ATE338056T1 - Steroid sulfataseinhibitoren, verfahren zu ihrer herstellung und ihre verwendung - Google Patents
Steroid sulfataseinhibitoren, verfahren zu ihrer herstellung und ihre verwendungInfo
- Publication number
- ATE338056T1 ATE338056T1 AT00904516T AT00904516T ATE338056T1 AT E338056 T1 ATE338056 T1 AT E338056T1 AT 00904516 T AT00904516 T AT 00904516T AT 00904516 T AT00904516 T AT 00904516T AT E338056 T1 ATE338056 T1 AT E338056T1
- Authority
- AT
- Austria
- Prior art keywords
- production
- steroid sulfatase
- sulfatase inhibitors
- disclosed
- compounds
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 229940123142 Steroid sulfatase inhibitor Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 102000005262 Sulfatase Human genes 0.000 abstract 1
- 230000001419 dependent effect Effects 0.000 abstract 1
- 229940011871 estrogen Drugs 0.000 abstract 1
- 239000000262 estrogen Substances 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 150000003431 steroids Chemical class 0.000 abstract 1
- 108060007951 sulfatase Proteins 0.000 abstract 1
- 230000002194 synthesizing effect Effects 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0072—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the A ring of the steroid being aromatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/32—Antioestrogens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
- C07J41/0011—Unsubstituted amino radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0066—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by a carbon atom forming part of an amide group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0073—Sulfur-containing hetero ring
- C07J71/0094—Sulfur-containing hetero ring containing sulfur and nitrogen
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/236,842 US6288050B1 (en) | 1997-07-18 | 1999-01-25 | Steroid sulfatase inhibitors and methods for making and using the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE338056T1 true ATE338056T1 (de) | 2006-09-15 |
Family
ID=22891204
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00904516T ATE338056T1 (de) | 1999-01-25 | 2000-01-24 | Steroid sulfataseinhibitoren, verfahren zu ihrer herstellung und ihre verwendung |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US6288050B1 (de) |
| EP (1) | EP1147124B1 (de) |
| JP (1) | JP3913475B2 (de) |
| KR (1) | KR20010108127A (de) |
| CN (1) | CN1159337C (de) |
| AT (1) | ATE338056T1 (de) |
| AU (1) | AU768677C (de) |
| BR (1) | BR0008437A (de) |
| CA (1) | CA2361168A1 (de) |
| DE (1) | DE60030410T2 (de) |
| ES (1) | ES2272256T3 (de) |
| HU (1) | HUP0200096A3 (de) |
| MX (1) | MXPA01007506A (de) |
| NO (1) | NO318836B1 (de) |
| NZ (1) | NZ512923A (de) |
| WO (1) | WO2000043408A2 (de) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6476011B1 (en) * | 1991-08-28 | 2002-11-05 | Sterix Limited | Methods for introducing an estrogenic compound |
| JP2000309599A (ja) * | 1999-04-13 | 2000-11-07 | Kyowa Hakko Kogyo Co Ltd | エストラ−１，３，５（１０），１６−テトラエン誘導体 |
| US7335650B2 (en) | 2000-01-14 | 2008-02-26 | Sterix Limited | Composition |
| EP1284272A4 (de) | 2000-04-24 | 2003-09-10 | Kyowa Hakko Kogyo Kk | Östra-1,3,5(10)-trienderivate |
| CA2430288C (en) | 2000-12-01 | 2009-03-10 | Kyowa Hakko Kogyo Co., Ltd. | A composition improved in the solubility or oral absorbability |
| US8026229B2 (en) * | 2001-08-13 | 2011-09-27 | Sterix Limited | Antitumor-active 2-alkoxyestradiol sulfamates |
| IL161630A0 (en) * | 2001-11-06 | 2004-09-27 | Applied Research Systems | Methods of treating endometreosis |
| IL161762A0 (en) * | 2001-11-06 | 2005-11-20 | Applied Research Systems | Estradiol inhibiting agents in breast cancer |
| US20040042416A1 (en) * | 2002-08-27 | 2004-03-04 | Ngo Chuong Ngoc | Virtual Local Area Network auto-discovery methods |
| US20060035875A1 (en) * | 2002-10-09 | 2006-02-16 | Yukimasa Shiotsu | Remedy for hormone-dependent cancer |
| WO2004085459A1 (en) | 2003-03-24 | 2004-10-07 | Sterix Limited | Oestrogen derivatives as inhibitors of steroid sulphatase |
| GB0306717D0 (en) * | 2003-03-24 | 2003-04-30 | Sterix Ltd | Compound |
| WO2005095437A1 (ja) * | 2004-03-30 | 2005-10-13 | Kyowa Hakko Kogyo Co., Ltd. | ステロイド誘導体の製造法 |
