ATE337797T1 - Tc and re karbonylkomplexen zur herstellung von pertechnaten und perrhenaten - Google Patents

Tc and re karbonylkomplexen zur herstellung von pertechnaten und perrhenaten

Info

Publication number
ATE337797T1
ATE337797T1 AT01944139T AT01944139T ATE337797T1 AT E337797 T1 ATE337797 T1 AT E337797T1 AT 01944139 T AT01944139 T AT 01944139T AT 01944139 T AT01944139 T AT 01944139T AT E337797 T1 ATE337797 T1 AT E337797T1
Authority
AT
Austria
Prior art keywords
sub
sup
line
formulae
compound
Prior art date
Application number
AT01944139T
Other languages
English (en)
Inventor
David W Pipes
Mary E Dyszlewski
Elizabeth G Webb
Original Assignee
Mallinckrodt Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mallinckrodt Inc filed Critical Mallinckrodt Inc
Application granted granted Critical
Publication of ATE337797T1 publication Critical patent/ATE337797T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0476—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from monodendate ligands, e.g. sestamibi
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
    • C07F13/005—Compounds without a metal-carbon linkage
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
    • Y10S530/811—Peptides or proteins is immobilized on, or in, an inorganic carrier

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Radiology & Medical Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)
AT01944139T 2000-05-24 2001-05-08 Tc and re karbonylkomplexen zur herstellung von pertechnaten und perrhenaten ATE337797T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/576,960 US6359119B1 (en) 2000-05-24 2000-05-24 Formulation of Tc and Re carbonyl complexes using stannous ion as the reductant for pertechnetate and perrhenate

Publications (1)

Publication Number Publication Date
ATE337797T1 true ATE337797T1 (de) 2006-09-15

Family

ID=24306711

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01944139T ATE337797T1 (de) 2000-05-24 2001-05-08 Tc and re karbonylkomplexen zur herstellung von pertechnaten und perrhenaten

Country Status (7)

Country Link
US (3) US6359119B1 (de)
EP (1) EP1283729B1 (de)
JP (1) JP2003535005A (de)
AT (1) ATE337797T1 (de)
DE (1) DE60122706T2 (de)
DK (1) DK1283729T3 (de)
WO (1) WO2001089586A2 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6926883B1 (en) * 1999-06-29 2005-08-09 Mallinckrodt Inc Group (VII) transition-metal complexes with multidentate aminopolycarboxylate ligands and a kit for producing them
US6359119B1 (en) * 2000-05-24 2002-03-19 Mallinckrodt Inc. Formulation of Tc and Re carbonyl complexes using stannous ion as the reductant for pertechnetate and perrhenate
CN1136921C (zh) * 2001-04-27 2004-02-04 北京师范大学 一种心肌显像剂及其制备方法
CN100366297C (zh) * 2002-09-03 2008-02-06 苏黎世大学 通过固相技术经金属辅助的从固体载体上裂解制备m(co)3－配合物的方法
JP2008037752A (ja) * 2004-11-19 2008-02-21 Nihon Medi Physics Co Ltd 新規放射性テクネチウム−ビスホスフィノアミン錯体および該錯体を含む放射性画像診断剤
JP4578425B2 (ja) * 2006-03-20 2010-11-10 行政院原子能委員會核能研究所 テクネチウム−９９ｍ過テクネチウム酸溶液の濃縮装置及びその方法
GB0804406D0 (en) * 2008-03-10 2008-04-16 Univ Zuerich Metal complexes
CN101398413B (zh) * 2008-11-10 2012-05-30 浙江工业大学 亚氨基二乙酸的液相分析方法

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3725295A (en) * 1971-07-20 1973-04-03 Atomic Energy Commission Technetium labeling
US4020109A (en) * 1972-12-26 1977-04-26 Union Oil Company Of California Stabilizing alkanals
US4027005A (en) * 1974-06-07 1977-05-31 New England Nuclear Corporation Diagnostic agents
US4075314A (en) * 1976-04-29 1978-02-21 Mallinckrodt, Inc. Stannous pyrophosphate technetium-99m compositions
US4233284A (en) 1978-03-31 1980-11-11 The Procter & Gamble Company Stabilized radiographic scanning agents
US4232000A (en) 1978-06-28 1980-11-04 The Procter & Gamble Company Radioactive scanning agents with stabilizer
GB2046000B (en) * 1979-02-27 1982-11-24 Radiochemical Centre Ltd Method and container for reducing pertechnetate
US4427647A (en) * 1980-08-12 1984-01-24 Amersham International Limited Method and reagent for making a radiopharmaceutical composition based on pertechnetate
JPS5867647A (ja) * 1981-10-15 1983-04-22 Ube Ind Ltd マロン酸ジエステルの製造法
JPS61103841A (ja) * 1984-10-26 1986-05-22 Nippon Mejifuijitsukusu Kk 放射性テクネチウム標識に供する安定な塩化第一スズ組成物
US4897255A (en) * 1985-01-14 1990-01-30 Neorx Corporation Metal radionuclide labeled proteins for diagnosis and therapy
WO1996030054A1 (en) 1995-03-28 1996-10-03 Mallinckrodt Medical, Inc. 99mTc - LABELLED SEROTONIN RECEPTOR BINDING SUBSTANCES
US5774782A (en) * 1996-05-22 1998-06-30 Lockheed Martin Energy Systems, Inc. Technetium-99m generator system
US6344178B1 (en) * 1997-04-25 2002-02-05 Mallinckrodt Inc. Method for the preparation of facial metal tricarbonyl compounds and their use in the labelling of biologically active substrates
EP0879606A1 (de) * 1997-04-25 1998-11-25 Paul Scherrer Institut Verfahren zur Herstellung von facial Metall Tricarbonyl Verbindungen und ihre Anwendung zur Markierung von Biosubstraten
FR2765596B1 (fr) * 1997-07-04 1999-08-27 Commissariat Energie Atomique Procede de separation du technetium d'une solution nitrique
EP1192166B1 (de) * 1999-06-29 2004-09-29 Mallinckrodt Inc. Uebergangsmetallkomplexe der vii-nebengruppe mit multidentaten aminopolycarboxylat-liganden und ein kit zu deren herstellung
US6926883B1 (en) * 1999-06-29 2005-08-09 Mallinckrodt Inc Group (VII) transition-metal complexes with multidentate aminopolycarboxylate ligands and a kit for producing them
CN1187359C (zh) * 1999-10-05 2005-02-02 马林克罗特公司 用于制备过渡金属羰基配合物的一氧化碳源
US6359119B1 (en) * 2000-05-24 2002-03-19 Mallinckrodt Inc. Formulation of Tc and Re carbonyl complexes using stannous ion as the reductant for pertechnetate and perrhenate

