ATE330635T1 - Prostaglandinenthaltende zusammensetzungen und verfahren zur behandlung vom impotenz - Google Patents
Prostaglandinenthaltende zusammensetzungen und verfahren zur behandlung vom impotenzInfo
- Publication number
- ATE330635T1 ATE330635T1 AT02757647T AT02757647T ATE330635T1 AT E330635 T1 ATE330635 T1 AT E330635T1 AT 02757647 T AT02757647 T AT 02757647T AT 02757647 T AT02757647 T AT 02757647T AT E330635 T1 ATE330635 T1 AT E330635T1
- Authority
- AT
- Austria
- Prior art keywords
- aliphatic
- composition
- ester
- prostagland
- methods
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 7
- 125000001931 aliphatic group Chemical group 0.000 abstract 3
- 150000002148 esters Chemical class 0.000 abstract 3
- GMVPRGQOIOIIMI-UHFFFAOYSA-N (8R,11R,12R,13E,15S)-11,15-Dihydroxy-9-oxo-13-prostenoic acid Natural products CCCCCC(O)C=CC1C(O)CC(=O)C1CCCCCCC(O)=O GMVPRGQOIOIIMI-UHFFFAOYSA-N 0.000 abstract 2
- 229960000711 alprostadil Drugs 0.000 abstract 2
- 239000007853 buffer solution Substances 0.000 abstract 2
- 150000002634 lipophilic molecules Chemical class 0.000 abstract 2
- 239000003961 penetration enhancing agent Substances 0.000 abstract 2
- GMVPRGQOIOIIMI-DWKJAMRDSA-N prostaglandin E1 Chemical compound CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(O)=O GMVPRGQOIOIIMI-DWKJAMRDSA-N 0.000 abstract 2
- XEYBRNLFEZDVAW-UHFFFAOYSA-N prostaglandin E2 Natural products CCCCCC(O)C=CC1C(O)CC(=O)C1CC=CCCCC(O)=O XEYBRNLFEZDVAW-UHFFFAOYSA-N 0.000 abstract 2
- KBPLFHHGFOOTCA-UHFFFAOYSA-N 1-Octanol Chemical compound CCCCCCCCO KBPLFHHGFOOTCA-UHFFFAOYSA-N 0.000 abstract 1
- 208000010228 Erectile Dysfunction Diseases 0.000 abstract 1
- -1 N,N-disubstituted amino Chemical group 0.000 abstract 1
- 230000002378 acidificating effect Effects 0.000 abstract 1
- 150000004676 glycans Chemical class 0.000 abstract 1
- 201000001881 impotence Diseases 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 229920001282 polysaccharide Polymers 0.000 abstract 1
- 239000005017 polysaccharide Substances 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gynecology & Obstetrics (AREA)
- Reproductive Health (AREA)
- Dermatology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Inorganic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/947,617 US6693135B2 (en) | 2000-01-10 | 2001-09-06 | Prostaglandin compositions and methods of treatment for male erectile dysfunction |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE330635T1 true ATE330635T1 (de) | 2006-07-15 |
Family
ID=25486427
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02757647T ATE330635T1 (de) | 2001-09-06 | 2002-09-06 | Prostaglandinenthaltende zusammensetzungen und verfahren zur behandlung vom impotenz |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US6693135B2 (de) |
| EP (1) | EP1423147B1 (de) |
| JP (1) | JP4544859B2 (de) |
| KR (1) | KR20040033024A (de) |
| CN (1) | CN1551784A (de) |
| AT (1) | ATE330635T1 (de) |
| AU (1) | AU2002323650B2 (de) |
| BR (1) | BR0212352A (de) |
| CA (1) | CA2457895A1 (de) |
| DE (1) | DE60212651D1 (de) |
| EA (1) | EA009384B1 (de) |
| GE (1) | GEP20063982B (de) |
| HU (1) | HU229602B1 (de) |
| IL (1) | IL160404A0 (de) |
| MX (1) | MXPA04002133A (de) |
