ATE335007T1 - Monoklonale antikörper gegen phf-tau, hybridomen die diese ausscheiden, antigenerkennung durch diesen antikörper und deren verwendungen - Google Patents

Monoklonale antikörper gegen phf-tau, hybridomen die diese ausscheiden, antigenerkennung durch diesen antikörper und deren verwendungen

Info

Publication number
ATE335007T1
ATE335007T1 AT95903798T AT95903798T ATE335007T1 AT E335007 T1 ATE335007 T1 AT E335007T1 AT 95903798 T AT95903798 T AT 95903798T AT 95903798 T AT95903798 T AT 95903798T AT E335007 T1 ATE335007 T1 AT E335007T1
Authority
AT
Austria
Prior art keywords
pro
tau
excrete
hybridomas
thr
Prior art date
Application number
AT95903798T
Other languages
English (en)
Inventor
Marc Vandermeeren
Eugeen Vanmechelen
De Voorde Andre Van
Original Assignee
Innogenetics Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Innogenetics Nv filed Critical Innogenetics Nv
Application granted granted Critical
Publication of ATE335007T1 publication Critical patent/ATE335007T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4711—Alzheimer's disease; Amyloid plaque core protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AT95903798T 1993-12-21 1994-12-14 Monoklonale antikörper gegen phf-tau, hybridomen die diese ausscheiden, antigenerkennung durch diesen antikörper und deren verwendungen ATE335007T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP93403133 1993-12-21

Publications (1)

Publication Number Publication Date
ATE335007T1 true ATE335007T1 (de) 2006-08-15

Family

ID=8214780

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95903798T ATE335007T1 (de) 1993-12-21 1994-12-14 Monoklonale antikörper gegen phf-tau, hybridomen die diese ausscheiden, antigenerkennung durch diesen antikörper und deren verwendungen

Country Status (11)

