ATE353081T1 - Verfahren zur herstellung von duloxetin und deren verwendeten zwischenprodukten - Google Patents

Verfahren zur herstellung von duloxetin und deren verwendeten zwischenprodukten

Info

Publication number: ATE353081T1
Authority: AT; Austria
Prior art keywords: duloxetine; acid addition; addition salt; intermediate products; products used
Prior art date: 2002-12-19

Application number

AT03767973T

Other languages

English (en)

Inventor

Dharmaraj R Rao

Rajendra Narayanrao Kankan

Original Assignee

Cipla Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-12-19

Filing date

2003-12-10

Publication date

2007-02-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9949985&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE353081(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2003-12-10 Application filed by Cipla Ltd filed Critical Cipla Ltd

2007-02-15 Application granted granted Critical

2007-02-15 Publication of ATE353081T1 publication Critical patent/ATE353081T1/de

Links

ZEUITGRIYCTCEM-KRWDZBQOSA-N (S)-duloxetine Chemical compound C1([C@@H](OC=2C3=CC=CC=C3C=CC=2)CCNC)=CC=CS1 ZEUITGRIYCTCEM-KRWDZBQOSA-N 0.000 title 1
229960002866 duloxetine Drugs 0.000 title 1
239000013067 intermediate product Substances 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
239000002253 acid Substances 0.000 abstract 4
150000003839 salts Chemical class 0.000 abstract 4
150000001875 compounds Chemical class 0.000 abstract 3
ZEUITGRIYCTCEM-UHFFFAOYSA-N duloxetine Chemical compound C=1C=CC2=CC=CC=C2C=1OC(CCNC)C1=CC=CS1 ZEUITGRIYCTCEM-UHFFFAOYSA-N 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
ZEUITGRIYCTCEM-QGZVFWFLSA-N (R)-duloxetine Chemical compound C1([C@H](OC=2C3=CC=CC=C3C=CC=2)CCNC)=CC=CS1 ZEUITGRIYCTCEM-QGZVFWFLSA-N 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
239000003444 phase transfer catalyst Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/16—Radicals substituted by singly bound hetero atoms other than halogen by oxygen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Neurology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Epidemiology (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Plural Heterocyclic Compounds (AREA)
Steroid Compounds (AREA)

AT03767973T 2002-12-19 2003-12-10 Verfahren zur herstellung von duloxetin und deren verwendeten zwischenprodukten ATE353081T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GBGB0229583.0A GB0229583D0 (en)	2002-12-19	2002-12-19	A process for preparing duloxetine and intermediates for use therein

Publications (1)

Publication Number	Publication Date
ATE353081T1 true ATE353081T1 (de)	2007-02-15

Family

ID=9949985

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT03767973T ATE353081T1 (de)	2002-12-19	2003-12-10	Verfahren zur herstellung von duloxetin und deren verwendeten zwischenprodukten

Country Status (24)