| NZ (1) | NZ531806A (de) |
| UA (1) | UA79759C2 (de) |
| WO (1) | WO2003022310A1 (de) |
| ZA (1) | ZA200401437B (de) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA008720B1 (ru) * | 1998-12-10 | 2007-06-29 | Нексмед (Холдингс), Инк. | Применение композиции на основе простагландина для лечения расстройства сексуального возбуждения у женщин |
| US6825234B2 (en) | 1998-12-10 | 2004-11-30 | Nexmed (Holdings) , Inc. | Compositions and methods for amelioration of human female sexual dysfunction |
| US20050004226A1 (en) * | 1998-12-10 | 2005-01-06 | Nexmed (Holdings), Inc. | Compositions and methods for amelioration of human female sexual dysfunction |
| US7105571B2 (en) * | 2000-01-10 | 2006-09-12 | Nexmed Holdings, Inc. | Prostaglandin compositions and methods of treatment for male erectile dysfunction |
| GB0222522D0 (en) | 2002-09-27 | 2002-11-06 | Controlled Therapeutics Sct | Water-swellable polymers |
| BRPI0408454A (pt) | 2003-03-21 | 2006-04-04 | Nexmed Holdings Inc | composição tópica, método de tratar a ejaculação precoce, e, uso da composição |
| JP2006520788A (ja) * | 2003-03-21 | 2006-09-14 | ネックスメド ホールディングス インコーポレイテッド | プロスタグランジン組成物による血管形成促進および方法 |
| GB0417401D0 (en) * | 2004-08-05 | 2004-09-08 | Controlled Therapeutics Sct | Stabilised prostaglandin composition |
| US20060127483A1 (en) * | 2004-12-10 | 2006-06-15 | Alan Drizen | Topical drug delivery system |
| GB0613333D0 (en) | 2006-07-05 | 2006-08-16 | Controlled Therapeutics Sct | Hydrophilic polyurethane compositions |
| GB0613638D0 (en) | 2006-07-08 | 2006-08-16 | Controlled Therapeutics Sct | Polyurethane elastomers |
| US20090221703A1 (en) | 2006-07-09 | 2009-09-03 | Chongxi Yu | High penetration composition and uses thereof |
| US20090238763A1 (en) | 2006-07-09 | 2009-09-24 | Chongxi Yu | High penetration compositions and uses thereof |
| PL2084124T3 (pl) | 2006-10-02 | 2014-08-29 | Techfields Biochem Co Ltd | Dodatnio naładowane rozpuszczalne w wodzie proleki prostaglandyn i związków pokrewnych o bardzo dużych szybkościach przenikania przez skórę |
| US7560489B2 (en) * | 2006-10-11 | 2009-07-14 | Nexmed Holdings, Inc. | Stabilized prostaglandin E composition |
| GB0620685D0 (en) * | 2006-10-18 | 2006-11-29 | Controlled Therapeutics Sct | Bioresorbable polymers |
| WO2008056207A1 (en) | 2006-11-08 | 2008-05-15 | Chongxi Yu | Transdermal delivery systems of peptides and related compounds |
| CN113636966B (zh) | 2007-01-15 | 2024-01-12 | 于崇曦 | 维生素a酸类和类维生素a酸化合物的前药 |
| WO2008149181A1 (en) * | 2007-06-04 | 2008-12-11 | Techfields Inc | Pro-drugs of nsaias with very high skin and membranes penetration rates and their new medicinal uses |
| WO2010065936A1 (en) | 2008-12-04 | 2010-06-10 | Chongxi Yu | High penetration compositions and their applications |
| EP2427475B1 (de) | 2009-05-08 | 2020-11-04 | Techfields Biochem Co., Ltd. | Prodrug-zusammensetzungen mit hoher durchdringung aus peptiden und peptidverbindungen |
| CA2745320A1 (en) | 2011-07-06 | 2013-01-06 | Duoject Medical Systems Inc. | Reconstitution device |
| CN104161720A (zh) * | 2014-07-07 | 2014-11-26 | 中山尼克美制药有限公司 | 一种治疗勃起功能障碍的外用前列腺素e1乳膏及制备方法 |
