ATE330941T1 - Isatinderivate mit neurotropen aktivität - Google Patents

Isatinderivate mit neurotropen aktivität

Info

Publication number
ATE330941T1
ATE330941T1 AT01946852T AT01946852T ATE330941T1 AT E330941 T1 ATE330941 T1 AT E330941T1 AT 01946852 T AT01946852 T AT 01946852T AT 01946852 T AT01946852 T AT 01946852T AT E330941 T1 ATE330941 T1 AT E330941T1
Authority
AT
Austria
Prior art keywords
isatin derivatives
neurotropic activity
derivatives
isatin
formula
Prior art date
Application number
AT01946852T
Other languages
English (en)
Inventor
Mette Groenborg
Dan Peters
Arne Moeller
Original Assignee
Neurosearch As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurosearch As filed Critical Neurosearch As
Application granted granted Critical
Publication of ATE330941T1 publication Critical patent/ATE330941T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/60—Naphtho [b] pyrroles; Hydrogenated naphtho [b] pyrroles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurosurgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT01946852T 2000-01-24 2001-01-23 Isatinderivate mit neurotropen aktivität ATE330941T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DKPA200000106 2000-01-24

Publications (1)

Publication Number Publication Date
ATE330941T1 true ATE330941T1 (de) 2006-07-15

Family

ID=8158986

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01946852T ATE330941T1 (de) 2000-01-24 2001-01-23 Isatinderivate mit neurotropen aktivität

Country Status (12)

Country Link
US (2) US7282511B2 (de)
EP (2) EP1736468A3 (de)
JP (1) JP2003520851A (de)
CN (1) CN1298704C (de)
AT (1) ATE330941T1 (de)
AU (1) AU781067B2 (de)
CA (1) CA2394292A1 (de)
DE (1) DE60120925T2 (de)
DK (1) DK1255734T3 (de)
ES (1) ES2266214T3 (de)
PT (1) PT1255734E (de)
WO (1) WO2001055110A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000071102A2 (en) 1999-05-19 2000-11-30 Neurosearch A/S Inhibitors of proton-gated cation channels and their use in the treatment of ischaemic disorders
JP2004523543A (ja) * 2001-02-15 2004-08-05 ニューロサーチ、アクティーゼルスカブ 神経栄養活性を有する化合物とドパミン活性を増加させる化合物の組み合わせ作用によるパーキンソン病の治療法
WO2006047299A2 (en) * 2004-10-22 2006-05-04 University Of Florida Research Foundation, Inc. Organotypic slice cultures and uses thereof
KR20080070749A (ko) 2005-11-23 2008-07-30 페인셉터 파마 코포레이션 개폐 이온 통로를 조절하기 위한 조성물 및 방법
US20080004282A1 (en) * 2006-04-10 2008-01-03 Painceptor Pharma Corporation Compositions and methods for modulating gated ion channels
HUP0600409A3 (en) * 2006-05-15 2008-05-28 Univ Szegedi Izatin and it's derivatives for use as a medicine
US20090246134A1 (en) * 2007-05-30 2009-10-01 Painceptor Pharma Corporation Compositions and methods for modulating gated ion channels
DE102008022221A1 (de) * 2008-05-06 2009-11-12 Universität des Saarlandes Inhibitoren der humanen Aldosteronsynthase CYP11B2
KR20250151545A (ko) * 2023-03-10 2025-10-21 조에티스 서비시즈 엘엘씨 포스포다이에스터레이스 3(pde3) 억제제

