ATE337324T1 - Neue phosphor enthaltende medikamentenvorläuferverbindungen - Google Patents
Neue phosphor enthaltende medikamentenvorläuferverbindungenInfo
- Publication number
- ATE337324T1 ATE337324T1 AT00917729T AT00917729T ATE337324T1 AT E337324 T1 ATE337324 T1 AT E337324T1 AT 00917729 T AT00917729 T AT 00917729T AT 00917729 T AT00917729 T AT 00917729T AT E337324 T1 ATE337324 T1 AT E337324T1
- Authority
- AT
- Austria
- Prior art keywords
- phosphorus containing
- drug compounds
- containing pre
- new phosphorus
- drugs
- Prior art date
Links
- 229940079593 drug Drugs 0.000 title abstract 3
- 239000003814 drug Substances 0.000 title abstract 3
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 229910052698 phosphorus Inorganic materials 0.000 title 1
- 239000011574 phosphorus Substances 0.000 title 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 210000004185 liver Anatomy 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- PTMHPRAIXMAOOB-UHFFFAOYSA-L phosphoramidate Chemical compound NP([O-])([O-])=O PTMHPRAIXMAOOB-UHFFFAOYSA-L 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
- C07F9/6584—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having one phosphorus atom as ring hetero atom
- C07F9/65842—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring
- C07F9/65846—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring the phosphorus atom being part of a six-membered ring which may be condensed with another ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
- C07F9/6584—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having one phosphorus atom as ring hetero atom
- C07F9/65848—Cyclic amide derivatives of acids of phosphorus, in which two nitrogen atoms belong to the ring
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Obesity (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Vascular Medicine (AREA)
- Endocrinology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Heart & Thoracic Surgery (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Virology (AREA)
- Gastroenterology & Hepatology (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12301399P | 1999-03-05 | 1999-03-05 | |
| US15312799P | 1999-09-08 | 1999-09-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE337324T1 true ATE337324T1 (de) | 2006-09-15 |
Family
ID=26821130
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00917729T ATE337324T1 (de) | 1999-03-05 | 2000-03-03 | Neue phosphor enthaltende medikamentenvorläuferverbindungen |
Country Status (19)
| Country | Link |
|---|---|
| EP (2) | EP1724276A1 (de) |
| JP (1) | JP5063837B2 (de) |
| CN (1) | CN1321999C (de) |
| AT (1) | ATE337324T1 (de) |
| AU (1) | AU775332B2 (de) |
| CA (1) | CA2362805A1 (de) |
| CY (1) | CY1105799T1 (de) |
| CZ (1) | CZ20013180A3 (de) |
| DE (1) | DE60030263T2 (de) |
| DK (1) | DK1165570T3 (de) |
| ES (1) | ES2272268T3 (de) |
| HK (1) | HK1043796B (de) |
| HU (1) | HUP0200260A3 (de) |
| IL (2) | IL145052A0 (de) |
| MX (1) | MXPA01008937A (de) |
| NZ (1) | NZ513728A (de) |
| PT (1) | PT1165570E (de) |