| EP3071541B1 (de) | 2013-11-21 | 2023-06-07 | Marquette University | Substituierte (4'-hydroxyphenyl)cycloalkanverbindungen und verwendungen davon als selektive agonisten der östrogenrezeptor-isoform beta |
| JP2022506513A (ja) * | 2018-11-01 | 2022-01-17 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | アンドロゲン媒介性疾患の処置のための化合物、組成物、および方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE86393C (de) | ||||
| GB9118478D0 (en) * | 1991-08-29 | 1991-10-16 | Imperial College | Steroid sulphatase inhibitors |
| GB9118465D0 (en) | 1991-08-29 | 1991-10-16 | Imperial College | Steroid sulphatase inhibitors |
| US5556847A (en) | 1994-10-27 | 1996-09-17 | Duquesne University Of The Holy Ghost | Methods of effecting memory enhancement mediated by steroid sulfatase inhibitors |
| US5571933A (en) | 1994-11-17 | 1996-11-05 | Duquesne University Of The Holy Ghost | Derivatives of estra 1,3,5(10)triene-17-one, 3-amino compounds and their use |
| US5567831A (en) | 1995-08-16 | 1996-10-22 | Duguesne University Of The Holy Ghost | Non-steroidal sulfatase inhibitor compounds and their method of use |
| DE19540233B4 (de) * | 1995-10-19 | 2005-08-25 | Schering Ag | Sulfamat-Derivate von 1,3,5(10)-Estratrien-Derivaten, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen |
| US5763492A (en) | 1996-10-01 | 1998-06-09 | Duguesne University Of The Holy Ghost | Methods for effecting memory enhancement mediated by non-steroidal sulfatase inhibitors |
| US5763432A (en) | 1997-01-29 | 1998-06-09 | Sri International | Steriod inhibitors of estrone sulfatase and associated pharmaceutical compositions and methods of use |
| US5880115A (en) * | 1997-07-18 | 1999-03-09 | Duquesne University Of The Holy Ghost | Steroid sulfatase inhibitors and methods for making and using the same |
| US6046186A (en) * | 1997-12-24 | 2000-04-04 | Sri International | Estrone sulfamate inhibitors of estrone sulfatase, and associated pharmaceutical compositions and methods of use |
-
1999
- 1999-01-25 US US09/236,842 patent/US6288050B1/en not_active Expired - Fee Related
-
2000
- 2000-01-24 AU AU26259/00A patent/AU768677C/en not_active Ceased
- 2000-01-24 WO PCT/US2000/001723 patent/WO2000043408A2/en not_active Ceased
- 2000-01-24 CN CNB008031088A patent/CN1159337C/zh not_active Expired - Fee Related
- 2000-01-24 MX MXPA01007506A patent/MXPA01007506A/es unknown
- 2000-01-24 DE DE60030410T patent/DE60030410T2/de not_active Expired - Fee Related
- 2000-01-24 HU HU0200096A patent/HUP0200096A3/hu unknown
- 2000-01-24 NZ NZ512923A patent/NZ512923A/xx unknown
- 2000-01-24 BR BR0008437-9A patent/BR0008437A/pt not_active IP Right Cessation
- 2000-01-24 EP EP00904516A patent/EP1147124B1/de not_active Expired - Lifetime
- 2000-01-24 KR KR1020017009333A patent/KR20010108127A/ko not_active Abandoned
- 2000-01-24 AT AT00904516T patent/ATE338056T1/de not_active IP Right Cessation
- 2000-01-24 CA CA002361168A patent/CA2361168A1/en not_active Abandoned
- 2000-01-24 JP JP2000594824A patent/JP3913475B2/ja not_active Expired - Fee Related
- 2000-01-24 ES ES00904516T patent/ES2272256T3/es not_active Expired - Lifetime
-
2001
- 2001-07-24 NO NO20013632A patent/NO318836B1/no unknown
- 2001-08-03 US US09/921,668 patent/US6399595B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP1147124B1 (de) | 2006-08-30 |
| CN1340056A (zh) | 2002-03-13 |
| DE60030410D1 (de) | 2006-10-12 |
| AU2625900A (en) | 2000-08-07 |
| NO20013632D0 (no) | 2001-07-24 |
| JP3913475B2 (ja) | 2007-05-09 |
| HUP0200096A3 (en) | 2003-01-28 |
| KR20010108127A (ko) | 2001-12-07 |
| EP1147124A2 (de) | 2001-10-24 |
| CA2361168A1 (en) | 2000-07-27 |
| CN1159337C (zh) | 2004-07-28 |
| MXPA01007506A (es) | 2003-06-24 |
| US6288050B1 (en) | 2001-09-11 |
| HUP0200096A2 (hu) | 2002-07-29 |
| WO2000043408A3 (en) | 2000-11-30 |
| AU768677C (en) | 2004-11-11 |
| JP2002535340A (ja) | 2002-10-22 |
| NZ512923A (en) | 2003-01-31 |
| ES2272256T3 (es) | 2007-05-01 |
| BR0008437A (pt) | 2001-10-30 |
| NO20013632L (no) | 2001-09-03 |
| US6399595B1 (en) | 2002-06-04 |
| NO318836B1 (no) | 2005-05-09 |
| DE60030410T2 (de) | 2007-08-30 |
| WO2000043408A2 (en) | 2000-07-27 |
| AU768677B2 (en) | 2003-12-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |