ATE330016T1 - Enzymatisches verfahren zur herstellung von aminosäure-derivaten mit hoher enantiomerenreinheit - Google Patents

Enzymatisches verfahren zur herstellung von aminosäure-derivaten mit hoher enantiomerenreinheit

Info

Publication number: ATE330016T1
Authority: AT; Austria
Prior art keywords: alkyl; aryl group; chosen; amino acid; acid derivatives
Prior art date: 1998-12-22

Application number

AT99962575T

Other languages

English (en)

Inventor

Peter Jan Leonard M Quaedflieg

Theodorus Sonke

Adolf Fritz Volker Wagner

Original Assignee

Dsm Ip Assets Bv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-12-22

Filing date

1999-12-17

Publication date

2006-07-15

1999-12-17 Application filed by Dsm Ip Assets Bv filed Critical Dsm Ip Assets Bv

2006-07-15 Application granted granted Critical

2006-07-15 Publication of ATE330016T1 publication Critical patent/ATE330016T1/de

Links

238000000034 method Methods 0.000 title abstract 2
150000003862 amino acid derivatives Chemical class 0.000 title 1
230000002255 enzymatic effect Effects 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 4
125000003118 aryl group Chemical group 0.000 abstract 4
150000001875 compounds Chemical class 0.000 abstract 4
HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 2
108010026809 Peptide deformylase Proteins 0.000 abstract 2
239000002184 metal Substances 0.000 abstract 2
229910052751 metal Inorganic materials 0.000 abstract 2
239000000203 mixture Substances 0.000 abstract 2
229910052759 nickel Inorganic materials 0.000 abstract 2
230000003287 optical effect Effects 0.000 abstract 2
108090000790 Enzymes Proteins 0.000 abstract 1
102000004190 Enzymes Human genes 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
230000022244 formylation Effects 0.000 abstract 1
238000006170 formylation reaction Methods 0.000 abstract 1
CBOIHMRHGLHBPB-UHFFFAOYSA-N hydroxymethyl Chemical compound O[CH2] CBOIHMRHGLHBPB-UHFFFAOYSA-N 0.000 abstract 1
229910021645 metal ion Inorganic materials 0.000 abstract 1
230000000737 periodic effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C12P41/006—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures
- C12P41/007—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures by reactions involving acyl derivatives of racemic amines
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Zoology (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Wood Science & Technology (AREA)
Chemical Kinetics & Catalysis (AREA)
Genetics & Genomics (AREA)
General Chemical & Material Sciences (AREA)
Biotechnology (AREA)
Microbiology (AREA)
Health & Medical Sciences (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Analytical Chemistry (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Enzymes And Modification Thereof (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT99962575T 1998-12-22 1999-12-17 Enzymatisches verfahren zur herstellung von aminosäure-derivaten mit hoher enantiomerenreinheit ATE330016T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP98204371A EP1013769A1 (de)	1998-12-22	1998-12-22	Enzymatisches Verfahren zur Herstellung von Aminosäure-Derivaten mit hoher enantiomerenreinheit

Publications (1)

Publication Number	Publication Date
ATE330016T1 true ATE330016T1 (de)	2006-07-15

Family

ID=8234516

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99962575T ATE330016T1 (de)	1998-12-22	1999-12-17	Enzymatisches verfahren zur herstellung von aminosäure-derivaten mit hoher enantiomerenreinheit

Country Status (7)

Country	Link
US (2)	US7018817B1 (de)
EP (2)	EP1013769A1 (de)
JP (1)	JP2002533086A (de)
AT (1)	ATE330016T1 (de)
AU (1)	AU1898100A (de)
DE (1)	DE69931958T2 (de)
WO (1)	WO2000037657A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1451147A4 (de) *	2001-07-24	2007-06-06	Pharmacore Inc	Aminosäurederivate
JP4126921B2 (ja) *	2002-02-15	2008-07-30	味の素株式会社	光学活性なβ−フェニルアラニン誘導体の製造方法
NI200300043A (es)	2002-03-28	2003-11-05	Warner Lambert Co	AMINOACIDOS CON AFINIDAD POR LA PROTEINA a2DELTA.
CA2540247C (en)	2003-09-25	2011-01-25	Warner-Lambert Company Llc	Prodrugs of amino acids with affinity for the .alpha.2.delta.-protein
US11084848B2 (en)	2015-11-04	2021-08-10	The Trustees Of The University Of Pennsylvania	Artificial proteins and compositions and methods thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4745067A (en) *	1985-05-02	1988-05-17	Microbial Chemistry Research Foundation	L-aminoacylases
AU7359198A (en) *	1997-05-01	1998-11-27	G.D. Searle & Co.	Method and apparatus for preparation of chiral beta amino acids
US6617127B2 (en) *	1998-12-22	2003-09-09	Holland Sweetener Company, V.O.F.	Synthesis and recovery of aspartame involving enzymatic deformylation step

1998
- 1998-12-22 EP EP98204371A patent/EP1013769A1/de not_active Withdrawn
1999
- 1999-12-17 AT AT99962575T patent/ATE330016T1/de not_active IP Right Cessation
- 1999-12-17 EP EP99962575A patent/EP1141333B1/de not_active Expired - Lifetime
- 1999-12-17 JP JP2000589711A patent/JP2002533086A/ja active Pending
- 1999-12-17 WO PCT/NL1999/000783 patent/WO2000037657A1/en not_active Ceased
- 1999-12-17 DE DE69931958T patent/DE69931958T2/de not_active Expired - Fee Related
- 1999-12-17 AU AU18981/00A patent/AU1898100A/en not_active Abandoned
- 1999-12-17 US US09/869,088 patent/US7018817B1/en not_active Expired - Fee Related
2006
- 2006-02-08 US US11/350,647 patent/US7129059B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
WO2000037657A1 (en)	2000-06-29
DE69931958D1 (de)	2006-07-27
DE69931958T2 (de)	2006-12-21
US7018817B1 (en)	2006-03-28
EP1141333B1 (de)	2006-06-14
JP2002533086A (ja)	2002-10-08
EP1141333A1 (de)	2001-10-10
US20060127997A1 (en)	2006-06-15
EP1013769A1 (de)	2000-06-28
US7129059B2 (en)	2006-10-31
AU1898100A (en)	2000-07-12

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2007-03-15

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