| SK (1) | SK12442001A3 (de) |
| WO (1) | WO2000052015A2 (de) |
Families Citing this family (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6312662B1 (en) | 1998-03-06 | 2001-11-06 | Metabasis Therapeutics, Inc. | Prodrugs phosphorus-containing compounds |
| US7205404B1 (en) | 1999-03-05 | 2007-04-17 | Metabasis Therapeutics, Inc. | Phosphorus-containing prodrugs |
| AU7361400A (en) | 1999-09-08 | 2001-04-10 | Metabasis Therapeutics, Inc. | Prodrugs for liver specific drug delivery |
| JP2003525944A (ja) | 2000-03-08 | 2003-09-02 | メタバシス・セラピューティクス・インコーポレイテッド | 新規アリールフルクトース−１，６−ビスホスファターゼ阻害剤 |
| MY164523A (en) | 2000-05-23 | 2017-12-29 | Univ Degli Studi Cagliari | Methods and compositions for treating hepatitis c virus |
| EP1736478B1 (de) | 2000-05-26 | 2015-07-22 | IDENIX Pharmaceuticals, Inc. | Verfahren und Zusammensetzungen zur Behandlung von Flaviviren und Pestiviren |
| RU2196775C2 (ru) * | 2001-03-27 | 2003-01-20 | Государственный научный центр Российской Федерации "НИОПИК" | Способ получения 2-[бис-(2-хлорэтил)амино]тетрагидро-2н-1,3,2-оксазафосфорин-2-оксида, моногидрата |
| EP1435974A4 (de) | 2001-09-28 | 2006-09-06 | Idenix Cayman Ltd | Verfahren und zusamemnsetzungen zur behandlung des hepatitis-c-virus mit 4'-modifizierten nucleosiden |
| IL162017A0 (en) | 2002-01-18 | 2005-11-20 | Leo Pharma As | Mmp inhibitors |
| EP2223927B1 (de) | 2002-05-13 | 2014-10-15 | Metabasis Therapeutics, Inc. | Salze einer auf Phosphonsäure basierenden Prodrug von PMEA |
| WO2003095665A2 (en) | 2002-05-13 | 2003-11-20 | Metabasis Therapeutics, Inc. | Pmea and pmpa cyclic producing synthesis |
| NZ537662A (en) | 2002-06-28 | 2007-10-26 | Idenix Cayman Ltd | 2'-C-methyl-3'-O-L-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections |
| CN1678326A (zh) | 2002-06-28 | 2005-10-05 | 埃迪尼克斯(开曼)有限公司 | 用于治疗黄病毒感染的2'－c－甲基－3'－o－l－缬氨酸酯核糖呋喃基胞苷 |
| TW200500375A (en) | 2002-06-28 | 2005-01-01 | Idenix Cayman Ltd | Modified 2' and 3'-nucleoside prodrugs for treating flaviviridae |
| US7608600B2 (en) | 2002-06-28 | 2009-10-27 | Idenix Pharmaceuticals, Inc. | Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections |
| BR0315795A (pt) | 2002-10-31 | 2005-09-13 | Metabasis Therapeutics Inc | Pró-medicamentos de monofosfato de citarabina |
| LT1576138T (lt) | 2002-11-15 | 2017-06-26 | Idenix Pharmaceuticals Llc | 2`-šakoti nukleozidai derinyje su interferonu ir flaviviridae mutacija |
| AU2003300901A1 (en) | 2002-12-12 | 2004-06-30 | Idenix (Cayman) Limited | Process for the production of 2'-branched nucleosides |
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| US7470724B2 (en) | 2003-04-25 | 2008-12-30 | Gilead Sciences, Inc. | Phosphonate compounds having immuno-modulatory activity |
| WO2005002626A2 (en) | 2003-04-25 | 2005-01-13 | Gilead Sciences, Inc. | Therapeutic phosphonate compounds |
| EA014685B1 (ru) | 2003-04-25 | 2010-12-30 | Джилид Сайэнс, Инк. | Фосфонатсодержащие антивирусные соединения (варианты) и фармацевтическая композиция на их основе |
| KR20060022647A (ko) | 2003-04-25 | 2006-03-10 | 길리애드 사이언시즈, 인코포레이티드 | 키나아제 억제 포스포네이트 유사체 |
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| AU2005330489B2 (en) | 2004-07-27 | 2011-08-25 | Gilead Sciences, Inc. | Nucleoside phosphonate conjugates as anti HIV agents |
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| US8394969B2 (en) | 2008-09-26 | 2013-03-12 | Merck Sharp & Dohme Corp. | Cyclic benzimidazole derivatives useful as anti-diabetic agents |
| EP2348857B1 (de) | 2008-10-22 | 2016-02-24 | Merck Sharp & Dohme Corp. | Neue cyclische benzimidazolderivate als antidiabetika |
| EP2352374B1 (de) | 2008-10-29 | 2014-09-24 | Merck Sharp & Dohme Corp. | Neue cyclische benzimidazolderivate als antidiabetika |
| US8329914B2 (en) | 2008-10-31 | 2012-12-11 | Merck Sharp & Dohme Corp | Cyclic benzimidazole derivatives useful as anti-diabetic agents |
| JP2013520502A (ja) | 2010-02-25 | 2013-06-06 | メルク・シャープ・エンド・ドーム・コーポレイション | 有用な抗糖尿病薬である新規な環状ベンズイミダゾール誘導体 |
| AU2015217221A1 (en) | 2014-02-13 | 2016-08-11 | Ligand Pharmaceuticals, Inc. | Prodrug compounds and their uses |
| CN106687118A (zh) | 2014-07-02 | 2017-05-17 | 配体药物公司 | 前药化合物及其用途 |
| WO2017044453A1 (en) | 2015-09-10 | 2017-03-16 | Becton, Dickinson And Company | Cyclophosphamide analogs for use as immunogens and assay conjugates for an immunoassay of cyclophosphamide and ifosfamide |
| CN106565626B (zh) * | 2016-10-10 | 2022-06-10 | 淮海工学院 | 2-氨基-4-芳基-5-甲硫基噻唑类化合物的合成方法 |
| JP2020500199A (ja) | 2016-11-21 | 2020-01-09 | バイキング・セラピューティクス・インコーポレイテッド | グリコーゲン蓄積症の治療方法 |
| AU2018280118B2 (en) | 2017-06-05 | 2021-07-15 | Viking Therapeutics, Inc. | Compositions for the treatment of fibrosis |
| SI3661937T1 (sl) | 2017-08-01 | 2021-11-30 | Gilead Sciences, Inc. | Kristalinične oblike etil((S)-((((2R,5R)-5-(6-amino-9H-purin-9-IL)-4- fluoro-2,5-dihidrofuran-2-IL)oksi)metil)(fenoksi)fosforil)-L-alaninata (GS-9131) za zdravljenje virusnih okužb |
| EP3684944B1 (de) | 2017-09-21 | 2025-01-01 | Becton, Dickinson and Company | Kit zur probenahme von gefährlichen schadstoffen und schnelltest |
| USD859683S1 (en) | 2017-09-21 | 2019-09-10 | Becton, Dickinson And Company | Collection device |
| CN111107939B (zh) | 2017-09-21 | 2022-04-12 | 贝克顿·迪金森公司 | 引导有害污染物样品的收集的系统和模板及使用其的方法 |
| CN209400423U (zh) | 2017-09-21 | 2019-09-17 | 贝克顿·迪金森公司 | 横向流测定物、测定物读取器装置和包括其的系统 |
| CA3087932A1 (en) | 2018-01-09 | 2019-07-18 | Ligand Pharmaceuticals, Inc. | Acetal compounds and therapeutic uses thereof |
| ES3053674T3 (en) | 2018-03-22 | 2026-01-23 | Viking Therapeutics Inc | Crystalline forms and methods of producing crystalline forms of a compound |
| CN117866015A (zh) * | 2018-04-30 | 2024-04-12 | 联合生物科技公司 | 一种临床管理中使用的化合物及其用途 |
| EP3788053B1 (de) * | 2018-05-04 | 2024-07-10 | Amgen Inc. | Kras-g12c-inhibitoren und verfahren zu deren verwendung |
| WO2020117962A1 (en) | 2018-12-05 | 2020-06-11 | Viking Therapeutics, Inc. | Compositions for the treatment of fibrosis and inflammation |
| CN111434671B (zh) * | 2019-01-11 | 2023-07-11 | 凯思凯迪（上海）医药科技有限公司 | 肝脏特异性ampk激动剂及其制法和应用 |
| CN113383222A (zh) | 2019-01-28 | 2021-09-10 | 贝克顿·迪金森公司 | 具有集成的拭子和测试装置的有害污染物收集装置 |
