ATE32915T1 - Fuer das menschliche transferrinrezeptorglykoprotein spezifische monoklonale antikoerper. - Google Patents

Fuer das menschliche transferrinrezeptorglykoprotein spezifische monoklonale antikoerper.

Info

Publication number
ATE32915T1
ATE32915T1 AT82305658T AT82305658T ATE32915T1 AT E32915 T1 ATE32915 T1 AT E32915T1 AT 82305658 T AT82305658 T AT 82305658T AT 82305658 T AT82305658 T AT 82305658T AT E32915 T1 ATE32915 T1 AT E32915T1
Authority
AT
Austria
Prior art keywords
transferrin receptor
monoclonal antibodies
human
produce
clones
Prior art date
Application number
AT82305658T
Other languages
English (en)
Inventor
Ian Trowbridge
Original Assignee
Salk Inst For Biological Studi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Salk Inst For Biological Studi filed Critical Salk Inst For Biological Studi
Application granted granted Critical
Publication of ATE32915T1 publication Critical patent/ATE32915T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2881—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD71
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AT82305658T 1981-10-26 1982-10-25 Fuer das menschliche transferrinrezeptorglykoprotein spezifische monoklonale antikoerper. ATE32915T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/315,194 US4434156A (en) 1981-10-26 1981-10-26 Monoclonal antibodies specific for the human transferrin receptor glycoprotein
EP82305658A EP0079696B1 (de) 1981-10-26 1982-10-25 Für das menschliche Transferrinrezeptor-Glykoprotein spezifische monoklonale Antikörper

Publications (1)

Publication Number Publication Date
ATE32915T1 true ATE32915T1 (de) 1988-03-15

Family

ID=23223310

Family Applications (1)

Application Number Title Priority Date Filing Date
AT82305658T ATE32915T1 (de) 1981-10-26 1982-10-25 Fuer das menschliche transferrinrezeptorglykoprotein spezifische monoklonale antikoerper.

Country Status (6)

Country Link
US (1) US4434156A (de)
EP (1) EP0079696B1 (de)
JP (1) JPH066067B2 (de)
AT (1) ATE32915T1 (de)
CA (1) CA1179952A (de)
DE (1) DE3278203D1 (de)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4624925A (en) * 1979-12-04 1986-11-25 Ortho Pharmaceutical Corporation Hybrid cell line for producing monoclonal antibody to a human early thymocyte antigens, antibody, and methods
US4691010A (en) * 1979-12-04 1987-09-01 Ortho Pharmaceutical Corporation Hybrid cell line for producing monoclonal antibody to a human early thymocyte antigen, antibody, and methods
GB2116979B (en) * 1982-02-25 1985-05-15 Ward Page Faulk Conjugates of proteins with anti-tumour agents
AU576499B2 (en) * 1983-08-18 1988-09-01 Quidel Suppressive factor of allergy
US4778752A (en) * 1983-10-11 1988-10-18 Scripps Clinic And Research Foundation Receptors specific for hapten-modified self proteins
US4522750A (en) * 1984-02-21 1985-06-11 Eli Lilly And Company Cytotoxic compositions of transferrin coupled to vinca alkaloids
US4632901A (en) * 1984-05-11 1986-12-30 Hybritech Incorporated Method and apparatus for immunoassays
US4722891A (en) * 1984-06-20 1988-02-02 Board Of Regents, The University Of Texas System Methods and compositions for detection of Legionnaires' disease
JPS61294366A (ja) * 1985-06-24 1986-12-25 Toubishi Yakuhin Kogyo Kk 糖鎖に特異的な抗体の検出用試薬及びその使用
US5776093A (en) * 1985-07-05 1998-07-07 Immunomedics, Inc. Method for imaging and treating organs and tissues
GB8519457D0 (en) * 1985-08-02 1985-09-11 Faulk Ward Page Tumour imaging agents
US4956453A (en) * 1985-12-06 1990-09-11 Cetus Corporation Anti-human ovarian cancer immunotoxins and methods of use thereof
CA1289880C (en) * 1985-12-06 1991-10-01 Jeffrey L. Winkelhake Anti-human ovarian cancer immunotoxins and methods of use thereof
US4962188A (en) * 1985-12-06 1990-10-09 Cetus Corporation Recombinant ricin toxin A chain conjugates
US5670151A (en) * 1986-04-28 1997-09-23 Chiron Corporation Method for controlling hyperproliferative diseases
US4946778A (en) * 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
US6121424A (en) * 1991-11-25 2000-09-19 Enzon, Inc. Multivalent antigen-binding proteins
US5260203A (en) * 1986-09-02 1993-11-09 Enzon, Inc. Single polypeptide chain binding molecules
US5869620A (en) * 1986-09-02 1999-02-09 Enzon, Inc. Multivalent antigen-binding proteins
US5292869A (en) * 1989-04-27 1994-03-08 The Board Of Governors Of The University Method for isolating and purifying transferrin and lactoferrin receptor proteins from bacteria and the preparation of vaccines containing the same
US5141743A (en) * 1989-04-27 1992-08-25 University Technologies International, Inc. Method for isolating and purifying transferrin and lactoferrin receptor proteins and vaccines containing the same
US5672683A (en) * 1989-09-07 1997-09-30 Alkermes, Inc. Transferrin neuropharmaceutical agent fusion protein
US5977307A (en) * 1989-09-07 1999-11-02 Alkermes, Inc. Transferrin receptor specific ligand-neuropharmaceutical agent fusion proteins
US5182107A (en) * 1989-09-07 1993-01-26 Alkermes, Inc. Transferrin receptor specific antibody-neuropharmaceutical or diagnostic agent conjugates
US5154924A (en) * 1989-09-07 1992-10-13 Alkermes, Inc. Transferrin receptor specific antibody-neuropharmaceutical agent conjugates
US5527527A (en) * 1989-09-07 1996-06-18 Alkermes, Inc. Transferrin receptor specific antibody-neuropharmaceutical agent conjugates
US6329508B1 (en) 1989-09-07 2001-12-11 Alkermes, Inc. Transferrin receptor reactive chimeric antibodies
WO1991014452A1 (en) 1990-03-27 1991-10-03 The Salk Institute For Biological Studies Method for inhibiting cell growth and compositions useful therefor
DE4222573C1 (de) * 1992-05-16 1993-08-12 Dorothee Dr. 4400 Muenster De Ahlert
WO1994012520A1 (en) * 1992-11-20 1994-06-09 Enzon, Inc. Linker for linked fusion polypeptides
US6015555A (en) * 1995-05-19 2000-01-18 Alkermes, Inc. Transferrin receptor specific antibody-neuropharmaceutical or diagnostic agent conjugates
US7026116B1 (en) * 1996-04-04 2006-04-11 Bio-Rad Laboratories, Inc. Polymorphisms in the region of the human hemochromatosis gene
US6140305A (en) * 1996-04-04 2000-10-31 Bio-Rad Laboratories, Inc. Hereditary hemochromatosis gene products
US6849399B1 (en) 1996-05-23 2005-02-01 Bio-Rad Laboratories, Inc. Methods and compositions for diagnosis and treatment of iron misregulation diseases
WO1997047655A1 (en) * 1996-06-14 1997-12-18 Rothenberg Barry E Methods for the detection of a mutant receptor diagnostic for hemochromatosis
DE69841593D1 (de) 1997-06-13 2010-05-12 Bio Rad Laboratories Verfahren und Zusammensetzungen für die Diagnose und die Behandlung von Krankheiten, die mit Eisenüberschuss oder Eisenmangel assoziiert sind
US6692952B1 (en) * 1999-11-10 2004-02-17 Massachusetts Institute Of Technology Cell analysis and sorting apparatus for manipulation of cells
EP2359689B1 (de) 2002-09-27 2015-08-26 The General Hospital Corporation Mikrofluid-Vorrichtung zur Zelltrennung, sowie Verwendung derselben
EP1604184A4 (de) * 2003-02-27 2010-10-27 Stephen A Lesko Standardisierte bewertung von therapeutischer wirksamkeit auf basis zellulärer biomarker
EP1620564A4 (de) * 2003-04-18 2008-03-12 Cytovia Inc Verfahren zur behandlung von auf apoptoseinduktion reagierenden krankheiten und screening-tests
EP1636564A1 (de) * 2003-06-13 2006-03-22 The General Hospital Corporation Mikrofluidsysteme zur abtrennung roter blutkörperchen und von blutplättchen nach grösse aus blut
JP4824025B2 (ja) * 2004-06-07 2011-11-24 マクロジェニックス ウエスト，インコーポレイテッド トランスフェリンレセプター抗体
US20070196820A1 (en) 2005-04-05 2007-08-23 Ravi Kapur Devices and methods for enrichment and alteration of cells and other particles
US8921102B2 (en) * 2005-07-29 2014-12-30 Gpb Scientific, Llc Devices and methods for enrichment and alteration of circulating tumor cells and other particles
US8187979B2 (en) * 2009-12-23 2012-05-29 Varian Semiconductor Equipment Associates, Inc. Workpiece patterning with plasma sheath modulation
CA2818173C (en) 2010-11-30 2022-05-03 Genentech, Inc. Low affinity blood brain barrier receptor antibodies and uses therefor
WO2014152678A1 (en) * 2013-03-15 2014-09-25 University Of Massachusetts Compositions and methods for delivering agents to the central nervous system
BR112017023862A2 (pt) 2015-05-04 2018-07-17 Cytomx Therapeutics Inc anticorpos anti-cd71, anticorpos anti-cd71 ativáveis, e métodos de uso destes
RU2737637C2 (ru) 2015-07-22 2020-12-01 Инатерис Антитела против tfr и их применение при лечении пролиферативных и воспалительных расстройств
WO2018165619A1 (en) 2017-03-09 2018-09-13 Cytomx Therapeutics, Inc. Cd147 antibodies, activatable cd147 antibodies, and methods of making and use thereof
WO2019173771A1 (en) 2018-03-09 2019-09-12 Cytomx Therapeutics, Inc. Activatable cd147 antibodies and methods of making and use thereof
JP2022548310A (ja) 2019-09-23 2022-11-17 シートムエックス セラピューティクス，インコーポレイテッド 抗ｃｄ４７抗体、活性化可能抗ｃｄ４７抗体、およびその使用方法
CN112409487B (zh) * 2020-11-27 2022-04-29 宁波赛珀生物技术有限公司 抗可溶性转铁蛋白受体抗体及其应用
AU2024299328A1 (en) 2023-07-21 2026-01-22 Marrow Therapeutics, Inc. Hematopoietic cell targeting conjugates and related methods

