ATE332692T1 - Wässerige flüssige zubereitungen - Google Patents
Wässerige flüssige zubereitungenInfo
- Publication number
- ATE332692T1 ATE332692T1 AT99938550T AT99938550T ATE332692T1 AT E332692 T1 ATE332692 T1 AT E332692T1 AT 99938550 T AT99938550 T AT 99938550T AT 99938550 T AT99938550 T AT 99938550T AT E332692 T1 ATE332692 T1 AT E332692T1
- Authority
- AT
- Austria
- Prior art keywords
- gatifloxacin
- aqueous liquid
- liquid preparations
- salt
- sodium edetate
- Prior art date
Links
- 239000007788 liquid Substances 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- XUBOMFCQGDBHNK-JTQLQIEISA-N (S)-gatifloxacin Chemical compound FC1=CC(C(C(C(O)=O)=CN2C3CC3)=O)=C2C(OC)=C1N1CCN[C@@H](C)C1 XUBOMFCQGDBHNK-JTQLQIEISA-N 0.000 abstract 5
- 229960003923 gatifloxacin Drugs 0.000 abstract 5
- 238000000034 method Methods 0.000 abstract 3
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 229940037001 sodium edetate Drugs 0.000 abstract 2
- 231100000478 corneal permeability Toxicity 0.000 abstract 1
- 238000002425 crystallisation Methods 0.000 abstract 1
- 230000008025 crystallization Effects 0.000 abstract 1
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 238000002156 mixing Methods 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Ophthalmology & Optometry (AREA)
- Otolaryngology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP23543298 | 1998-08-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE332692T1 true ATE332692T1 (de) | 2006-08-15 |
Family
ID=16986030
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99938550T ATE332692T1 (de) | 1998-08-21 | 1999-08-20 | Wässerige flüssige zubereitungen |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US6333045B1 (de) |
| EP (1) | EP1025846B1 (de) |
| JP (1) | JP5138128B2 (de) |
| KR (1) | KR100595956B1 (de) |
| CN (1) | CN1133432C (de) |
| AT (1) | ATE332692T1 (de) |
| AU (1) | AU761040B2 (de) |
| BR (1) | BRPI9906735B8 (de) |
| CA (1) | CA2307632C (de) |
| DE (1) | DE69932313T2 (de) |
| DK (1) | DK1025846T3 (de) |
| ES (1) | ES2264266T3 (de) |
| NZ (1) | NZ504017A (de) |
| PT (1) | PT1025846E (de) |
| TW (1) | TW537895B (de) |
| WO (1) | WO2000010570A1 (de) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6509327B1 (en) | 1998-09-30 | 2003-01-21 | Alcon Manufacturing, Ltd. | Compositions and methods for treating otic, ophthalmic and nasal infections |
| US6716830B2 (en) | 1998-09-30 | 2004-04-06 | Alcon, Inc. | Ophthalmic antibiotic compositions containing moxifloxacin |
| US6740664B2 (en) | 1998-09-30 | 2004-05-25 | Alcon, Inc. | Methods for treating otic and ophthalmic infections |
| HU230030B1 (hu) | 1999-10-08 | 2015-05-28 | Debiopharm International Sa | Fab I inhibitorok |
| WO2001057017A1 (en) * | 2000-02-01 | 2001-08-09 | Kyorin Pharmaceutical Co., Ltd. | Sulfate salt of quinolonecarboxylic acid derivative and use thereof |
| EP1560584B1 (de) | 2001-04-06 | 2009-01-14 | Affinium Pharmaceuticals, Inc. | Fab-i-inhibitoren |
| WO2002089853A2 (en) * | 2001-05-03 | 2002-11-14 | Allergan, Inc. | Compositions having enhanced pharmacokinetic characteristics |
| US20020198209A1 (en) * | 2001-05-03 | 2002-12-26 | Allergan Sales Inc. | Compositions having enhanced pharmacokinetic characteristics |
| EP1575951B1 (de) | 2002-12-06 | 2014-06-25 | Debiopharm International SA | Heterozyclische verbindungen, verfahren zu deren herstellung und ihre verwendung als heilmittel |
| WO2004082586A2 (en) | 2003-03-17 | 2004-09-30 | Affinium Pharmaceuticals, Inc. | Phamaceutical compositions comprising inhibitors of fab i and further antibiotics |
