ATE335746T1 - Verfahren zur herstellung von epothilonen - Google Patents

Verfahren zur herstellung von epothilonen

Info

Publication number
ATE335746T1
ATE335746T1 AT04019590T AT04019590T ATE335746T1 AT E335746 T1 ATE335746 T1 AT E335746T1 AT 04019590 T AT04019590 T AT 04019590T AT 04019590 T AT04019590 T AT 04019590T AT E335746 T1 ATE335746 T1 AT E335746T1
Authority
AT
Austria
Prior art keywords
formula
compound
scheme
converted
epothilone
Prior art date
Application number
AT04019590T
Other languages
English (en)
Inventor
Gerhard Prof Dr Hoefle
Usama Karama
Original Assignee
Biotechnolog Forschung Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biotechnolog Forschung Gmbh filed Critical Biotechnolog Forschung Gmbh
Application granted granted Critical
Publication of ATE335746T1 publication Critical patent/ATE335746T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D493/00Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/24Radicals substituted by oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • C07F7/18Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804Compounds having Si-O-C linkages
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • C07F7/18Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804Compounds having Si-O-C linkages
    • C07F7/1872Preparation; Treatments not provided for in C07F7/20
    • C07F7/188Preparation; Treatments not provided for in C07F7/20 by reactions involving the formation of Si-O linkages
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • C07F7/18Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804Compounds having Si-O-C linkages
    • C07F7/1872Preparation; Treatments not provided for in C07F7/20
    • C07F7/1892Preparation; Treatments not provided for in C07F7/20 by reactions not provided for in C07F7/1876 - C07F7/1888
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/14Nitrogen or oxygen as hetero atom and at least one other diverse hetero ring atom in the same ring
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/181Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/62Carboxylic acid esters
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/14Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/141111Diverse hetero atoms in same or different rings [e.g., alkaloids, opiates, etc.]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Silicon Polymers (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT04019590T 2001-02-27 2002-02-27 Verfahren zur herstellung von epothilonen ATE335746T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP01104448 2001-02-27

Publications (1)

Publication Number Publication Date
ATE335746T1 true ATE335746T1 (de) 2006-09-15

Family

ID=8176579

Family Applications (2)

Application Number Title Priority Date Filing Date
AT04019590T ATE335746T1 (de) 2001-02-27 2002-02-27 Verfahren zur herstellung von epothilonen
AT02719946T ATE325201T1 (de) 2001-02-27 2002-02-27 Abbau von epothilonen und ethynyl substituierte epothilone

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT02719946T ATE325201T1 (de) 2001-02-27 2002-02-27 Abbau von epothilonen und ethynyl substituierte epothilone

Country Status (19)

Country Link
US (1) US7157595B2 (de)
EP (2) EP1564217B1 (de)
JP (1) JP2004522801A (de)
KR (1) KR20030084952A (de)
CN (1) CN1501980A (de)
AT (2) ATE335746T1 (de)
BR (1) BR0207675A (de)
CA (1) CA2437707A1 (de)
CZ (1) CZ20032291A3 (de)
DE (2) DE60213884T2 (de)
HU (1) HUP0303895A3 (de)
IL (1) IL157312A0 (de)
MX (1) MXPA03007466A (de)
NO (1) NO20033784D0 (de)
NZ (2) NZ527557A (de)
PL (1) PL362556A1 (de)
RU (1) RU2003128953A (de)
WO (1) WO2002072858A2 (de)
ZA (1) ZA200306034B (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6204388B1 (en) 1996-12-03 2001-03-20 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
US6242469B1 (en) 1996-12-03 2001-06-05 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto, analogues and uses thereof
DE19826988A1 (de) * 1998-06-18 1999-12-23 Biotechnolog Forschung Gmbh Epothilon-Nebenkomponenten
US20020058286A1 (en) * 1999-02-24 2002-05-16 Danishefsky Samuel J. Synthesis of epothilones, intermediates thereto and analogues thereof
WO2004018478A2 (en) * 2002-08-23 2004-03-04 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto, analogues and uses thereof
US7649006B2 (en) 2002-08-23 2010-01-19 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
US6921769B2 (en) 2002-08-23 2005-07-26 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0057736B1 (de) 1981-02-05 1986-11-20 Phillips Petroleum Company Olefin-Disproportionierungs-Verfahren und Katalysator
ATE218556T1 (de) 1995-11-17 2002-06-15 Biotechnolog Forschung Gmbh Epothilon-derivate und deren herstellung
AU716610B2 (en) * 1996-08-30 2000-03-02 Novartis Ag Method for producing epothilones, and intermediate products obtained during the production process
US5969145A (en) 1996-08-30 1999-10-19 Novartis Ag Process for the production of epothilones and intermediate products within the process
JP4274583B2 (ja) 1996-11-18 2009-06-10 ゲゼルシャフト・フュア・ビオテクノロギッシェ・フォルシュンク・ミット・ベシュレンクテル・ハフツング(ゲー・ベー・エフ) エポチロンc,d,e及びf、製造と薬剤
US6441186B1 (en) * 1996-12-13 2002-08-27 The Scripps Research Institute Epothilone analogs
US6380394B1 (en) 1996-12-13 2002-04-30 The Scripps Research Institute Epothilone analogs
EP1201666A3 (de) * 1997-02-25 2003-03-05 Gesellschaft für biotechnologische Forschung mbH (GBF) Seitenkettenmodifizierte Epothilone
US6605599B1 (en) 1997-07-08 2003-08-12 Bristol-Myers Squibb Company Epothilone derivatives
US6365749B1 (en) 1997-12-04 2002-04-02 Bristol-Myers Squibb Company Process for the preparation of ring-opened epothilone intermediates which are useful for the preparation of epothilone analogs
US6498257B1 (en) 1998-04-21 2002-12-24 Bristol-Myers Squibb Company 2,3-olefinic epothilone derivatives
US6211412B1 (en) 1999-03-29 2001-04-03 The University Of Kansas Synthesis of epothilones
US6518421B1 (en) 2000-03-20 2003-02-11 Bristol-Myers Squibb Company Process for the preparation of epothilone analogs
US6593115B2 (en) 2000-03-24 2003-07-15 Bristol-Myers Squibb Co. Preparation of epothilone intermediates

