)	2004-04-15	1,3-bis-(substituted-phenyl)-2-propyn-1-ones and their use to treat disorders
ATE413388T1 (de)	2008-11-15	Muskarin antagonisten
DE60121461D1 (de)	2006-08-24	Kondensierte pyridoindolderivate
SE0101932D0 (sv)	2001-05-31	Pharmaceutical combinations
BR0105563A (pt)	2002-04-02	Derivados e análogos de galantamina
SE9901077D0 (sv)	1999-03-23	Novel use
ATE380174T1 (de)	2007-12-15	Arginin-mimetika als faktor xa-inhibitoren
DE60104697D1 (de)	2004-09-09	Sulfonamid-derivate
ATE479657T1 (de)	2010-09-15	N-(aryl)-2-arylethensulfonamide und ihre therapeutischen anwendungen
CY1108224T1 (el)	2014-02-12	Καινοτομες κρυσταλλικες μορφες ενος αναστολεα του παραγοντα χα
MXPA03010766A (es)	2005-03-07	Nuevos compuestos y composiciones como inhibicores de las catepsinas.
SE9801494D0 (sv)	1998-04-28	Novel use
ATE308540T1 (de)	2005-11-15	Antithrombosemittel
ATE266029T1 (de)	2004-05-15	Substituierte pyrrolobenzimidazolderivate zur entzündungshemmung
NO20051282L (no)	2005-05-11	Antitumorale analoger av lamellariner.