Country Link
US (4) US6008024A (de)
EP (1) EP0737208B1 (de)
JP (2) JP3992729B2 (de)
AT (1) ATE335007T1 (de)
AU (1) AU698383B2 (de)
CA (1) CA2178212C (de)
DE (1) DE69434811T2 (de)
DK (1) DK0737208T3 (de)
ES (1) ES2270421T3 (de)
PT (1) PT737208E (de)
WO (1) WO1995017429A1 (de)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
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DK0610330T3 (da) * 1991-10-25 1998-01-26 Innogenetics Nv Monoklonale antistoffer mod microtubulus-associeret protein tau
EP0772634B1 (de) * 1994-07-29 2003-03-12 Innogenetics N.V. Monoklonale antikörper gegen ein epitop einer gewissen unterklasse oder form von phosphoryliertem tau, hybridome die diese sezernieren,antigenerkennung durch diese antikörper und deren verwendung
US6797478B1 (en) * 1998-03-05 2004-09-28 University Of Cincinnati Method of detecting axonal damage, from associated disease states using tau monoclonal antibodies
DE60123752T2 (de) * 2000-01-24 2007-08-23 Innogenetics N.V. Diagnose von tauopathien durch bestimmung des verhältnisses von tau/phospho-tau
DE60141752D1 (de) 2000-06-30 2010-05-20 Innogenetics Nv Differentielle diagnose von neurologischen krankheiten
DK1295129T3 (da) * 2000-06-30 2010-07-12 Innogenetics Nv Differentialdiagnose af neurologiske sygdomme
US20030162230A1 (en) 2000-09-27 2003-08-28 Reagan Kevin J. Method for quantifying phosphokinase activity on proteins
AU2002324947B2 (en) * 2001-09-10 2007-11-15 Meso Scale Technologies, Llc. Assay buffer, compositions containing the same, and methods of using the same
ES2352668T3 (es) * 2002-08-14 2011-02-22 Mitsubishi Chemical Medience Corporation Anticuerpo específico para una proteína tau del sistema nervioso central.
EP1587409B1 (de) * 2002-10-09 2013-01-16 DMI Biosciences, Inc. Diagnose und überwachung von akuten koronaren syndromen
US7238788B2 (en) * 2004-02-18 2007-07-03 University Of Iowa Foundation Antibodies to phosphorylated tau, methods of making and methods of use
CA2599731A1 (en) * 2005-03-03 2006-09-08 Dmi Biosciences, Inc. Quantification of proteins
US7368712B2 (en) * 2005-12-06 2008-05-06 International Business Machines Corporation Y-shaped carbon nanotubes as AFM probe for analyzing substrates with angled topography
WO2008153692A2 (en) * 2007-05-22 2008-12-18 The Brigham And Women's Hospital, Inc. Microrna expression profiling of cerebrospinal fluid
WO2011053565A2 (en) * 2009-10-29 2011-05-05 Biomedical Sciences Research Centre "Alexander Fleming" Compositions and methods for detecting a tauopathy
US8574336B2 (en) 2010-04-09 2013-11-05 Southwire Company Ultrasonic degassing of molten metals
US8652397B2 (en) 2010-04-09 2014-02-18 Southwire Company Ultrasonic device with integrated gas delivery system
BR112013008765B8 (pt) 2010-10-11 2023-05-02 Biogen Idec Int Neuroscience Gmbh Anticorpos monoclonais anti-tau humano isolados ou um fragmento de ligação à tau dos mesmos, métodos de preparação dos mesmos, polinucleotídeo ou polinucleotídeos, vetor ou vetores, composição, método in vitro de diagnóstico ou monitoramento da progressão de uma tauopatia neurodegenerativa em um indivíduo humano, método in vitro para diagnosticar uma tauopatia neurodegenerativa em um indivíduo humano, e kit útil para o diagnóstico de uma tauopatia neurodegenerativa
WO2012142301A2 (en) 2011-04-12 2012-10-18 Quanterix Corporation Methods of determining a treatment protocol for and/or a prognosis of a patients recovery from a brain injury
WO2012151093A1 (en) * 2011-04-30 2012-11-08 Marv Enterprises Llc Treatment for tauopathies
GB201112056D0 (en) 2011-07-14 2011-08-31 Univ Leuven Kath Antibodies
US9371376B2 (en) 2011-12-20 2016-06-21 Janssen Biotech, Inc. Anti-PHF-tau antibodies and their uses
PE20150646A1 (es) * 2012-08-16 2015-05-21 Ipierian Inc Metodos de tratamiento de una tauopatia
US9200068B2 (en) 2012-12-18 2015-12-01 Regents Of The University Of Minnesota Compositions and methods related to tauopathy
PT2935326T (pt) 2012-12-21 2020-09-14 Biogen Ma Inc Anticorpos anti-tau humanos
US8980270B2 (en) 2013-01-18 2015-03-17 Ipierian, Inc. Methods of treating a tauopathy
WO2015035190A1 (en) 2013-09-05 2015-03-12 Cornell University Gene therapy for alzheimer's and other neurodegenerative diseases and conditions
WO2015122922A1 (en) 2014-02-14 2015-08-20 Ipierian, Inc. Tau peptides, anti-tau antibodies, and methods of use thereof
WO2015165961A1 (en) 2014-04-29 2015-11-05 Affiris Ag Treatment and prevention of alzheimer's disease (ad)
DE102014013571A1 (de) * 2014-09-18 2016-03-24 Aj Roboscreen Gmbh Monoklonaler Antikörper gegen humanes TAU-Protein
CA2991264C (en) 2015-07-06 2023-10-10 Ucb Biopharma Sprl Tau-binding antibodies
US10233515B1 (en) 2015-08-14 2019-03-19 Southwire Company, Llc Metal treatment station for use with ultrasonic degassing system
TWI771389B (zh) 2017-03-16 2022-07-21 美商健生生物科技公司 抗phf-tau抗體及其用途
JP7029718B2 (ja) * 2017-07-31 2022-03-04 国立研究開発法人量子科学技術研究開発機構 リン酸化タウタンパク質の測定方法
MA53338A (fr) 2018-03-05 2022-01-05 Janssen Pharmaceutica Nv Dosages pour détecter la neurodégénérescence
CA3093200A1 (en) * 2018-03-05 2019-09-12 Janssen Pharmaceutica Nv Anti-phf-tau antibodies and uses thereof
US20210137861A1 (en) * 2018-05-03 2021-05-13 Hough Ear Institute Methods for reducing accumulated pathologic tau protein
CN113166235A (zh) 2018-11-22 2021-07-23 富士瑞必欧株式会社 抗体偶联物
CN111349617B (zh) * 2020-05-25 2020-09-22 苏州仁端生物医药科技有限公司 一种分泌抗Tau或pTau-181/231/396单克隆抗体杂交瘤细胞株及其应用
CN111349151B (zh) * 2020-05-25 2020-10-02 苏州仁端生物医药科技有限公司 一种磷酸化多肽和截短蛋白的共价偶联方法及其应用
US20240101654A1 (en) 2020-12-29 2024-03-28 Neurimmune Ag Human anti-tau antibodies
CN113005096B (zh) * 2021-01-19 2022-10-14 华中科技大学 分泌抗丝氨酸磷酸化tau蛋白单克隆抗体的杂交瘤细胞株
CN114539400B (zh) * 2022-02-15 2024-06-07 武汉天德生物科技有限公司 一种磷酸化Tau pT217蛋白单克隆抗体、ELISA试剂盒及其应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5733734A (en) * 1991-08-14 1998-03-31 The Trustees Of The University Of Pennsylvania Method of screening for Alzheimer's disease or disease associated with the accumulation of paired helical filaments
DK0610330T3 (da) * 1991-10-25 1998-01-26 Innogenetics Nv Monoklonale antistoffer mod microtubulus-associeret protein tau
ATE398176T1 (de) * 1991-12-06 2008-07-15 Max Planck Gesellschaft Phosphorylierungsepitope aus dem tau-protein zur diagnose und behandlung der alzheimer-krankheit
EP0544942A1 (de) * 1991-12-06 1993-06-09 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Neue Werkzeuge für die Diagnose und die Behandlung der Alzheimer-Krankheit

Also Published As

Publication number Publication date
US20030138972A1 (en) 2003-07-24
EP0737208A1 (de) 1996-10-16
JPH09506771A (ja) 1997-07-08
US6500674B1 (en) 2002-12-31
AU1273695A (en) 1995-07-10
AU698383B2 (en) 1998-10-29
CA2178212A1 (en) 1995-06-29
JP2004045417A (ja) 2004-02-12
JP4110057B2 (ja) 2008-07-02
DE69434811T2 (de) 2007-03-01
EP0737208B1 (de) 2006-08-02
US6008024A (en) 1999-12-28
WO1995017429A1 (en) 1995-06-29
ES2270421T3 (es) 2007-04-01
PT737208E (pt) 2006-12-29
DK0737208T3 (da) 2006-11-27
CA2178212C (en) 2011-06-14
US20040038430A1 (en) 2004-02-26
JP3992729B2 (ja) 2007-10-17
DE69434811D1 (de) 2006-09-14

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