ATE331782T1 - Vorrichtung mit vertiefungen für die herstellung eines zellularen netzwerkes - Google Patents

Vorrichtung mit vertiefungen für die herstellung eines zellularen netzwerkes

Info

Publication number
ATE331782T1
ATE331782T1 AT02770114T AT02770114T ATE331782T1 AT E331782 T1 ATE331782 T1 AT E331782T1 AT 02770114 T AT02770114 T AT 02770114T AT 02770114 T AT02770114 T AT 02770114T AT E331782 T1 ATE331782 T1 AT E331782T1
Authority
AT
Austria
Prior art keywords
hydrophilic
cellular network
sites
substrate
recesses
Prior art date
Application number
AT02770114T
Other languages
English (en)
Inventor
Richard David Albert Heal
Chi-Kong Yeung
Alan Thomas Parsons
Original Assignee
Qinetiq Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Qinetiq Ltd filed Critical Qinetiq Ltd
Application granted granted Critical
Publication of ATE331782T1 publication Critical patent/ATE331782T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5032—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects on intercellular interactions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/14—Scaffolds; Matrices
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0068—General culture methods using substrates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0619—Neurons
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5058—Neurological cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5082—Supracellular entities, e.g. tissue, organisms
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2535/00—Supports or coatings for cell culture characterised by topography
    • C12N2535/10—Patterned coating

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Neurology (AREA)
  • General Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Sustainable Development (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AT02770114T 2001-10-30 2002-10-25 Vorrichtung mit vertiefungen für die herstellung eines zellularen netzwerkes ATE331782T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB0126045A GB2381535A (en) 2001-10-30 2001-10-30 Device for forming a cellular network

Publications (1)

Publication Number Publication Date
ATE331782T1 true ATE331782T1 (de) 2006-07-15

Family

ID=9924804

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02770114T ATE331782T1 (de) 2001-10-30 2002-10-25 Vorrichtung mit vertiefungen für die herstellung eines zellularen netzwerkes

Country Status (7)

Country Link
US (1) US20050002985A1 (de)
EP (1) EP1440143B1 (de)
JP (1) JP2005507253A (de)
AT (1) ATE331782T1 (de)
DE (1) DE60212870T2 (de)
GB (1) GB2381535A (de)
WO (1) WO2003038030A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10326748B4 (de) * 2003-06-13 2006-11-23 Gerlach, Jörg, Dr.med. Nervenzellkulturbioreaktor und hybrides Nervenzellsystem
JP4950426B2 (ja) * 2005-02-17 2012-06-13 株式会社日立製作所 神経細胞の培養方法、神経細胞培養基材および神経細胞システムの製造方法
WO2010133301A1 (de) * 2009-05-19 2010-11-25 Leibnitz - Institut Für Analytische Wissenschaften Isa - E.V. Verfahren zur analyse des neuritenwachstums
WO2011092120A1 (en) * 2010-01-29 2011-08-04 Nerviano Medical Sciences S.R.L. 6,7- dihydroimidazo [1,5-a] pyrazin-8 (5h) - one derivatives as protein kinase modulators
KR101347854B1 (ko) 2010-02-19 2014-01-07 한국과학기술원 표면에너지 차이를 이용한 바이오칩 제작방법
KR101324199B1 (ko) 2010-09-16 2013-11-06 한국과학기술원 혼합된 자기조립 단분자 막을 이용한 단백질 결합 방법 및 그 방법을 이용한 단백질 칩
CN103156600A (zh) * 2011-12-16 2013-06-19 马劼 脑片实验仪
WO2016159068A1 (ja) * 2015-03-30 2016-10-06 凸版印刷株式会社 マイクロウェルアレイ及びその製造方法、マイクロ流体デバイス、マイクロウェルアレイのウェル内に水性液体を封入する方法及び水性液体の分析方法
DK179667B1 (en) 2017-06-30 2019-03-14 Mbh-International A/S An enema device and a method of refilling said device with an enema
JP7229110B2 (ja) * 2019-06-25 2023-02-27 株式会社Ｓｃｒｅｅｎホールディングス 細胞電位測定装置
CN118022867B (zh) * 2024-02-26 2025-02-21 深圳大学 具有局部亲水区的数字微流控芯片制备及点样方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8331865D0 (en) * 1983-11-29 1984-01-04 Univ Glasgow Microstructures
US5661349A (en) * 1988-09-28 1997-08-26 Luck; Jonathan M. Graceful energization and degradation of an electronic device micropowered by a source of energy in its environment, particularly an irrigation controller powered by light energy
US4982176A (en) * 1990-01-17 1991-01-01 Frank Schwarz Solar powered lighting and alarm systems activated by motion detection
JP3069122B2 (ja) * 1990-08-04 2000-07-24 鐘淵化学工業株式会社 神経線維の成長方向制御用基材およびその製法、神経線維の成長方向制御法ならびに神経線維の回路網
US5462658A (en) * 1994-01-14 1995-10-31 Thermo King Corporation Fuel filter system
JP3296526B2 (ja) * 1994-08-02 2002-07-02 ホーチキ株式会社 走査型火災検出装置
BE1008955A3 (fr) * 1994-11-14 1996-10-01 Univ Catholique Louvain Procede d'obtention de biomateriaux et produits obtenus.
US6103479A (en) * 1996-05-30 2000-08-15 Cellomics, Inc. Miniaturized cell array methods and apparatus for cell-based screening
US6352758B1 (en) * 1998-05-04 2002-03-05 3M Innovative Properties Company Patterned article having alternating hydrophilic and hydrophobic surface regions
SE9901100D0 (sv) * 1999-03-24 1999-03-24 Amersham Pharm Biotech Ab Surface and tis manufacture and uses
EP1265994A2 (de) * 2000-03-17 2002-12-18 President And Fellows of Harvard College Zellmusterungsverfahren

Also Published As

Publication number Publication date
GB0126045D0 (en) 2001-12-19
DE60212870T2 (de) 2007-08-30
DE60212870D1 (de) 2006-08-10
GB2381535A (en) 2003-05-07
WO2003038030A1 (en) 2003-05-08
US20050002985A1 (en) 2005-01-06
EP1440143A1 (de) 2004-07-28
EP1440143B1 (de) 2006-06-28
JP2005507253A (ja) 2005-03-17

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