IS7325A - alfa-(N-súlfonamíðó)acetamíð afleiður sem beta-amýlóíð tálmar - Google Patents

alfa-(N-súlfonamíðó)acetamíð afleiður sem beta-amýlóíð tálmar

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Publication number
IS7325A
IS7325A IS7325A IS7325A IS7325A IS 7325 A IS7325 A IS 7325A IS 7325 A IS7325 A IS 7325A IS 7325 A IS7325 A IS 7325A IS 7325 A IS7325 A IS 7325A
Authority
IS
Iceland
Prior art keywords
beta
sulfonamido
alpha
acetamide derivatives
amyloid inhibitors
Prior art date
Application number
IS7325A
Other languages
English (en)
Other versions
IS2879B (is
Inventor
F. Parker Michael
E. Mcelhone Katharine
A. Mate Robert
J. Bronson Joanne
Gai Yonghua
P. Bergstrom Carl
R. Marcin Lawrence
E. Macor John
Original Assignee
Bristol-Myers Squibb Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol-Myers Squibb Company filed Critical Bristol-Myers Squibb Company
Publication of IS7325A publication Critical patent/IS7325A/is
Publication of IS2879B publication Critical patent/IS2879B/is

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    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C07C311/18—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms, not being part of nitro or nitroso groups
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    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/325—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/00—Drugs for disorders of the nervous system
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C07C311/19—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
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    • C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
    • C07D211/28—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms to which a second hetero atom is attached
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    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
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    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
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IS7325A 2001-12-20 2004-06-18 a-(N-súlfonamíðó)asetamíðafleiður sem ß-amýlóíðtálmar IS2879B (is)

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KR100966705B1 (ko) 2010-06-29
US8513253B2 (en) 2013-08-20
CA2471099C (en) 2011-04-12
RS51155B (sr) 2010-10-31
AU2002357333B2 (en) 2008-02-28
US20040127494A1 (en) 2004-07-01
PL204281B1 (pl) 2009-12-31
CY1109275T1 (el) 2014-07-02
ATE430727T1 (de) 2009-05-15
US7300936B2 (en) 2007-11-27
IL162498A0 (en) 2005-11-20
DE60232276D1 (de) 2009-06-18
HK1067963A1 (en) 2005-04-22
IL162498A (en) 2010-06-16
WO2003053912A1 (en) 2003-07-03
GEP20063920B (en) 2006-09-11
RS53704A (sr) 2006-12-15
KR20040068957A (ko) 2004-08-02
JP2009102435A (ja) 2009-05-14
HUP0500173A2 (hu) 2005-05-30
SI1465861T1 (sl) 2009-12-31
EP1465861B1 (en) 2009-05-06
HRP20040566A2 (en) 2004-10-31
DK1465861T3 (da) 2009-08-31
EP1465861A4 (en) 2005-12-07
CN1617852A (zh) 2005-05-18
NZ533603A (en) 2007-02-23
PT1465861E (pt) 2009-07-08
US20110105485A1 (en) 2011-05-05
MXPA04005927A (es) 2004-11-01
US7786122B2 (en) 2010-08-31
ZA200404811B (en) 2006-02-22
UA78537C2 (en) 2007-04-10
ES2325205T3 (es) 2009-08-28
AU2002357333A1 (en) 2003-07-09
PL371046A1 (en) 2005-06-13
JP4287746B2 (ja) 2009-07-01
CO5590894A2 (es) 2005-12-30
IS2879B (is) 2014-04-15
HUP0500173A3 (en) 2009-03-30
EP1465861A1 (en) 2004-10-13
BR0215182A (pt) 2004-10-19
RU2004122481A (ru) 2006-01-20
CN1289469C (zh) 2006-12-13
JP5030982B2 (ja) 2012-09-19
NO328976B1 (no) 2010-07-05
US20080085894A1 (en) 2008-04-10
RU2300518C2 (ru) 2007-06-10
JP2005513123A (ja) 2005-05-12
CA2471099A1 (en) 2003-07-03
NO20043098L (no) 2004-09-01

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