Also Published As

Publication number Publication date
DE60122706D1 (de) 2006-10-12
US20050276755A1 (en) 2005-12-15
EP1283729A2 (de) 2003-02-19
US6359119B1 (en) 2002-03-19
EP1283729B1 (de) 2006-08-30
JP2003535005A (ja) 2003-11-25
WO2001089586A2 (en) 2001-11-29
DE60122706T2 (de) 2007-10-04
WO2001089586A3 (en) 2002-08-22
DK1283729T3 (da) 2006-12-18
US20020147316A1 (en) 2002-10-10

Similar Documents

Publication Publication Date Title
Moerlein et al. The chemistry of gallium and indium as related to radiopharmaceutical production
ES8706965A1 (es) Un metodo de formacion de un conjugado de proteina y quelato metalico
HUT47075A (en) Process for producing cyclic, n-containing ligands, theyr metal-complexes and diagnostical compositions containing these compounds
Ramadan et al. Synthesis, characterization and demonstration of superoxide dismutase-like activity of copper (II) chloride, bromide, nitrate, thiocyanate, sulphate, and perchlorate complexes with 2-methyl-amino pyridine
ATE337797T1 (de) Tc and re karbonylkomplexen zur herstellung von pertechnaten und perrhenaten
DK1417183T3 (da) Multidentate aza-ligander i stand til at kompleksdanne metalioner og anvendelse heraf til diagnostik og terapi
Magnuson et al. Mixed oxidation states in osmium ammine dinitrogen complexes
ATE187731T1 (de) Technetium-99m-komplexe zur verwendung als radiopharmazeutische mittel
Floriani et al. Sodium [NN′-ethylenebis (salicylideneiminato) cobaltate (I)], a reversible carbon dioxide carrier
Kumar et al. Oxidation-reduction reactions of complexes with macrocyclic ligands. Electron-transfer reactivity of a 1: 1 cobalt (II)-dioxygen adduct
AU6488900A (en) Group (vii) transition-metal complexes with multidentate aminopolycarboxylate ligands and a kit for producing them
Jurisson et al. Syntheses, characterization, and reactivity of manganese and rhenium dioxime complexes. X-ray crystal structure of MnII (CDO)(CDOH) 2 (BPh (OCH3)) 2, an unusual pseudoclathrochelate complex, and ReIIICl (CDO)(CDOH) 2BPh
Legg et al. Absolute configuration of aspartic acid complexes. Cobalt (III) complex of a new stereospecific hexadentate ligand containing the aspartic acid unit
NZ218020A (en) Pharmaceutical compositions containing radiosensitising amounts of cobalt (iii) or iron (iii) co-ordination compounds
Murakami et al. Transition-metal Complexes of Pyrrole Pigments. IX. Divalent and Trivalent Iron Chelates of Dipyrromethenes
Radecka-Paryzek et al. Coordination compounds of 2, 6-diacetylpyridinedihydrazone. Part 1. Preparation and characterization of the complexes with lighter lanthanide chlorides, perchlorates and nitrates
Tomita et al. Ferric complexes with L-cysteine at low temperature
Bolzati et al. Technetium and rhenium in five-coordinate symmetrical and dissymmetrical nitrido complexes with alkyl phosphino-thiol ligands. Synthesis and structural characterization
Suzuki et al. Preparation, and thermal and electronic properties of double complex salts and cyanide-bridged complexes containing cationic copper (II) complexes and hexacyanoferrate (II) ion.
Noll et al. Preparation and characterization of technetium (IV)-complexes with diethylenetriaminepentaacetic acid and ethylenediaminetetraacetic acid as ligands
DE60004439D1 (de) Herstellung von Metallkomplexen durch Komproportionierung
Radecka-Paryzek et al. Yttrium (III) complexes of pentadentate Schiff base macrocyclic ligands with N3O2 and N5 set of donor atoms
DE3864071D1 (de) Herstellung eines tc-99m radiopharmaka.
NO20055334L (no) Bifunksjonelle tridentate pyrazolylinneholdende ligander for RE og TC trikarbonylkomplekser
JP4020697B2 (ja) 半人工ヘムタンパク質から成る酸素センサー

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1283729

Country of ref document: EP

REN Ceased due to non-payment of the annual fee