ATE370146T1 - Verfahren zur herstellung von cephalosporin- derivaten - Google Patents
Verfahren zur herstellung von cephalosporin- derivatenInfo
- Publication number
- ATE370146T1 ATE370146T1 AT00113739T AT00113739T ATE370146T1 AT E370146 T1 ATE370146 T1 AT E370146T1 AT 00113739 T AT00113739 T AT 00113739T AT 00113739 T AT00113739 T AT 00113739T AT E370146 T1 ATE370146 T1 AT E370146T1
- Authority
- AT
- Austria
- Prior art keywords
- chem
- general formula
- cephalosporine derivatives
- producing
- derivatives
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- HOKIDJSKDBPKTQ-UHFFFAOYSA-N 3-(acetyloxymethyl)-7-[(5-amino-5-carboxypentanoyl)amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid Chemical class S1CC(COC(=O)C)=C(C(O)=O)N2C(=O)C(NC(=O)CCCC(N)C(O)=O)C12 HOKIDJSKDBPKTQ-UHFFFAOYSA-N 0.000 title 1
- 238000000034 method Methods 0.000 abstract 2
- 229930186147 Cephalosporin Natural products 0.000 abstract 1
- 229940124587 cephalosporin Drugs 0.000 abstract 1
- 150000001780 cephalosporins Chemical class 0.000 abstract 1
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000004714 phosphonium salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/48—Methylene radicals, substituted by hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP99112911 | 1999-07-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE370146T1 true ATE370146T1 (de) | 2007-09-15 |
Family
ID=8238511
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00113739T ATE370146T1 (de) | 1999-07-05 | 2000-06-29 | Verfahren zur herstellung von cephalosporin- derivaten |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6384214B1 (de) |
| EP (1) | EP1067131B1 (de) |
| JP (1) | JP4033608B2 (de) |
| KR (1) | KR20010049719A (de) |
| CN (1) | CN1292380A (de) |
| AT (1) | ATE370146T1 (de) |
| CA (1) | CA2313379A1 (de) |
| DE (1) | DE60035925T2 (de) |
| DK (1) | DK1067131T3 (de) |
| ES (1) | ES2291159T3 (de) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010136423A1 (de) | 2009-05-25 | 2010-12-02 | Sandoz Ag | Verfahren zur herstellung von ceftobiprol medocaril |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5523400A (en) | 1993-04-16 | 1996-06-04 | Hoffmann-La Roche Inc. | Cephalosporin antibiotics |
| ES2185634T3 (es) | 1993-04-16 | 2003-05-01 | Basilea Pharmaceutica Ag | Derivados de cefalosporina. |
| US5856474A (en) * | 1994-04-25 | 1999-01-05 | Biochemie Gesellschaft, M.B.H. | Cephalosporin synthesis |
| EP0761673A1 (de) * | 1995-09-12 | 1997-03-12 | F. Hoffmann-La Roche Ag | Cephalosporin-Derivate |
| EP0831093A1 (de) * | 1996-09-23 | 1998-03-25 | F. Hoffmann-La Roche Ag | 1-Carba-(desthia)-cephalosporinderivate |
| TW415949B (en) * | 1996-12-19 | 2000-12-21 | Hoffmann La Roche | Vinyl pyrrolidine cephalosporin derivatives with basic substituents |
| AU1654900A (en) * | 1998-12-03 | 2000-06-19 | F. Hoffmann-La Roche Ag | Bi-pyrrolidinylvinl (carba) cephalosporins |
-
2000
- 2000-06-29 AT AT00113739T patent/ATE370146T1/de active
- 2000-06-29 EP EP00113739A patent/EP1067131B1/de not_active Expired - Lifetime
- 2000-06-29 DK DK00113739T patent/DK1067131T3/da active
- 2000-06-29 ES ES00113739T patent/ES2291159T3/es not_active Expired - Lifetime
- 2000-06-29 DE DE60035925T patent/DE60035925T2/de not_active Expired - Lifetime
- 2000-06-29 US US09/610,647 patent/US6384214B1/en not_active Expired - Lifetime
- 2000-07-04 CN CN001199676A patent/CN1292380A/zh active Pending
- 2000-07-04 CA CA002313379A patent/CA2313379A1/en not_active Abandoned
- 2000-07-05 JP JP2000202997A patent/JP4033608B2/ja not_active Expired - Fee Related
- 2000-07-05 KR KR1020000038364A patent/KR20010049719A/ko not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| JP4033608B2 (ja) | 2008-01-16 |
| DE60035925D1 (de) | 2007-09-27 |
| ES2291159T3 (es) | 2008-03-01 |
| US6384214B1 (en) | 2002-05-07 |
| EP1067131A1 (de) | 2001-01-10 |
| EP1067131B1 (de) | 2007-08-15 |
| CA2313379A1 (en) | 2001-01-05 |
| KR20010049719A (ko) | 2001-06-15 |
| CN1292380A (zh) | 2001-04-25 |
| DE60035925T2 (de) | 2008-05-15 |
| JP2001055392A (ja) | 2001-02-27 |
| DK1067131T3 (da) | 2007-12-10 |
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