Also Published As

Publication number Publication date
DE60211124D1 (de) 2006-06-08
HUP0303895A3 (en) 2007-06-28
RU2003128953A (ru) 2005-03-10
JP2004522801A (ja) 2004-07-29
MXPA03007466A (es) 2003-12-08
NZ527557A (en) 2005-05-27
PL362556A1 (en) 2004-11-02
ZA200306034B (en) 2004-08-05
KR20030084952A (ko) 2003-11-01
WO2002072858A3 (en) 2002-12-19
NO20033784L (no) 2003-08-26
EP1364040A2 (de) 2003-11-26
CA2437707A1 (en) 2002-09-19
NO20033784D0 (no) 2003-08-26
WO2002072858A2 (en) 2002-09-19
CZ20032291A3 (cs) 2004-02-18
US7157595B2 (en) 2007-01-02
DE60213884D1 (de) 2006-09-21
EP1564217A2 (de) 2005-08-17
CN1501980A (zh) 2004-06-02
IL157312A0 (en) 2004-02-19
EP1364040B1 (de) 2006-05-03
NZ539204A (en) 2005-12-23
HUP0303895A2 (hu) 2004-03-29
DE60211124T2 (de) 2006-11-30
BR0207675A (pt) 2004-03-09
DE60213884T2 (de) 2007-02-22
EP1564217B1 (de) 2006-08-09
ATE325201T1 (de) 2006-06-15
US20040092560A1 (en) 2004-05-13
EP1564217A3 (de) 2005-08-31

Similar Documents

Publication Publication Date Title
AU2001252595A1 (en) Process for producing optically active sulfoxide derivative
DE60311599D1 (de) Verfahren zur herstellung von duloxetin und deren verwendeten zwischenprodukten
DE69528762D1 (de) Herstellung von camptothecinderivaten durch intramolekulare cyclisierung
ATE178058T1 (de) Verfahren zur herstellung von gewissen biphenyltetrazolderivaten
ATE207884T1 (de) Verfahren zur herstellung von aminobenzol- derivaten
DE60213884D1 (de) Verfahren zur Herstellung von Epothilonen
ATE277915T1 (de) Verfahren sowie neue zwischenprodukte zur herstellung von isoxazolin-3-yl-acylbenzolen
DE69622862D1 (de) Verfahren zur herstellung von zyklischen verbindungen
DE60012587D1 (de) Friedel-craft verfahren zur herstellung von thioxanthonen
DE60335865D1 (de) Verfahren zur herstellung von cilostazol
ATE223414T1 (de) Prozess zur herstellung von zwischebprodukten für imidazodeazepinen
EP1211239A4 (de) Verfahren zur herstellung von 2,3-dihydroazepin-derivaten
EP1431278A4 (de) Verfahren zur herstellung von (2-nitrophenyl)acetonitrilderivaten und zwischenprodukte dafür
EP0739885A4 (de) Verfahren zur herstellung von 3-isoxazol carbonsäure
ATE308493T1 (de) Verfahren zur herstellung von cycloalkadienen durch metathesereaktion
ATE373631T1 (de) Verfahren zur herstellung von 1-chlor-4-arylbutan
DE60028998D1 (de) Verfahren zur herstellung einer benzylamin-verbindung
EP1698611A4 (de) Verfahren zur herstellung von phenylessigsäurederivaten
ATE370146T1 (de) Verfahren zur herstellung von cephalosporin- derivaten
DE60008561D1 (de) Verfahren zur herstellung von oxazol-derivaten
ATE206109T1 (de) Verfahren zur herstellung von carbamoylmethylharnstoff-derivaten
ATE448208T1 (de) Verfahren zur herstellung von 1-2-(benzimidazol-2-yl-thio)ethyl piperazin bzw. salzen davon
ATE295350T1 (de) Verfahren zur herstellung von 3 spiro'cyclohexan- 1,3'-'3höindolin-2'-onöderivaten
EP1489061A4 (de) Verfahren zur herstellung einer cyclischen verbindung

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties