ATE334687T1 - Heterozyklische siliziumverbindungen und deren verwendung zur behandlung von krankheiten oder zuständen, die mit gonadotropin-freisetzenden hormon assoziiert sind - Google Patents

Heterozyklische siliziumverbindungen und deren verwendung zur behandlung von krankheiten oder zuständen, die mit gonadotropin-freisetzenden hormon assoziiert sind

Info

Publication number
ATE334687T1
ATE334687T1 AT03775585T AT03775585T ATE334687T1 AT E334687 T1 ATE334687 T1 AT E334687T1 AT 03775585 T AT03775585 T AT 03775585T AT 03775585 T AT03775585 T AT 03775585T AT E334687 T1 ATE334687 T1 AT E334687T1
Authority
AT
Austria
Prior art keywords
alkyl
sup
releasing hormone
cycloalkyl
conditions associated
Prior art date
Application number
AT03775585T
Other languages
English (en)
Inventor
John Gary Montana
Ian Fleming
Road Lensfiel
Reinhold Tacke
Jurgen Daiss
Original Assignee
Paradigm Therapeutics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0227131A external-priority patent/GB0227131D0/en
Priority claimed from GB0310472A external-priority patent/GB0310472D0/en
Priority claimed from GB0317283A external-priority patent/GB0317283D0/en
Application filed by Paradigm Therapeutics Ltd filed Critical Paradigm Therapeutics Ltd
Application granted granted Critical
Publication of ATE334687T1 publication Critical patent/ATE334687T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A61P5/04—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin for decreasing, blocking or antagonising the activity of the hypothalamic hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurosurgery (AREA)
  • Virology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Communicable Diseases (AREA)
  • Psychiatry (AREA)
  • AIDS & HIV (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT03775585T 2002-11-20 2003-11-19 Heterozyklische siliziumverbindungen und deren verwendung zur behandlung von krankheiten oder zuständen, die mit gonadotropin-freisetzenden hormon assoziiert sind ATE334687T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0227131A GB0227131D0 (en) 2002-11-20 2002-11-20 Compounds and their use
GB0310472A GB0310472D0 (en) 2003-05-07 2003-05-07 Compounds and their use
GB0317283A GB0317283D0 (en) 2003-07-23 2003-07-23 Compounds and their use

Publications (1)

Publication Number Publication Date
ATE334687T1 true ATE334687T1 (de) 2006-08-15

Family

ID=32329550

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03775585T ATE334687T1 (de) 2002-11-20 2003-11-19 Heterozyklische siliziumverbindungen und deren verwendung zur behandlung von krankheiten oder zuständen, die mit gonadotropin-freisetzenden hormon assoziiert sind

Country Status (10)

Country Link
US (1) US20060052344A1 (de)
EP (1) EP1562611B1 (de)
JP (1) JP2006510725A (de)
AT (1) ATE334687T1 (de)
AU (1) AU2003283607A1 (de)
CA (1) CA2507532A1 (de)
DE (1) DE60307313T2 (de)
DK (1) DK1562611T3 (de)
ES (1) ES2270129T3 (de)
WO (1) WO2004045625A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2531512A1 (en) * 2003-07-09 2005-01-20 Paradigm Therapeutics Ltd. Organosilicon compounds and their use
US20080261918A1 (en) * 2004-12-17 2008-10-23 Graham Andrew Showell Silicon Compounds and Their Use
US20090291915A1 (en) * 2004-12-17 2009-11-26 Graham Andrew Showell Silicon Compounds and Their Use
DE102008062878A1 (de) * 2008-12-17 2010-06-24 Aicuris Gmbh & Co. Kg Substituierte Furancarboxamide und ihre Verwendung
CN101921286B (zh) * 2009-06-15 2013-06-05 海门瑞一医药科技有限公司 一种三甲基硅乙炔的合成工艺
CN102391298A (zh) * 2011-12-27 2012-03-28 上海立科药物化学有限公司 双三甲基硅基乙炔的合成方法
US10717035B2 (en) 2017-02-13 2020-07-21 Praxair Technology, Inc. Tunable adsorbents
WO2020252787A1 (zh) * 2019-06-21 2020-12-24 辽宁凯莱英医药化学有限公司 三甲基硅基乙炔的连续化合成系统及连续化合成方法
CN114805542A (zh) * 2022-04-29 2022-07-29 江苏尤里卡生物科技有限公司 一种基于尿液中促性腺激素的纯化方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP0103622A3 (en) * 1998-08-20 2003-01-28 Agouron Pharmaceuticals Inc La Non-peptide gnrh agents, methods and intermediates for their preparation and medicaments containing them
WO2003068769A1 (en) * 2002-02-12 2003-08-21 Pfizer Inc. Non-peptide compounds affecting the action of gonadotropin-releasing hormone (gnrh)
CA2489252A1 (en) * 2002-06-13 2003-12-24 Pfizer Inc. Non-peptide gnrh agents, pharmaceutical compositions and methods for their use

Also Published As

Publication number Publication date
US20060052344A1 (en) 2006-03-09
JP2006510725A (ja) 2006-03-30
CA2507532A1 (en) 2004-06-03
DE60307313T2 (de) 2006-12-14
AU2003283607A1 (en) 2004-06-15
WO2004045625A1 (en) 2004-06-03
ES2270129T3 (es) 2007-04-01
EP1562611A1 (de) 2005-08-17
EP1562611B1 (de) 2006-08-02
DE60307313D1 (de) 2006-09-14
DK1562611T3 (da) 2006-12-04

Similar Documents

Publication Publication Date Title
SE0100567D0 (sv) Compounds
HUP9802678A2 (hu) Biciklusos aminszármazékok és ezeket tartalmazó PGD2 antagonista hatású készítmények
GB0128108D0 (en) Therapeutic use
CY1122863T1 (el) Φαρμακευτικη συνθεση που περιεχει γλυκοπυρρολικο και εναν αγωνιστη βητα2 αδρενοϋποδοχεα
SE0100568D0 (sv) Compounds
NO20044475L (no) 2-(2,6-diklorfenyl)-diarulimidazoler
HUP0203971A2 (hu) Imidazoimidazolok és -triazolok mint gyulladásellenes szerek és ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk
CY1116730T1 (el) Παραγωγα ετεροαρυλ-υποκατεστημενης 1,3-διυδροϊνδολ-2-ονης και φαρμακα που περιεχουν αυτα
HUP0303037A2 (hu) Alzheimer-kór kezelésére alkalmas vegyületek és ezeket tartalmazó gyógyszerkészítmények
SE9902987D0 (sv) Novel compounds
DE69330058D1 (de) Substituierte Phenylimidazolidine, ihre Anwendung als Medikamente und die sie enthaltende pharmazeutische Präparate
ATE334687T1 (de) Heterozyklische siliziumverbindungen und deren verwendung zur behandlung von krankheiten oder zuständen, die mit gonadotropin-freisetzenden hormon assoziiert sind
CY1109401T1 (el) Παραγωγα πιπεριδινης ως ανταγωνιστες του δεκτου nmda
DE60234577D1 (de) Pharmazeutische mischung zur behandlung von krebs, die dioxolan nukleosidanalogen enthält
DK0975595T3 (da) Kokainanaloger
DE60005054D1 (de) Chinuclidin-acrylamide
MXPA05006196A (es) Compuestos y metodos para el tratamiento o prevencion de infecciones por flavivirus.
RU2004121688A (ru) 7-аминобензотиазольные производные в качестве лигандов аденозинового рецептора
IS6970A (is) Lyfjablanda á föstu formi sem felur í sér 4-sýanó-tríflúor-3-(4-flúorfenýlsúlfonýl)-2-hýdroxý-2-metýlprópíón-m-tólúidíð og PVP
DE60001586D1 (de) Diphenyl-piperidin derivate
DE60201259D1 (de) Chemische verbindungen
DE60221283D1 (de) Verwendung von oxindolderivaten zur behandlung von mit demenz in zusammenhang stehenden krankheiten, alzheimer-krankheit und mit glycogensynthasekinase-3 assoziierten leiden
SE0100566D0 (sv) Compounds
ATE369348T1 (de) Zyklisierte benzamid-neurokinin-antagonisten zur verwendung in therapie
BR0315837A (pt) Derivados de amida de ácido heteroaril-hexanóico como agentes imunomoduladores

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1562611

Country of ref document: EP

REN Ceased due to non-payment of the annual fee