| US20050085446A1 (en) * | 2003-04-14 | 2005-04-21 | Babu M.K. M. | Fluoroquinolone formulations and methods of making and using the same |
| US20040202687A1 (en) * | 2003-04-14 | 2004-10-14 | Babu M.K. Manoj | Ciprofloxacin formulations and methods of making and using the same |
| JP2005008625A (ja) * | 2003-05-23 | 2005-01-13 | Santen Pharmaceut Co Ltd | キノロン系抗菌化合物を含有する点眼液 |
| DK1828167T3 (da) | 2004-06-04 | 2014-10-20 | Debiopharm Int Sa | Acrylamidderivater som antibiotiske midler |
| WO2006099325A2 (en) | 2005-03-10 | 2006-09-21 | 3M Innovative Properties Company | Methods of treating ear infections |
| US7838532B2 (en) * | 2005-05-18 | 2010-11-23 | Mpex Pharmaceuticals, Inc. | Aerosolized fluoroquinolones and uses thereof |
| US8546423B2 (en) | 2005-05-18 | 2013-10-01 | Mpex Pharmaceuticals, Inc. | Aerosolized fluoroquinolones and uses thereof |
| JP5468899B2 (ja) | 2006-07-20 | 2014-04-09 | アフィニウム ファーマシューティカルズ, インク. | Fabiインヒビターとしてのアクリルアミド誘導体 |
| WO2008044733A1 (en) | 2006-10-12 | 2008-04-17 | Kyorin Pharmaceutical Co., Ltd. | Aqueous liquid preparation having improved intraocular gatifloxacin penetration |
| KR20090064572A (ko) | 2006-10-12 | 2009-06-19 | 교린 세이야꾸 가부시키 가이샤 | 가티플록사신을 포함하는 수성 액제 |
| EP2125802A4 (de) | 2007-02-16 | 2014-08-20 | Debiopharm Int Sa | Salze, prodrugs und polymorphe von fab-i-inhibitoren |
| CA2621616A1 (en) * | 2007-02-19 | 2008-08-19 | Alcon Research, Ltd. | Topical gatifloxacin formulations |
| JP2008247828A (ja) * | 2007-03-30 | 2008-10-16 | Wakamoto Pharmaceut Co Ltd | ラタノプロストを含有する水性医薬組成物。 |
| JP5258331B2 (ja) * | 2008-03-03 | 2013-08-07 | ロート製薬株式会社 | 光安定性が改善されたニューキノロン系抗菌剤含有医薬組成物 |
| EP2260847A4 (de) * | 2008-03-31 | 2011-12-28 | Kyorin Seiyaku Kk | Wasserhaltige flüssigkeit mit gatifloxacin |
| KR20110002840A (ko) * | 2008-03-31 | 2011-01-10 | 교린 세이야꾸 가부시키 가이샤 | 가티플록사신 함유 수성액, 이의 제조 방법 및 저온에서 상기 수성액의 보존 동안 또는 상기 수성액의 동결/융해시에 침전물의 생성 방지 방법 |
| KR101959873B1 (ko) | 2008-10-07 | 2019-03-19 | 랩터 파마슈티컬스 인코포레이티드 | 약동학 개선을 위한 에어로졸 플루오로퀴놀론 제형 |
| CA2739893C (en) | 2008-10-07 | 2016-10-04 | Mpex Pharmaceuticals, Inc. | Inhalation of levofloxacin for reducing lung inflammation |
| JP5960434B2 (ja) * | 2009-02-18 | 2016-08-02 | アラダイム コーポレーション | 肺送達のためのpH調節された製剤 |
| UA92423C2 (ru) * | 2009-07-24 | 2010-10-25 | Анатолій Альбертович Кузьмін | Антибактериальная композиция |
| WO2011029059A1 (en) | 2009-09-04 | 2011-03-10 | Mpex Pharmaceuticals, Inc. | Use of aerosolized levofloxacin for treating cystic fibrosis |
| KR101536885B1 (ko) | 2012-03-26 | 2015-07-14 | 산텐 세이야꾸 가부시키가이샤 | 디쿠아포솔 함유 점안액 |
| AU2013279021C1 (en) | 2012-06-19 | 2017-03-16 | Debiopharm International Sa | Prodrug derivatives of (E)-N-methyl-N-((3-methylbenzofuran-2-yl)methyl)-3-(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-3-yl)acrylamide |
| RS61312B1 (sr) | 2016-02-26 | 2021-02-26 | Debiopharm Int Sa | Lek za lečenje infekcija dijabetskog stopala |
| JP6886322B2 (ja) * | 2016-03-25 | 2021-06-16 | 興和株式会社 | 眼科用組成物 |
| US11242367B2 (en) | 2016-08-12 | 2022-02-08 | Silk Technologies, Ltd. | Silk-derived protein for treating inflammation |
| TN2021000159A1 (en) | 2019-02-14 | 2023-04-04 | Debiopharm Int Sa | Afabicin formulation, method for making the same and uses thereof |
| JP7599838B2 (ja) * | 2019-04-10 | 2024-12-16 | 参天製薬株式会社 | エピナスチン又はその塩を含有する水性医薬組成物 |
| SG11202113174SA (en) | 2019-06-14 | 2021-12-30 | Debiopharm Int Sa | Medicament and use thereof for treating bacterial infections involving biofilm |
| AU2020419590A1 (en) | 2019-11-15 | 2022-06-30 | Silk Technologies, Ltd. | Stable formulations of silk-derived protein |
| US11510930B2 (en) | 2020-08-26 | 2022-11-29 | Somerset Therapeutics, Llc | Gatifloxacin, prednisolone, and bromfenac compositions and methods |
| US11523987B2 (en) | 2020-08-26 | 2022-12-13 | Somerset Therapeutics, Llc | Trimcinolone and moxifloxacin methods |
| US11382910B2 (en) | 2020-08-26 | 2022-07-12 | Somerset Therapeutics, Llc. | Loteprednol and moxifloxacin compositions and methods |
| US12102632B2 (en) | 2020-08-26 | 2024-10-01 | Somerset Therapeutics, Llc | Quinolone dispersions |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU553415B2 (en) * | 1983-09-19 | 1986-07-17 | Abbott Japan Co., Ltd. | 6-fluoro-1-4-dihydro-4-oxo-7-substituted piperazinyl- quinoline-3-carboxylic acids |
| JPH089597B2 (ja) * | 1986-01-21 | 1996-01-31 | 杏林製薬株式会社 | 選択毒性に優れた8‐アルコキシキノロンカルボン酸およびその塩並びにその製造方法 |
| JPH0696533B2 (ja) * | 1987-01-14 | 1994-11-30 | 北陸製薬株式会社 | キノロンカルボン酸の水性組成物 |
| JP2549285B2 (ja) * | 1987-02-02 | 1996-10-30 | 第一製薬株式会社 | 鼻用噴霧剤 |
| JPH01258620A (ja) * | 1988-04-08 | 1989-10-16 | Dai Ichi Seiyaku Co Ltd | 耳疾患用局所製剤 |
| JP3996659B2 (ja) * | 1995-10-25 | 2007-10-24 | 千寿製薬株式会社 | 血管新生抑制剤 |
| JPH09124484A (ja) * | 1995-10-27 | 1997-05-13 | Schering Purau Kk | 点眼剤 |
| WO1998030221A1 (fr) * | 1997-01-10 | 1998-07-16 | Wakamoto Pharmaceutical Co., Ltd. | Composition de type emulsion huile/eau a usage ophtalmique et contenant du difluprednate |
-
1999
- 1999-08-20 KR KR1020007004221A patent/KR100595956B1/ko not_active Expired - Lifetime
- 1999-08-20 NZ NZ504017A patent/NZ504017A/xx not_active IP Right Cessation
- 1999-08-20 AU AU53026/99A patent/AU761040B2/en not_active Expired
- 1999-08-20 ES ES99938550T patent/ES2264266T3/es not_active Expired - Lifetime
- 1999-08-20 EP EP99938550A patent/EP1025846B1/de not_active Expired - Lifetime
- 1999-08-20 TW TW088114247A patent/TW537895B/zh not_active IP Right Cessation
- 1999-08-20 CN CNB998014087A patent/CN1133432C/zh not_active Expired - Lifetime
- 1999-08-20 WO PCT/JP1999/004483 patent/WO2000010570A1/ja not_active Ceased
- 1999-08-20 DK DK99938550T patent/DK1025846T3/da active
- 1999-08-20 US US09/529,882 patent/US6333045B1/en not_active Expired - Lifetime
- 1999-08-20 DE DE69932313T patent/DE69932313T2/de not_active Expired - Lifetime
- 1999-08-20 CA CA002307632A patent/CA2307632C/en not_active Expired - Lifetime
- 1999-08-20 JP JP2000565891A patent/JP5138128B2/ja not_active Expired - Lifetime
- 1999-08-20 AT AT99938550T patent/ATE332692T1/de active
- 1999-08-20 BR BRPI9906735A patent/BRPI9906735B8/pt not_active IP Right Cessation
- 1999-08-20 PT PT99938550T patent/PT1025846E/pt unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2264266T3 (es) | 2006-12-16 |
| EP1025846A1 (de) | 2000-08-09 |
| BR9906735A (pt) | 2000-08-15 |
| CN1275081A (zh) | 2000-11-29 |
| HK1029934A1 (en) | 2001-04-20 |
| DE69932313D1 (de) | 2006-08-24 |
| DE69932313T2 (de) | 2007-07-19 |
| AU5302699A (en) | 2000-03-14 |
| US6333045B1 (en) | 2001-12-25 |
| CA2307632C (en) | 2007-05-22 |
| KR20010031240A (ko) | 2001-04-16 |
| CN1133432C (zh) | 2004-01-07 |
| NZ504017A (en) | 2001-09-28 |
| DK1025846T3 (da) | 2006-11-06 |
| WO2000010570A1 (en) | 2000-03-02 |
| EP1025846A4 (de) | 2004-12-29 |
| AU761040B2 (en) | 2003-05-29 |
| BRPI9906735B1 (pt) | 2015-09-01 |
| EP1025846B1 (de) | 2006-07-12 |
| CA2307632A1 (en) | 2000-03-02 |
| BRPI9906735B8 (pt) | 2021-05-25 |
| KR100595956B1 (ko) | 2006-07-03 |
| JP5138128B2 (ja) | 2013-02-06 |
| PT1025846E (pt) | 2006-10-31 |
| TW537895B (en) | 2003-06-21 |
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