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4364935A (en) 1979-12-04 1982-12-21 Ortho Pharmaceutical Corporation Monoclonal antibody to a human prothymocyte antigen and methods of preparing same
US4364933A (en) 1979-12-04 1982-12-21 Ortho Pharmaceutical Corporation Monoclonal antibody to a human thymocyte antigen and methods of preparing same
US4361550A (en) 1979-12-04 1982-11-30 Ortho Pharmaceutical Corporation Complement-fixing monoclonal antibody to human suppressor T cells and methods of preparing same
US4364934A (en) 1979-12-04 1982-12-21 Ortho Pharmaceutical Corporation Monoclonal antibody to a human early thymocyte antigen and methods for preparing same
US4364937A (en) 1980-01-08 1982-12-21 Ortho Pharmaceutical Corporation Monoclonal antibody to a human T cell antigen and methods of preparing same
US4364936A (en) 1980-01-08 1982-12-21 Ortho Pharmaceutical Corporation Monoclonal antibody to a human monocyte antigen and methods of preparing same
US4332785A (en) 1980-04-09 1982-06-01 University Patents, Inc. Immunoassay for measurement of reticulocytes, and immunoreactive reagents for use therein

Also Published As

Publication number Publication date
JPS5883632A (ja) 1983-05-19
EP0079696B1 (de) 1988-03-09
EP0079696A1 (de) 1983-05-25
CA1179952A (en) 1984-12-27
JPH066067B2 (ja) 1994-01-26
DE3278203D1 (en) 1988-04-14
US4434156A (en) 1984-02-28

Similar Documents

Publication Publication Date Title
ATE32915T1 (de) Fuer das menschliche transferrinrezeptorglykoprotein spezifische monoklonale antikoerper.
Koopman et al. Activated human lymphocytes and aggressive non-Hodgkin's lymphomas express a homologue of the rat metastasis-associated variant of CD44.
CA1142466A (en) Cell lines
Ellis et al. Monoclonal antibody preparation and purification of a tumor cell collagenasestimulatory factor
Shulman et al. A better cell line for making hybridomas secreting specific antibodies
Matzku et al. Antigenic differences between metastatic and nonmetastatic BSp73 rat tumor variants characterized by monoclonal antibodies
YU48442B (sh) Postupak za dobivanje monoklonalnog antitela okt 3
AU577745B2 (en) Somatic human hybridoma fusion partner for the production of human monoclonal antibodies
Eshhar et al. Induction of secretion of IgM from cells of the B cell line 38C-13 by somatic cell hybridization
JPS5673029A (en) Production of antibody against hepatitis virus and cell system therefor
DE60039596D1 (de) Verfahren zur herstellung von monoklonalen antikörpern
ES2131527T3 (es) Anticuerpos monoclonales contra c-kit.
ATE55780T1 (de) Hybridomazellinie und ihr monoklonaler antikoerper gegen erythropoietin.
CA2185656A1 (en) Protein tyrosine kinase agonist antibodies
EP0344134A3 (en) Monoclonal antibody specific to a fibronectin sequence expressed in transformed cells, hybridoma secreting said antibody and use of said monoclonal antibody in the diagnosis of tumors
Baumal et al. Synthesis, Assembly and Secretion of γ-Globulin by Mouse Myeloma Cells: V. Balanced and Unbalanced Synthesis of Heavy and Light Chains by IgG-Producing Tumors and Cell Lines
Chatterjee et al. Identification and partial characterization of a M r 40,000 nucleolar antigen associated with cell proliferation
EP0102601A2 (de) Monoklonaler Antikörper, Verfahren zu seiner Herstellung und Verwendung dieses monoklonalen Antikörpers
DE3585778D1 (de) Monoklonaler antikoerper, spezifisch fuer brustkrebszelloberflaechenantigen.
Mingari et al. B cell growth factor activity of immunoaffinity‐purified and recombinant human interleukin 2
Hamburger et al. Isolation and characterization of monoclonal antibodies reactive with endothelial cells
Luben et al. Production of hybridomas secreting monoclonal antibodies against the lympholine osteoclast activating factor.
DE3685145D1 (de) Monoklonale antikoerper gegen atriale, natriurethische peptide.
Ghosh et al. Generation of heavy chain-loss mutants in a B cell hybrid mediated by syngeneic idiotype-specific spleen cells.
Faller et al. HAB-1, a new heteromyeloma for continuous production of human monoclonal antibodies

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee