ATE337306T1 - Verfahren zur herstellung von optisch aktiven imidazolverbindungen, zwischenprodukte zu deren herstellung und ihre herstellung - Google Patents

Verfahren zur herstellung von optisch aktiven imidazolverbindungen, zwischenprodukte zu deren herstellung und ihre herstellung

Info

Publication number: ATE337306T1
Authority: AT; Austria
Prior art keywords: production; optically active; compound; intermediate products; imidazole compounds
Prior art date: 1997-01-23

Application number

AT03022830T

Other languages

English (en)

Inventor

Kazuyuki Kawasaki

Haruhito Kobayashi

Syuji Ehara

Hideaki Sato

Original Assignee

Mitsubishi Pharma Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-01-23

Filing date

1998-01-14

Publication date

2006-09-15

1998-01-14 Application filed by Mitsubishi Pharma Corp filed Critical Mitsubishi Pharma Corp

2006-09-15 Application granted granted Critical

2006-09-15 Publication of ATE337306T1 publication Critical patent/ATE337306T1/de

Links

238000004519 manufacturing process Methods 0.000 title abstract 4
RAXXELZNTBOGNW-UHFFFAOYSA-N 1H-imidazole Chemical class C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 title 1
239000013067 intermediate product Substances 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 4
238000000034 method Methods 0.000 abstract 2
208000002249 Diabetes Complications Diseases 0.000 abstract 1
206010012655 Diabetic complications Diseases 0.000 abstract 1
108010069102 Thromboxane-A synthase Proteins 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
238000001640 fractional crystallisation Methods 0.000 abstract 1
238000006460 hydrolysis reaction Methods 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1
238000011031 large-scale manufacturing process Methods 0.000 abstract 1
230000003287 optical effect Effects 0.000 abstract 1
238000011321 prophylaxis Methods 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
238000011282 treatment Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C07D233/60—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to ring nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Diabetes (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Obesity (AREA)
Hematology (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Plural Heterocyclic Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

AT03022830T 1997-01-23 1998-01-14 Verfahren zur herstellung von optisch aktiven imidazolverbindungen, zwischenprodukte zu deren herstellung und ihre herstellung ATE337306T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP09010114A JP2000290259A (ja)	1997-01-23	1997-01-23	光学活性なイミダゾール化合物の製造方法およびその合成中間体

Publications (1)

Publication Number	Publication Date
ATE337306T1 true ATE337306T1 (de)	2006-09-15

Family

ID=11741291

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT03022830T ATE337306T1 (de)	1997-01-23	1998-01-14	Verfahren zur herstellung von optisch aktiven imidazolverbindungen, zwischenprodukte zu deren herstellung und ihre herstellung
AT98900397T ATE252085T1 (de)	1997-01-23	1998-01-14	Verfahren zur herstellung optisch aktiver imidazolverbindungen, zwischenprodukte zu ihrer herstellung und verfahren zu ihrer herstellung

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
AT98900397T ATE252085T1 (de)	1997-01-23	1998-01-14	Verfahren zur herstellung optisch aktiver imidazolverbindungen, zwischenprodukte zu ihrer herstellung und verfahren zu ihrer herstellung

Country Status (11)

Country	Link
US (2)	US6066739A (de)
EP (2)	EP1378507B1 (de)
JP (1)	JP2000290259A (de)
KR (1)	KR100490891B1 (de)
CN (1)	CN1133623C (de)
AT (2)	ATE337306T1 (de)
AU (1)	AU5496698A (de)
CA (1)	CA2278509C (de)
DE (2)	DE69818983T2 (de)
ES (1)	ES2209104T3 (de)
WO (1)	WO1998032740A1 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2000290259A (ja) *	1997-01-23	2000-10-17	Welfide Corp	光学活性なイミダゾール化合物の製造方法およびその合成中間体
JPWO2005082861A1 (ja) *	2004-02-27	2007-11-15	三菱ウェルファーマ株式会社	４−［５−（イミダゾール−１−イル）−２−メチルベンゾイル］−３，５−ジメチル安息香酸またはそのエステルの不斉還元法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5770884A (en) *	1980-10-21	1982-05-01	Kyowa Hakko Kogyo Co Ltd	Novel piperidine derivative and its preparation
JPS6314771A (ja) *	1986-07-08	1988-01-21	Sankyo Co Ltd	光学活性イミダゾ−ル誘導体およびその製法
JPH02215771A (ja) *	1989-02-14	1990-08-28	Yoshitomi Pharmaceut Ind Ltd	光学活性なイミダゾール化合物の製造方法およびその合成中間体
US5633377A (en) *	1990-12-28	1997-05-27	Neurogen Corporation	4-piperidino- and piperazinomethyl-2-cyclohexyl imidazole derivatives; dopamine receptor subtype specific ligands
JP2000290259A (ja) *	1997-01-23	2000-10-17	Welfide Corp	光学活性なイミダゾール化合物の製造方法およびその合成中間体

1997
- 1997-01-23 JP JP09010114A patent/JP2000290259A/ja active Pending
1998
- 1998-01-14 EP EP03022830A patent/EP1378507B1/de not_active Expired - Lifetime
- 1998-01-14 DE DE69818983T patent/DE69818983T2/de not_active Expired - Fee Related
- 1998-01-14 AT AT03022830T patent/ATE337306T1/de not_active IP Right Cessation
- 1998-01-14 WO PCT/JP1998/000150 patent/WO1998032740A1/ja not_active Ceased
- 1998-01-14 CA CA002278509A patent/CA2278509C/en not_active Expired - Fee Related
- 1998-01-14 EP EP98900397A patent/EP0972768B1/de not_active Expired - Lifetime
- 1998-01-14 US US09/355,096 patent/US6066739A/en not_active Expired - Fee Related
- 1998-01-14 KR KR10-1999-7006595A patent/KR100490891B1/ko not_active Expired - Fee Related
- 1998-01-14 DE DE69835705T patent/DE69835705D1/de not_active Expired - Lifetime
- 1998-01-14 AU AU54966/98A patent/AU5496698A/en not_active Abandoned
- 1998-01-14 ES ES98900397T patent/ES2209104T3/es not_active Expired - Lifetime
- 1998-01-14 CN CNB988035235A patent/CN1133623C/zh not_active Expired - Fee Related
- 1998-01-14 AT AT98900397T patent/ATE252085T1/de not_active IP Right Cessation
2000
- 2000-02-23 US US09/511,782 patent/US6166221A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
KR20000070362A (ko)	2000-11-25
WO1998032740A1 (en)	1998-07-30
EP0972768A1 (de)	2000-01-19
US6066739A (en)	2000-05-23
DE69818983T2 (de)	2004-09-09
US6166221A (en)	2000-12-26
EP0972768A4 (de)	2001-06-27
CN1251093A (zh)	2000-04-19
DE69818983D1 (de)	2003-11-20
CA2278509C (en)	2007-03-20
AU5496698A (en)	1998-08-18
DE69835705D1 (de)	2006-10-05
ES2209104T3 (es)	2004-06-16
EP1378507A2 (de)	2004-01-07
EP1378507B1 (de)	2006-08-23
JP2000290259A (ja)	2000-10-17
CN1133623C (zh)	2004-01-07
CA2278509A1 (en)	1998-07-30
ATE252085T1 (de)	2003-11-15
EP1378507A3 (de)	2004-02-04
EP0972768B1 (de)	2003-10-15
KR100490891B1 (ko)	2005-05-24

Legal Events

Date	Code	Title	Description
2007-02-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE353081T1 (de)	2007-02-15	Verfahren zur herstellung von duloxetin und deren verwendeten zwischenprodukten
CY1112350T1 (el)	2015-12-09	Διαδικασια παραγωγης ενος οπτικα ενεργου οξοεπτενοϊκου οξινου εστερα
EP1460065A4 (de)	2005-04-20	Verfahren zur herstellung von cyclischen diaminverbindungen bzw. deren salzen
DE69835705D1 (de)	2006-10-05	Verfahren zur Herstellung von optisch aktiven Imidazolverbindungen, Zwischenprodukte zu deren Herstellung und ihre Herstellung
ATE201410T1 (de)	2001-06-15	Verfahren zur herstellung von 1-(4,5-dihydro)2- thiazolyl-3-azetidinthiolderivaten
DE69507887D1 (de)	1999-03-25	Verfahren zur herstellung von n-biphenylmethylthiadiazolin derivaten oder deren salzen sowie dafür benötigte zwischen verbindungen
ATE384067T1 (de)	2008-02-15	Verfahren zur herstellung von 3-cephemderivaten
ATE334972T1 (de)	2006-08-15	Verfahren für die herstellung von 4(5)-amino-5(4)-carboxamidoimidazolen und deren zwischenprodukte
ATE271043T1 (de)	2004-07-15	Verfahren zur herstellung von 2-chlor-5- chloromethyl-thiazol
HU208525B (en)	1993-11-29	Direct process for producing captopril
DE69821763D1 (de)	2004-03-25	Verfahren zur herstellung von 2-alkylthio-substituierten benzoesäurederivaten
CA2200604A1 (en)	1996-03-28	Novel production intermediate and process for producing pyridine derivative
ATE60319T1 (de)	1991-02-15	Verfahren zur herstellung von tetrafluorphthalsaeure.
ATE188209T1 (de)	2000-01-15	Verfahren zur herstellung von isothiocyanat- derivaten
EP1211239A4 (de)	2003-08-06	Verfahren zur herstellung von 2,3-dihydroazepin-derivaten
ATE251135T1 (de)	2003-10-15	Verfahren zur herstellung von 1-substituierten pyrrol-3-carbonsäure-derivaten
ATE139765T1 (de)	1996-07-15	Verfahren zur herstellung von halogenanthranilsäuren
ATE236909T1 (de)	2003-04-15	Verfahren zur herstellung von phosphorohalidaten
DE60239793D1 (de)	2011-06-01	Verfahren zur herstellung von 7-chinolinyl-3,5-dihydroxyhept-6-enoat
ATE341642T1 (de)	2006-10-15	Verfahren zur herstellung von d- asparaginderivaten
ATE249434T1 (de)	2003-09-15	Ein verfahren zur herstellung von pyrrolidinon- derivaten
ATE253553T1 (de)	2003-11-15	Verfahren zur herstellung von 2- alkylthiobenzonitril-derivaten
AU2003211514A1 (en)	2003-09-16	Process for production of optically active carboxylic acid
ATE555089T1 (de)	2012-05-15	Verfahren zur herstellung von -ketoacetalen
CA2307976A1 (en)	1996-03-28	Novel production intermediate and process for producing pyridine derivative