DK1283729T3 - Tc- og Re-carbonyl-komplekser fremstillet ud fra pertechnetater og perrhenater - Google Patents

Tc- og Re-carbonyl-komplekser fremstillet ud fra pertechnetater og perrhenater

Info

Publication number
DK1283729T3
DK1283729T3 DK01944139T DK01944139T DK1283729T3 DK 1283729 T3 DK1283729 T3 DK 1283729T3 DK 01944139 T DK01944139 T DK 01944139T DK 01944139 T DK01944139 T DK 01944139T DK 1283729 T3 DK1283729 T3 DK 1283729T3
Authority
DK
Denmark
Prior art keywords
sub
sup
line
formulae
compound
Prior art date
Application number
DK01944139T
Other languages
English (en)
Inventor
David W Pipes
Mary E Dyszlewski
Elizabeth G Webb
Original Assignee
Mallinckrodt Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mallinckrodt Inc filed Critical Mallinckrodt Inc
Application granted granted Critical
Publication of DK1283729T3 publication Critical patent/DK1283729T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0476—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from monodendate ligands, e.g. sestamibi
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
    • C07F13/005—Compounds without a metal-carbon linkage
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
    • Y10S530/811—Peptides or proteins is immobilized on, or in, an inorganic carrier

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Radiology & Medical Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)
DK01944139T 2000-05-24 2001-05-08 Tc- og Re-carbonyl-komplekser fremstillet ud fra pertechnetater og perrhenater DK1283729T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/576,960 US6359119B1 (en) 2000-05-24 2000-05-24 Formulation of Tc and Re carbonyl complexes using stannous ion as the reductant for pertechnetate and perrhenate

Publications (1)

Publication Number Publication Date
DK1283729T3 true DK1283729T3 (da) 2006-12-18

Family

ID=24306711

Family Applications (1)

Application Number Title Priority Date Filing Date
DK01944139T DK1283729T3 (da) 2000-05-24 2001-05-08 Tc- og Re-carbonyl-komplekser fremstillet ud fra pertechnetater og perrhenater

Country Status (7)

Country Link
US (3) US6359119B1 (da)
EP (1) EP1283729B1 (da)
JP (1) JP2003535005A (da)
AT (1) ATE337797T1 (da)
DE (1) DE60122706T2 (da)
DK (1) DK1283729T3 (da)
WO (1) WO2001089586A2 (da)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6926883B1 (en) * 1999-06-29 2005-08-09 Mallinckrodt Inc Group (VII) transition-metal complexes with multidentate aminopolycarboxylate ligands and a kit for producing them
US6359119B1 (en) * 2000-05-24 2002-03-19 Mallinckrodt Inc. Formulation of Tc and Re carbonyl complexes using stannous ion as the reductant for pertechnetate and perrhenate
CN1136921C (zh) * 2001-04-27 2004-02-04 北京师范大学 一种心肌显像剂及其制备方法
PL375530A1 (en) * 2002-09-03 2005-11-28 University Of Zurich Preparation of m(co)3-complexes by solid phase techniques via metal assisted cleavage from the solid support
JP2008037752A (ja) * 2004-11-19 2008-02-21 Nihon Medi Physics Co Ltd 新規放射性テクネチウム−ビスホスフィノアミン錯体および該錯体を含む放射性画像診断剤
JP4578425B2 (ja) * 2006-03-20 2010-11-10 行政院原子能委員會核能研究所 テクネチウム−９９ｍ過テクネチウム酸溶液の濃縮装置及びその方法
GB0804406D0 (en) 2008-03-10 2008-04-16 Univ Zuerich Metal complexes
CN101398413B (zh) * 2008-11-10 2012-05-30 浙江工业大学 亚氨基二乙酸的液相分析方法

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3725295A (en) * 1971-07-20 1973-04-03 Atomic Energy Commission Technetium labeling
US4020109A (en) * 1972-12-26 1977-04-26 Union Oil Company Of California Stabilizing alkanals
US4027005A (en) * 1974-06-07 1977-05-31 New England Nuclear Corporation Diagnostic agents
US4075314A (en) * 1976-04-29 1978-02-21 Mallinckrodt, Inc. Stannous pyrophosphate technetium-99m compositions
US4233284A (en) 1978-03-31 1980-11-11 The Procter & Gamble Company Stabilized radiographic scanning agents
US4232000A (en) 1978-06-28 1980-11-04 The Procter & Gamble Company Radioactive scanning agents with stabilizer
GB2046000B (en) * 1979-02-27 1982-11-24 Radiochemical Centre Ltd Method and container for reducing pertechnetate
US4427647A (en) * 1980-08-12 1984-01-24 Amersham International Limited Method and reagent for making a radiopharmaceutical composition based on pertechnetate
JPS5867647A (ja) * 1981-10-15 1983-04-22 Ube Ind Ltd マロン酸ジエステルの製造法
JPS61103841A (ja) * 1984-10-26 1986-05-22 Nippon Mejifuijitsukusu Kk 放射性テクネチウム標識に供する安定な塩化第一スズ組成物
US4897255A (en) * 1985-01-14 1990-01-30 Neorx Corporation Metal radionuclide labeled proteins for diagnosis and therapy
WO1996030054A1 (en) 1995-03-28 1996-10-03 Mallinckrodt Medical, Inc. 99mTc - LABELLED SEROTONIN RECEPTOR BINDING SUBSTANCES
US5774782A (en) * 1996-05-22 1998-06-30 Lockheed Martin Energy Systems, Inc. Technetium-99m generator system
US6344178B1 (en) * 1997-04-25 2002-02-05 Mallinckrodt Inc. Method for the preparation of facial metal tricarbonyl compounds and their use in the labelling of biologically active substrates
EP0879606A1 (en) 1997-04-25 1998-11-25 Paul Scherrer Institut Method for the preparation of facial metal tricarbonyl compounds and their use in the labelling of biologically active substrates
FR2765596B1 (fr) * 1997-07-04 1999-08-27 Commissariat Energie Atomique Procede de separation du technetium d'une solution nitrique
US6926883B1 (en) * 1999-06-29 2005-08-09 Mallinckrodt Inc Group (VII) transition-metal complexes with multidentate aminopolycarboxylate ligands and a kit for producing them
CZ20014603A3 (cs) * 1999-06-29 2002-11-13 Mallinckrodt Inc. Pouľití aminopolykarboxylátových ligandů při značení biologicky aktivních substrátů Tc-99m-trikarbonylovými prekurzory
US7053242B1 (en) * 1999-10-05 2006-05-30 Mallinckrodt Inc. Carbon monoxide source for preparation of transition-metal-carbonyl-complexes
US6359119B1 (en) * 2000-05-24 2002-03-19 Mallinckrodt Inc. Formulation of Tc and Re carbonyl complexes using stannous ion as the reductant for pertechnetate and perrhenate