| JP2018502889A (ja) | 2015-01-20 | 2018-02-01 | エックスオーシー ファーマシューティカルズ インコーポレイテッドＸｏｃ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ | イソエルゴリン化合物およびその使用 |
| JP6856532B2 (ja) | 2015-01-20 | 2021-04-07 | エックスオーシー ファーマシューティカルズ インコーポレイテッドＸｏｃ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ | エルゴリン化合物およびその使用 |
| EP3630758A1 (de) | 2017-06-01 | 2020-04-08 | Xoc Pharmaceuticals, Inc | Ergolinderivate zur verwendung in der medizin |
| GB2571696B (en) | 2017-10-09 | 2020-05-27 | Compass Pathways Ltd | Large scale method for the preparation of Psilocybin and formulations of Psilocybin so produced |
| US12459965B2 (en) | 2017-10-09 | 2025-11-04 | Compass Pathfinder Limited | Preparation of psilocybin, different polymorphic forms, intermediates, formulations and their use |
| KR20220009954A (ko) | 2019-04-17 | 2022-01-25 | 컴퍼스 패쓰파인더 리미티드 | 신경인지 장애, 만성 통증을 치료하고 염증을 감소시키는 방법 |
| WO2022265537A1 (ru) * | 2021-06-18 | 2022-12-22 | Общество с ограниченной ответственностью "ИнертГаз Медикал" | Способ лечения эректильной дисфункции |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2818855A (en) | 1954-02-11 | 1958-01-07 | Anthony P Miller | Surgical device |
| BE790840A (fr) | 1971-11-01 | 1973-04-30 | Upjohn Co | Solutions de medicaments instables et leur preparation |
| US4127118B1 (en) | 1977-03-16 | 1995-12-19 | Alvaro Latorre | Method of effecting and enhancing an erection |
| US4254145A (en) | 1978-08-16 | 1981-03-03 | American Cyanamid Company | Topical application of prostaglandin hypotensive agents |
| US4311707A (en) | 1979-02-12 | 1982-01-19 | American Cyanamid Company | Process for topically producing cutaneous vasodilation for the treatment of vasospastic or ischemic conditions |
| US4801587A (en) | 1987-03-02 | 1989-01-31 | Gene Voss | Impotence ointment |
| US5256652A (en) | 1987-11-12 | 1993-10-26 | Pharmedic Co. | Topical compositions and methods for treatment of male impotence |
| US4980378A (en) | 1988-06-01 | 1990-12-25 | Odontex, Inc. | Biodegradable absorption enhancers |
| SE463851B (sv) | 1988-09-02 | 1991-02-04 | Amsu Ltd | Komposition foer behandling av erektil dysfunktion via uretra |
| US5242391A (en) | 1990-04-25 | 1993-09-07 | Alza Corporation | Urethral insert for treatment of erectile dysfunction |
| PT97441B (pt) | 1990-04-25 | 1998-08-31 | Alza Corp | Processo para a preparacao de composicoes farmaceuticas que compreendem agentes vasodilatadores, nomeadamente, nitratos, alcaloides ergoticos ou prostaglandinas, ou agentes vasoconstritores, nomeadamente, alcoois benzilicos ou benzenodiois substituidos ou ainda agentes antiflamatorios esteroides e nao esteroides e dispositivos para a sua administracao transuretral |
| JP3202777B2 (ja) | 1992-01-24 | 2001-08-27 | リンテック株式会社 | 経皮吸収促進剤及びテープ製剤 |
| US5380760A (en) | 1993-11-19 | 1995-01-10 | Minnesota Mining And Manufacturing Company | Transdermal prostaglandin composition |
| NZ305560A (en) | 1995-03-14 | 1998-11-25 | Vivus Inc | Method for preventing erectile dysfunction by administering vasoactive agent, particularly a prostaglandin, kit therefor |
| US6414028B1 (en) * | 1997-11-05 | 2002-07-02 | Nexmed Holdings, Inc. | Topical compositions containing prostaglandin E1 |