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4322833A (en) * 1977-05-09 1982-03-30 Micro Display Systems, Inc. Electronic timepiece having conductive face cover for implementing display function
US4322533A (en) * 1980-03-17 1982-03-30 Lesher George Y 1H-Indole-2,3-dione derivatives
EP0089394A1 (de) 1982-03-23 1983-09-28 Sterling Drug Inc. 1-H-Indole-2,3-dione-Derivate und deren Herstellung
IE69677B1 (en) * 1989-12-11 1996-10-02 Neurosearch As Isatine derivatives their preparation and use
ATE194985T1 (de) 1990-11-06 2000-08-15 Yamanouchi Pharma Co Ltd Kondensiertes pyrazinderivat
MX9204914A (es) 1991-08-28 1993-07-01 Frank Watjen Nuevos derivados de isatinoxima, metodo para su preparacion y composicion farmaceutica que los comprende.
DE4217952A1 (de) * 1992-05-30 1993-12-02 Basf Ag Chinoxalin-2,3(1H,4H)-dione
JPH06228112A (ja) 1993-02-05 1994-08-16 Yamanouchi Pharmaceut Co Ltd （１ｈ，４ｈ）キノキサリン誘導体
NZ267081A (en) * 1993-05-13 1997-11-24 Neurosearch As Hetero-fused indole and quinoxaline compounds and medicaments thereof
US5843945A (en) * 1993-05-13 1998-12-01 Neurosearch A/S AMPA antagonists and a method of treatment
JPH083159A (ja) * 1994-06-17 1996-01-09 Nippon Kayaku Co Ltd ６−（１−ｈ−イミダゾール−１−イル）−７−ニトロ−２，３−（１ｈ，４ｈ）−キノキサリンジオン塩酸塩の製造方法
AU686888B2 (en) * 1994-09-14 1998-02-12 Neurosearch A/S Fused indole and quinoxaline derivatives, their preparation and use
NZ293265A (en) * 1994-09-14 1998-01-26 Neurosearch As 5-aryl-isoquinoline-2-one-3-acyloxime derivatives fused with a n-heterocyclic ring
DE69524246T2 (de) * 1994-09-27 2002-06-27 Yamanouchi Pharmaceutical Co., Ltd. 1,2,3,4-Tetrahydroquinoxalindion Derivate und ihre Verwendung als Glutamat Rezeptor Antagonisten
DE4436852A1 (de) * 1994-10-14 1996-04-18 Basf Ag Pyrrolyl-tetrahydrobenzochinoxalindione, ihre Herstellung und Verwendung
DE4439492A1 (de) 1994-10-25 1996-05-02 Schering Ag Neue Chinoxalindionderivate, deren Herstellung und Verwendung in Arzneimitteln
TW448171B (en) 1996-06-06 2001-08-01 Yamanouchi Pharma Co Ltd Imidazole-substituted quinoxalinedione derivatives
UA54403C2 (uk) * 1996-10-01 2003-03-17 Н'Юросерч А/С Похідні індол-2,3-діон-3-оксиму, фармацевтична композиція, спосіб лікування розладу чи захворювання ссавців, у тому числі людини та спосіб одержання похідних індол-2,3-діон-3-оксиму
WO1999049864A1 (en) * 1998-03-31 1999-10-07 Neurosearch A/S Indole-2,3-dione-3-oxime derivatives for therapeutic use
WO2000001376A2 (en) 1998-07-02 2000-01-13 Eisai Co., Ltd Pharmaceutical compositions and their uses for treatment of demyelinating disorders
EP1002535A1 (de) * 1998-10-28 2000-05-24 Hrissanthi Ikonomidou Neue Verwendung von Glutamat-Antagonisten zur Behandlung von Krebs
WO2000033834A1 (en) * 1998-12-04 2000-06-15 Neurosearch A/S Use of isatin derivatives as ion channel activating agents
WO2000071102A2 (en) * 1999-05-19 2000-11-30 Neurosearch A/S Inhibitors of proton-gated cation channels and their use in the treatment of ischaemic disorders

Also Published As

Publication number Publication date
JP2003520851A (ja) 2003-07-08
CA2394292A1 (en) 2001-08-02
US20060229311A1 (en) 2006-10-12
US7595336B2 (en) 2009-09-29
CN1298704C (zh) 2007-02-07
EP1736468A2 (de) 2006-12-27
DE60120925D1 (de) 2006-08-03
US7282511B2 (en) 2007-10-16
DE60120925T2 (de) 2006-11-09
AU2831201A (en) 2001-08-07
AU781067B2 (en) 2005-05-05
PT1255734E (pt) 2006-09-29
EP1255734A1 (de) 2002-11-13
DK1255734T3 (da) 2006-10-09
US20030040518A1 (en) 2003-02-27
EP1255734B1 (de) 2006-06-21
ES2266214T3 (es) 2007-03-01
CN1395563A (zh) 2003-02-05
EP1736468A3 (de) 2007-01-03
WO2001055110A1 (en) 2001-08-02

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