Also Published As

Publication number Publication date
WO2001089586A2 (en) 2001-11-29
DE60122706T2 (de) 2007-10-04
US6359119B1 (en) 2002-03-19
EP1283729A2 (en) 2003-02-19
US20050276755A1 (en) 2005-12-15
ATE337797T1 (de) 2006-09-15
EP1283729B1 (en) 2006-08-30
US20020147316A1 (en) 2002-10-10
WO2001089586A3 (en) 2002-08-22
DE60122706D1 (de) 2006-10-12
JP2003535005A (ja) 2003-11-25

Similar Documents

Publication Publication Date Title
US4996312A (en) Porphyrin derivatives, and their production and use
Fenton et al. Macrocyclic Schiff base complexes of lanthanides and actinides
US5428139A (en) Bicyclopolyazamacrocyclophosphonic acid complexes for use as radiopharmaceuticals
IL90409A0 (en) Macrocyclic chelates
DK1283729T3 (da) Tc- og Re-carbonyl-komplekser fremstillet ud fra pertechnetater og perrhenater
EP2922830A1 (en) SYNTHESIS OF IMIDAZO[1,2-a]PYRAZIN-4-IUM SALTS FOR THE SYNTHESIS OF 1,4,7-TRIAZACYCLONONANE (TACN) AND N- AND/OR C-FUNCTIONALIZED DERIVATIVES THEREOF
McArdle et al. Coordination chemistry of microbial iron transport compounds. 13. Preparation and chirality of the rhodium (III) enterobactin complex and model tris (catecholato) rhodate (III) analogs
EP2536691A1 (en) Bifunctional chelating agents
CA2407592A1 (en) Small technetium-99m and rhenium labeled agents and methods for imaging tumors
AU6488900A (en) Group (vii) transition-metal complexes with multidentate aminopolycarboxylate ligands and a kit for producing them
GB0105224D0 (en) Improved peptide-chelate conjugates
Jurisson et al. Syntheses, characterization, and reactivity of manganese and rhenium dioxime complexes. X-ray crystal structure of MnII (CDO)(CDOH) 2 (BPh (OCH3)) 2, an unusual pseudoclathrochelate complex, and ReIIICl (CDO)(CDOH) 2BPh
Yang et al. Synthesis and characterization of a novel macrocyclic chelator with 3-hydroxy-4-pyrone chelating arms and its complexes with medicinally important metals
Sun et al. New multidentate ligands. 27. Synthesis and evaluation of metal ion affinities of new endocyclic hydroxamate macrocycles
JP2003503415A5 (da)
Hoshino et al. A novel family of binuclear cobalt (II) complexes with face-to-face bis (cyclidene) ligands: structural characterization, unusual reactions with dioxygen, and a distinctive host-guest complexation with a bridging ligand
Sun et al. New multidentate ligands. 28. Synthesis and evaluation of new macrocyclic ligands containing bidentate endocyclic catechol donor groups
JP2003535005A5 (da)
Suzuki et al. Preparation, and thermal and electronic properties of double complex salts and cyanide-bridged complexes containing cationic copper (II) complexes and hexacyanoferrate (II) ion.
JP4020697B2 (ja) 半人工ヘムタンパク質から成る酸素センサー
WO1993020852A2 (en) Macrocyclic chelating agents, chelates and conjugates thereof
NO20055334L (no) Bifunksjonelle tridentate pyrazolylinneholdende ligander for RE og TC trikarbonylkomplekser
Lin et al. Neutral Technetium (V) and Rhenium (V) Complexes with Tetradentate Ligands Containing N2OS Donor Sets
WO1994026315A1 (en) Bicyclopolyazamacrocyclocarboxylic acid complexes, their conjugates, processes for their preparation, and use as radiopharmaceuticals
Choudhary Non-macrocyclic chelators for metal-based radiopharmaceuticals