| US6046244A (en) | 1997-11-05 | 2000-04-04 | Nexmed Holdings, Inc. | Topical compositions for prostaglandin E1 delivery |
| US5942545A (en) | 1998-06-15 | 1999-08-24 | Macrochem Corporation | Composition and method for treating penile erectile dysfunction |
| US6486207B2 (en) | 1998-12-10 | 2002-11-26 | Nexmed (Holdings), Inc. | Compositions and methods for amelioration of human female sexual dysfunction |
| US6224573B1 (en) * | 1999-01-15 | 2001-05-01 | Nexmed Holdings, Inc. | Medicament dispenser |
| US6102849A (en) | 1999-04-03 | 2000-08-15 | Hakac; John R. | Non-surgical penile prosthesis |
| AU1262501A (en) | 1999-11-12 | 2001-05-30 | Pharmaderm Laboratories, Ltd. | Compositions for transdermal and transmucosal administration of therapeutic agents |
| US6323241B1 (en) * | 2000-01-10 | 2001-11-27 | Nexmed (Holdings) Inc. | Prostaglandin compositions and methods of treatment for male erectile dysfunction |
-
2001
- 2001-09-06 US US09/947,617 patent/US6693135B2/en not_active Expired - Lifetime
-
2002
- 2002-06-09 UA UA2004042542A patent/UA79759C2/uk unknown
- 2002-09-06 IL IL16040402A patent/IL160404A0/xx unknown
- 2002-09-06 JP JP2003526438A patent/JP4544859B2/ja not_active Expired - Fee Related
- 2002-09-06 CA CA002457895A patent/CA2457895A1/en not_active Abandoned
- 2002-09-06 AU AU2002323650A patent/AU2002323650B2/en not_active Ceased
- 2002-09-06 EP EP02757647A patent/EP1423147B1/de not_active Expired - Lifetime
- 2002-09-06 AT AT02757647T patent/ATE330635T1/de not_active IP Right Cessation
- 2002-09-06 WO PCT/US2002/028507 patent/WO2003022310A1/en not_active Ceased
- 2002-09-06 GE GE5510A patent/GEP20063982B/en unknown
- 2002-09-06 EA EA200400398A patent/EA009384B1/ru not_active IP Right Cessation
- 2002-09-06 HU HU0401816A patent/HU229602B1/hu unknown
- 2002-09-06 CN CNA028172833A patent/CN1551784A/zh active Pending
- 2002-09-06 KR KR10-2004-7003390A patent/KR20040033024A/ko not_active Ceased
- 2002-09-06 NZ NZ531806A patent/NZ531806A/en not_active IP Right Cessation
- 2002-09-06 BR BR0212352-5A patent/BR0212352A/pt not_active Application Discontinuation
- 2002-09-06 DE DE60212651T patent/DE60212651D1/de not_active Expired - Lifetime
- 2002-09-06 MX MXPA04002133A patent/MXPA04002133A/es active IP Right Grant
-
2004
- 2004-02-23 ZA ZA2004/01437A patent/ZA200401437B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1423147A1 (de) | 2004-06-02 |
| US20020045665A1 (en) | 2002-04-18 |
| US6693135B2 (en) | 2004-02-17 |
| EP1423147B1 (de) | 2006-06-21 |
| NZ531806A (en) | 2006-05-26 |
| ZA200401437B (en) | 2005-05-25 |
| CN1551784A (zh) | 2004-12-01 |
| DE60212651D1 (de) | 2006-08-03 |
| IL160404A0 (en) | 2004-07-25 |
| GEP20063982B (en) | 2006-12-11 |
| HUP0401816A2 (hu) | 2004-12-28 |
| AU2002323650B2 (en) | 2007-12-13 |
| KR20040033024A (ko) | 2004-04-17 |
| HUP0401816A3 (en) | 2012-09-28 |
| EA200400398A1 (ru) | 2004-08-26 |
| CA2457895A1 (en) | 2003-03-20 |
| EA009384B1 (ru) | 2007-12-28 |
| BR0212352A (pt) | 2004-07-27 |
| UA79759C2 (en) | 2007-07-25 |
| MXPA04002133A (es) | 2004-06-29 |
| JP4544859B2 (ja) | 2010-09-15 |
| HU229602B1 (en) | 2014-02-28 |
| JP2005504073A (ja) | 2005-02-10 |
| WO2003022310A1 (en) | 2003-03-20 |
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