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| US6284748B1 (en) | 1997-03-07 | 2001-09-04 | Metabasis Therapeutics, Inc. | Purine inhibitors of fructose 1,6-bisphosphatase |
| US6054587A (en) | 1997-03-07 | 2000-04-25 | Metabasis Therapeutics, Inc. | Indole and azaindole inhibitors of fructose-1,6-bisphosphatase |
| KR100818845B1 (ko) * | 1998-09-09 | 2008-04-01 | 메타베이시스 테라퓨틱스, 인크. | 신규한 프럭토스 1,6-비스포스파타제의 헤테로방향족 억제제 |
-
2000
- 2000-03-03 MX MXPA01008937A patent/MXPA01008937A/es active IP Right Grant
- 2000-03-03 EP EP06119343A patent/EP1724276A1/de not_active Withdrawn
- 2000-03-03 IL IL14505200A patent/IL145052A0/xx active IP Right Grant
- 2000-03-03 CZ CZ20013180A patent/CZ20013180A3/cs unknown
- 2000-03-03 NZ NZ513728A patent/NZ513728A/en not_active IP Right Cessation
- 2000-03-03 EP EP00917729A patent/EP1165570B9/de not_active Expired - Lifetime
- 2000-03-03 ES ES00917729T patent/ES2272268T3/es not_active Expired - Lifetime
- 2000-03-03 SK SK1244-2001A patent/SK12442001A3/sk unknown
- 2000-03-03 AT AT00917729T patent/ATE337324T1/de not_active IP Right Cessation
- 2000-03-03 CA CA002362805A patent/CA2362805A1/en not_active Abandoned
- 2000-03-03 DE DE60030263T patent/DE60030263T2/de not_active Expired - Lifetime
- 2000-03-03 CN CNB00807173XA patent/CN1321999C/zh not_active Expired - Lifetime
- 2000-03-03 WO PCT/US2000/005672 patent/WO2000052015A2/en not_active Ceased
- 2000-03-03 PT PT00917729T patent/PT1165570E/pt unknown
- 2000-03-03 HK HK02104972.2A patent/HK1043796B/en not_active IP Right Cessation
- 2000-03-03 AU AU38658/00A patent/AU775332B2/en not_active Expired
- 2000-03-03 HU HU0200260A patent/HUP0200260A3/hu unknown
- 2000-03-03 DK DK00917729T patent/DK1165570T3/da active
- 2000-03-03 JP JP2000602240A patent/JP5063837B2/ja not_active Expired - Lifetime
-
2001
- 2001-08-22 IL IL145052A patent/IL145052A/en not_active IP Right Cessation
-
2006
- 2006-11-20 CY CY20061101686T patent/CY1105799T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2362805A1 (en) | 2000-09-08 |
| EP1165570A2 (de) | 2002-01-02 |
| JP5063837B2 (ja) | 2012-10-31 |
| JP2002538161A (ja) | 2002-11-12 |
| HUP0200260A2 (en) | 2002-06-29 |
| DK1165570T3 (da) | 2006-12-18 |
| ES2272268T3 (es) | 2007-05-01 |
| CZ20013180A3 (cs) | 2002-02-13 |
| CY1105799T1 (el) | 2011-02-02 |
| SK12442001A3 (sk) | 2002-06-04 |
| IL145052A (en) | 2007-07-24 |
| HK1043796A1 (en) | 2002-09-27 |
| MXPA01008937A (es) | 2004-04-05 |
| CN1353719A (zh) | 2002-06-12 |
| EP1724276A1 (de) | 2006-11-22 |
| NZ513728A (en) | 2001-09-28 |
| HUP0200260A3 (en) | 2002-11-28 |
| AU3865800A (en) | 2000-09-21 |
| HK1043796B (en) | 2007-02-23 |
| DE60030263D1 (de) | 2006-10-05 |
| IL145052A0 (en) | 2002-06-30 |
| PT1165570E (pt) | 2007-01-31 |
| EP1165570B9 (de) | 2007-02-21 |
| EP1165570B1 (de) | 2006-08-23 |
| WO2000052015A3 (en) | 2001-02-15 |
| CN1321999C (zh) | 2007-06-20 |
| WO2000052015A2 (en) | 2000-09-08 |
| DE60030263T2 (de) | 2007-08-30 |
| AU775332B2 (en) | 2004-07-29 |
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