Country	Link
US (1)	US7645890B2 (de)
EP (2)	EP1587801B1 (de)
JP (1)	JP5259048B2 (de)
KR (1)	KR100926723B1 (de)
CN (2)	CN101125848B (de)
AT (1)	ATE353081T1 (de)
AU (2)	AU2003292396B2 (de)
BR (1)	BR0316902A (de)
CA (1)	CA2510750A1 (de)
DE (1)	DE60311599T2 (de)
ES (1)	ES2279971T3 (de)
GB (1)	GB0229583D0 (de)
HR (1)	HRP20050657A2 (de)
IL (1)	IL169232A (de)
IS (1)	IS7915A (de)
MA (1)	MA27706A1 (de)
MX (1)	MXPA05006659A (de)
NZ (2)	NZ569874A (de)
PL (1)	PL377380A1 (de)
PT (1)	PT1587801E (de)
RU (1)	RU2351594C2 (de)
TN (1)	TNSN05167A1 (de)
WO (1)	WO2004056795A1 (de)
ZA (1)	ZA200505656B (de)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7550605B2 (en) *	2004-08-05	2009-06-23	Sun Pharmaceutical Industries Ltd.	Process for preparation of an anitdepressant compound
CZ297560B6 (cs)	2004-10-26	2007-02-07	Zentiva, A. S.	Zpusob výroby hydrochloridu (S)-N-methyl-3-(1-naftyloxy)-3-(2-thienyl)propylaminu (duloxetinu)
TWI306858B (en) *	2004-12-23	2009-03-01	Teva Pharma	Process for preparing pharmaceutically acceptable salts of duloxetine and intermediates thereof
EP1776049A2 (de) *	2005-01-27	2007-04-25	Teva Pharmaceutical Industries Ltd.	Duloxetin-hcl-polymorphe
WO2006096809A1 (en)	2005-03-08	2006-09-14	Teva Pharmaceutical Industries Ltd.	Crystal forms of (s)-(+)-n,n-dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl) propanamine oxalate and the preparation thereof
TW200639162A (en) *	2005-03-14	2006-11-16	Teva Pharma	Pure duloxetine hydrochloride
US8093408B2 (en) *	2005-06-21	2012-01-10	The Company Wockhardt	Antidepressant oral pharmaceutical compositions
US8153824B2 (en) *	2005-06-22	2012-04-10	The Wockhardt Company	Antidepressant oral liquid compositions
WO2007038253A2 (en) *	2005-09-22	2007-04-05	Teva Pharmaceutical Industries Ltd.	Dnt-maleate and methods of preparation thereof
EP1863782A1 (de) *	2005-12-05	2007-12-12	Teva Pharmaceutical Industries Ltd.	2-(n-methyl-propanamin)-3-(2-naphthol) thiophen, eine verunreinigung von duloxetin hydrochlorid
EP1971593A2 (de) *	2005-12-12	2008-09-24	Medichem, S.A.	Verbesserte synthese und zubereitungen von duloxetinsalzen
CZ299270B6 (cs) *	2006-01-04	2008-06-04	Zentiva, A. S.	Zpusob výroby hydrochloridu (S)-N-methyl-3-(1-naftyloxy)-3-(2-thienyl)propylaminu
EP1976844A4 (de) *	2006-01-06	2010-11-03	Msn Lab Ltd	Verbessertes verfahren für reines duloxetin-hydrochlorid
US7538232B2 (en)	2006-01-19	2009-05-26	Eli Lilly And Company	Process for the asymmetric synthesis of duloxetine
CA2640212A1 (en) *	2006-02-13	2007-08-23	Teva Pharmaceutical Industries Ltd.	A process for the preparation of (s)-(+)-n,n-dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanamine, a duloxetine intermediate
HU228458B1 (en) *	2006-03-13	2013-03-28	Egis Gyogyszergyar Nyrt	Duloxetine salts for producing pharmaceutical compositions
SI1857451T1 (sl)	2006-05-05	2010-11-30	Fidia Farmaceutici	Postopek priprave intermediata ki je uporaben zaasimetrično sintezo duloksetina
US20080027128A1 (en) *	2006-05-23	2008-01-31	Santiago Ini	Duloxetine HCL polymorphs
EP2044049A2 (de)	2006-07-03	2009-04-08	Ranbaxy Laboratories Limited	Verfahren zur herstellung von enantiomerenreinen salzen von n-methyl-3 -( 1-naph-thaleneoxy)- 3 - (-2-thienyl)-propanamin
CZ300116B6 (cs) *	2006-12-05	2009-02-11	Zentiva, A. S.	Zpusob cištení hydrochloridu (S)-N-methyl-3-(1-naftyloxy)-3-(2-thienyl)propylaminu
HU227730B1 (en)	2006-12-22	2012-01-30	Richter Gedeon Nyrt	Process for the preparation of duloxetine and for their the intermediates
CN101657438A (zh)	2006-12-22	2010-02-24	斯索恩有限公司	制备度洛西汀和相关化合物的方法
US8269023B2 (en)	2007-03-05	2012-09-18	Lupin Ltd.	Process for preparation of duloxetine hydrochloride
WO2009019719A2 (en) *	2007-08-09	2009-02-12	Ind-Swift Laboratories Limited	Process for the preparation of 3-aryloxy-3-arylpropanamines
WO2009130708A2 (en) *	2008-04-22	2009-10-29	Shodhana Laboratories Limited	Preparation of duloxetine and its salts
WO2010025287A2 (en)	2008-08-27	2010-03-04	Codexis, Inc.	Ketoreductase polypeptides for the production of 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine
EP2329013B1 (de)	2008-08-27	2015-10-28	Codexis, Inc.	Ketoreduktasepolypeptide zur herstellung von einem 3-aryl-3-hydroxypropanamin aus einem 3-aryl-3-ketopropanamin
WO2011033366A2 (en)	2009-09-16	2011-03-24	Jubilant Life Sciences Limited	Process for the preparation of duloxetine hydrochloride and its precursors
CN103360365A (zh) *	2012-04-06	2013-10-23	李晓红	一种抗抑郁症药物原料药盐酸度洛西汀的制备新工艺
CN104230882B (zh) *	2014-08-29	2017-03-08	宁波美诺华药业股份有限公司	一种度洛西汀盐酸盐杂质的制备方法
CN104829587B (zh) *	2015-05-08	2017-07-21	上海万巷制药有限公司	盐酸度洛西汀的制备
CN107382958B (zh) *	2017-07-05	2021-11-09	浙江华海药业股份有限公司	一种度洛西汀中间体的结晶方法

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CH578532A5 (de) *	1971-08-03	1976-08-13	Cassella Farbwerke Mainkur Ag
PL233786A1 (de)	1980-11-14	1982-05-24	Lilly Co Eli
US4777291A (en) *	1985-02-27	1988-10-11	Eli Lilly And Company	Racemization process
JPS62286959A (ja) *	1986-06-05	1987-12-12	Seitetsu Kagaku Co Ltd	光学活性シアノカルニチン塩の製造方法
US4956388A (en) *	1986-12-22	1990-09-11	Eli Lilly And Company	3-aryloxy-3-substituted propanamines
KR880007433A (ko) *	1986-12-22	1988-08-27	메리 앤 터커	3-아릴옥시-3-치환된 프로판아민
CA2042346A1 (en) *	1990-05-17	1991-11-18	Michael Alexander Staszak	Chiral synthesis of 1-aryl-3-aminopropan-1-ols
JPH09176157A (ja) *	1992-12-09	1997-07-08	Takeda Chem Ind Ltd	光学活性アミノクマラン誘導体
US5362886A (en) *	1993-10-12	1994-11-08	Eli Lilly And Company	Asymmetric synthesis
US6458955B1 (en)	1994-12-16	2002-10-01	Uop Llc	Process for preparation of pharmaceutically desired enantiomers
US6162949A (en)	1994-12-16	2000-12-19	Uop Llc	Process for preparation of the pharmaceutically desired (S)-oxetine enantiomers
EP0792649A1 (de) *	1996-02-29	1997-09-03	Eli Lilly And Company	Behandlung von Schlafstörungen
HUP0101901A3 (en) *	1998-05-22	2002-06-28	Lilly Co Eli	Pharmaceutical composition for combined therapeutic treatment of refractory depression and combined treating process
CA2350531A1 (en) *	1998-11-13	2000-05-25	Smriti Iyengar	Method for treating pain
ATE309196T1 (de) *	1999-04-09	2005-11-15	Lilly Co Eli	Verfahren zur herstellung von 3-aryloxy-3- arylpropylamine und deren zwischenprodukte
WO2001044166A1 (en) *	1999-12-17	2001-06-21	Ranbaxy Laboratories Limited	Process for the preparation of fluoxetine hydrochloride
WO2003062219A1 (en)	2002-01-24	2003-07-31	Eli Lilly And Company	Process for preparing an intermediate useful for the asymmetric synthesis of duloxetine

2002
- 2002-12-19 GB GBGB0229583.0A patent/GB0229583D0/en not_active Ceased
2003
- 2003-12-10 NZ NZ569874A patent/NZ569874A/en not_active IP Right Cessation
- 2003-12-10 CN CN2007101531328A patent/CN101125848B/zh not_active Expired - Fee Related
- 2003-12-10 JP JP2004561607A patent/JP5259048B2/ja not_active Expired - Fee Related
- 2003-12-10 RU RU2005122662/04A patent/RU2351594C2/ru not_active IP Right Cessation
- 2003-12-10 ES ES03767973T patent/ES2279971T3/es not_active Expired - Lifetime
- 2003-12-10 MX MXPA05006659A patent/MXPA05006659A/es active IP Right Grant
- 2003-12-10 HR HR20050657A patent/HRP20050657A2/hr not_active Application Discontinuation
- 2003-12-10 EP EP03767973A patent/EP1587801B1/de not_active Revoked
- 2003-12-10 AT AT03767973T patent/ATE353081T1/de not_active IP Right Cessation
- 2003-12-10 DE DE60311599T patent/DE60311599T2/de not_active Revoked
- 2003-12-10 AU AU2003292396A patent/AU2003292396B2/en not_active Ceased
- 2003-12-10 NZ NZ540881A patent/NZ540881A/en not_active IP Right Cessation
- 2003-12-10 EP EP06075798A patent/EP1690861B1/de not_active Expired - Lifetime
- 2003-12-10 KR KR1020057011506A patent/KR100926723B1/ko not_active Expired - Fee Related
- 2003-12-10 US US10/539,415 patent/US7645890B2/en not_active Expired - Fee Related
- 2003-12-10 PL PL377380A patent/PL377380A1/pl unknown
- 2003-12-10 PT PT03767973T patent/PT1587801E/pt unknown
- 2003-12-10 BR BR0316902-2A patent/BR0316902A/pt not_active IP Right Cessation
- 2003-12-10 CN CN200380109793A patent/CN100579975C/zh not_active Expired - Fee Related
- 2003-12-10 WO PCT/GB2003/005357 patent/WO2004056795A1/en not_active Ceased
- 2003-12-10 CA CA002510750A patent/CA2510750A1/en not_active Abandoned
2005
- 2005-06-16 IL IL169232A patent/IL169232A/en not_active IP Right Cessation
- 2005-06-17 TN TNP2005000167A patent/TNSN05167A1/en unknown
- 2005-06-24 IS IS7915A patent/IS7915A/is unknown
- 2005-07-14 ZA ZA200505656A patent/ZA200505656B/en unknown
- 2005-07-18 MA MA28400A patent/MA27706A1/fr unknown
2010
- 2010-01-14 AU AU2010200142A patent/AU2010200142B2/en not_active Ceased

Also Published As

Publication number	Publication date
RU2351594C2 (ru)	2009-04-10
EP1690861B1 (de)	2012-09-12
NZ569874A (en)	2009-11-27
DE60311599T2 (de)	2007-10-25
ES2279971T3 (es)	2007-09-01
AU2003292396B2 (en)	2010-05-20
CN1747947A (zh)	2006-03-15
AU2010200142A1 (en)	2010-02-04
PT1587801E (pt)	2007-04-30
NZ540881A (en)	2008-09-26
EP1690861A2 (de)	2006-08-16
EP1587801A1 (de)	2005-10-26
IL169232A (en)	2010-02-17
WO2004056795A8 (en)	2005-08-11
CA2510750A1 (en)	2004-07-08
KR20050089839A (ko)	2005-09-08
EP1587801B1 (de)	2007-01-31
CN100579975C (zh)	2010-01-13
MXPA05006659A (es)	2006-02-22
ZA200505656B (en)	2006-04-26
HRP20050657A2 (en)	2005-10-31
JP2006514030A (ja)	2006-04-27
JP5259048B2 (ja)	2013-08-07
AU2010200142B2 (en)	2012-04-12
EP1690861A3 (de)	2006-09-06
RU2005122662A (ru)	2006-01-20
DE60311599D1 (de)	2007-03-22
TNSN05167A1 (en)	2007-05-14
MA27706A1 (fr)	2006-01-02
PL377380A1 (pl)	2006-02-06
US7645890B2 (en)	2010-01-12
GB0229583D0 (en)	2003-01-22
AU2003292396A1 (en)	2004-07-14
BR0316902A (pt)	2005-10-25
US20060205956A1 (en)	2006-09-14
KR100926723B1 (ko)	2009-11-16
IS7915A (is)	2005-06-24
CN101125848B (zh)	2012-09-12
WO2004056795A1 (en)	2004-07-08
CN101125848A (zh)	2008-02-20

Legal Events

Date	Code	Title	Description
2007-07-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE353081T1 (de)	2007-02-15	Verfahren zur herstellung von duloxetin und deren verwendeten zwischenprodukten
ATE261946T1 (de)	2004-04-15	Verfahren zur herstellung von thiazolidin
DE69830507D1 (de)	2005-07-14	Verfahren zur herstellung organischer boronsäurederivate mit hilfe von diboronsäure
ATE157647T1 (de)	1997-09-15	Verfahren zur herstellung von alpha- ketoamidderivaten
ATE477227T1 (de)	2010-08-15	Verfahren zur herstellung eines trans-4-amino-1- cyclohexancarbonsäurederivats
EP1247791A4 (de)	2005-05-11	Verfahren zur herstellung von perfluoroalkadienen
ATE359272T1 (de)	2007-05-15	Verfahren zur herstellung von 3-hydroxy-n-1,6-
DE58900982D1 (de)	1992-04-23	Verfahren zur herstellung von alpha, beta -ungesaettigten ketonen.
ATE310735T1 (de)	2005-12-15	Verfahren zur herstellung von spirocyclischen tetronsäurederivaten
DE60233256D1 (de)	2009-09-17	Verfahren zur herstellung von diphosphinverbindungen und zwischenprodukte für das verfahren
ATE334972T1 (de)	2006-08-15	Verfahren für die herstellung von 4(5)-amino-5(4)-carboxamidoimidazolen und deren zwischenprodukte
ATE384067T1 (de)	2008-02-15	Verfahren zur herstellung von 3-cephemderivaten
EP1211239A4 (de)	2003-08-06	Verfahren zur herstellung von 2,3-dihydroazepin-derivaten
ATE459617T1 (de)	2010-03-15	Verfahren zur herstellung von pyridinmethylsulphinylverbindungen
EP1229031A4 (de)	2003-04-16	Verfahren für die herstellung von 3,4-methylendioxy-mandelsäure
ATE478837T1 (de)	2010-09-15	Verfahren zur herstellung von benzylaminderivaten
ATE387421T1 (de)	2008-03-15	Verfahren zur herstellung von michael-addukten
ATE489385T1 (de)	2010-12-15	Verfahren zur herstellung von imidazopyridinen
ATE249434T1 (de)	2003-09-15	Ein verfahren zur herstellung von pyrrolidinon- derivaten
ATE256099T1 (de)	2003-12-15	Verfahren zur herstellung einer kristallsuspensionhenonen
ATE131483T1 (de)	1995-12-15	Verfahren zur herstellung von penemen
DE69909646D1 (de)	2003-08-21	Derivate der aminoacryl-säure und ein verfahren zur herstellung derselben
DE60028998T8 (de)	2007-02-22	Verfahren zur herstellung einer benzylamin-verbindung
ATE162182T1 (de)	1998-01-15	Verfahren zur herstellung von alpha- hydroximinophenylacetonitril
ATE516361T1 (de)	2011-07-15	Verfahren zur herstellung eines carbonsäure- isomers