ATE337306T1 - Verfahren zur herstellung von optisch aktiven imidazolverbindungen, zwischenprodukte zu deren herstellung und ihre herstellung - Google Patents
Verfahren zur herstellung von optisch aktiven imidazolverbindungen, zwischenprodukte zu deren herstellung und ihre herstellungInfo
- Publication number
- ATE337306T1 ATE337306T1 AT03022830T AT03022830T ATE337306T1 AT E337306 T1 ATE337306 T1 AT E337306T1 AT 03022830 T AT03022830 T AT 03022830T AT 03022830 T AT03022830 T AT 03022830T AT E337306 T1 ATE337306 T1 AT E337306T1
- Authority
- AT
- Austria
- Prior art keywords
- production
- optically active
- compound
- intermediate products
- imidazole compounds
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 4
- RAXXELZNTBOGNW-UHFFFAOYSA-N 1H-imidazole Chemical class C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 title 1
- 239000013067 intermediate product Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 238000000034 method Methods 0.000 abstract 2
- 208000002249 Diabetes Complications Diseases 0.000 abstract 1
- 206010012655 Diabetic complications Diseases 0.000 abstract 1
- 108010069102 Thromboxane-A synthase Proteins 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 238000001640 fractional crystallisation Methods 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 238000011031 large-scale manufacturing process Methods 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C07D233/60—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to ring nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP09010114A JP2000290259A (ja) | 1997-01-23 | 1997-01-23 | 光学活性なイミダゾール化合物の製造方法およびその合成中間体 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE337306T1 true ATE337306T1 (de) | 2006-09-15 |
Family
ID=11741291
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03022830T ATE337306T1 (de) | 1997-01-23 | 1998-01-14 | Verfahren zur herstellung von optisch aktiven imidazolverbindungen, zwischenprodukte zu deren herstellung und ihre herstellung |
| AT98900397T ATE252085T1 (de) | 1997-01-23 | 1998-01-14 | Verfahren zur herstellung optisch aktiver imidazolverbindungen, zwischenprodukte zu ihrer herstellung und verfahren zu ihrer herstellung |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98900397T ATE252085T1 (de) | 1997-01-23 | 1998-01-14 | Verfahren zur herstellung optisch aktiver imidazolverbindungen, zwischenprodukte zu ihrer herstellung und verfahren zu ihrer herstellung |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US6066739A (de) |
| EP (2) | EP1378507B1 (de) |
| JP (1) | JP2000290259A (de) |
| KR (1) | KR100490891B1 (de) |
| CN (1) | CN1133623C (de) |
| AT (2) | ATE337306T1 (de) |
| AU (1) | AU5496698A (de) |
| CA (1) | CA2278509C (de) |
| DE (2) | DE69818983T2 (de) |
| ES (1) | ES2209104T3 (de) |
| WO (1) | WO1998032740A1 (de) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2000290259A (ja) * | 1997-01-23 | 2000-10-17 | Welfide Corp | 光学活性なイミダゾール化合物の製造方法およびその合成中間体 |
| CA2556075A1 (en) * | 2004-02-27 | 2005-09-09 | Mitsubishi Pharma Corporation | Method of asymmetrically reducing 4-[5-(imidazol-1-yl)-2-methylbenzoyl]-3,5-dimethylbenzoic acid or ester thereof |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5770884A (en) * | 1980-10-21 | 1982-05-01 | Kyowa Hakko Kogyo Co Ltd | Novel piperidine derivative and its preparation |
| JPS6314771A (ja) * | 1986-07-08 | 1988-01-21 | Sankyo Co Ltd | 光学活性イミダゾ−ル誘導体およびその製法 |
| JPH02215771A (ja) * | 1989-02-14 | 1990-08-28 | Yoshitomi Pharmaceut Ind Ltd | 光学活性なイミダゾール化合物の製造方法およびその合成中間体 |
| US5656762A (en) * | 1990-12-28 | 1997-08-12 | Neurogen Corporation | 4-piperidino-and piperazinomethyl-2-phenylimidazole derivatives, dopamine receptor subtype specific ligands |
| JP2000290259A (ja) * | 1997-01-23 | 2000-10-17 | Welfide Corp | 光学活性なイミダゾール化合物の製造方法およびその合成中間体 |
-
1997
- 1997-01-23 JP JP09010114A patent/JP2000290259A/ja active Pending
-
1998
- 1998-01-14 US US09/355,096 patent/US6066739A/en not_active Expired - Fee Related
- 1998-01-14 AU AU54966/98A patent/AU5496698A/en not_active Abandoned
- 1998-01-14 CA CA002278509A patent/CA2278509C/en not_active Expired - Fee Related
- 1998-01-14 KR KR10-1999-7006595A patent/KR100490891B1/ko not_active Expired - Fee Related
- 1998-01-14 WO PCT/JP1998/000150 patent/WO1998032740A1/ja not_active Ceased
- 1998-01-14 CN CNB988035235A patent/CN1133623C/zh not_active Expired - Fee Related
- 1998-01-14 DE DE69818983T patent/DE69818983T2/de not_active Expired - Fee Related
- 1998-01-14 DE DE69835705T patent/DE69835705D1/de not_active Expired - Lifetime
- 1998-01-14 AT AT03022830T patent/ATE337306T1/de not_active IP Right Cessation
- 1998-01-14 EP EP03022830A patent/EP1378507B1/de not_active Expired - Lifetime
- 1998-01-14 AT AT98900397T patent/ATE252085T1/de not_active IP Right Cessation
- 1998-01-14 EP EP98900397A patent/EP0972768B1/de not_active Expired - Lifetime
- 1998-01-14 ES ES98900397T patent/ES2209104T3/es not_active Expired - Lifetime
-
2000
- 2000-02-23 US US09/511,782 patent/US6166221A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AU5496698A (en) | 1998-08-18 |
| EP0972768A4 (de) | 2001-06-27 |
| EP0972768A1 (de) | 2000-01-19 |
| CN1251093A (zh) | 2000-04-19 |
| EP1378507A3 (de) | 2004-02-04 |
| US6066739A (en) | 2000-05-23 |
| DE69818983D1 (de) | 2003-11-20 |
| WO1998032740A1 (en) | 1998-07-30 |
| ATE252085T1 (de) | 2003-11-15 |
| CA2278509C (en) | 2007-03-20 |
| US6166221A (en) | 2000-12-26 |
| KR100490891B1 (ko) | 2005-05-24 |
| DE69818983T2 (de) | 2004-09-09 |
| EP1378507A2 (de) | 2004-01-07 |
| EP1378507B1 (de) | 2006-08-23 |
| KR20000070362A (ko) | 2000-11-25 |
| JP2000290259A (ja) | 2000-10-17 |
| ES2209104T3 (es) | 2004-06-16 |
| CA2278509A1 (en) | 1998-07-30 |
| EP0972768B1 (de) | 2003-10-15 |
| DE69835705D1 (de) | 2006-10-05 |
| CN1133623C (zh) | 2004-01-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |