ATE336578T1 - Nukleinsäurebindungsproteine - Google Patents

Nukleinsäurebindungsproteine

Info

Publication number
ATE336578T1
ATE336578T1 AT99910512T AT99910512T ATE336578T1 AT E336578 T1 ATE336578 T1 AT E336578T1 AT 99910512 T AT99910512 T AT 99910512T AT 99910512 T AT99910512 T AT 99910512T AT E336578 T1 ATE336578 T1 AT E336578T1
Authority
AT
Austria
Prior art keywords
nucleic acid
binding proteins
acid binding
sequence containing
base
Prior art date
Application number
AT99910512T
Other languages
English (en)
Inventor
Yen Choo
Road Hills
Original Assignee
Gendaq Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9805576.7A external-priority patent/GB9805576D0/en
Priority claimed from GBGB9806895.0A external-priority patent/GB9806895D0/en
Priority claimed from GBGB9807246.5A external-priority patent/GB9807246D0/en
Application filed by Gendaq Ltd filed Critical Gendaq Ltd
Application granted granted Critical
Publication of ATE336578T1 publication Critical patent/ATE336578T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/02—Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Virology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT99910512T 1998-03-17 1999-03-17 Nukleinsäurebindungsproteine ATE336578T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9805576.7A GB9805576D0 (en) 1998-03-17 1998-03-17 Proteins
GBGB9806895.0A GB9806895D0 (en) 1998-03-31 1998-03-31 Nucleic acid binding proteins
GBGB9807246.5A GB9807246D0 (en) 1998-04-03 1998-04-03 Nucleic acid binding proteins

Publications (1)

Publication Number Publication Date
ATE336578T1 true ATE336578T1 (de) 2006-09-15

Family

ID=27269244

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99910512T ATE336578T1 (de) 1998-03-17 1999-03-17 Nukleinsäurebindungsproteine

Country Status (9)

Country Link
US (1) US6977154B1 (de)
EP (1) EP1064369B1 (de)
JP (1) JP2002506640A (de)
AT (1) ATE336578T1 (de)
AU (1) AU751487B2 (de)
CA (1) CA2323064C (de)
DE (1) DE69932813D1 (de)
NZ (1) NZ506987A (de)
WO (1) WO1999047656A2 (de)

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US7262055B2 (en) 1998-08-25 2007-08-28 Gendaq Limited Regulated gene expression in plants
US7285416B2 (en) 2000-01-24 2007-10-23 Gendaq Limited Regulated gene expression in plants
GB9710809D0 (en) 1997-05-23 1997-07-23 Medical Res Council Nucleic acid binding proteins
US6410248B1 (en) 1998-01-30 2002-06-25 Massachusetts Institute Of Technology General strategy for selecting high-affinity zinc finger proteins for diverse DNA target sites
AU746454B2 (en) 1998-03-02 2002-05-02 Massachusetts Institute Of Technology Poly zinc finger proteins with improved linkers
DE69932813D1 (de) 1998-03-17 2006-09-28 Gendaq Ltd Nukleinsäurebindungsproteine
US6599692B1 (en) 1999-09-14 2003-07-29 Sangamo Bioscience, Inc. Functional genomics using zinc finger proteins
US6534261B1 (en) 1999-01-12 2003-03-18 Sangamo Biosciences, Inc. Regulation of endogenous gene expression in cells using zinc finger proteins
US7070934B2 (en) 1999-01-12 2006-07-04 Sangamo Biosciences, Inc. Ligand-controlled regulation of endogenous gene expression
US6453242B1 (en) 1999-01-12 2002-09-17 Sangamo Biosciences, Inc. Selection of sites for targeting by zinc finger proteins and methods of designing zinc finger proteins to bind to preselected sites
US7013219B2 (en) 1999-01-12 2006-03-14 Sangamo Biosciences, Inc. Regulation of endogenous gene expression in cells using zinc finger proteins
US6794136B1 (en) 2000-11-20 2004-09-21 Sangamo Biosciences, Inc. Iterative optimization in the design of binding proteins
US20030104526A1 (en) 1999-03-24 2003-06-05 Qiang Liu Position dependent recognition of GNN nucleotide triplets by zinc fingers
US7030215B2 (en) 1999-03-24 2006-04-18 Sangamo Biosciences, Inc. Position dependent recognition of GNN nucleotide triplets by zinc fingers
HK1049515B (en) 1999-12-06 2006-01-13 Sangamo Biosciences Inc. Methods of using randomized libraries of zinc finger proteins for the identification of gene function
WO2001053480A1 (en) * 2000-01-24 2001-07-26 Sangamo Biosciences, Inc. Nucleic acid binding polypeptides characterized by flexible linkers connected nucleic acid binding modules
CN1307027A (zh) * 2000-01-26 2001-08-08 上海博道基因技术有限公司 一种新的多肽——人含tfiis特征性序列片段的锌指蛋白43和编码这种多肽的多核苷酸
DE60143192D1 (de) * 2000-02-08 2010-11-18 Sangamo Biosciences Inc Zellen zur entdeckung von medikamenten
EP1276860B1 (de) 2000-04-28 2007-09-26 Sangamo Biosciences Inc. Datenbanken von regulatorischen sequenzen, methoden zu ihrer herstellung und verwendung
US7923542B2 (en) 2000-04-28 2011-04-12 Sangamo Biosciences, Inc. Libraries of regulatory sequences, methods of making and using same
WO2001083819A2 (en) 2000-04-28 2001-11-08 Sangamo Biosciences, Inc. Methods for designing exogenous regulatory molecules
WO2001084148A2 (en) 2000-04-28 2001-11-08 Sangamo Biosciences, Inc. Pharmacogenomics and identification of drug targets by reconstruction of signal transduction pathways based on sequences of accessible regions
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NZ523649A (en) * 2000-07-18 2005-02-25 Novartis Ag Regulation of gene expression using single-chain, monomeric, ligand dependent polypeptide switches
EP1303608A2 (de) * 2000-07-21 2003-04-23 Syngenta Participations AG Code zur erkennung von zinkfingerdomänen und dessen verwendungen
US7067317B2 (en) 2000-12-07 2006-06-27 Sangamo Biosciences, Inc. Regulation of angiogenesis with zinc finger proteins
AU2884102A (en) 2000-12-07 2002-06-18 Sangamo Biosciences Inc Regulation of angiogenesis with zinc finger proteins
AU2002225187A1 (en) * 2001-01-22 2002-07-30 Sangamo Biosciences, Inc. Zinc finger polypeptides and their use
CA2435394C (en) 2001-01-22 2018-01-09 Sangamo Biosciences, Inc. Modified zinc finger binding proteins
DE10146129A1 (de) * 2001-09-19 2003-04-03 Ina Schaeffler Kg Schaltelement für einen Ventiltrieb einer Brennkraftmaschine
US7262054B2 (en) 2002-01-22 2007-08-28 Sangamo Biosciences, Inc. Zinc finger proteins for DNA binding and gene regulation in plants
EP1472438B1 (de) 2002-02-06 2005-07-27 INA-Schaeffler KG Schaltelement für einen ventiltrieb einer brennkraftmaschine
US7361635B2 (en) 2002-08-29 2008-04-22 Sangamo Biosciences, Inc. Simultaneous modulation of multiple genes
US8399218B2 (en) * 2007-09-27 2013-03-19 Dow Agrosciences, Llc Engineered zinc finger proteins targeting 5-enolpyruvyl shikimate-3-phosphate synthase genes
US8161929B2 (en) 2007-11-21 2012-04-24 Schaeffler Kg Switchable tappet
EP2130836B1 (de) * 2008-06-03 2013-02-13 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Mittel und Verfahren zur Herstellung von Zinkfingern und Konkatemere daraus
MY160435A (en) * 2008-06-12 2017-03-15 Univ Putra Malaysia A novel antiviral peptide against avian influenza virus h9n2
JP5854464B2 (ja) * 2009-10-16 2016-02-09 国立研究開発法人理化学研究所 メチル化ｄｎａ結合ペプチド
EP3917571A4 (de) 2019-01-31 2022-10-12 Agency For Science, Technology And Research Cnx/erp57-inhibitor zur verwendung bei der behandlung oder prävention von krebs

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Also Published As

Publication number Publication date
JP2002506640A (ja) 2002-03-05
EP1064369B1 (de) 2006-08-16
AU751487B2 (en) 2002-08-15
WO1999047656A3 (en) 1999-11-25
CA2323064A1 (en) 1999-09-23
AU2944999A (en) 1999-10-11
CA2323064C (en) 2011-05-31
US6977154B1 (en) 2005-12-20
DE69932813D1 (de) 2006-09-28
WO1999047656A2 (en) 1999-09-23
EP1064369A2 (de) 2001-01-03
NZ506987A (en) 2003-01-31

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